PE20050945A1 - Ester de rapamicin-42 amorfo con el acido 3-hidroxi-2-(hidroximetil)-2-metilpropionico y sus composiciones farmaceuticas - Google Patents
Ester de rapamicin-42 amorfo con el acido 3-hidroxi-2-(hidroximetil)-2-metilpropionico y sus composiciones farmaceuticasInfo
- Publication number
- PE20050945A1 PE20050945A1 PE2004000844A PE2004000844A PE20050945A1 PE 20050945 A1 PE20050945 A1 PE 20050945A1 PE 2004000844 A PE2004000844 A PE 2004000844A PE 2004000844 A PE2004000844 A PE 2004000844A PE 20050945 A1 PE20050945 A1 PE 20050945A1
- Authority
- PE
- Peru
- Prior art keywords
- ester
- amorphous
- hydroximethyl
- hydroxy
- solvent
- Prior art date
Links
- 150000002148 esters Chemical class 0.000 title abstract 4
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000002904 solvent Substances 0.000 abstract 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- 238000001556 precipitation Methods 0.000 abstract 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 238000001704 evaporation Methods 0.000 abstract 2
- 230000008020 evaporation Effects 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- -1 ISOPROPYL Chemical class 0.000 abstract 1
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 abstract 1
- 150000001335 aliphatic alkanes Chemical class 0.000 abstract 1
- 238000004458 analytical method Methods 0.000 abstract 1
- 238000004811 liquid chromatography Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Cardiology (AREA)
- Ophthalmology & Optometry (AREA)
- Transplantation (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicinal Preparation (AREA)
Abstract
SE REFIERE A UNA FORMA AMORFA DEL ESTER DE RAPAMICIN-42 AMORFO CON EL ACIDO 3-HIDROXI-2-(HIDROXIMETIL)-2-METILPROPIONICO, EL CUAL FUE AISLADO Y CARACTERIZADO POR UNA CROMATOGRAFIA LIQUIDA DE ALTA CAPACIDAD (CLAC), DRX Y CALORIMETRIA DE ANALIISIS DIFERENCIAL(CAD). LA FORMA AMORFA ES POR LO MENOS TRES VECES MAS SOLUBLE QUE LA FORMA CRISTALINA. TAMBIEN SE REFIERE A UN PROCEDIMIENTO DE PREPARACION QUE COMPRENDE: a) LA EVAPORACION DE LA COMBINACION DEL ESTER AMORFO Y EL ACIDO, A PARTIR DE UNA SOLUCION QUE CONTIENE EL ESTER DE RAPAMICIN-42 CRISTALINO CON EL ACIDO 3-HIDROXI-2-(HIDROXIMETIL)-2-METILPROPIONICO Y UN AGENTE DISOLVENTE COMO ALCOHOL O ETER Y PUEDE SER DESHIDRATADO O CONTENER AGUA COMO METANOL, ETANOL O ISOPROPIL, LA TEMPERATURA DE EVAPORACION ES DE POR LO MENOS DE 20°C; b) ALTERNATIVAMENTE LA FORMA AMORFA ES OBTENIDA POR PRECIPITACION, MEDIANTE LA ADICION DE UN SOLVENTE DE PRECIPITACION DE LA DISOLUCION ANTERIOR, DONDE EL SOLVENTE DE PRECIPITACION ES AGUA O ALCANO COMO N-HEPTANO A UNA TEMPERATURA DE, O BAJO DE, APROXIMADAMENTE 50°C
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49978903P | 2003-09-03 | 2003-09-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20050945A1 true PE20050945A1 (es) | 2005-12-14 |
Family
ID=34272870
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2004000844A PE20050945A1 (es) | 2003-09-03 | 2004-09-01 | Ester de rapamicin-42 amorfo con el acido 3-hidroxi-2-(hidroximetil)-2-metilpropionico y sus composiciones farmaceuticas |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US7271177B2 (es) |
