PE20060875A1 - Derivados de triazol sustituidos como antagonistas de oxitocina - Google Patents
Derivados de triazol sustituidos como antagonistas de oxitocinaInfo
- Publication number
- PE20060875A1 PE20060875A1 PE2006000072A PE2006000072A PE20060875A1 PE 20060875 A1 PE20060875 A1 PE 20060875A1 PE 2006000072 A PE2006000072 A PE 2006000072A PE 2006000072 A PE2006000072 A PE 2006000072A PE 20060875 A1 PE20060875 A1 PE 20060875A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- metoxypyridine
- triazol
- piperidin
- triazole derivatives
- Prior art date
Links
- 239000003336 oxytocin antagonist Substances 0.000 title 1
- 229940121361 oxytocin antagonists Drugs 0.000 title 1
- 229940042055 systemic antimycotics triazole derivative Drugs 0.000 title 1
- -1 3-FLUORO-2-METHYLPHENOXY Chemical class 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical class [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 2
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 abstract 1
- 208000005171 Dysmenorrhea Diseases 0.000 abstract 1
- 206010013935 Dysmenorrhoea Diseases 0.000 abstract 1
- XNOPRXBHLZRZKH-UHFFFAOYSA-N Oxytocin Natural products N1C(=O)C(N)CSSCC(C(=O)N2C(CCC2)C(=O)NC(CC(C)C)C(=O)NCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C(C(C)CC)NC(=O)C1CC1=CC=C(O)C=C1 XNOPRXBHLZRZKH-UHFFFAOYSA-N 0.000 abstract 1
- 101800000989 Oxytocin Proteins 0.000 abstract 1
- 102100031951 Oxytocin-neurophysin 1 Human genes 0.000 abstract 1
- 208000006399 Premature Obstetric Labor Diseases 0.000 abstract 1
- 206010036600 Premature labour Diseases 0.000 abstract 1
- 208000004403 Prostatic Hyperplasia Diseases 0.000 abstract 1
- 201000001880 Sexual dysfunction Diseases 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical group [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 abstract 1
- XNOPRXBHLZRZKH-DSZYJQQASA-N oxytocin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@H](N)C(=O)N1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 XNOPRXBHLZRZKH-DSZYJQQASA-N 0.000 abstract 1
- 229960001723 oxytocin Drugs 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 208000026440 premature labor Diseases 0.000 abstract 1
- 231100000872 sexual dysfunction Toxicity 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Reproductive Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Gastroenterology & Hepatology (AREA)
- Gynecology & Obstetrics (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
SE REFIERE A UN COMPUESTO DE FORMULA (I) DONDE m ES 1-4;n ES 1-2 CON LA CONDICION DE QUE m+n ESTA EN EL INTERVALO DE 2 A 5 X ES O, NH, N-ALQUILO(C1-C6), ENTRE OTROS; R1 ES FENILO, NAFTILO, ANILLO HETEROCICLICO AROMATICO DE 5-6 MIEMBROS QUE CONTIENE 1-3 HETEROATOMOS SELECCIONADOS ENTRE N, O, S Y N-OXIDOS DE LOS MISMOS, ENTRE OTROS; R2 ES H, HIDROXI, ALQUILO C1-C6 SUSTITUIDO O NO CON O-ALQUILO C1-C6, ENTRE OTROS; R3 ES H, ALQUILO C1-C6, ALCOXI C1-C6-(ALQUILO C1-C6); R4, R5, R6 Y R7 SON CADA UNO H, HALO, HIDROXI, CN, ENTRE OTROS; R8 ES H, ALQUILO C1-C6, CH2OH, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 