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PE20040833A1 - Derivado de 1-aminociclohexano sustituidos en la posicion 4 - Google Patents

Derivado de 1-aminociclohexano sustituidos en la posicion 4

Info

Publication number
PE20040833A1
PE20040833A1 PE2003001140A PE2003001140A PE20040833A1 PE 20040833 A1 PE20040833 A1 PE 20040833A1 PE 2003001140 A PE2003001140 A PE 2003001140A PE 2003001140 A PE2003001140 A PE 2003001140A PE 20040833 A1 PE20040833 A1 PE 20040833A1
Authority
PE
Peru
Prior art keywords
ilo
alkyl
substituted
dichlorhydrate
indol
Prior art date
Application number
PE2003001140A
Other languages
English (en)
Inventor
Claudia Hinze
Hans Schick
Helmut Sonnenschein
Original Assignee
Gruenenthal Chemie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Chemie filed Critical Gruenenthal Chemie
Publication of PE20040833A1 publication Critical patent/PE20040833A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE REFIERE A DERIVADOS DEL 1-AMINOCICLOHEXANO SUSTITUIDO EN LA POSICION 4, DE FORMULA GENERAL I, EN DONDE n ES 0, 1 o 2; X ES UN ENLACE o C(O), C(O)NH, C(O)CH2, ENTRE OTROS; R1 Y R2 SON H, ALQUILO C1-C8 O CICLOALQUILO C3-C8, CADA UNO SATURADO O NO, RAMIFICADO O NO, SUSTITUIDO UNA O MAS VECES O NO SUSTITUIDO, ENTRE OTROS; O BIEN R1 Y R2 JUNTOS FORMAN UN ANILLO Y SON CH2CH2OCH2CH2, CH2CH2NR6CH2CH2 o (CH2)3-6; R6 ES H, ALQUILO C1-C8 O CICLOALQUILO C3-C8, ENTRE OTROS; R3 ES ALQUILO C1-C8 o CICLOALQUILO C3-C8, CADA UNO SATURADO O NO; R4 Y R5 SON H, ALQUILO C1-C6, O-ALQUILO C1-C3, ENTRE OTROS. ESTOS COMPUESTOS SE PUEDEN PRESENTAR EN FORMA DE SUS RACEMATOS, ESTEREOISOMEROS PUROS, ENANTIOMEROS, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: DICLORHIDRATO DE {4-[3-(1H-INDOL-3-ILO)-PIRROLIDIN-1-ILO]-1-FENIL-CICLOHEXIL}-DIMETILAMINA (DIASTEREOMERO NO POLAR); DICLORHIDRATO DE {4-[3-(1H-INDOL-3-ILO)-PIRROLIDIN-1-ILO]-1-FENIL-CICLOHEXIL}-DIMETILAMINA (MEZCLA DE DIASTEREOISOMEROS); DICLORHIDRATO DE {4-[4-(5-CLORO-1H-INDOL-3-ILO)-PIPERIDIN-1-ILO]-1-FENIL-CICLOHEXIL}-DIMETILAMINA (DIASTEREOMERO NO POLAR); ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA SU PREPARACION. ESTOS COMPUESTOS INFLUYEN SOBRE EL RECEPTOR ORL1 DE NOCICEPTINA Y/O EL RECEPTOR OPIATO m Y SON UTILES PARA TRATAMIENTO DEL DOLOR, EN ESPECIAL DEL DOLOR AGUDO, VISCERAL, NEUROPATICO O CRONICO
PE2003001140A 2002-11-11 2003-11-11 Derivado de 1-aminociclohexano sustituidos en la posicion 4 PE20040833A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10252666A DE10252666A1 (de) 2002-11-11 2002-11-11 N-Piperidyl-cyclohexan-Derivate

Publications (1)

Publication Number Publication Date
PE20040833A1 true PE20040833A1 (es) 2004-11-17

Family

ID=32308522

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2003001140A PE20040833A1 (es) 2002-11-11 2003-11-11 Derivado de 1-aminociclohexano sustituidos en la posicion 4

