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TW200637847A - Substituted triazole derivatives as oxytocin antagonists - Google Patents

Substituted triazole derivatives as oxytocin antagonists

Info

Publication number
TW200637847A
TW200637847A TW095102071A TW95102071A TW200637847A TW 200637847 A TW200637847 A TW 200637847A TW 095102071 A TW095102071 A TW 095102071A TW 95102071 A TW95102071 A TW 95102071A TW 200637847 A TW200637847 A TW 200637847A
Authority
TW
Taiwan
Prior art keywords
triazole derivatives
substituted triazole
oxytocin antagonists
oxytocin
antagonists
Prior art date
Application number
TW095102071A
Other languages
English (en)
Inventor
Alan Daniel Brown
Andrew Antony Calabrese
David Ellis
Original Assignee
Pfizer Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Ltd filed Critical Pfizer Ltd
Publication of TW200637847A publication Critical patent/TW200637847A/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Hospice & Palliative Care (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
TW095102071A 2005-01-20 2006-01-19 Substituted triazole derivatives as oxytocin antagonists TW200637847A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0501190.3A GB0501190D0 (en) 2005-01-20 2005-01-20 Novel pharmaceuticals

Publications (1)

Publication Number Publication Date
TW200637847A true TW200637847A (en) 2006-11-01

Family

ID=34259404

Family Applications (1)

Application Number Title Priority Date Filing Date
TW095102071A TW200637847A (en) 2005-01-20 2006-01-19 Substituted triazole derivatives as oxytocin antagonists

Country Status (31)

Country Link
US (5) US7557131B2 (zh)
EP (1) EP1841758B1 (zh)
JP (1) JP4124805B1 (zh)
KR (1) KR100936854B1 (zh)
CN (1) CN101107243B (zh)
AP (1) AP2007004047A0 (zh)
AR (1) AR055303A1 (zh)
AT (1) ATE449091T1 (zh)
AU (1) AU2006207300B2 (zh)
BR (1) BRPI0606463A2 (zh)
CA (1) CA2595569C (zh)
CR (1) CR9219A (zh)
DE (1) DE602006010508D1 (zh)
DK (1) DK1841758T3 (zh)
DO (1) DOP2006000014A (zh)
EA (1) EA200701328A1 (zh)
ES (1) ES2334517T3 (zh)
GB (1) GB0501190D0 (zh)
GT (1) GT200600024A (zh)
IL (1) IL184148A (zh)
MA (1) MA29160B1 (zh)
MX (1) MX2007008757A (zh)
NL (1) NL1030961C2 (zh)
NO (1) NO338420B1 (zh)
PA (1) PA8660401A1 (zh)
PE (1) PE20060875A1 (zh)
TN (1) TNSN07275A1 (zh)
TW (1) TW200637847A (zh)
UY (1) UY29339A1 (zh)
WO (1) WO2006077496A1 (zh)
ZA (1) ZA200705718B (zh)