5-[3-[4-(3-FLUORO-2-METILFENOXI)PIPERIDIN-1-IL]-5-METIL-4H-1,2,4-TRIAZOL-4-IL]-2-METOXIPIRIDINA; 5-[3-[4-(5-FLUORO-2-METILFENOXI)PIPERIDIN-1-IL]-5-(METOXIMETIL)-4H-1,2,4-TRIAZOL-4-IL]-2-METOXIPIRIDINA; 5-[3-[4-(2-CLOROFENOXI)PIPERIDIN-1-IL]-5-(METOXIMETIL)-4H-1,2,4-TRIAZOL-4-IL]-2-METOXIPIRIDINA; ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON ANTAGONISTAS DE OXITOCINA, UTILES EN EL TRATAMIENTO DE DISFUNCION SEXUAL, PARTO PREMATURO, HIPERPLASIA PROSTATICA BENIGNA, DISMENORREA, ENTRE OTROS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0501190.3A GB0501190D0 (en) | 2005-01-20 | 2005-01-20 | Novel pharmaceuticals |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20060875A1 true PE20060875A1 (es) | 2006-09-04 |
Family
ID=34259404
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2006000072A PE20060875A1 (es) | 2005-01-20 | 2006-01-17 | Derivados de triazol sustituidos como antagonistas de oxitocina |
Country Status (31)
| Country | Link |
|---|---|
| US (5) | US7557131B2 (es) |
| EP (1) | EP1841758B1 (es) |
| JP (1) | JP4124805B1 (es) |
| KR (1) | KR100936854B1 (es) |
| CN (1) | CN101107243B (es) |
| AP (1) | AP2007004047A0 (es) |
| AR (1) | AR055303A1 (es) |
| AT (1) | ATE449091T1 (es) |
| AU (1) | AU2006207300B2 (es) |
| BR (1) | BRPI0606463A2 (es) |
| CA (1) | CA2595569C (es) |
| CR (1) | CR9219A (es) |
| DE (1) | DE602006010508D1 (es) |
| DK (1) | DK1841758T3 (es) |
| DO (1) | DOP2006000014A (es) |
| EA (1) | EA200701328A1 (es) |
| ES (1) | ES2334517T3 (es) |
| GB (1) | GB0501190D0 (es) |
| GT (1) | GT200600024A (es) |
| IL (1) | IL184148A (es) |
| MA (1) | MA29160B1 (es) |
| MX (1) | MX2007008757A (es) |
| NL (1) | NL1030961C2 (es) |
| NO (1) | NO338420B1 (es) |
| PA (1) | PA8660401A1 (es) |
| PE (1) | PE20060875A1 (es) |
| TN (1) | TNSN07275A1 (es) |
| TW (1) | TW200637847A (es) |
| UY (1) | UY29339A1 (es) |
| WO (1) | WO2006077496A1 (es) |
| ZA (1) | ZA200705718B (es) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06284516A (ja) * | 1993-03-31 | 1994-10-07 | Mitsubishi Electric Corp | 電気車制御装置 |
| AP2007004047A0 (en) | 2005-01-20 | 2007-06-30 | Pfizer Ltd | Substituted triazole derivatives as oxtocin antagonists |
| GB0504556D0 (en) * | 2005-03-04 | 2005-04-13 | Pfizer Ltd | Novel pharmaceuticals |
| EP1902051A1 (en) * | 2005-06-09 | 2008-03-26 | Merck Frosst Canada Ltd. | Azacyclohexane derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase |
| GB0607196D0 (en) * | 2006-04-11 | 2006-05-17 | Prosidion Ltd | G-protein coupled receptor agonists |
| US20090170828A1 (en) * | 2006-06-12 | 2009-07-02 | Elise Isabel | Azetidine Derivatives as Inhibitors of Stearoyl-Coenzyme a Delta-9 Desaturase |
| EP2032570A4 (en) * | 2006-06-13 | 2010-10-27 | Merck Frosst Canada Ltd | AZACYCLOPENTATE DERIVATIVES AS INHIBITORS OF STEAROYL-COENZYME-A-DELTA-9-DESATURASE |
| JP2010527915A (ja) * | 2007-04-26 | 2010-08-19 | アバロン ファーマシューティカルズ，インコーポレイテッド | 多重環化合物及びその用途 |
| MX2010007660A (es) * | 2008-01-31 | 2010-08-10 | Sanofi Aventis | Indol-3-carboxamidas ciclicas, su preparacion y su uso como productos farmaceuticos. |