Country Status (13)

Country Link
US (1) US7759385B2 (es)
EP (1) EP1560823B1 (es)
AR (1) AR041941A1 (es)
AT (1) ATE400569T1 (es)
AU (1) AU2003287993A1 (es)
CY (1) CY1108378T1 (es)
DE (2) DE10252666A1 (es)
DK (1) DK1560823T3 (es)
ES (1) ES2309373T3 (es)
PE (1) PE20040833A1 (es)
PT (1) PT1560823E (es)
SI (1) SI1560823T1 (es)
WO (1) WO2004043949A1 (es)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10252665A1 (de) * 2002-11-11 2004-06-03 Grünenthal GmbH 4-Aminomethyl-1-aryl-cyclohexylamin-Derivate
CA2533509C (en) * 2003-07-24 2011-02-22 Euro-Celtique S.A. Piperidine compounds and pharmaceutical compositions containing them
CN1856484B (zh) * 2003-07-24 2010-09-22 欧洲凯尔蒂克公司 用于治疗或预防疼痛的杂芳基-四氢吡啶基化合物
DE10337184A1 (de) * 2003-08-13 2005-03-10 Gruenenthal Gmbh Substituierte 3-Pyrrolidin-Indol-Derivate
DE102004023507A1 (de) 2004-05-10 2005-12-01 Grünenthal GmbH Substituierte Cyclohexylessigsäure-Derivate
DE102004023635A1 (de) * 2004-05-10 2006-04-13 Grünenthal GmbH Heteroarylsubstituierte Cyclohexyl-1,4-diamin-Derivate
DE102004023522A1 (de) * 2004-05-10 2005-12-01 Grünenthal GmbH Substituierte Cyclohexyl-1,4-diamin-Derivate
DE102004023632A1 (de) * 2004-05-10 2005-12-08 Grünenthal GmbH Substituierte Cyclohexylcarbonsäure-Derivate
DE102006033109A1 (de) * 2006-07-18 2008-01-31 Grünenthal GmbH Substituierte Heteroaryl-Derivate
DE102006046745A1 (de) * 2006-09-29 2008-04-03 Grünenthal GmbH Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz
EP2178534A4 (en) 2007-07-17 2011-03-30 Merck Sharp & Dohme SOLUBLE EPOXYHYDROLASE HEMMER, COMPOSITIONS WITH SUCH COMPOUNDS AND TREATMENT METHODS THEREWITH
ES2400105T3 (es) * 2007-11-05 2013-04-05 Merck Patent Gmbh Derivados de 7-azaindol como inhibidores selectivos de la 11-beta-hidroxiesteroide deshidrogenasa de tipo 1
AR070398A1 (es) 2008-02-22 2010-03-31 Gruenenthal Chemie Derivados sustituidos de indol
ES2375543T3 (es) 2008-03-27 2012-03-01 Grünenthal GmbH Derivados de espiro(5.5)undecano.
JP5650637B2 (ja) 2008-03-27 2015-01-07 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング （ヘテロ−）アリール−シクロヘキサン誘導体
AU2009228647B2 (en) 2008-03-27 2013-07-04 Grunenthal Gmbh Substituted spirocyclic cyclohexane derivatives
RU2514192C2 (ru) 2008-03-27 2014-04-27 Грюненталь Гмбх Гидроксиметилциклогексиламины
CN102046596B (zh) 2008-03-27 2013-12-25 格吕伦塔尔有限公司 取代的环己二胺
AU2009228642B2 (en) 2008-03-27 2013-11-07 Grunenthal Gmbh Substituted 4-aminocyclohexane derivatives
WO2013070659A1 (en) 2011-11-07 2013-05-16 Sunovion Pharmaceuticals Inc. Modulators of opioid receptors and methods of use thereof
US10702498B2 (en) 2015-07-09 2020-07-07 The Regents Of The University Of California MU opioid receptor modulators
EP3331530A4 (en) * 2015-08-03 2018-12-19 Raze Therapeutics Inc. Mthfd2 inhibitors and uses thereof
CA3096059A1 (en) 2018-04-04 2019-10-10 Epiodyne, Inc. Opioid receptor modulators and products and methods related thereto
WO2020120606A1 (en) * 2018-12-12 2020-06-18 Esteve Pharmaceuticals, S.A. New pyrrolidine-2-carboxylic acid derivatives for treating pain and pain related conditions
TW202026281A (zh) * 2018-12-12 2020-07-16 西班牙商艾斯提夫製藥股份有限公司 用於治療疼痛和疼痛相關病症之新吡咯啶–2– 甲酸衍生物
CN115190815B (zh) 2019-12-26 2024-06-18 吉尔伽美什制药公司 芳基环己基胺衍生物及其在精神障碍的治疗中的用途
LT4084791T (lt) 2020-02-18 2025-02-25 Gilgamesh Pharmaceuticals, Inc. Specifiniai triptaminai, skirti nuotaikos sutrikimams gydyti
TW202304869A (zh) 2021-04-05 2023-02-01 美商艾碧奧戴股份有限公司 類鴉片受體調節劑
US12129234B1 (en) 2023-08-03 2024-10-29 Gilgamesh Pharmaceuticals, Inc. Crystalline salts of N-ethyl-(5-fluoro-1H-indol-3-yl)-N-methylethan-1-amine
US12180158B1 (en) 2023-08-03 2024-12-31 Gilgamesh Pharmaceuticals, Inc. Crystalline fumarate salts of n-ethyl-2-(5-fluoro-1H-indol-3-yl)-n-methylethan-1-amine

