PE20060504A1 - Derivados de pirimidina en el tratamiento de cancer - Google Patents
Derivados de pirimidina en el tratamiento de cancerInfo
- Publication number
- PE20060504A1 PE20060504A1 PE2005000980A PE2005000980A PE20060504A1 PE 20060504 A1 PE20060504 A1 PE 20060504A1 PE 2005000980 A PE2005000980 A PE 2005000980A PE 2005000980 A PE2005000980 A PE 2005000980A PE 20060504 A1 PE20060504 A1 PE 20060504A1
- Authority
- PE
- Peru
- Prior art keywords
- kinase
- methyl
- substituted
- cancer
- treatment
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical class C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- KKFDJZZADQONDE-UHFFFAOYSA-N (hydridonitrato)hydroxidocarbon(.) Chemical group O[C]=N KKFDJZZADQONDE-UHFFFAOYSA-N 0.000 abstract 1
- 102100033793 ALK tyrosine kinase receptor Human genes 0.000 abstract 1
- 101710168331 ALK tyrosine kinase receptor Proteins 0.000 abstract 1
- 208000005016 Intestinal Neoplasms Diseases 0.000 abstract 1
- 206010025323 Lymphomas Diseases 0.000 abstract 1
- 108091000080 Phosphotransferase Proteins 0.000 abstract 1
- 208000005718 Stomach Neoplasms Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 206010017758 gastric cancer Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 201000002313 intestinal cancer Diseases 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 210000003205 muscle Anatomy 0.000 abstract 1
- VMPITZXILSNTON-UHFFFAOYSA-N o-anisidine Chemical compound COC1=CC=CC=C1N VMPITZXILSNTON-UHFFFAOYSA-N 0.000 abstract 1
- 102000020233 phosphotransferase Human genes 0.000 abstract 1
- 201000011549 stomach cancer Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE R0 ES H, R1 ES MONOCICLO SUSTITUIDO DE 6 ELEMENTOS O BICICLO-HETEROCICLO DE 10 ELEMENTOS CON 1-2 HETEROATOMOS DE N, O; R2 Y R3 JUNTO AL C Y N AL QUE ESTA UNIDO, FORMA UN HETEROCICLO QUE CONTIENE UN HETEROATOMO SELECCIONADO DE N, SUSTITUIDO O NO; R4 ES H; R5 ES HALOGENO; R6 Y R7 SON H; R8 ES H, ALCOXI C1-C7, CARBAMOILO SUSTITUIDO O NO POR ALQUILO C1-C7, ENTRE OTROS; R9 ES H; R10 ES H, HALOGENO, ALCOXI C1-C7. SON COMPUESTOS PREFERIDOS: 7-[5-CLORO-2-(2-METOXI-FENILAMINO)PIRIMIDI-4-NILAMINO]-2-METIL-4-PIPERAZI-1-NIL-2,3DIHIDRO-ISOINDO-1-LONA; 7-[5-CLORO-2-(2-METOXI-FENILAMINO)-PIRIMIDI-4-NILAMINO]-2-METIL-4-(4-METIL-PIPERAZI-1-NIL)-2,3-DIHIDRO-ISOINDO-1-LONA; ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FERMACEUTICA Y A UN METODO DE PREPARACION. DICHOS COMPUESTOS SON INHIBIDORES DE CINASA NPM-ALK (ACTIVDAD TIROSIN-CINASA PROTEICA DEL LIGANDO INDEPENDIENTE DEL LINFOMA CINASA ANAPLASICA) UTILES EN EL TRATAMIENTO DE TUMOR DE PECHO, CANCER INTESTINAL, CANCER ESTOMACAL, MELANOMA, TUMOR DE VEJIGA, ENTRE OTROS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0419160.7A GB0419160D0 (en) | 2004-08-27 | 2004-08-27 | Organic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20060504A1 true PE20060504A1 (es) | 2006-07-18 |
Family
ID=33104745
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2005000980A PE20060504A1 (es) | 2004-08-27 | 2005-08-25 | Derivados de pirimidina en el tratamiento de cancer |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US7910585B2 (es) |
| EP (1) | EP1784399B1 (es) |
| JP (1) | JP4674236B2 (es) |
| KR (1) | KR100894349B1 (es) |
| CN (1) | CN101006079A (es) |
| AR (1) | AR050536A1 (es) |
| AT (1) | ATE512960T1 (es) |
| AU (1) | AU2005276585B2 (es) |
| BR (1) | BRPI0514731A (es) |
| CA (1) | CA2575720C (es) |
| EC (1) | ECSP077259A (es) |
| ES (1) | ES2366038T3 (es) |
| GB (1) | GB0419160D0 (es) |
| GT (1) | GT200500229A (es) |
