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PE20060622A1 - Derivados de pirimidina como inhibidores de fak - Google Patents

Derivados de pirimidina como inhibidores de fak

Info

Publication number
PE20060622A1
PE20060622A1 PE2005000982A PE2005000982A PE20060622A1 PE 20060622 A1 PE20060622 A1 PE 20060622A1 PE 2005000982 A PE2005000982 A PE 2005000982A PE 2005000982 A PE2005000982 A PE 2005000982A PE 20060622 A1 PE20060622 A1 PE 20060622A1
Authority
PE
Peru
Prior art keywords
elements
fak inhibitors
pyrimidine derivatives
benzenosulfonamide
heterocicle
Prior art date
Application number
PE2005000982A
Other languages
English (en)
Inventor
Ichiro Umemura
Naoki Teno
Eiji Kawahara
Naoko Matsuura
Kazuhide Konishi
Takahiro Miyake
Osamu Ohmori
Patricia Imbach
Johannes Roesel
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PE20060622A1 publication Critical patent/PE20060622A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A—HUMAN NECESSITIES
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Engineering & Computer Science (AREA)
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  • Diabetes (AREA)
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  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Pain & Pain Management (AREA)
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  • AIDS & HIV (AREA)
  • Transplantation (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Tropical Medicine & Parasitology (AREA)

Abstract

REFERIDA A UN COMPUESTO DERIVADO DE PIRIMIDINA DE FORMULA I, DONDE R0 ES H; R1 ES H, HETEROCICLO DE 5 O 6 ELEMENTOS, ENTRE OTROS; R2 ES H; R3 ES SULFAMOILO SUSTITUIDO POR ALQUILO C1-C7, HETEROCICLO DE 5 O 6 ELEMENTOS QUE COMPRENDE 1,2,3 O 4 ATOMOS DE N, ENTRE OTROS; R4 ES H; R5 ES HALOGENO; R6 ES H; R7 ES H, ALCOXI C1-C7, ENTRE OTROS; R8 ES H, HALOGENO, ALCOXI C1-C7, ENTRE OTROS; R9 ES H, HETEROCICLO DE 5 O 6 ELEMENTOS QUE COMPRENDE 1,2 O 3 ATOMOS DE N U O, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 2-{5-BROMO-2-[5-(3-DIMETILAMINO-PIRROLIDI-1-NIL)-2-METOXI-FENILAMINO]-PIRIMIDI-4-NILAMINO}-N-METIL-BENCENOSULFONAMIDA, 2-{5-BROMO-2-[2-METOXI-5-(2-MORFOLI-4-NIL-ETOXI)-FENILAMINO]-PIRIMIDI-4-NILAMINO}-N-ISOPROPIL-BENCENOSULFONAMIDA, ENTRE OTROS. DICHOS COMPUESTOS SON INHIBIDORES DE LA FAK Y SON UTILES PARA EL TRATAMIENTO DE DESORDENES DEL SISTEMA INMUNOLOGICO, DESORDENES INDUCIDOS POR LINFOCITOS T, LINFOCITOS B, MASTOCITOS Y/O EOSINOFILOS, ARTEROSCLEROSIS, ENTRE OTROS
PE2005000982A 2004-08-27 2005-08-25 Derivados de pirimidina como inhibidores de fak PE20060622A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0419161.5A GB0419161D0 (en) 2004-08-27 2004-08-27 Organic compounds

Publications (1)

Publication Number Publication Date
PE20060622A1 true PE20060622A1 (es) 2006-08-14

Family

ID=33104746

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2005000982A PE20060622A1 (es) 2004-08-27 2005-08-25 Derivados de pirimidina como inhibidores de fak

Country Status (23)

Country Link
US (1) US20090131436A1 (es)
EP (1) EP1784392A2 (es)
JP (1) JP2008510763A (es)
KR (1) KR20070054223A (es)
CN (1) CN101048386A (es)
AR (1) AR054081A1 (es)
AU (1) AU2005276582B2 (es)
BR (1) BRPI0514681A (es)
CA (1) CA2577251A1 (es)
EC (1) ECSP077271A (es)
GB (1) GB0419161D0 (es)
GT (1) GT200500237A (es)
HR (1) HRP20070076A2 (es)
IL (1) IL181433A0 (es)
MA (1) MA28824B1 (es)
MX (1) MX2007002254A (es)
NO (1) NO20071593L (es)
PE (1) PE20060622A1 (es)
RU (1) RU2401260C2 (es)
TN (1) TNSN07075A1 (es)
TW (1) TW200621729A (es)
WO (1) WO2006021454A2 (es)
ZA (1) ZA200701406B (es)

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