PE20040593A1 - DERIVADOS DE DIHIDROPIRIMIDO[4,5-d]PIRIMIDONA AMINO SUSTITUIDOS COMO INHIBIDORES DE TIROSINACINASAS DEL GRUPO SRC - Google Patents
DERIVADOS DE DIHIDROPIRIMIDO[4,5-d]PIRIMIDONA AMINO SUSTITUIDOS COMO INHIBIDORES DE TIROSINACINASAS DEL GRUPO SRCInfo
- Publication number
- PE20040593A1 PE20040593A1 PE2003001103A PE2003001103A PE20040593A1 PE 20040593 A1 PE20040593 A1 PE 20040593A1 PE 2003001103 A PE2003001103 A PE 2003001103A PE 2003001103 A PE2003001103 A PE 2003001103A PE 20040593 A1 PE20040593 A1 PE 20040593A1
- Authority
- PE
- Peru
- Prior art keywords
- methyl
- pyrimidin
- dihydro
- bromo
- phenyl
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- -1 2-BROMO-PHENYL Chemical class 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- PUYHFXLCBSPKLN-UHFFFAOYSA-N 4-amino-1-methylpyrimido[4,5-d]pyrimidin-2-one Chemical compound C1=NC=C2C(N)=NC(=O)N(C)C2=N1 PUYHFXLCBSPKLN-UHFFFAOYSA-N 0.000 abstract 1
- 206010005949 Bone cancer Diseases 0.000 abstract 1
- 208000020084 Bone disease Diseases 0.000 abstract 1
- 208000018084 Bone neoplasm Diseases 0.000 abstract 1
- 229910006074 SO2NH2 Inorganic materials 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical group [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
- SFDJOSRHYKHMOK-UHFFFAOYSA-N nitramide Chemical compound N[N+]([O-])=O SFDJOSRHYKHMOK-UHFFFAOYSA-N 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
SE REFIERE A COMPUESTOS DE FORMULA (I), DONDE R1 ES H, ALQUILO, CICLOALQUILO, ARILO, HETEROARILO, ARILALQUILO, ARILO, HETEROARILALQUILO, EVENTUALMENTE SUSTITUIDOS; R2 ES HALOGENO, H, CIANO, CF3; R3 ES HALOGENO, HIDROXI, CIANO, NITRO, AMINO, ACILAMINO, -CONH2, -SO2NH2, -S(O)m-ALQUILO, ENTRE OTRAS, EVENTUALMENTE SUSTITUIDOS, R4 ES H, ALQUILO, ALCOXI, CIANO Y A ES DE FORMULA: A-1, A-2, A-3, A-4, A-5 O A-6 DONDE X ES O O S(O)m; n ES 0,1,2 O 3; m ES 0,1,2 O 3. SON COMPUESTOS PREFERIDOS: 3-(2-BROMO-FENIL)-3,4-DIHIDRO-7-(1'-ACETIL-ESPIRO[1,3-BENZO-DIOXOLO-2,4'-PIPERIDINA]-5-IL)AMINO-1-METIL-PIRIMIDO[4,5-d]-PIRIMIDIN-2(1H)-ONA, 3-(2-BROMO-FENIL)-7-(2,3-DIHIDRO-BENZO[1,4]DIOXIN-6-ILAMINO)-1-METIL-3,4-DIHIDRO-1H-PIRIMIDO[4,5-d]PIRIMIDIN-2-ONA, 5-[6-(2-BROMO-FENIL)-8-METIL-7-OXO-5,6,7,8-TETRAHIDRO-PIRIMIDO[4,5-d]PIRIMIDIN-2-ILAMINO]-2-METIL-ISOINDOL-1,3-DIONA, 7-(BENZO[1,3]DIOXOL-5-ILAMINO)-3-(2-BROMO-FENIL)-1-METIL-3,4-DIHIDRO-1H-PIRIMIDO[4,5-d]PIRIMIDIN-2-ONA, ENTRE OTOS. TAMBIEN SE REFIERE A UN PROCESO DE ELABORACION. ESTOS COMPUESTOS SON INHIBIDORES DE PROTEINOCINASAS, EN ESPECIAL DEL GRUPO SRC DE TIROSINACINASAS Y SON UTILES PARA EL TRATAMIENTO DE TRANSTORNOS INFLAMATORIOS, INMUNOLOGICOS, DEL SNC, TRANSTORNOS OSEOS Y TRATAMIENTO DEL CANCER
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02024573 | 2002-11-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20040593A1 true PE20040593A1 (es) | 2004-09-09 |
Family
ID=32116230
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2003001103A PE20040593A1 (es) | 2002-11-04 | 2003-10-31 | DERIVADOS DE DIHIDROPIRIMIDO[4,5-d]PIRIMIDONA AMINO SUSTITUIDOS COMO INHIBIDORES DE TIROSINACINASAS DEL GRUPO SRC |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7091345B2 (es) |