| EP (1) | EP1660081A1 (es) |
| JP (1) | JP2007504226A (es) |
| KR (1) | KR20060090803A (es) |
| CN (1) | CN1874771A (es) |
| AR (1) | AR045559A1 (es) |
| AU (1) | AU2004270154A1 (es) |
| BR (1) | BRPI0414066A (es) |
| CA (1) | CA2536775A1 (es) |
| CO (1) | CO5680426A2 (es) |
| CR (1) | CR8293A (es) |
| EC (1) | ECSP066473A (es) |
| GT (1) | GT200400175A (es) |
| IL (1) | IL173786A0 (es) |
| MX (1) | MXPA06002123A (es) |
| NO (1) | NO20061048L (es) |
| PA (1) | PA8611201A1 (es) |
| PE (1) | PE20050945A1 (es) |
| RU (1) | RU2345999C2 (es) |
| SA (1) | SA04250334B1 (es) |
| SG (1) | SG145716A1 (es) |
| TW (1) | TW200510428A (es) |
| UA (1) | UA84881C2 (es) |
| WO (1) | WO2005023254A1 (es) |
| ZA (1) | ZA200601822B (es) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005023254A1 (en) * | 2003-09-03 | 2005-03-17 | Wyeth | Amorphous rapamycin 42-ester with 3-hydroxy-2-(hydroxymethyl)-2-methylpropionic acid and its pharmaceutical compositions containing the same |
| DE602004011398T2 (de) * | 2004-01-08 | 2009-01-15 | Wyeth | Direkt komprimierbare pharmazeutische zusammensetzung für die orale verabreichung von cci-779 |
| US7349971B2 (en) * | 2004-02-05 | 2008-03-25 | Scenera Technologies, Llc | System for transmitting data utilizing multiple communication applications simultaneously in response to user request without specifying recipient's communication information |
| US7268144B2 (en) | 2004-04-14 | 2007-09-11 | Wyeth | Regiospecific synthesis of rapamycin 42-ester derivatives |
| BRPI0510277A (pt) * | 2004-04-27 | 2007-10-30 | Wyeth Corp | método para marcar especificamente uma rapamicina, rapamicina especificamente marcada, composição, e, kit |
| CA2578245C (en) | 2004-08-27 | 2013-10-29 | Cordis Corporation | Solvent free amorphous rapamycin |
| EP1809247A1 (en) * | 2004-09-29 | 2007-07-25 | Cordis Corporation | Pharmaceutical dosage forms of stable amorphous rapamycin like compounds |
| WO2006086172A1 (en) | 2005-02-09 | 2006-08-17 | Wyeth | Cci-779 polymorph and use thereof |
| JP2009518412A (ja) * | 2005-12-07 | 2009-05-07 | ワイス | ラパマイシン４２−エステルボロネートからラパマイシン４２−エステルを調製するためのスケーラブルな方法 |
| PE20071000A1 (es) * | 2005-12-07 | 2007-10-10 | Wyeth Corp | Metodos para la preparacion de rapamicina cristalina y para la medicion de la cristalinidad de los compuestos de rapamicina utilizando calorimetria diferencial de barrido |
| PE20071041A1 (es) * | 2005-12-07 | 2007-12-07 | Wyeth Corp | Forma cristalina purificada de cci-779 y proceso para la preparacion del mismo |
| AU2006328385B2 (en) * | 2005-12-21 | 2011-08-25 | Eisai R & D Management Co., Ltd. | Amorphous form of 1,2-dihydropyridine compound |
| US8414525B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Drug releasing coatings for medical devices |
| US8414910B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Drug releasing coatings for medical devices |
| US9737640B2 (en) | 2006-11-20 | 2017-08-22 | Lutonix, Inc. | Drug releasing coatings for medical devices |
