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PE20070014A1 - Compuestos de alquilquinolina y alquilquinazolina como moduladores de quinasas - Google Patents

Compuestos de alquilquinolina y alquilquinazolina como moduladores de quinasas

Info

Publication number
PE20070014A1
PE20070014A1 PE2006000627A PE2006000627A PE20070014A1 PE 20070014 A1 PE20070014 A1 PE 20070014A1 PE 2006000627 A PE2006000627 A PE 2006000627A PE 2006000627 A PE2006000627 A PE 2006000627A PE 20070014 A1 PE20070014 A1 PE 20070014A1
Authority
PE
Peru
Prior art keywords
compounds
phenyl
quinazolin
pyrrolidin
piperidin
Prior art date
Application number
PE2006000627A
Other languages
English (en)
Inventor
Nand Baindur
Michael David Gaul
Christian Andrew Baumann
Guozhang Xu
Dana L Johnson
Robert W Tuman
Alexander J Kim
Kevin Douglas Kreutter
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of PE20070014A1 publication Critical patent/PE20070014A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

SE REFIERE A COMPUESTOS DE FORMULA (I) DONDE Q ES CH2 O UN ENLACE DIRECTO; G ES O U S; X ES N O CH; Z ES NH, N(ALQUILO(C1-C8)) O CH2; B ES FENILO, CICLOALQUILO(C3-C20), HETEROARILO TAL COMO FURILO, TIENILO, PIRROLILO, OXAZOLILO, ENTRE OTROS; R1 Y R2 FORMAN: -Y-(CH2)n-Ra, -CH=CH-(CH2)n-Ra, -C=C-(CH2)n-Ra, -Rbb, -O-Rc, ENTRE OTROS; DONDE Ra ES ALCOXI(C1-C8), FENOXI, HIDROXILO, ALQUILAMINO TAL COMO BUTILAMINA, ENTRE OTROS, Y n ES DE 1 A 4; R3 ES H, ALQUILO(C1-C8), HALOGENO, AMINO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: (4-MORFOLIN-4-IL-FENIL)-AMIDA DEL ACIDO 4-7-[3-(4-METIL-PIPERAZIN-1-IL)-PROPOXI]-QUINAZOLIN-4-IL-PIPERIDIN-1-CARBOXILICO, (4-PIRROLIDIN-1-IL-FENIL)-AMIDA DEL ACIDO 4-7-[2-(2-OXO-PIRROLIDIN-1-IL)-ETOXI]-QUINAZOLIN-4-IL-PIPERIDIN-1-CARBOXILICO, (4-MORFOLIN-4-IL-FENIL)-AMIDA DEL ACIDO 4-7-[2-(2-OXO-PIRROLIDIN-1-IL)-ETOXI]-QUINAZOLIN-4-IL-PIPERIDIN-1-CARBOXILICO, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCESO DE PREPARACION Y UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE TIROSINA QUINASAS TALES COMO FLT3, c-kit Y/O TrkB SIENDO UTILES EN EL TRATAMIENTO DE TRASTORNOS PROLIFERATIVOS CELULARES TALES COMO METAPLASIA MIELOIDE AGNOGENICA, MIELOFIBROSIS, CANCER DE PULMON, CANCER DE MAMA, LEUCEMIA LINFOCITICA CRONICA
PE2006000627A 2005-06-10 2006-06-07 Compuestos de alquilquinolina y alquilquinazolina como moduladores de quinasas PE20070014A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68938405P 2005-06-10 2005-06-10
US73091905P 2005-10-27 2005-10-27

Publications (1)

Publication Number Publication Date
PE20070014A1 true PE20070014A1 (es) 2007-03-08

Family

ID=37038081

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2006000627A PE20070014A1 (es) 2005-06-10 2006-06-07 Compuestos de alquilquinolina y alquilquinazolina como moduladores de quinasas

Country Status (18)

Country Link
US (1) US8071768B2 (es)
EP (1) EP1893598A1 (es)
JP (1) JP2009501135A (es)
KR (1) KR20080028912A (es)
AR (1) AR054386A1 (es)
AU (1) AU2006257945A1 (es)
BR (1) BRPI0611964A2 (es)
CA (1) CA2611242A1 (es)
CR (1) CR9652A (es)
EA (1) EA200800017A1 (es)
EC (1) ECSP077997A (es)
GT (1) GT200600251A (es)
IL (1) IL187692A0 (es)
NO (1) NO20080174L (es)
PE (1) PE20070014A1 (es)
TW (1) TW200716599A (es)
UY (1) UY29588A1 (es)
WO (1) WO2006135721A1 (es)

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WO2012041872A1 (en) 2010-09-29 2012-04-05 Intervet International B.V. N-heteroaryl compounds with cyclic bridging unit for the treatment of parasitic diseases
WO2013014170A1 (en) 2011-07-27 2013-01-31 Ab Science Oxazole and thiazole derivatives as selective protein kinase inhibitors (c-kit)
NZ716598A (en) * 2012-11-20 2017-02-24 Merial Inc Anthelmintic compounds and compositions and method of using thereof
BR112016008080B1 (pt) * 2013-10-16 2021-02-23 Fujifilm Corporation sal de ácido carboxílico ou um sal de ácido mineral, cristal de succinato, cristal de fumarato e composição farmacêutica
US20170305857A1 (en) * 2013-12-20 2017-10-26 Pfizer Limited N-acylpiperidine ether tropomyosin-related kinase inhibitors
UY36390A (es) * 2014-11-05 2016-06-01 Flexus Biosciences Inc Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido), sus métodos de síntesis y composiciones farmacéuticas que los contienen
CN107205970A (zh) 2014-11-05 2017-09-26 弗莱塞斯生物科学公司 免疫调节剂
JP6412471B2 (ja) * 2015-07-15 2018-10-24 富士フイルム株式会社 含窒素複素環化合物の製造方法およびその中間体
TWI731420B (zh) * 2018-09-27 2021-06-21 大陸商深圳微芯生物科技股份有限公司 具有吲哚胺-2,3-雙加氧酶抑制活性的喹啉衍生物及其製備方法、藥物組合物、聯合用藥物與用途
US20220154220A1 (en) * 2018-12-21 2022-05-19 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Small molecules for increasing precise genome editing efficiency

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Also Published As

Publication number Publication date
CA2611242A1 (en) 2006-12-21
KR20080028912A (ko) 2008-04-02
JP2009501135A (ja) 2009-01-15
TW200716599A (en) 2007-05-01
IL187692A0 (en) 2008-08-07
CR9652A (es) 2008-09-09
AU2006257945A1 (en) 2006-12-21
BRPI0611964A2 (pt) 2009-01-27
GT200600251A (es) 2007-01-12
UY29588A1 (es) 2006-10-02
US8071768B2 (en) 2011-12-06
ECSP077997A (es) 2008-01-23
EP1893598A1 (en) 2008-03-05
NO20080174L (no) 2008-02-19
WO2006135721A1 (en) 2006-12-21
EA200800017A1 (ru) 2008-08-29
AR054386A1 (es) 2007-06-20
US20060281772A1 (en) 2006-12-14

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