PE20060734A1 - Derivado de pirrol sustituido como antagonistas del receptor de androgenos - Google Patents
Derivado de pirrol sustituido como antagonistas del receptor de androgenosInfo
- Publication number
- PE20060734A1 PE20060734A1 PE2005001433A PE2005001433A PE20060734A1 PE 20060734 A1 PE20060734 A1 PE 20060734A1 PE 2005001433 A PE2005001433 A PE 2005001433A PE 2005001433 A PE2005001433 A PE 2005001433A PE 20060734 A1 PE20060734 A1 PE 20060734A1
- Authority
- PE
- Peru
- Prior art keywords
- substituted
- pirrol
- androgen receptor
- methyl
- antagonists
- Prior art date
Links
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical group C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 title abstract 2
- 102000001307 androgen receptors Human genes 0.000 title 1
- 108010080146 androgen receptors Proteins 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 2
- 229940123407 Androgen receptor antagonist Drugs 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- WZKSXHQDXQKIQJ-UHFFFAOYSA-N F[C](F)F Chemical class F[C](F)F WZKSXHQDXQKIQJ-UHFFFAOYSA-N 0.000 abstract 1
- 239000003936 androgen receptor antagonist Substances 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
- C07D207/327—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
REFERIDA A UN COMPUESTO DERIVADO DE PIRROL DE FORMULA I, DONDE R1 ES H, CN, COORA; RA ES ALQUILO C1-C6 OPCIONALMENTE SUSTITUIDO; R2 Y R4 SON H, ALQUILO C1-C6, TRIFLUOROMETILO, ENTRE OTROS; R3 ES UN GRUPO DE FORMULA (a); X ES HALOGENO; Y ES CARBONO O N; Alk ES ALQUILENO C1-C4 OPCIONALMENTE SUSTITUIDO; RB ES H O ACILO; R5 ES FENILO QUE TIENE UN GRUPO CIANO EN LA POSICION 4 O EN LA POSICION 3 Y TAMBIEN PUEDE ESTAR SUSTITUIDO. SON COMPUESTOS PREFERIDOS: 1-{[6-CLORO-5-(HIDROXIMETIL)PIRIDIN-3-IL]METIL}-4-(4-CIANOFENIL)-2,5-DIMETIL-1H-PIRROL-3-CARBONITRILO, 1-{[6-CLORO-5-(HIDROXIMETIL)PIRIDIN-3-IL]METIL}-4-(4-CIANOFENIL)-2-ETIL-5-METIL-1H-PIRROL-3-CARBONITRILO, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UN MEDICAMENTO Y A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS SON ANTAGONISTAS DEL RECEPTOR DE ANDROGENOS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004361641 | 2004-12-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20060734A1 true PE20060734A1 (es) | 2006-09-05 |
Family
ID=35883518
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2005001433A PE20060734A1 (es) | 2004-12-14 | 2005-12-12 | Derivado de pirrol sustituido como antagonistas del receptor de androgenos |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20080176906A1 (es) |
| EP (1) | EP1824841A1 (es) |
| JP (1) | JP2008523052A (es) |
| AR (1) | AR051713A1 (es) |
| PE (1) | PE20060734A1 (es) |
| TW (1) | TW200628446A (es) |
| WO (1) | WO2006064944A1 (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008153091A1 (ja) | 2007-06-13 | 2008-12-18 | Takeda Pharmaceutical Company Limited | スクリーニング方法 |
| GB0711776D0 (en) * | 2007-06-18 | 2007-07-25 | Syngenta Participations Ag | Substituted aromatic heterocyclic compounds as fungicides |
| US20100227846A1 (en) * | 2007-08-30 | 2010-09-09 | Takeda Pharmaceutical Company Limited | Substituted pyrazole derivative |
| ES2413504T3 (es) | 2007-12-21 | 2013-07-16 | Ligand Pharmaceuticals Inc. | Moduladores selectivos del receptor de andrógeno (SARM) y usos de los mismos |
| PE20091653A1 (es) * | 2008-03-26 | 2009-11-14 | Takeda Pharmaceutical | Derivados sustituidos de pirazol y su uso |
| EP2765130B1 (en) | 2009-02-25 | 2017-07-26 | Takeda Pharmaceutical Company Limited | Intermediates for use in a process of producing pyrrole compounds |
| PH12013500534A1 (en) | 2010-10-22 | 2017-08-09 | Astellas Pharma Inc | Antagonist for mutant androgen receptor |
| EP3233127A1 (de) * | 2014-12-15 | 2017-10-25 | Bayer Pharma Aktiengesellschaft | Antikörper-wirkstoff-konjugate (adcs) von ksp-inhibitoren mit aglycosylierten anti-tweakrantikörpern |
| CN105218437A (zh) * | 2015-10-31 | 2016-01-06 | 高大元 | 一种3-氯-5-溴-2-吡啶甲酸的合成方法 |
| BR112021020864A2 (pt) | 2019-04-19 | 2021-12-14 | Ligand Pharm Inc | Formas cristalinas e métodos de produção de formas cristalinas de um composto |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6017924A (en) * | 1996-06-27 | 2000-01-25 | Ligand Pharmaceuticals Incorporated | Androgen receptor modulator compounds and methods |
| GB0016453D0 (en) * | 2000-07-04 | 2000-08-23 | Hoffmann La Roche | Pyrrole derivatives |
| US6861432B2 (en) * | 2001-11-23 | 2005-03-01 | Schering Aktiengesellschaft | Piperazine derivatives that destabilize androgen receptors |
| WO2003057669A1 (fr) * | 2001-12-28 | 2003-07-17 | Takeda Chemical Industries, Ltd. | Antagonistes du recepteur androgene |
| US7297698B2 (en) * | 2002-07-12 | 2007-11-20 | Astellas Pharma Inc. | N-phenyl-(2R,5S) dimethylpiperazine derivative |
| MXPA05007605A (es) * | 2003-01-17 | 2005-09-30 | Warner Lambert Co | Antagonista del receptor de androgenos. |
-
2005
- 2005-12-08 TW TW094143316A patent/TW200628446A/zh unknown
- 2005-12-12 PE PE2005001433A patent/PE20060734A1/es not_active Application Discontinuation
- 2005-12-12 AR ARP050105189A patent/AR051713A1/es not_active Application Discontinuation
- 2005-12-13 WO PCT/JP2005/023215 patent/WO2006064944A1/en not_active Ceased
- 2005-12-13 EP EP05816739A patent/EP1824841A1/en not_active Withdrawn
- 2005-12-13 US US11/793,113 patent/US20080176906A1/en not_active Abandoned
- 2005-12-13 JP JP2007545156A patent/JP2008523052A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| US20080176906A1 (en) | 2008-07-24 |
| EP1824841A1 (en) | 2007-08-29 |
| AR051713A1 (es) | 2007-01-31 |
| JP2008523052A (ja) | 2008-07-03 |
| WO2006064944A1 (en) | 2006-06-22 |
| TW200628446A (en) | 2006-08-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |