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PE20040365A1 - Inhibidores de la transcriptasa inversa no nucleosidos - Google Patents

Inhibidores de la transcriptasa inversa no nucleosidos

Info

Publication number
PE20040365A1
PE20040365A1 PE2003000461A PE2003000461A PE20040365A1 PE 20040365 A1 PE20040365 A1 PE 20040365A1 PE 2003000461 A PE2003000461 A PE 2003000461A PE 2003000461 A PE2003000461 A PE 2003000461A PE 20040365 A1 PE20040365 A1 PE 20040365A1
Authority
PE
Peru
Prior art keywords
methyl
alkyl
dipyride
diazepin
dihydro
Prior art date
Application number
PE2003000461A
Other languages
English (en)
Inventor
Landry Bruno Simon Eau Serge
Eric Malenfant
Julie Naud
Jeffrey O'meara
Bounklam Thavonekham
Christiane Yoakim
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of PE20040365A1 publication Critical patent/PE20040365A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE R2 ES H, ALQUILO C1-C4, HIDROXI, ENTRE OTROS; R4 Y R5 SON H O METILO; R11 ES H, ALQUILO C1-C4, CICLOALQUILO C3-C4, ENTRE OTROS; A ES UNA CADENA DE CONEXION DE ALQUILO C1-C3; B ES S U O; n ES 0 O 1; ANILLO C Y ANILLO D SON ARILOS DE 6 O 10 MIEMBROS O HETEROCICLOS DE 5 O 6 MIEMBROS; E ES UN ENLACE SENCILLO, CARBONILO, CONR12R13, ENTRE OTROS; R12 Y R13 SON H, SO2(ALQUILO C1-C6), ALQUIL (C1-C6)-COOH, ENTRE OTROS. SON COMPUESTOS PREFERIDOS ACIDO 4'-[2-(11-ETIL-6,11-DIHIDRO-5-METIL-6-OXO-5H-DIPIRIDO[3,2-b:2',3'-e][1,4]DIAZEPIN-8-IL)ETOXI]-3'-METIL-[1,1'-BIFENIL]-3-CARBOXILICO, ACIDO 4-AMINO-4'-[2-(11-ETIL-6,11-DIHIDRO-5-METIL-6-OXO-5H-DIPIRIDO[3,2-b:2',3'-e][1,4]DIAZEPIN-8-IL)ETOXI]-3'-METIL-[1,1'-BIFENIL]-3-CARBOXILICO Y ACIDO 3-(4[2-(11-ETIL-6,11-DIHIDRO-5-METIL-6-OXO-5H-DIPIRIDO[3,2-b:2',3'-e][1,4] DIAZEPIN-8-IL)ETOXI]-3-METILFENIL)-5-ISOXAZOLCARBOXILICO, ENTRE OTROS. DICHOS COMPUESTOS INHIBIDORES DE LA TRASCRIPTASA INVERSA SON UTILES PARA EL TRATAMIENTO O PROFILAXIS DE INFECCIONES POR VIH
PE2003000461A 2002-05-16 2003-05-14 Inhibidores de la transcriptasa inversa no nucleosidos PE20040365A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US38088602P 2002-05-16 2002-05-16

Publications (1)

Publication Number Publication Date
PE20040365A1 true PE20040365A1 (es) 2004-07-22

Family

ID=29550032

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2003000461A PE20040365A1 (es) 2002-05-16 2003-05-14 Inhibidores de la transcriptasa inversa no nucleosidos

Country Status (28)

Country Link
US (1) US6806265B2 (es)
EP (1) EP1506195B1 (es)
JP (1) JP4230448B2 (es)
KR (1) KR20050008716A (es)
CN (1) CN1318421C (es)
AR (1) AR040027A1 (es)
AT (1) ATE412653T1 (es)
AU (1) AU2003229186A1 (es)
BR (1) BR0310033A (es)
CA (1) CA2485916C (es)
DE (1) DE60324418D1 (es)
EA (1) EA009178B1 (es)
EC (1) ECSP045432A (es)
ES (1) ES2315492T3 (es)
HR (1) HRP20041065A2 (es)
IL (1) IL163753A0 (es)
MX (1) MXPA04010409A (es)
MY (1) MY134646A (es)
NO (1) NO20044104L (es)
NZ (1) NZ536736A (es)
PE (1) PE20040365A1 (es)
PL (1) PL371663A1 (es)
RS (1) RS98004A (es)
TW (1) TW200404071A (es)
UA (1) UA79285C2 (es)
UY (1) UY27809A1 (es)
WO (1) WO2003097644A2 (es)
ZA (1) ZA200406912B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0302094D0 (en) 2003-01-29 2003-02-26 Pharmagene Lab Ltd EP4 receptor antagonists
EP1610797A1 (en) * 2003-03-27 2006-01-04 Boehringer Ingelheim International GmbH Antiviral combination of nevirapine and a further antiretroviral compound
US7348338B2 (en) 2003-07-17 2008-03-25 Plexxikon, Inc. PPAR active compounds
RU2356889C2 (ru) * 2003-07-17 2009-05-27 Плекссикон, Инк. Соединения, являющиеся активными по отношению к рецепторам, активируемым пролифератором пероксисом
GB0324269D0 (en) 2003-10-16 2003-11-19 Pharmagene Lab Ltd EP4 receptor antagonists
DE102004051277A1 (de) * 2004-10-21 2006-04-27 Merck Patent Gmbh Heterocyclische Carbonylverbindungen
EP1819673A2 (en) * 2004-11-30 2007-08-22 Plexxikon, Inc. Indole derivatives for use as ppar active compounds
BRPI0615948A2 (pt) * 2005-09-07 2011-05-31 Plexxikon Inc composto ativo de ppar, sua composição, seu kit e seu uso
SG165362A1 (en) * 2005-09-07 2010-10-28 Plexxikon Inc Ppar active compounds
EP1931658A2 (en) * 2005-09-07 2008-06-18 Plexxikon, Inc. 1 , 4 and 1 , 5-disubstituted indole derivatives for use as ppar active compounds
US8492428B2 (en) 2005-09-20 2013-07-23 Mayo Foundation For Medical Education And Research Small-molecule botulinum toxin inhibitors
PE20090159A1 (es) * 2007-03-08 2009-02-21 Plexxikon Inc COMPUESTOS DERIVADOS DE ACIDO INDOL-PROPIONICO COMO MODULADORES PPARs
EP3223821A1 (de) 2014-11-25 2017-10-04 Bayer Pharma Aktiengesellschaft Substituierte pyridobenzodiazepinon-derivate und ihre verwendung
CN115745910B (zh) 2017-07-21 2025-05-27 安塔比奥公司 化学化合物
CR20200464A (es) 2018-03-08 2021-04-14 Incyte Corp Compuestos diólicos de aminopirazina como inhibidores de pi3k-y
US11046658B2 (en) 2018-07-02 2021-06-29 Incyte Corporation Aminopyrazine derivatives as PI3K-γ inhibitors
US12384753B2 (en) * 2021-08-20 2025-08-12 Enanta Pharmaceuticals, Inc. 17-beta-hydroxysteroid dehydrogenase type 13 inhibitors and methods of use thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5366972A (en) 1989-04-20 1994-11-22 Boehringer Ingelheim Pharmaceuticals, Inc. 5,11-dihydro-6H-dipyrido(3,2-B:2',3'-E)(1,4)diazepines and their use in the prevention or treatment of HIV infection
US5705499A (en) * 1995-10-06 1998-01-06 Boehringer Ingelheim Pharmaceuticals, Inc. 8-arylalkyl- and 8-arylheteroalkyl-5,11-dihydro-6H-dipyrido 3,2-B:2',3'-e! 1!diazepines and their use in the treatment of HIV-1 infection
TWI270547B (en) 2000-06-16 2007-01-11 Boehringer Ingelheim Ca Ltd Non-nucleoside reverse transcriptase inhibitors
US6716836B2 (en) 2001-03-22 2004-04-06 Boehringer Ingelheim (Canada) Ltd. Non-nucleoside reverse transcriptase inhibitors
US6673791B2 (en) 2001-07-30 2004-01-06 Boehringer Ingelheim (Canada) Ltd. Non-nucleoside reverse transcriptase inhibitors

Also Published As

Publication number Publication date
WO2003097644A3 (en) 2004-02-05
CN1653066A (zh) 2005-08-10
EP1506195A2 (en) 2005-02-16
DE60324418D1 (de) 2008-12-11
CA2485916C (en) 2009-12-08
UY27809A1 (es) 2003-12-31
BR0310033A (pt) 2005-02-15
WO2003097644A2 (en) 2003-11-27
US6806265B2 (en) 2004-10-19
NZ536736A (en) 2006-11-30
EA200401482A1 (ru) 2005-06-30
EA009178B1 (ru) 2007-12-28
CA2485916A1 (en) 2003-11-27
UA79285C2 (en) 2007-06-11
ZA200406912B (en) 2006-06-28
ES2315492T3 (es) 2009-04-01
TW200404071A (en) 2004-03-16
EP1506195B1 (en) 2008-10-29
HRP20041065A2 (en) 2005-04-30
ATE412653T1 (de) 2008-11-15
RS98004A (sr) 2006-12-15
AR040027A1 (es) 2005-03-09
KR20050008716A (ko) 2005-01-21
US20040006071A1 (en) 2004-01-08
IL163753A0 (en) 2005-12-18
NO20044104L (no) 2004-12-01
MXPA04010409A (es) 2005-02-17
HK1080849A1 (en) 2006-05-04
JP2005526851A (ja) 2005-09-08
CN1318421C (zh) 2007-05-30
MY134646A (en) 2007-12-31
ECSP045432A (es) 2005-01-03
AU2003229186A1 (en) 2003-12-02
PL371663A1 (en) 2005-06-27
JP4230448B2 (ja) 2009-02-25

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