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4113555A (en) * 1973-11-08 1978-09-12 Svenska Traforskningsinstitutet Hard board or medium density board, process for production thereof and means for practicizing the process
US4113866A (en) * 1977-04-01 1978-09-12 The Upjohn Company Analgetic compounds, compositions and process of treatment
TW438587B (en) * 1995-06-20 2001-06-07 Takeda Chemical Industries Ltd A pharmaceutical composition for prophylaxis and treatment of diabetes
US5763445A (en) * 1996-03-08 1998-06-09 Adolor Corporation Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
US5760023A (en) * 1997-07-14 1998-06-02 Adolor Corporation Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith
US6172087B1 (en) * 1998-06-03 2001-01-09 Gpi Nil Holding, Inc. N-oxide of heterocyclic ester, amide, thioester, or ketone hair growth compositions and uses
MA26659A1 (fr) * 1998-08-06 2004-12-20 Pfizer Dérivés de benzimidazole nouveaux, compositions pharmaceutiques les contenant et procédé pour leur préparation.
DE60022226D1 (de) * 1999-12-06 2005-09-29 Euro Celtique Sa Benzimidazolverbindungen die nociceptinrezeptoraffinität haben
GB0012240D0 (en) * 2000-05-19 2000-07-12 Merck Sharp & Dohme Therapeutic agents
DE60135764D1 (de) * 2000-10-06 2008-10-23 Mitsubishi Tanabe Pharma Corp Stickstoffhaltige, fünfgliedrige ringverbindungen
DE10252665A1 (de) * 2002-11-11 2004-06-03 Grünenthal GmbH 4-Aminomethyl-1-aryl-cyclohexylamin-Derivate

Also Published As

Publication number Publication date
US7759385B2 (en) 2010-07-20
SI1560823T1 (sl) 2008-12-31
WO2004043949A1 (de) 2004-05-27
ATE400569T1 (de) 2008-07-15
EP1560823A1 (de) 2005-08-10
CY1108378T1 (el) 2014-02-12
DE50310122D1 (de) 2008-08-21
DK1560823T3 (da) 2008-11-10
US20050277674A1 (en) 2005-12-15
PT1560823E (pt) 2008-09-25
AR041941A1 (es) 2005-06-01
AU2003287993A1 (en) 2004-06-03
EP1560823B1 (de) 2008-07-09
DE10252666A1 (de) 2004-08-05
ES2309373T3 (es) 2008-12-16

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