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PE20090591A1 - Derivados monoamida como antagonistas del receptor de orexina - Google Patents

Derivados monoamida como antagonistas del receptor de orexina

Info

Publication number
PE20090591A1
PE20090591A1 PE2008001297A PE2008001297A PE20090591A1 PE 20090591 A1 PE20090591 A1 PE 20090591A1 PE 2008001297 A PE2008001297 A PE 2008001297A PE 2008001297 A PE2008001297 A PE 2008001297A PE 20090591 A1 PE20090591 A1 PE 20090591A1
Authority
PE
Peru
Prior art keywords
hydroxy
phenyl
acetamide
ethyl
lower alkyl
Prior art date
Application number
PE2008001297A
Other languages
English (en)
Inventor
Henner Knust
Matthias Nettekoven
Emmanuel Pinard
Olivier Roche
Mark Rogers-Evans
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PE20090591A1 publication Critical patent/PE20090591A1/es

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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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Abstract

REFERIDA A COMPUESTOS DERIVADOS DE MONOAMIDA DE FORMULA (I) DONDE Ar ES ARILO O HETEROARILO; R1 ES H, HALOGENO, CN, SO2-ALQUILO INFERIOR, ENTRE OTROS; R2 ES H, ALQUILO INFERIOR, NO2, HIDROXI, ENTRE OTROS; R3 ES H, ALCOXI INFERIOR, 3-HIDROXI-OXETAN-3-ILO, ENTRE OTROS; R4 Y R5 SON CADA UNO H, -(CR''2)mOH, -NRR', ENTRE OTROS, DONDE R Y R' SON CADA UNO H, C(O)H, -(CR''2)m-NR''2, ENTRE OTROS, EN DONDE R'' ES H, ALCOXI INFERIOR, FENILO O ALQUILO INFERIOR; n ES DE 1 A 4; o, p Y m SON CADA UNO DE 1 A 3. SON COMPUESTOS PREFERIDOS: N-(3,4-DIMETOXIFENIL)-2-HIDROXI-2-(2-METOXIFENIL)-N-{2-[4-(TRIFLUOROMETIL)FENIL]ETIL}ACETAMIDA, (2S)-N-(3,4-DIMETOXIFENIL)-2-HIDROXI-2-FENIL-N-{2-[4-(TRIFLUOROMETIL)FENIL]ETIL}ACETAMIDA, N-(3,4-DIMETOXIFENIL)-2-(4-FLUOROFENIL)-2-HIDROXI-N-{2-[4-(TRIFLUOROMETIL)FENIL]ETIL}ACETAMIDA, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON ANTAGONISTAS DEL RECEPTOR DE OREXINA SIENDO UTILES EN EL TRATAMIENTO DE NARCOLEPSIA, NEUROSIS DEPRESIVA, ENFERMEDAD DE ALZHEIMER, SINDROME DE TOURETTE
PE2008001297A 2007-08-02 2008-08-01 Derivados monoamida como antagonistas del receptor de orexina PE20090591A1 (es)

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PT2491038T (pt) 2009-10-23 2016-07-14 Janssen Pharmaceutica Nv Octahidropirrolo[3,4-c]pirrolos disubstituídos como modeladores de recetores de orexina
EP2493299A4 (en) * 2009-10-29 2013-04-17 Merck Sharp & Dohme TERTIARY AMIDOREXIN RECEPTOR ANTAGONISTS
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SG11201404738QA (en) 2012-02-07 2014-10-30 Eolas Therapeutics Inc Substituted prolines / piperidines as orexin receptor antagonists
US9440982B2 (en) 2012-02-07 2016-09-13 Eolas Therapeutics, Inc. Substituted prolines/piperidines as orexin receptor antagonists
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WO2016025669A1 (en) 2014-08-13 2016-02-18 Eolas Therapeutics, Inc. Difluoropyrrolidines as orexin receptor modulators
CN104496841B (zh) * 2014-11-26 2017-01-25 南京工业大学 一种米拉贝隆中间体的合成方法
WO2017139603A1 (en) 2016-02-12 2017-08-17 Astrazeneca Ab Halo-substituted piperidines as orexin receptor modulators
KR102559922B1 (ko) 2016-03-10 2023-07-25 얀센 파마슈티카 엔.브이. 오렉신-2 수용체 길항제를 사용한 우울증의 치료 방법
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