| WO2009095162A1 (en) | 2008-01-31 | 2009-08-06 | Sanofi-Aventis | Cyclic azaindole-3-carboxamides, their preparation and their use as pharmaceuticals |
| PL2872487T3 (pl) * | 2012-07-16 | 2017-09-29 | Fibrogen, Inc. | Sposób wytwarzania związków izochinolinowych |
| US10570146B2 (en) * | 2014-07-25 | 2020-02-25 | Northeastern University | Urea/carbamates FAAH MAGL or dual FAAH/MAGL inhibitors and uses thereof |
| JOP20190072A1 (ar) * | 2016-10-13 | 2019-04-07 | Glaxosmithkline Ip Dev Ltd | مشتقات 1، 3 سيكلوبوتان ثنائي الاستبدال أو آزيتيدين كمثبطات للإنزيم المخلق للبروستاجلاندين d المكون للدم |
| FI3541784T3 (fi) | 2016-11-18 | 2023-10-02 | Integrative Res Laboratories Sweden Ab | Uudet atsetidiinijohdannaiset, jotka ovat hyödyllisiä kortikaalisen katekoliamiini-neurotransmission modulaattoreina |
| CN108884071B (zh) * | 2016-12-21 | 2021-05-14 | 江苏恒瑞医药股份有限公司 | 稠环基氮杂环丁基三唑类衍生物、其制备方法及其在医药上的应用 |
| MX2019007360A (es) * | 2016-12-28 | 2019-08-16 | Jiangsu Hengrui Medicine Co | Derivado de triazol azabiciclo-sustituido, preparacion, metodo del mismo, y aplicacion de la misma en medicina. |
| CN111094272B (zh) * | 2018-06-20 | 2022-05-27 | 江苏恒瑞医药股份有限公司 | 一种otr抑制剂的可药用盐、晶型及制备方法 |
| CN111094273B (zh) * | 2018-06-20 | 2022-04-12 | 江苏恒瑞医药股份有限公司 | 催产素受体抑制剂的晶型及其制备方法 |
| CN111902406B (zh) * | 2018-06-27 | 2022-11-18 | 江苏恒瑞医药股份有限公司 | 氮杂双环基取代的三唑类衍生物的可药用盐、晶型及制备方法 |
| CN113004250B (zh) * | 2019-12-19 | 2022-07-26 | 上海森辉医药有限公司 | 一种制备取代的三唑衍生物的方法 |
| CN113582818B (zh) * | 2021-08-30 | 2023-08-01 | 上海日异生物科技有限公司 | 一种3-卤-2-烷基苯酚的合成方法 |
| MX2024010096A (es) * | 2022-02-16 | 2024-08-28 | Duke Street Bio Ltd | Compuesto farmaceutico. |
| CN114805161B (zh) * | 2022-06-14 | 2023-08-25 | 南通华祥医药科技有限公司 | 一种3-氟丫丁啶盐酸盐的制备方法 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4554276A (en) | 1983-10-03 | 1985-11-19 | Pfizer Inc. | 2-Amino-5-hydroxy-4-methylpyrimidine derivatives |
| US5053411A (en) | 1989-04-20 | 1991-10-01 | Anaquest, Inc. | N-aryl-N-[4-(1-heterocyclicalkyl)piperidinyl]amides and pharmaceutical compositions and methods employing such compounds |
| DE4124942A1 (de) | 1991-07-27 | 1993-01-28 | Thomae Gmbh Dr K | 5-gliedrige heterocyclen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| DE4302051A1 (de) | 1993-01-26 | 1994-07-28 | Thomae Gmbh Dr K | 5-gliedrige Heterocyclen, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
| JP2000509371A (ja) | 1996-04-03 | 2000-07-25 | メルク エンド カンパニー インコーポレーテッド | ファルネシル―タンパク質トランスフェラーゼ阻害剤 |
| WO1997036585A1 (en) | 1996-04-03 | 1997-10-09 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| EP0891356A1 (en) | 1996-04-03 | 1999-01-20 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| JP2000507955A (ja) | 1996-04-03 | 2000-06-27 | メルク エンド カンパニー インコーポレーテッド | ファルネシル―タンパク質転移酵素の阻害剤 |
| EP1003374A1 (en) | 1996-12-30 | 2000-05-31 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| ES2258300T3 (es) | 1997-12-16 | 2006-08-16 | Pfizer Products Inc. | Combinacion de antagonistas del receptor alfa-1-adrenergico y un inhibidor gmpc pdev para el tratamiento de la impotencia. |
