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BRPI0507506A - compostos - Google Patents

compostos

Info

Publication number
BRPI0507506A
BRPI0507506A BRPI0507506-8A BRPI0507506A BRPI0507506A BR PI0507506 A BRPI0507506 A BR PI0507506A BR PI0507506 A BRPI0507506 A BR PI0507506A BR PI0507506 A BRPI0507506 A BR PI0507506A
Authority
BR
Brazil
Prior art keywords
independently
compounds
pyrimidineamine
disorder
formula
Prior art date
Application number
BRPI0507506-8A
Other languages
English (en)
Inventor
Kenneth W Duncan
Darren Gibson
Shudong Wang
Daniella I Zheleva
Peter Fischer
Original Assignee
Cyclacel Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cyclacel Ltd filed Critical Cyclacel Ltd
Publication of BRPI0507506A publication Critical patent/BRPI0507506A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Molecular Biology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Obesity (AREA)
  • Biotechnology (AREA)
  • Hospice & Palliative Care (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

COMPOSTOS. A presente invenção refere-se aos compostos da fórmula I, ou uns sais farmaceuticamente aceitáveis destes, em que: Z¬1¬ é N ou CH; Z¬2¬ e Z¬3¬ são cada um independentemente N ou CR¬7¬; R¬1¬, R¬2¬, R¬3¬, R¬4¬, R¬5¬, R¬6¬, e R¬7¬ são cada um independentemente H, R¬8¬ ou R¬9¬; cada R¬8¬ é independentemente um grupo hidrocarbila; e cada R¬9¬ é independentemente halo, NO~2~, alcóxi, CN, CF~3~, SO~3~H, SO~2~NR¬10¬R¬11¬, SO~2~R¬12¬, NR¬13¬R¬14¬, (CH~2~)~a~COOR¬15¬, (CH~2~)~b~CONR¬16¬R¬17¬, (CH~2~)~c~COR¬18¬ ou (CH~2~) ~d~OH; a, b, c e d são cada um independentemente 0, 1, 2, 3 ou 4; R¬10¬-¬18¬ são cada um independemente H ou alquila; contanto que quando R¬1¬ e R¬2¬ forem ambos H, Z¬1¬ seja CH; ou Z¬2¬ seja N; ou Z¬1¬ seja CH e Z¬2¬ seja N; e em que o composto é diferente de 4-(4,5-dimetiltiazol-2-il)-N-(3,4,5-trimetoxifenil)-2-pirimidinoamina ou 4-(5-(2-hidroxietil)-4-metiltiazol-2-il)-N-(3,4,5-trimetoxifenil)-2-pirimidino amina. Outros aspectos referem-se ao uso dos compostos da fórmula I na preparação de um medicamento para tratar um ou mais distúrbios selecionados de um distúrbio proliferativo, um distúrbio viral, um distúbio de CNS, diabetes, acidente vascular cerebral ou alopecia.
BRPI0507506-8A 2004-02-06 2005-02-07 compostos BRPI0507506A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0402653.0A GB0402653D0 (en) 2004-02-06 2004-02-06 Compounds
PCT/GB2005/000405 WO2005075468A2 (en) 2004-02-06 2005-02-07 Pyridinyl - or pyrimidinyl thiazoles with protein kinase inhibiting activity

Publications (1)

Publication Number Publication Date
BRPI0507506A true BRPI0507506A (pt) 2007-06-26

Family

ID=31985793

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0507506-8A BRPI0507506A (pt) 2004-02-06 2005-02-07 compostos

Country Status (12)

Country Link
US (1) US20080318954A1 (pt)
EP (1) EP1751146B1 (pt)
JP (1) JP2007520540A (pt)
CN (1) CN1914199A (pt)
AT (1) ATE450532T1 (pt)
AU (1) AU2005210254A1 (pt)
BR (1) BRPI0507506A (pt)
CA (1) CA2554329A1 (pt)
DE (1) DE602005018044D1 (pt)
GB (1) GB0402653D0 (pt)
IL (1) IL177252A0 (pt)
WO (1) WO2005075468A2 (pt)

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Also Published As

Publication number Publication date
EP1751146B1 (en) 2009-12-02
IL177252A0 (en) 2006-12-10
DE602005018044D1 (de) 2010-01-14
WO2005075468A2 (en) 2005-08-18
WO2005075468A3 (en) 2005-10-13
US20080318954A1 (en) 2008-12-25
AU2005210254A1 (en) 2005-08-18
GB0402653D0 (en) 2004-03-10
EP1751146A2 (en) 2007-02-14
CA2554329A1 (en) 2005-08-18
JP2007520540A (ja) 2007-07-26
CN1914199A (zh) 2007-02-14
ATE450532T1 (de) 2009-12-15

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