| US20080175887A1 (en) * | 2006-11-20 | 2008-07-24 | Lixiao Wang | Treatment of Asthma and Chronic Obstructive Pulmonary Disease With Anti-proliferate and Anti-inflammatory Drugs |
| US8430055B2 (en) | 2008-08-29 | 2013-04-30 | Lutonix, Inc. | Methods and apparatuses for coating balloon catheters |
| US8425459B2 (en) | 2006-11-20 | 2013-04-23 | Lutonix, Inc. | Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent |
| US8414526B2 (en) * | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Medical device rapid drug releasing coatings comprising oils, fatty acids, and/or lipids |
| US20080276935A1 (en) * | 2006-11-20 | 2008-11-13 | Lixiao Wang | Treatment of asthma and chronic obstructive pulmonary disease with anti-proliferate and anti-inflammatory drugs |
| US8998846B2 (en) | 2006-11-20 | 2015-04-07 | Lutonix, Inc. | Drug releasing coatings for balloon catheters |
| US9700704B2 (en) | 2006-11-20 | 2017-07-11 | Lutonix, Inc. | Drug releasing coatings for balloon catheters |
| US20080234657A1 (en) * | 2007-03-22 | 2008-09-25 | Medtronic Vascular, Inc. | Methods for contributing to cardiovascular treatments |
| JP2008305262A (ja) * | 2007-06-08 | 2008-12-18 | Konica Minolta Business Technologies Inc | サーバ及びシンクライアント環境でのプリンタ紹介方法 |
| US8852620B2 (en) | 2007-07-20 | 2014-10-07 | Medtronic Vascular, Inc. | Medical devices comprising polymeric drug delivery systems with drug solubility gradients |
| US20090269480A1 (en) * | 2008-04-24 | 2009-10-29 | Medtronic Vascular, Inc. | Supercritical Fluid Loading of Porous Medical Devices With Bioactive Agents |
| ES2645692T3 (es) | 2008-11-11 | 2017-12-07 | The Board Of Regents,The University Of Texas System | Microcápsulas de rapamicina y su uso para el tratamiento del cáncer |
| US20100227799A1 (en) * | 2009-03-09 | 2010-09-09 | Medtronic Vascular, Inc. | Simultaneous photodynamic therapy and photo induced polymerization |
| CA2761255C (en) | 2009-05-12 | 2017-05-09 | Corcept Therapeutics, Inc. | Solid forms and process for preparing (r)-4a-ethoxymethyl-1-(4-fluoro-phenyl)-6-(4-trifluoromethyl-benzenesulfonyl)-4,4a,5,6,7,8-hexahydro-1h,1,2,6-triaza-cyclopenta[b]naphthalene |
| US9283211B1 (en) | 2009-11-11 | 2016-03-15 | Rapamycin Holdings, Llc | Oral rapamycin preparation and use for stomatitis |
| WO2015103447A1 (en) | 2013-12-31 | 2015-07-09 | Rapamycin Holdings, Llc | Oral rapamycin nanoparticle preparations and use |
| WO2012094618A1 (en) | 2011-01-07 | 2012-07-12 | Corcept Therapeutics, Inc. | Combination steroid and glucocorticoid receptor antagonist therapy |
| US8859774B2 (en) | 2012-05-25 | 2014-10-14 | Corcept Therapeutics, Inc. | Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators |
| US12226412B2 (en) | 2012-05-25 | 2025-02-18 | Corcept Therapeutics, Inc. | Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators |
| DK2968281T3 (da) | 2013-03-13 | 2020-11-02 | Univ Texas | Mtor-hæmmere til forebyggelse af vækst af tarmpolyp |
| EP3039011A1 (en) * | 2013-08-29 | 2016-07-06 | Cadila Healthcare Limited | Polymorphic form of pyrrole derivative and intermediate thereof |
| EP3074011B1 (en) | 2013-11-25 | 2019-07-24 | Corcept Therapeutics Incorporated | Octahydro fused azadecalin glucocorticoid receptor modulators |
| US9700544B2 (en) | 2013-12-31 | 2017-07-11 | Neal K Vail | Oral rapamycin nanoparticle preparations |
| CN110520121B (zh) | 2017-03-31 | 2023-07-04 | 科赛普特治疗学股份有限公司 | 糖皮质激素受体调节剂治疗宫颈癌 |
| ES2871499T3 (es) | 2017-05-15 | 2021-10-29 | Bard Inc C R | Dispositivo médico con recubrimiento de elución de fármaco y capa intermedia |
| PT115056B (pt) * | 2018-10-04 | 2021-12-10 | Hovione Farm Sa | Formas amorfas de agentes quelantes e seus métodos de preparação |
| WO2020101675A1 (en) | 2018-11-14 | 2020-05-22 | Lutonix, Inc. | Medical device with drug-eluting coating on modified device surface |
| IL284061B2 (en) | 2018-12-19 | 2025-02-01 | Corcept Therapeutics Inc | A preparation containing a relaxant |
| WO2020132046A1 (en) | 2018-12-19 | 2020-06-25 | Corcept Therapeutics Incorporated | Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent |
| US11234971B2 (en) | 2018-12-19 | 2022-02-01 | Corcept Therapeutics Incorporated | Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent |
| PH12021552025A1 (en) | 2019-02-22 | 2022-08-22 | Corcept Therapeutics Inc | Therapeutic uses of relacorilant, a heteroaryl-ketone fused azadecalin glucocorticoid receptor modulator |
| WO2020209828A1 (en) | 2019-04-08 | 2020-10-15 | Bard Peripheral Vascular, Inc. | Medical device with drug-eluting coating on modified device surface |
| CA3158745A1 (en) | 2019-12-11 | 2021-06-17 | Corcept Therapeutics Incorporated | Methods of treating antipsychotic-induced weight gain with miricorilant |
| WO2022134033A1 (en) | 2020-12-25 | 2022-06-30 | Corcept Therapeutics Incorporated | Methods of preparing heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators |
| CN119997939A (zh) | 2022-10-06 | 2025-05-13 | 科赛普特治疗公司 | 糖皮质激素受体调节剂的制剂 |
| WO2024092195A1 (en) | 2022-10-28 | 2024-05-02 | Corcept Therapeutics Incorporated | Treatments for amyotrophic lateral sclerosis using dazucorilant |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5362718A (en) * | 1994-04-18 | 1994-11-08 | American Home Products Corporation | Rapamycin hydroxyesters |
| AU712193B2 (en) * | 1995-06-09 | 1999-10-28 | Novartis Ag | Rapamycin derivatives |
| FR2736550B1 (fr) | 1995-07-14 | 1998-07-24 | Sandoz Sa | Composition pharmaceutique sous la forme d'une dispersion solide comprenant un macrolide et un vehicule |
| US5780462A (en) * | 1995-12-27 | 1998-07-14 | American Home Products Corporation | Water soluble rapamycin esters |
| US5989591A (en) | 1997-03-14 | 1999-11-23 | American Home Products Corporation | Rapamycin formulations for oral administration |
| TWI256395B (en) * | 1999-09-29 | 2006-06-11 | Wyeth Corp | Regioselective synthesis of rapamycin derivatives |
| NZ538781A (en) | 2002-09-17 | 2007-11-30 | Wyeth Corp | Oral formulations |
| UA83245C2 (en) * | 2003-08-07 | 2008-06-25 | Уайт | Regioselective synthesis of cci-779 |
| WO2005023254A1 (en) | 2003-09-03 | 2005-03-17 | Wyeth | Amorphous rapamycin 42-ester with 3-hydroxy-2-(hydroxymethyl)-2-methylpropionic acid and its pharmaceutical compositions containing the same |
| DE602004011398T2 (de) | 2004-01-08 | 2009-01-15 | Wyeth | Direkt komprimierbare pharmazeutische zusammensetzung für die orale verabreichung von cci-779 |
-
2004
- 2004-08-16 WO PCT/US2004/026591 patent/WO2005023254A1/en not_active Ceased
- 2004-08-16 EP EP04781305A patent/EP1660081A1/en not_active Withdrawn
- 2004-08-16 KR KR1020067004527A patent/KR20060090803A/ko not_active Abandoned
- 2004-08-16 BR BRPI0414066-4A patent/BRPI0414066A/pt not_active IP Right Cessation
- 2004-08-16 UA UAA200603517A patent/UA84881C2/ru unknown
- 2004-08-16 RU RU2006110568/04A patent/RU2345999C2/ru not_active IP Right Cessation
- 2004-08-16 AU AU2004270154A patent/AU2004270154A1/en not_active Withdrawn
- 2004-08-16 CA CA002536775A patent/CA2536775A1/en not_active Abandoned
- 2004-08-16 MX MXPA06002123A patent/MXPA06002123A/es active IP Right Grant
- 2004-08-16 CN CNA2004800325370A patent/CN1874771A/zh active Pending
- 2004-08-16 JP JP2006525345A patent/JP2007504226A/ja not_active Withdrawn
- 2004-08-16 SG SG200805820-8A patent/SG145716A1/en unknown
- 2004-08-31 US US10/930,487 patent/US7271177B2/en not_active Expired - Fee Related
- 2004-09-01 PE PE2004000844A patent/PE20050945A1/es not_active Application Discontinuation
- 2004-09-01 TW TW093126302A patent/TW200510428A/zh unknown
- 2004-09-02 AR ARP040103142A patent/AR045559A1/es unknown
- 2004-09-03 GT GT200400175A patent/GT200400175A/es unknown
- 2004-09-03 PA PA20048611201A patent/PA8611201A1/es unknown
- 2004-10-12 SA SA4250334A patent/SA04250334B1/ar unknown
-
2006
- 2006-02-16 IL IL173786A patent/IL173786A0/en unknown
- 2006-03-02 ZA ZA200601822A patent/ZA200601822B/xx unknown
- 2006-03-03 NO NO20061048A patent/NO20061048L/no not_active Application Discontinuation
- 2006-03-16 CR CR8293A patent/CR8293A/es not_active Application Discontinuation
- 2006-03-17 CO CO06027353A patent/CO5680426A2/es unknown
- 2006-04-03 EC EC2006006473A patent/ECSP066473A/es unknown
-
2007
- 2007-08-10 US US11/891,500 patent/US7446111B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| RU2345999C2 (ru) | 2009-02-10 |
| AR045559A1 (es) | 2005-11-02 |
| BRPI0414066A (pt) | 2006-10-24 |
| CR8293A (es) | 2006-07-14 |
| NO20061048L (no) | 2006-05-24 |
| AU2004270154A1 (en) | 2005-03-17 |
| SA04250334B1 (ar) | 2008-05-19 |
| US20050049271A1 (en) | 2005-03-03 |
| IL173786A0 (en) | 2006-07-05 |
| GT200400175A (es) | 2005-04-18 |
| PA8611201A1 (es) | 2005-05-10 |
| ZA200601822B (en) | 2008-12-31 |
| TW200510428A (en) | 2005-03-16 |
| US20080070950A1 (en) | 2008-03-20 |
| UA84881C2 (ru) | 2008-12-10 |
| ECSP066473A (es) | 2006-10-10 |
| JP2007504226A (ja) | 2007-03-01 |
| KR20060090803A (ko) | 2006-08-16 |
| US7271177B2 (en) | 2007-09-18 |
| RU2006110568A (ru) | 2007-10-10 |
| MXPA06002123A (es) | 2006-05-17 |
| CO5680426A2 (es) | 2006-09-29 |
| CN1874771A (zh) | 2006-12-06 |
| EP1660081A1 (en) | 2006-05-31 |
| WO2005023254A1 (en) | 2005-03-17 |
| US7446111B2 (en) | 2008-11-04 |
| CA2536775A1 (en) | 2005-03-17 |
| SG145716A1 (en) | 2008-09-29 |
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