| EP (1) | EP1560831A1 (es) |
| JP (1) | JP2006506408A (es) |
| KR (1) | KR100755770B1 (es) |
| CN (1) | CN1711265A (es) |
| AR (1) | AR041740A1 (es) |
| AU (1) | AU2003287982A1 (es) |
| BR (1) | BR0315988A (es) |
| CA (1) | CA2502477A1 (es) |
| GT (1) | GT200300240A (es) |
| MX (1) | MXPA05004212A (es) |
| PA (1) | PA8587101A1 (es) |
| PE (1) | PE20040593A1 (es) |
| PL (1) | PL377239A1 (es) |
| RU (1) | RU2005117342A (es) |
| TW (1) | TW200413381A (es) |
| UY (1) | UY28059A1 (es) |
| WO (1) | WO2004041823A1 (es) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002059083A2 (en) * | 2000-10-23 | 2002-08-01 | Smithkline Beecham Corporation | Novel compounds |
| BRPI0413005A (pt) | 2003-07-29 | 2006-09-26 | Irm Llc | compostos e composições como inibidores da proteìna cinase |
| FR2873118B1 (fr) * | 2004-07-15 | 2007-11-23 | Sanofi Synthelabo | Derives de pyrido-pyrimidine, leur application en therapeutique |
| MX2007002096A (es) | 2004-08-31 | 2007-03-29 | Hoffmann La Roche | Derivados de amida de 3-fenil-dihidropirimido[4,5-d] pirimidinonas, su fabricacion y su uso como agentes farmaceuticos. |
| AU2005279337A1 (en) | 2004-08-31 | 2006-03-09 | F. Hoffmann-La Roche Ag | Amide derivatives of 7-amino-3-phenyl-dihydropyrimido [4,5-d]pyrimidinones, their manufacture and use as pharmaceutical agents |
| PE20100737A1 (es) * | 2005-03-25 | 2010-11-27 | Glaxo Group Ltd | Nuevos compuestos |
| SG160438A1 (en) * | 2005-03-25 | 2010-04-29 | Glaxo Group Ltd | Process for preparing pyrido[2,3-d]pyrimidin-7-one and 3,4-dihydropyrimido[4,5- d]pyrimidin-2(1h)-one derivatives |
| ES2329419T3 (es) | 2006-01-31 | 2009-11-25 | F. Hoffmann-La Roche Ag | 7h-pirido(3,4-d)pirimidin-8-onas, su preparacion y uso como inhibidores de proteinas cinasas. |
| US7939557B2 (en) * | 2006-04-20 | 2011-05-10 | Nova Southeastern University | Vascular endothelial receptor specific inhibitors |
| KR20080109095A (ko) * | 2006-05-15 | 2008-12-16 | 아이알엠 엘엘씨 | Ｆｇｆ 수용체 키나제 억제제를 위한 조성물 및 방법 |
| SI2168966T1 (sl) | 2007-06-15 | 2017-03-31 | Msd K.K. | Derivat biciklo anilina |
| TW200942537A (en) | 2008-02-01 | 2009-10-16 | Irm Llc | Compounds and compositions as kinase inhibitors |
| US8501804B2 (en) | 2008-10-27 | 2013-08-06 | Takeda Pharmaceutical Company Limited | Bicyclic compound |
| WO2010067886A1 (en) * | 2008-12-12 | 2010-06-17 | Banyu Pharmaceutical Co.,Ltd. | Dihydropyrimidopyrimidine derivative |
| US8575179B2 (en) | 2008-12-12 | 2013-11-05 | Msd K.K. | Dihydropyrazolopyrimidinone derivatives |
| EP2459558A2 (en) | 2009-07-30 | 2012-06-06 | Irm Llc | Compounds and compositions as syk kinase inhibitors |
| US8754114B2 (en) | 2010-12-22 | 2014-06-17 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3 |
| CN107652289B (zh) | 2012-06-13 | 2020-07-21 | 因塞特控股公司 | 作为fgfr抑制剂的取代的三环化合物 |
| US20150182490A1 (en) | 2012-06-26 | 2015-07-02 | Del Mar Pharmaceuticals | Methods for treating tyrosine-kinase-inhibitor-resistant malignancies in patients with genetic polymorphisms or ahi1 dysregulations or mutations employing dianhydrogalactitol, diacetyldianhydrogalactitol, dibromodulcitol, or analogs or derivatives thereof |
| US9388185B2 (en) | 2012-08-10 | 2016-07-12 | Incyte Holdings Corporation | Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors |
| CN102816164A (zh) * | 2012-08-31 | 2012-12-12 | 北京理工大学 | 一种合成7-氨基-2,3-二氢嘧啶[4,5-d]嘧啶-4(1H)-酮的方法 |
| US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
| AU2014228746B2 (en) * | 2013-03-15 | 2018-08-30 | Celgene Car Llc | Heteroaryl compounds and uses thereof |
| ES2892423T3 (es) | 2013-03-15 | 2022-02-04 | Celgene Car Llc | Compuestos de heteroarilo y usos de los mismos |
| US9321786B2 (en) | 2013-03-15 | 2016-04-26 | Celgene Avilomics Research, Inc. | Heteroaryl compounds and uses thereof |
| JP6449244B2 (ja) | 2013-04-19 | 2019-01-09 | インサイト・ホールディングス・コーポレイションＩｎｃｙｔｅ Ｈｏｌｄｉｎｇｓ Ｃｏｒｐｏｒａｔｉｏｎ | Ｆｇｆｒ抑制剤としての二環式複素環 |
| US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| WO2016134294A1 (en) | 2015-02-20 | 2016-08-25 | Incyte Corporation | Bicyclic heterocycles as fgfr4 inhibitors |
| MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
| ES2751669T3 (es) | 2015-02-20 | 2020-04-01 | Incyte Corp | Heterociclos bicíclicos como inhibidores FGFR |
| US10722484B2 (en) | 2016-03-09 | 2020-07-28 | K-Gen, Inc. | Methods of cancer treatment |
| CN108815167B (zh) * | 2017-05-24 | 2021-04-13 | 四川晶华生物科技有限公司 | 一种化合物在制备治疗肿瘤的药物中的用途 |
| AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
| PE20210919A1 (es) | 2018-05-04 | 2021-05-19 | Incyte Corp | Sales de un inhibidor de fgfr |
| CN119241541A (zh) | 2018-05-04 | 2025-01-03 | 因赛特公司 | Fgfr抑制剂的固体形式和其制备方法 |
| WO2020185532A1 (en) | 2019-03-08 | 2020-09-17 | Incyte Corporation | Methods of treating cancer with an fgfr inhibitor |
| US11591329B2 (en) | 2019-07-09 | 2023-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| WO2021067374A1 (en) | 2019-10-01 | 2021-04-08 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| GEP20247679B (en) | 2019-10-14 | 2024-10-10 | Incyte Corp | Bicyclic heterocycles as fgfr inhibitors |
| US11566028B2 (en) | 2019-10-16 | 2023-01-31 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| CA3163875A1 (en) | 2019-12-04 | 2021-06-10 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
| IL293001A (en) | 2019-12-04 | 2022-07-01 | Incyte Corp | Derivatives of fgfr repressors |
| US12012409B2 (en) | 2020-01-15 | 2024-06-18 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| JP2024513575A (ja) | 2021-04-12 | 2024-03-26 | インサイト・コーポレイション | Ｆｇｆｒ阻害剤及びネクチン－４標的化剤を含む併用療法 |
| AR126101A1 (es) | 2021-06-09 | 2023-09-13 | Incyte Corp | Heterociclos tricíclicos como inhibidores de fgfr |
| WO2022261160A1 (en) | 2021-06-09 | 2022-12-15 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0084822B1 (de) | 1982-01-27 | 1986-01-08 | Schering Aktiengesellschaft | Diphosphonsäure-Derivate und diese enthaltende pharmazeutische Präparate |
| DE3203308A1 (de) * | 1982-01-27 | 1983-07-28 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Diphosphonsaeure-derivate und diese enthaltende pharmazeutische praeparate |