| IL (1) | IL181386A0 (es) |
| MA (1) | MA28813B1 (es) |
| NO (1) | NO20071504L (es) |
| PE (1) | PE20060504A1 (es) |
| PL (1) | PL1784399T3 (es) |
| PT (1) | PT1784399E (es) |
| RU (1) | RU2395507C2 (es) |
| TN (1) | TNSN07074A1 (es) |
| TW (1) | TW200621728A (es) |
| WO (1) | WO2006021457A2 (es) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0305929D0 (en) * | 2003-03-14 | 2003-04-23 | Novartis Ag | Organic compounds |
| GB0419161D0 (en) * | 2004-08-27 | 2004-09-29 | Novartis Ag | Organic compounds |
| ES2561406T3 (es) | 2006-04-14 | 2016-02-26 | Cell Signaling Technology, Inc. | Defectos de genes y quinasa ALK mutante en tumores sólidos humanos |
| US8168383B2 (en) | 2006-04-14 | 2012-05-01 | Cell Signaling Technology, Inc. | Gene defects and mutant ALK kinase in human solid tumors |
| MX2009004426A (es) * | 2006-10-23 | 2009-08-12 | Cephalon Inc | Derivados biciclicos fusionados de 2,4-diaminopirimidina como inhibidores alk y c-met. |
| GEP20125691B (en) * | 2006-12-08 | 2012-11-26 | Irm Llc | Compounds and compositions as protein kinase inhibitors |
| EP2112880A4 (en) * | 2006-12-14 | 2011-12-21 | Merck Sharp & Dohme | ACYLBIPIPERIDINYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND TREATMENT METHOD |
| TWI389893B (zh) * | 2007-07-06 | 2013-03-21 | Astellas Pharma Inc | 二（芳胺基）芳基化合物 |
| EA020807B1 (ru) | 2008-06-17 | 2015-01-30 | Астразенека Аб | Соединения пиридина |
| JO3067B1 (ar) * | 2008-10-27 | 2017-03-15 | Glaxosmithkline Llc | بيرميدينات بيرازولو امينو كمثبطات ل fak |
| AR074210A1 (es) * | 2008-11-24 | 2010-12-29 | Boehringer Ingelheim Int | Derivados de pirimidina como inhibidores de ptk2-quinasa |
| TW201024281A (en) | 2008-11-24 | 2010-07-01 | Boehringer Ingelheim Int | New compounds |
| US9908884B2 (en) | 2009-05-05 | 2018-03-06 | Dana-Farber Cancer Institute, Inc. | EGFR inhibitors and methods of treating disorders |
| TW201100441A (en) * | 2009-06-01 | 2011-01-01 | Osi Pharm Inc | Amino pyrimidine anticancer compounds |
| CN101935317B (zh) * | 2009-07-01 | 2013-08-28 | 上海药明康德新药开发有限公司 | 2-甲基-7-(取代嘧啶-4-氨基)-4-(取代哌啶-1-基)异吲哚啉-1-酮及中间体的合成方法 |
| TWI513694B (zh) * | 2010-05-11 | 2015-12-21 | Amgen Inc | 抑制間變性淋巴瘤激酶的嘧啶化合物 |
| US20120244141A1 (en) | 2010-09-28 | 2012-09-27 | Boehringer Ingelheim International Gmbh | Stratification of cancer patients for susceptibility to therapy with PTK2 inhibitors |
| PT2646448T (pt) | 2010-11-29 | 2017-10-04 | Osi Pharmaceuticals Llc | Inibidores macrocíclicos de cinases |
| WO2012110773A1 (en) | 2011-02-17 | 2012-08-23 | Cancer Therapeutics Crc Pty Limited | Fak inhibitors |
| AU2012216894B2 (en) | 2011-02-17 | 2016-07-14 | Cancer Therapeutics Crc Pty Limited | Selective FAK inhibitors |
| JP6469567B2 (ja) | 2012-05-05 | 2019-02-13 | アリアド・ファーマシューティカルズ・インコーポレイテッド | Ｅｇｆｒ発動性がんの細胞増殖阻害用化合物 |
| EP2975403B1 (en) | 2013-02-13 | 2018-05-02 | Hirotomo Shibaguchi | Rapid allergy testing method |
| CN104803925B (zh) * | 2015-04-16 | 2018-01-12 | 温州医科大学 | 一类以fgfr为靶点的2，4，5‑三取代嘧啶类化合物及其制备方法和用途 |
| WO2018010142A1 (en) * | 2016-07-14 | 2018-01-18 | Shanghai Meton Pharmaceutical Co., Ltd | Iso-citrate dehydrogenase (idh) inhibitor |
| AU2020347274A1 (en) | 2019-09-13 | 2022-03-31 | Nimbus Saturn, Inc. | HPK1 antagonists and uses thereof |
| WO2022213062A1 (en) | 2021-03-29 | 2022-10-06 | Nimbus Saturn, Inc. | Hpk1 antagonists and uses thereof |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9828511D0 (en) * | 1998-12-24 | 1999-02-17 | Zeneca Ltd | Chemical compounds |
