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JO3067B1 - بيرميدينات بيرازولو امينو كمثبطات ل fak - Google Patents

بيرميدينات بيرازولو امينو كمثبطات ل fak

Info

Publication number
JO3067B1
JO3067B1 JOP/2009/0395A JOP20090395A JO3067B1 JO 3067 B1 JO3067 B1 JO 3067B1 JO P20090395 A JOP20090395 A JO P20090395A JO 3067 B1 JO3067 B1 JO 3067B1
Authority
JO
Jordan
Prior art keywords
pyrazolylaminopyridines
fak
inhibitors
present
cancers
Prior art date
Application number
JOP/2009/0395A
Other languages
English (en)
Inventor
H Faitg Thomas
Leroy Adams Jerry
W Johnson Neil
Lin Hong
Original Assignee
Glaxosmithkline Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42132177&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JO3067(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glaxosmithkline Llc filed Critical Glaxosmithkline Llc
Application granted granted Critical
Publication of JO3067B1 publication Critical patent/JO3067B1/ar

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57423—Specifically defined cancers of lung

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

يتعلق الاختراع الحالي لمركب الصياغة(I): (I) أو ملح مقبول صيدلانيا لهم, حيث R1, R2, R3, R11, R12, R13, Q, Z وp هم كما وصف هنا. مركبات الاختراع الحالي تكون مفيدة لعلاج السرطانات.
JOP/2009/0395A 2008-10-27 2009-10-25 بيرميدينات بيرازولو امينو كمثبطات ل fak JO3067B1 (ar)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10856808P 2008-10-27 2008-10-27
US17851709P 2009-05-15 2009-05-15
US24243209P 2009-09-15 2009-09-15

Publications (1)

Publication Number Publication Date
JO3067B1 true JO3067B1 (ar) 2017-03-15

Family

ID=42132177

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2009/0395A JO3067B1 (ar) 2008-10-27 2009-10-25 بيرميدينات بيرازولو امينو كمثبطات ل fak

Country Status (35)

Country Link
US (6) US20110207743A1 (ar)
EP (1) EP2421537B1 (ar)
JP (1) JP5642689B2 (ar)
KR (1) KR101512217B1 (ar)
CN (1) CN102264371B (ar)
AR (1) AR073993A1 (ar)
AU (1) AU2009320144B2 (ar)
BR (1) BRPI0920053B8 (ar)
CA (1) CA2741760C (ar)
CL (1) CL2011000933A1 (ar)
CO (1) CO6361929A2 (ar)
CR (1) CR20110264A (ar)
CY (1) CY1116399T1 (ar)
DK (1) DK2421537T3 (ar)
DO (1) DOP2011000113A (ar)
EA (1) EA021927B1 (ar)
ES (1) ES2539835T3 (ar)
HR (1) HRP20150531T1 (ar)
IL (1) IL212444A (ar)
JO (1) JO3067B1 (ar)
MA (1) MA32727B1 (ar)
MX (1) MX2011004369A (ar)
MY (1) MY161890A (ar)
NZ (1) NZ592477A (ar)
PE (1) PE20110941A1 (ar)
PL (1) PL2421537T3 (ar)
PT (1) PT2421537E (ar)
RS (1) RS54045B1 (ar)
SG (1) SG195608A1 (ar)
SI (1) SI2421537T1 (ar)
SM (1) SMT201500157B (ar)
TW (1) TWI454467B (ar)
UY (1) UY32200A (ar)
WO (1) WO2010062578A1 (ar)
ZA (1) ZA201102892B (ar)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8338441B2 (en) 2009-05-15 2012-12-25 Gilead Sciences, Inc. Inhibitors of human immunodeficiency virus replication
US20120244141A1 (en) 2010-09-28 2012-09-27 Boehringer Ingelheim International Gmbh Stratification of cancer patients for susceptibility to therapy with PTK2 inhibitors
US20130296356A1 (en) * 2011-01-26 2013-11-07 Kurt R. Auger Combinations
EP2675794B1 (en) 2011-02-17 2019-02-13 Cancer Therapeutics Crc Pty Limited Selective fak inhibitors
AU2012216893B2 (en) 2011-02-17 2016-08-11 Cancer Therapeutics Crc Pty Limited FAK inhibitors
EP2726079A4 (en) * 2011-06-28 2014-12-17 Glaxosmithkline Ip No 2 Ltd METHOD OF ADMINISTRATION AND TREATMENT
US10106834B2 (en) 2013-10-09 2018-10-23 The General Hospital Corporation Methods of diagnosing and treating B cell acute lymphoblastic leukemia
KR102783581B1 (ko) 2015-06-29 2025-03-17 베라스템, 인코포레이티드 치료용 조성물, 병용 및 적용과 관련된 사용방법
CN108948019B (zh) * 2017-05-18 2022-07-08 广东东阳光药业有限公司 黏着斑激酶抑制剂及其用途
WO2019117813A1 (en) * 2017-12-15 2019-06-20 National University Of Singapore Focal adhesion kinase targeted therapeutics for the treatment of glaucoma and fibrosis
CA3093742A1 (en) 2018-03-12 2019-09-19 Inserm (Institut National De La Sante Et De La Recherche Medicale) Use of caloric restriction mimetics for potentiating chemo-immunotherapy for the treatment of cancers
CN108912095B (zh) * 2018-08-09 2019-08-20 广州安岩仁医药科技有限公司 苯并咪唑类化合物及其制备方法和应用
WO2020069117A1 (en) * 2018-09-27 2020-04-02 Dana-Farber Cancer Institute, Inc. Degradation of fak or fak and alk by conjugation of fak and alk inhibitors with e3 ligase ligands and methods of use
BR112021012682A2 (pt) * 2018-12-27 2021-09-08 Hinova Pharmaceuticals Inc. Inibidor de fak e combinação de fármaco do mesmo
IL286352B1 (en) 2019-03-15 2025-10-01 Massachusetts Gen Hospital Novel small molecule inhibitors of TEAD transcription factors
CN113387947B (zh) * 2021-07-12 2022-07-01 中国科学院成都生物研究所 调节雌激素受体合成活性的吡唑并吡啶衍生物
TW202508595A (zh) 2023-05-04 2025-03-01 美商銳新醫藥公司 用於ｒａｓ相關疾病或病症之組合療法
US20250049810A1 (en) 2023-08-07 2025-02-13 Revolution Medicines, Inc. Methods of treating a ras protein-related disease or disorder
US20250154171A1 (en) 2023-10-12 2025-05-15 Revolution Medicines, Inc. Ras inhibitors
WO2025171296A1 (en) 2024-02-09 2025-08-14 Revolution Medicines, Inc. Ras inhibitors
WO2025240847A1 (en) 2024-05-17 2025-11-20 Revolution Medicines, Inc. Ras inhibitors

