[go: up one dir, main page]

PE20051138A1 - BLOQUEADORES DE Kv1.5 REFERIDOS AL AUMENTO SELECTIVO DE LA CONTRACTILIDAD - Google Patents

BLOQUEADORES DE Kv1.5 REFERIDOS AL AUMENTO SELECTIVO DE LA CONTRACTILIDAD

Info

Publication number
PE20051138A1
PE20051138A1 PE2005000178A PE2005000178A PE20051138A1 PE 20051138 A1 PE20051138 A1 PE 20051138A1 PE 2005000178 A PE2005000178 A PE 2005000178A PE 2005000178 A PE2005000178 A PE 2005000178A PE 20051138 A1 PE20051138 A1 PE 20051138A1
Authority
PE
Peru
Prior art keywords
referred
alkyl
compounds
phenyl
contractility
Prior art date
Application number
PE2005000178A
Other languages
English (en)
Inventor
Klaus Wirth
Original Assignee
Sanofi Aventis Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland
Publication of PE20051138A1 publication Critical patent/PE20051138A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

REFERIDA A COMPUESTOS DE FORMULA Ia Y/O Ib R1 ES ALQUILO C3-C5, QUINOLINILO; R2 ES ALQUILO C1-C4, CICLOPROPILO; R3 ES FENILO, PIRIDILO; A ES -CnH2n-; n ES 1, 2; R4, R5, R6 Y R7 SON CADA UNO H, F, CF3, ENTRE OTROS; B ES -CmH2m-; m ES 1, 2; R8 ES ALQUILO C2-C3, FENILO, PIRIDILO SUSTITUIDOS O NO; R9 ES COOR10, COR10; R10 ES -CxH2x-R11; x ES 1, 2; R11 ES FENILO SUSTITUIDO O NO. DICHOS COMPUESTOS SE PUEDEN SELECCIONAR DE: N-(2-PIRIDIN-3-ILETIL)-2'-{[2-(4-METOXIFENIL)ACETILAMINO]METIL}BIFENIL-2-CARBOXAMIDA; 2-(BUTIL-1-SULFONILAMINO)-N-[1(R)-(6-METOXIPIRIDIN-3-ILMETIL)PROPIL]BENZAMIDA Y (S)-5-FLUORO-2-(QUINOLINA-8-SULFONILAMINO)-N-(1-FENILPROPIL)BENZAMIDA; ENTRE OTROS. TAMBIEN REFERIDA AL USO DE ESTOS COMPUESTOS O UNA DE SUS SALES PARA PRODUCIR UN MEDICAMENTO PARA LA PROFILAXIS O TERAPIA DE LA INSUFICIENCIA CARDICA DIASTOLICA
PE2005000178A 2004-02-26 2005-02-15 BLOQUEADORES DE Kv1.5 REFERIDOS AL AUMENTO SELECTIVO DE LA CONTRACTILIDAD PE20051138A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102004009931A DE102004009931A1 (de) 2004-02-26 2004-02-26 Kv1.5-Blocker zur selektiven Steigerung der Vorhofkontraktilität und Behandlung der Herzinsuffizienz

Publications (1)

Publication Number Publication Date
PE20051138A1 true PE20051138A1 (es) 2006-02-06

Family

ID=34853866

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2005000178A PE20051138A1 (es) 2004-02-26 2005-02-15 BLOQUEADORES DE Kv1.5 REFERIDOS AL AUMENTO SELECTIVO DE LA CONTRACTILIDAD

Country Status (15)

Country Link
US (1) US20070043091A1 (es)
EP (1) EP1720549A1 (es)
JP (1) JP2007523926A (es)
KR (1) KR20060125862A (es)
CN (1) CN1921855A (es)
AR (1) AR047975A1 (es)
AU (1) AU2005218731A1 (es)
BR (1) BRPI0508054A (es)
CA (1) CA2557263A1 (es)
DE (1) DE102004009931A1 (es)
IL (1) IL177255A0 (es)
PE (1) PE20051138A1 (es)
TW (1) TW200536522A (es)
UY (1) UY28777A1 (es)
WO (1) WO2005084675A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1815027A1 (en) * 2004-11-22 2007-08-08 Integragen Human obesity susceptibility gene encoding potassium ion channels and uses thereof
EP2012758A2 (en) * 2006-04-27 2009-01-14 Sanofi-Aventis Deutschland GmbH Inhibitors of the task-1 and task-3 ion channel
US9101616B2 (en) * 2009-05-29 2015-08-11 Raqualia Pharma Inc. Aryl substituted carboxamide derivatives as calcium or sodium channel blockers
WO2010139585A2 (en) * 2009-06-03 2010-12-09 Sanofi-Aventis Deutschland Gmbh Crystalline phases of 2'-{[2-(4-methoxy-phenyl)-acetylamino]-methyl}-biphenyl-2-carboxylic acid (2-pyridin-3-yl-ethyl)-amide
CN107033064B (zh) * 2017-04-28 2019-07-09 西安医学院 一种3-(吗啉取代芳亚胺基)吲哚类化合物及其制备方法和应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2128644C1 (ru) * 1993-12-27 1999-04-10 Эйсай Ко., Лтд. Производные антраниловой кислоты или их фармакологически приемлемые соли, промежуточные продукты для их получения и лекарственный препарат на их основе
US5935945A (en) * 1996-10-31 1999-08-10 Merck & Co., Inc. Methods of treating or preventing cardiac arrhythmia
JP3786579B2 (ja) * 1998-07-08 2006-06-14 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 硫黄置換スルホニルアミノカルボン酸ｎ−アリールアミド、それらの製造、それらの使用、及びそれらを含む医薬製剤
US6129802A (en) 1998-11-05 2000-10-10 Stephen Key Design, Llc Rotatable label system and method of constructing same
US6531495B1 (en) * 1999-10-02 2003-03-11 Aventis Pharma Deutschland Gmbh 2′-Substituted 1,1′-biphenyl-2-carboxamides, processes for their preparation, their use as medicaments, and pharmaceutical preparations comprising them
DE19947457A1 (de) * 1999-10-02 2001-04-05 Aventis Pharma Gmbh 2'-Substituierte 1,1'-Biphenyl-2-carbonamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie enthaltende pharmazeutische Zubereitungen
DE10060809A1 (de) * 2000-12-07 2002-06-20 Aventis Pharma Gmbh Substituierte Anthranilsäuren, ihre Verwendung als Medikament oder Diagnostikum, sowie sie enthaltendes Medikament, sowie ein pharmazeutisches Kombinationspräparat mit einem Natrium/Wasserstoff-Austausch (NHE)-Blocker
DE10121002A1 (de) * 2001-04-28 2002-11-14 Aventis Pharma Gmbh Verwendung von Anthranilsäureamiden als Medikament zur Behandlung von Arrhythmien sowie sie enthaltende pharmazeutische Zubereitungen
DE10121003A1 (de) * 2001-04-28 2002-12-19 Aventis Pharma Gmbh Anthranilsäureamide, Verfahren zur Herstellung, ihrer Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen
DE10128331A1 (de) * 2001-06-12 2002-12-19 Aventis Pharma Gmbh Anthranilsäureamide mit Heteroarylsulfonyl-Seitenkette, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltende pharmazeutische Zubereitungen
DE10312073A1 (de) * 2003-03-18 2004-09-30 Aventis Pharma Deutschland Gmbh 2-(Butyl-1-sulfonylamino)-N-[1(R)-(6-methoxy-pyridin-3yl)-propyl]-benzamid, dessen Verwendung als Medikament sowie dieses enthaltende pharmazeutische Zubereitungen

Also Published As

Publication number Publication date
CN1921855A (zh) 2007-02-28
CA2557263A1 (en) 2005-09-15
IL177255A0 (en) 2006-12-10
AU2005218731A1 (en) 2005-09-15
US20070043091A1 (en) 2007-02-22
BRPI0508054A (pt) 2007-07-17
EP1720549A1 (de) 2006-11-15
AR047975A1 (es) 2006-03-15
KR20060125862A (ko) 2006-12-06
UY28777A1 (es) 2005-09-30
WO2005084675A1 (de) 2005-09-15
JP2007523926A (ja) 2007-08-23
TW200536522A (en) 2005-11-16
DE102004009931A1 (de) 2005-09-15

Similar Documents

Publication Publication Date Title
AR049110A1 (es) Compuestos terapeuticos: piridina como andamiaje estructural
PE20030968A1 (es) Derivados de 5-feniltiazol como inhibidores de cinasas
PE20090641A1 (es) Amidas heterociclicas
PE20080061A1 (es) Compuestos derivados de amida como inhibidores de los canales de potasio task-1 y task-3
PE20060693A1 (es) Nuevos derivados de trifluorometansulfonanilida oxamida eter
PE20141375A1 (es) Activadores de glucoquinasa
BRPI0507506A (pt) compostos
HRP20170638T1 (hr) MODULATORI RETINOIDNIMA SRODNOG SIROČETA RECEPTORA γ (ROR-γ), NAMIJENJENI UPOTREBI U LIJEČENJU AUTOIMUNIH I PROTUUPALNIH BOLESTI
NZ734744A (en) Aryl-or heteroaryl-substituted benzene compounds
MEP22008A (en) Derivatives of n-[heteroaryl(piperidine-2-yl)methyl]benzamide, preparation method thereof and application of same in therapeutics
PE20120136A1 (es) Compuestos derivados de n-acilsulfonamidas como inhibidores de bcl-2
PT998473E (pt) Modificacao da forma de cristal de um derivado de n-fenil-2-pirimidinoamina processos para a sua preparacao e sua utilizacao
PE20050132A1 (es) Piperazinas heterociclicas sustituidas
PE20061150A1 (es) Derivados de n-(n-sulfonilaminoarilmetil)ciclopropanocarboxamida sustituidos como antagonistas del receptor vainilloide tipo 1 (vdr1)
AR062299A1 (es) Derivados de bencimidazol
PE20011089A1 (es) Tioamidas de oxazolidinona con sustituyentes de piperazin-amida
DK0821682T3 (da) Benzimidazolforbindelser og deres anvendelse som modulatorer af gaba-a-receptorkomplekset
CO5611103A2 (es) Derivados de bencensulfonamida como agentes antisicoticos
PE20021061A1 (es) Arilsulfonamidas como agentes antivirales
PE20061163A1 (es) Compuestos de n-sulfonilaminofeniletil-2-fenoxiacetamida sustituidos
AR042362A1 (es) Derivados de 3h-quinazolin-4-ona, proceso de obtencion y composiciones farmaceuticas que los contienen
PE20070829A1 (es) Inhibidores cetp heterociclicos
AR036602A1 (es) Agonistas muscarinicos
CO5611136A2 (es) Derivados de 4-(fenil-(piperidin-4-iliden-metil)-benzamida y su uso para el tratramiento del dolor, ansiedad o desordenes gastrointestinales
PE20051138A1 (es) BLOQUEADORES DE Kv1.5 REFERIDOS AL AUMENTO SELECTIVO DE LA CONTRACTILIDAD

Legal Events

Date Code Title Description
FA Abandonment or withdrawal