| US6776480B2 (en) | 2001-07-18 | 2004-08-17 | Sola International Holdings, Ltd. | Spectacle frames for shaped lenses defined by monoformal carrier surfaces |
| US6939874B2 (en) | 2001-08-22 | 2005-09-06 | Amgen Inc. | Substituted pyrimidinyl derivatives and methods of use |
| TWI329105B (en) * | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
| GB0206215D0 (en) * | 2002-03-15 | 2002-05-01 | Novartis Ag | Organic compounds |
| AU2003231231A1 (en) * | 2002-05-06 | 2003-11-11 | Bayer Pharmaceuticals Corporation | Pyridinyl amino pyrimidine derivatives useful for treating hyper-proliferative disorders |
| GB0305929D0 (en) * | 2003-03-14 | 2003-04-23 | Novartis Ag | Organic compounds |
-
2004
- 2004-08-27 GB GBGB0419160.7A patent/GB0419160D0/en not_active Ceased
-
2005
- 2005-08-25 PE PE2005000980A patent/PE20060504A1/es not_active Application Discontinuation
- 2005-08-26 JP JP2007528756A patent/JP4674236B2/ja not_active Expired - Fee Related
- 2005-08-26 AU AU2005276585A patent/AU2005276585B2/en not_active Ceased
- 2005-08-26 EP EP05782820A patent/EP1784399B1/en not_active Expired - Lifetime
- 2005-08-26 PL PL05782820T patent/PL1784399T3/pl unknown
- 2005-08-26 CN CNA2005800280957A patent/CN101006079A/zh active Pending
- 2005-08-26 ES ES05782820T patent/ES2366038T3/es not_active Expired - Lifetime
- 2005-08-26 RU RU2007110946/04A patent/RU2395507C2/ru not_active IP Right Cessation
- 2005-08-26 WO PCT/EP2005/009255 patent/WO2006021457A2/en not_active Ceased
- 2005-08-26 AT AT05782820T patent/ATE512960T1/de active
- 2005-08-26 US US11/660,714 patent/US7910585B2/en not_active Expired - Fee Related
- 2005-08-26 PT PT05782820T patent/PT1784399E/pt unknown
- 2005-08-26 GT GT200500229A patent/GT200500229A/es unknown
- 2005-08-26 TW TW094129174A patent/TW200621728A/zh unknown
- 2005-08-26 AR ARP050103593A patent/AR050536A1/es not_active Application Discontinuation
- 2005-08-26 CA CA2575720A patent/CA2575720C/en not_active Expired - Fee Related
- 2005-08-26 BR BRPI0514731-0A patent/BRPI0514731A/pt not_active IP Right Cessation
- 2005-08-26 KR KR1020077004528A patent/KR100894349B1/ko not_active Expired - Fee Related
-
2007
- 2007-02-15 IL IL181386A patent/IL181386A0/en unknown
- 2007-02-15 EC EC2007007259A patent/ECSP077259A/es unknown
- 2007-02-21 MA MA29698A patent/MA28813B1/fr unknown
- 2007-02-26 TN TNP2007000074A patent/TNSN07074A1/en unknown
- 2007-03-22 NO NO20071504A patent/NO20071504L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0514731A (pt) | 2008-06-24 |
| CA2575720C (en) | 2012-10-02 |
| KR100894349B1 (ko) | 2009-04-22 |
| AU2005276585B2 (en) | 2009-07-30 |
| WO2006021457A3 (en) | 2006-07-13 |
| MA28813B1 (fr) | 2007-08-01 |
| AU2005276585A1 (en) | 2006-03-02 |
| ECSP077259A (es) | 2007-03-29 |
| GB0419160D0 (en) | 2004-09-29 |
| CN101006079A (zh) | 2007-07-25 |
| EP1784399B1 (en) | 2011-06-15 |
| RU2395507C2 (ru) | 2010-07-27 |
| NO20071504L (no) | 2007-05-25 |
| TW200621728A (en) | 2006-07-01 |
| US20080293708A1 (en) | 2008-11-27 |
| IL181386A0 (en) | 2007-07-04 |
| JP2008510765A (ja) | 2008-04-10 |
| GT200500229A (es) | 2006-03-29 |
| WO2006021457A2 (en) | 2006-03-02 |
| PL1784399T3 (pl) | 2011-11-30 |
| EP1784399A2 (en) | 2007-05-16 |
| TNSN07074A1 (en) | 2008-06-02 |
| ATE512960T1 (de) | 2011-07-15 |
| RU2007110946A (ru) | 2008-10-10 |
| ES2366038T3 (es) | 2011-10-14 |
| KR20070038567A (ko) | 2007-04-10 |
| PT1784399E (pt) | 2011-08-26 |
| JP4674236B2 (ja) | 2011-04-20 |
| AR050536A1 (es) | 2006-11-01 |
| CA2575720A1 (en) | 2006-03-02 |
| US7910585B2 (en) | 2011-03-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |