[go: up one dir, main page]

AR036018A1 - Proceso para aislar monohidrato de imipenem cristalino puro - Google Patents

Proceso para aislar monohidrato de imipenem cristalino puro

Info

Publication number
AR036018A1
AR036018A1 ARP020101854A ARP020101854A AR036018A1 AR 036018 A1 AR036018 A1 AR 036018A1 AR P020101854 A ARP020101854 A AR P020101854A AR P020101854 A ARP020101854 A AR P020101854A AR 036018 A1 AR036018 A1 AR 036018A1
Authority
AR
Argentina
Prior art keywords
imipenem
monohidrate
pure crystal
isolating pure
isolating
Prior art date
Application number
ARP020101854A
Other languages
English (en)
Inventor
Yatendra Kumar
Neera Tewari
Ram Chander Aryan
Bishwa Prakash Rai
Original Assignee
Ranbaxy Lab Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ranbaxy Lab Ltd filed Critical Ranbaxy Lab Ltd
Publication of AR036018A1 publication Critical patent/AR036018A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02—Preparation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)

Abstract

El presente se relaciona con un proceso de efectividad en el costo industrialmente ventajoso para aislar imipenem de alta pureza de la fórmula (1), que comprende cristalizar a temperatura baja monohidrato de imipenem a partir de una solución del mismo que contiene un solvente orgánico miscible en agua, un solvente acuoso o una mezcla de los mismos, sin utilizar liofilización, secado por congelamiento ni técnicas cromatográficas.
ARP020101854A 2001-05-18 2002-05-20 Proceso para aislar monohidrato de imipenem cristalino puro AR036018A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN595DE2001 2001-05-18

Publications (1)

Publication Number Publication Date
AR036018A1 true AR036018A1 (es) 2004-08-04

Family

ID=11097062

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP020101854A AR036018A1 (es) 2001-05-18 2002-05-20 Proceso para aislar monohidrato de imipenem cristalino puro

Country Status (17)

Country Link
US (1) US7241885B2 (es)
EP (1) EP1395588A4 (es)
JP (1) JP2005514323A (es)
KR (1) KR20040010649A (es)
CN (1) CN1522255A (es)
AR (1) AR036018A1 (es)
BR (1) BR0209844A (es)
CA (1) CA2447673A1 (es)
CZ (1) CZ20033351A3 (es)
HU (1) HUP0501093A2 (es)
MX (1) MXPA03010548A (es)
NO (1) NO20035137D0 (es)
OA (1) OA12608A (es)
PL (1) PL373527A1 (es)
SK (1) SK15092003A3 (es)
WO (1) WO2002094773A2 (es)
ZA (1) ZA200309288B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA03010498A (es) * 2001-05-18 2004-05-27 Ranbaxy Lab Ltd Proceso para la preparacion de imipenem.
EP1426376A4 (en) * 2001-08-13 2004-12-22 Eisai Co Ltd PROCESS FOR THE PREPARATION OF CARBAPENEM-BASED ANTIBIOTICS
BR0214209A (pt) * 2001-11-16 2004-10-26 Ranbaxy Lab Ltd Processo para a preparação de imipenem cristalino e composto preparado pelo dito processo
EP2209787A4 (en) 2007-10-08 2011-08-03 Orchid Chemicals & Pharm Ltd METHOD FOR PRODUCING A CARBAPENEM ANTIBIOTICS
CN103524508B (zh) * 2013-09-02 2016-03-30 上海龙翔生物医药开发有限公司 一种亚胺培南一水合物的结晶方法
CN108623598A (zh) * 2018-05-21 2018-10-09 重庆天地药业有限责任公司 一种亚胺培南中间体及亚胺培南的制备方法
CN113135916A (zh) * 2020-01-20 2021-07-20 鲁南制药集团股份有限公司 一种亚胺培南制备工艺的除钯方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4138433A (en) * 1975-06-26 1979-02-06 Hoechst Aktiengesellschaft Process for preparing 1,2-oxa-phospholanes
US4194047A (en) * 1975-11-21 1980-03-18 Merck & Co., Inc. Substituted N-methylene derivatives of thienamycin
US4081455A (en) * 1976-06-02 1978-03-28 Pfizer Inc. 6-Amino-2,2-dimethyl-3-cyanopenams
US4260543A (en) * 1978-07-03 1981-04-07 Merck & Co., Inc. Crystalline N-formimidoyl thienamycin
US4292436A (en) * 1980-06-25 1981-09-29 Merck & Co., Inc. Process for the preparation of N-protected N-formimidoyl 2-aminoethanethiol
US4374772A (en) * 1981-03-19 1983-02-22 Merck & Co., Inc. Process for the preparation of N-formimidoyl thienamycin and reagents therefor
US4894450A (en) * 1987-05-11 1990-01-16 Merck & Co., Inc. Process for 2-(aminoalkylthio) carbapenems
US5245069A (en) * 1992-10-27 1993-09-14 Merck & Co., Inc. Process for the preparation of bis(aryl)-phosphorohalidates
IN191798B (es) 2000-11-03 2004-01-03 Ranbaxy Lab Ltd
BR0214209A (pt) * 2001-11-16 2004-10-26 Ranbaxy Lab Ltd Processo para a preparação de imipenem cristalino e composto preparado pelo dito processo

Also Published As

Publication number Publication date
CZ20033351A3 (cs) 2007-12-27
SK15092003A3 (sk) 2004-09-08
OA12608A (en) 2006-06-08
MXPA03010548A (es) 2004-05-27
CN1522255A (zh) 2004-08-18
US20040242865A1 (en) 2004-12-02
PL373527A1 (en) 2005-09-05
ZA200309288B (en) 2005-02-28
KR20040010649A (ko) 2004-01-31
WO2002094773A3 (en) 2003-10-16
WO2002094773A2 (en) 2002-11-28
JP2005514323A (ja) 2005-05-19
CA2447673A1 (en) 2002-11-28
EP1395588A4 (en) 2004-09-15
US7241885B2 (en) 2007-07-10
HUP0501093A2 (en) 2006-03-28
NO20035137D0 (no) 2003-11-18
BR0209844A (pt) 2005-04-05
EP1395588A2 (en) 2004-03-10

Similar Documents

Publication Publication Date Title
CO5560540A2 (es) Composicion cristalina que contiene escitalopram
AR068527A2 (es) Un procedimiento para preparar monohidrato de bromuro de tiotropio cristalino
CU23873B1 (es) Nuevo procedimiento para la preparación de un intermediario útil en la preparación de imidazotriazinonas sustituidas con sulfonamida
ES2126355T3 (es) Procedimiento para la preparacion de creatina o monohidrato de creatina.
BR0005488A (pt) Processo para a preparação de carbonato de vinileno, e o uso do mesmo
Kakaei et al. Expeditious synthesis of 1-substituted taurines with diverse functionalized side-chains
PT1025067E (pt) Processo para a cristalizacao de compostos impedidos estereoquimicamente
AR036018A1 (es) Proceso para aislar monohidrato de imipenem cristalino puro
ES2881882T3 (es) Método para producir ácido N-retinoilaminoalcanosulfónico
BR0314067A (pt) Processo para a preparação de clorotris(trifenilfosfan)ródio(i)
AR048279A1 (es) La forma ii cristalina de cabergolina
BRPI0212411B8 (pt) ' processos para reduzir os níveis de solventes orgânicos em um sólido de carbapenem, e para fabricar um hidrato cristalino'
PE20061014A1 (es) Clorhidrato de lercanidipina amorfo
McIlwain 18. Amino-sulphonic acid analogues of natural amino-carboxylic acids
ES2239554T1 (es) Forma xvi polimorfica de hidrocloruro de fexofenadina.
AR035808A1 (es) Proceso de deshidratacion capaz de minimizar la epimerizacion de un grupo hidroxilo por ciertas equinocandinas
BRPI0415347A (pt) processo para a produção de bicalutamida e método para a purificação de intermediário da mesma
ES2634294T3 (es) Procedimiento para la preparación de 1,4-quinonametidas sustituidas
AR027053A1 (es) Procedimiento para la preparacion de poliamidas
ES8403487A1 (es) "procedimiento para la preparacion de n-(2-metoxietil)-noroximorfona".
CU23171A3 (es) Procedimiento para la preparacion de sal de calcio de zofenopril
BRPI0113939B8 (pt) método para a purificação de um ácido alfa-hidróxi em uma escala industrial.
AR071546A1 (es) Proceso para recuperar florfenicol y analogos de florfenicol. metodo.
BR112022001487A2 (pt) Processo contínuo para preparar a forma cristalina ii de sotagliflozina
DK1940772T3 (da) Ny fremgangsmåde til fremstilling af kvaternære syre- og ammoniumsalte

Legal Events

Date Code Title Description
FA Abandonment or withdrawal