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GB0504556D0 (en) * 2005-03-04 2005-04-13 Pfizer Ltd Novel pharmaceuticals
AU2006255465A1 (en) * 2005-06-09 2006-12-14 Merck Frosst Canada Ltd Azacyclohexane derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase
GB0607196D0 (en) * 2006-04-11 2006-05-17 Prosidion Ltd G-protein coupled receptor agonists
JP2009539884A (ja) * 2006-06-12 2009-11-19 メルク フロスト カナダ リミテツド ステアロイル−コエンザイムａデルタ−９デサチュラーゼのインヒビターとしてのアゼチジン誘導体
EP2032570A4 (en) * 2006-06-13 2010-10-27 Merck Frosst Canada Ltd AZACYCLOPENTATE DERIVATIVES AS INHIBITORS OF STEAROYL-COENZYME-A-DELTA-9-DESATURASE
CA2685029A1 (en) * 2007-04-26 2008-11-06 Avalon Pharmaceuticals Multi-ring compounds and uses thereof
BRPI0906727A2 (pt) * 2008-01-31 2015-08-04 Sanofi Aventis Azaindol-3-carboxamidas cíclicas, sua preparação e seu uso como produtos farmacêuticos
AU2009210297B2 (en) 2008-01-31 2013-11-21 Sanofi Cyclic indole-3-carboxamides, their preparation and their use as pharmaceuticals
CA2879238C (en) * 2012-07-16 2021-08-10 Fibrogen, Inc. Process for making isoquinoline compounds
WO2016014975A2 (en) * 2014-07-25 2016-01-28 Northeastern University Urea/carbamates faah magl or dual faah/magl inhibitors and uses thereof
JOP20190072A1 (ar) * 2016-10-13 2019-04-07 Glaxosmithkline Ip Dev Ltd مشتقات 1، 3 سيكلوبوتان ثنائي الاستبدال أو آزيتيدين كمثبطات للإنزيم المخلق للبروستاجلاندين d المكون للدم
JP6990702B2 (ja) 2016-11-18 2022-01-13 インテグレーティブ リサーチ ラボラトリーズ スウェーデン アーベー 皮質カテコールアミン作動性神経伝達のモジュレーターとして有用な新規アゼチジン誘導体
MX2019007213A (es) 2016-12-21 2019-08-16 Jiangsu Hengrui Medicine Co Derivado de azaciclobutil triazol del grupo anular condensado, metodo de preparacion del mismo y uso del mismo en medicina.
US20210040073A1 (en) * 2016-12-28 2021-02-11 Jiangsu Hengrui Medicine Co., Ltd. Azabicyclo-substituted triazole derivative, preparation method thereof, and application of same in medicine
TW202016092A (zh) * 2018-06-20 2020-05-01 大陸商江蘇恆瑞醫藥股份有限公司 Ｏｔｒ抑制劑的晶型及其製備方法
TW202016091A (zh) * 2018-06-20 2020-05-01 大陸商江蘇恆瑞醫藥股份有限公司 一種ｏｔｒ抑制劑的可藥用鹽、晶型及製備方法
WO2020001460A1 (zh) * 2018-06-27 2020-01-02 江苏恒瑞医药股份有限公司 氮杂双环基取代的三唑类衍生物的可药用盐、晶型及制备方法
CN113004250B (zh) * 2019-12-19 2022-07-26 上海森辉医药有限公司 一种制备取代的三唑衍生物的方法
CN113582818B (zh) * 2021-08-30 2023-08-01 上海日异生物科技有限公司 一种3-卤-2-烷基苯酚的合成方法
EP4444305A2 (en) * 2022-02-16 2024-10-16 Duke Street Bio Limited Pharmaceutical compound
CN114805161B (zh) * 2022-06-14 2023-08-25 南通华祥医药科技有限公司 一种3-氟丫丁啶盐酸盐的制备方法

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Also Published As

Publication number Publication date
NO338420B1 (no) 2016-08-15
US9023872B2 (en) 2015-05-05
EP1841758A1 (en) 2007-10-10
KR100936854B1 (ko) 2010-01-14
CN101107243B (zh) 2010-11-24
AP2007004047A0 (en) 2007-06-30
AU2006207300A1 (en) 2006-07-27
HK1113927A1 (zh) 2008-10-17
NL1030961C2 (nl) 2007-01-12
TNSN07275A1 (fr) 2008-12-31
CA2595569A1 (en) 2006-07-27
ATE449091T1 (de) 2009-12-15
IL184148A0 (en) 2007-10-31
GB0501190D0 (en) 2005-03-02
AU2006207300B2 (en) 2011-03-03
US10150752B2 (en) 2018-12-11
IL184148A (en) 2013-06-27
US20150322042A1 (en) 2015-11-12
ES2334517T3 (es) 2010-03-11
EP1841758B1 (en) 2009-11-18
ZA200705718B (en) 2008-08-27
UY29339A1 (es) 2006-08-31
NO20074177L (no) 2007-10-16
PE20060875A1 (es) 2006-09-04
DK1841758T3 (da) 2010-01-18
US7557131B2 (en) 2009-07-07
CA2595569C (en) 2010-07-20
US9394278B2 (en) 2016-07-19
PA8660401A1 (es) 2006-09-08
US20170114040A1 (en) 2017-04-27
GT200600024A (es) 2006-08-23
US8207198B2 (en) 2012-06-26
BRPI0606463A2 (pt) 2009-06-30
KR20070091023A (ko) 2007-09-06
MA29160B1 (fr) 2008-01-02
EA200701328A1 (ru) 2007-12-28
US20090253674A1 (en) 2009-10-08
US20060160786A1 (en) 2006-07-20
CN101107243A (zh) 2008-01-16
JP2008528476A (ja) 2008-07-31
AR055303A1 (es) 2007-08-15
NL1030961A1 (nl) 2006-07-21
WO2006077496A1 (en) 2006-07-27
US20130137671A1 (en) 2013-05-30
JP4124805B1 (ja) 2008-07-23
CR9219A (es) 2007-07-24
MX2007008757A (es) 2008-03-10
DOP2006000014A (es) 2006-07-31
DE602006010508D1 (de) 2009-12-31

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