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US166139A (en) * 1875-07-27 Improvement in dental pluggers
US6316603B1 (en) * 1998-09-08 2001-11-13 Agouron Pharmaceuticals, Inc. Modifications of the VEGF receptor-2 protein and methods of use
US7102009B2 (en) * 2001-01-12 2006-09-05 Amgen Inc. Substituted amine derivatives and methods of use
PL1660458T3 (pl) * 2003-08-15 2012-07-31 Novartis Ag 2,4-pirymidynodwuaminy stosowane w leczeniu chorób nowotworowych, chorób zapalnych i zaburzeń układu immunologicznego
GB0419160D0 (en) * 2004-08-27 2004-09-29 Novartis Ag Organic compounds
GB0419161D0 (en) * 2004-08-27 2004-09-29 Novartis Ag Organic compounds
EP1746096A1 (en) * 2005-07-15 2007-01-24 4Sc Ag 2-Arylbenzothiazole analogues and uses thereof in the treatment of cancer
ES2485040T3 (es) * 2007-03-16 2014-08-12 The Scripps Research Institute Inhibidores de cinasa de adhesión focal
JP2011512413A (ja) * 2008-02-19 2011-04-21 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー Ｆａｋの阻害剤としてのアニリノピリジン
MX2010014057A (es) * 2008-06-17 2011-03-21 Astrazeneca Ab Compuestos de piridina.

Also Published As

Publication number Publication date
KR101512217B1 (ko) 2015-04-15
US20110269774A1 (en) 2011-11-03
JP5642689B2 (ja) 2014-12-17
EA201170617A1 (ru) 2011-12-30
WO2010062578A1 (en) 2010-06-03
SG195608A1 (en) 2013-12-30
US20100113475A1 (en) 2010-05-06
MA32727B1 (ar) 2011-10-02
CO6361929A2 (es) 2012-01-20
SMT201500157B (it) 2015-09-07
EA021927B1 (ru) 2015-09-30
US9446034B2 (en) 2016-09-20
MY161890A (en) 2017-05-15
AU2009320144A1 (en) 2010-06-03
DOP2011000113A (es) 2011-07-15
PT2421537E (pt) 2015-07-03
CY1116399T1 (el) 2017-02-08
UY32200A (es) 2010-05-31
RS54045B1 (sr) 2015-10-30
CR20110264A (es) 2011-10-04
US20140107131A1 (en) 2014-04-17
KR20110080172A (ko) 2011-07-12
EP2421537B1 (en) 2015-04-08
CA2741760C (en) 2016-02-23
EP2421537A4 (en) 2012-06-13
CN102264371B (zh) 2013-10-02
PL2421537T3 (pl) 2015-08-31
TW201028394A (en) 2010-08-01
SI2421537T1 (sl) 2015-06-30
HK1161680A1 (en) 2012-08-03
BRPI0920053B8 (pt) 2021-05-25
JP2012506876A (ja) 2012-03-22
MX2011004369A (es) 2011-05-25
US20110207743A1 (en) 2011-08-25
HRP20150531T1 (hr) 2015-06-19
IL212444A0 (en) 2011-06-30
BRPI0920053B1 (pt) 2019-11-26
ES2539835T3 (es) 2015-07-06
CN102264371A (zh) 2011-11-30
PE20110941A1 (es) 2012-02-08
CA2741760A1 (en) 2010-06-03
US20160095841A1 (en) 2016-04-07
DK2421537T3 (da) 2015-06-22
US9012479B2 (en) 2015-04-21
AU2009320144B2 (en) 2013-11-21
BRPI0920053A2 (pt) 2015-12-15
NZ592477A (en) 2013-01-25
ZA201102892B (en) 2012-02-29
TWI454467B (zh) 2014-10-01
CL2011000933A1 (es) 2011-10-21
AR073993A1 (es) 2010-12-15
EP2421537A1 (en) 2012-02-29
IL212444A (en) 2015-11-30
US20150265589A1 (en) 2015-09-24

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