| BR0012697A (pt) | 1999-07-23 | 2002-04-09 | Shionogi & Co | Inibidores da diferenciação de th2 |
| WO2001029011A2 (en) | 1999-10-15 | 2001-04-26 | F. Hoffmann-La Roche Ag | Benzodiazepine derivatives as metabotropic glutamate receptor antagonists |
| AU779426B2 (en) | 1999-11-15 | 2005-01-27 | Janssen Pharmaceutica N.V. | Triazoles as farnesyl transferase inhibitors |
| WO2001076582A1 (fr) | 2000-04-05 | 2001-10-18 | Shionogi & Co., Ltd. | Micro-emulsions huile dans eau contenant des composes tricycliques ou des preconcentres de ceux-ci |
| PL359340A1 (en) | 2000-05-19 | 2004-08-23 | Triazole derivatives | |
| US20030216385A1 (en) | 2000-05-19 | 2003-11-20 | Takahiko Tobe | Triazole derivatives |
| CA2462645A1 (en) | 2001-10-03 | 2003-11-13 | Pharmacia Corporation | Substituted 5-membered polycyclic compounds useful for selective inhibition of the coagulation cascade |
| GB0130677D0 (en) | 2001-12-21 | 2002-02-06 | Glaxo Group Ltd | Medicaments and novel compounds |
| GB0208579D0 (en) | 2002-04-13 | 2002-05-22 | British Biotech Pharm | Antibacterial agents |
| GB0224919D0 (en) | 2002-10-25 | 2002-12-04 | Pfizer Ltd | Triazole compounds useful in therapy |
| US20040167188A1 (en) | 2003-02-14 | 2004-08-26 | Zhili Xin | Protein-tyrosine phosphatase inhibitors and uses thereof |
| US7169797B2 (en) | 2003-02-14 | 2007-01-30 | Abbott Laboratories | Protein-tyrosine phosphatase inhibitors and uses thereof |
| JP2007505888A (ja) * | 2003-09-22 | 2007-03-15 | ファイザー インコーポレイテッド | オキシトシン拮抗薬としての置換トリアゾール誘導体 |
| GEP20084571B (en) | 2003-12-22 | 2008-12-25 | Pfizer | Triazole derivatives as vasopressin antagonists |
| WO2005082866A2 (en) * | 2004-02-20 | 2005-09-09 | Pfizer Limited | Substituted 1, 2, 4- triazole derivatives as oxytocin antagonists |
| EP1742932A1 (en) | 2004-04-28 | 2007-01-17 | Pfizer Limited | 3-heterocyclyl-4-phenyl-triazole derivatives as inhibitors of the vasopressin v1a receptor |
| AP2007004047A0 (en) | 2005-01-20 | 2007-06-30 | Pfizer Ltd | Substituted triazole derivatives as oxtocin antagonists |
-
2005
- 2005-01-11 AP AP2007004047A patent/AP2007004047A0/xx unknown
- 2005-01-20 GB GBGB0501190.3A patent/GB0501190D0/en not_active Ceased
-
2006
- 2006-01-11 MX MX2007008757A patent/MX2007008757A/es active IP Right Grant
- 2006-01-11 CA CA2595569A patent/CA2595569C/en not_active Expired - Lifetime
- 2006-01-11 BR BRPI0606463-9A patent/BRPI0606463A2/pt not_active IP Right Cessation
- 2006-01-11 KR KR1020077016553A patent/KR100936854B1/ko not_active Expired - Fee Related
- 2006-01-11 EP EP06710261A patent/EP1841758B1/en not_active Expired - Lifetime
- 2006-01-11 AT AT06710261T patent/ATE449091T1/de not_active IP Right Cessation
- 2006-01-11 JP JP2007551766A patent/JP4124805B1/ja not_active Expired - Fee Related
- 2006-01-11 WO PCT/IB2006/000118 patent/WO2006077496A1/en not_active Ceased
- 2006-01-11 ES ES06710261T patent/ES2334517T3/es not_active Expired - Lifetime
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