| DE3365492D1 (en) * | 1982-01-27 | 1986-10-02 | Schering Ag | Diphosphonic acid derivatives and pharmaceutical preparations containing them |
| DE3428524A1 (de) * | 1984-08-02 | 1986-02-13 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
| IL77243A (en) | 1984-12-21 | 1996-11-14 | Procter & Gamble | Pharmaceutical compositions containing geminal diphosphonic acid compounds and certain such novel compounds |
| US4687768A (en) | 1984-12-21 | 1987-08-18 | The Procter & Gamble Company | Certain hexahydroindan-2,2-diphosphonic acids useful in treating diseases associated with abnormal calcium and phosphate metabolism |
| JPH08502287A (ja) | 1992-10-09 | 1996-03-12 | ジ・アップジョン・カンパニー | 抗炎症剤としてのピリミジンビスホスホン酸エステルおよび（アルコキシメチルホスフィニル）アルキルホスホン酸 |
| SE9402001D0 (sv) * | 1994-06-09 | 1994-06-09 | Leiras Oy | Pyridylbisphosphonates for use as a therapeutical agent |
| KR20010043829A (ko) | 1998-05-26 | 2001-05-25 | 로즈 암스트롱, 크리스틴 에이. 트러트웨인 | 세포 증식 억제제로서의 비시클릭 피리미딘 및 비시클릭3,4-디히드로피리미딘 |
| EP1123295B1 (en) | 1998-10-23 | 2004-09-29 | F. Hoffmann-La Roche Ag | Bicyclic nitrogen heterocycles |
| AU776250B2 (en) | 1999-10-21 | 2004-09-02 | F. Hoffmann-La Roche Ag | Heteroalkylamino-substituted bicyclic nitrogen heterocycles as inhibitors of P38 protein kinase |
| HUP0203477A3 (en) | 1999-10-21 | 2004-12-28 | Hoffmann La Roche | Alkylamino substituted bicyclic nitrogen heterocycles as inhibitors of p38 protein kinase, pharmaceutical compositions containing them and their preparations |
| IL150059A0 (en) | 1999-12-17 | 2002-12-01 | Ariad Pharma Inc | Novel heterocycles |
-
2003
- 2003-10-29 TW TW092130056A patent/TW200413381A/zh unknown
- 2003-10-30 PA PA20038587101A patent/PA8587101A1/es unknown
- 2003-10-30 US US10/697,543 patent/US7091345B2/en not_active Expired - Fee Related
- 2003-10-31 AR ARP030104001A patent/AR041740A1/es not_active Application Discontinuation
- 2003-10-31 UY UY28059A patent/UY28059A1/es not_active Application Discontinuation
- 2003-10-31 PE PE2003001103A patent/PE20040593A1/es not_active Application Discontinuation
- 2003-11-03 PL PL377239A patent/PL377239A1/pl not_active Application Discontinuation
- 2003-11-03 GT GT200300240A patent/GT200300240A/es unknown
- 2003-11-03 CA CA002502477A patent/CA2502477A1/en not_active Abandoned
- 2003-11-03 JP JP2004548850A patent/JP2006506408A/ja active Pending
- 2003-11-03 KR KR1020057007978A patent/KR100755770B1/ko not_active Expired - Fee Related
- 2003-11-03 AU AU2003287982A patent/AU2003287982A1/en not_active Abandoned
- 2003-11-03 WO PCT/EP2003/012203 patent/WO2004041823A1/en not_active Ceased
- 2003-11-03 RU RU2005117342/04A patent/RU2005117342A/ru not_active Application Discontinuation
- 2003-11-03 MX MXPA05004212A patent/MXPA05004212A/es active IP Right Grant
- 2003-11-03 CN CNA200380102849XA patent/CN1711265A/zh active Pending
- 2003-11-03 EP EP03779831A patent/EP1560831A1/en not_active Withdrawn
- 2003-11-03 BR BR0315988-4A patent/BR0315988A/pt not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| UY28059A1 (es) | 2004-04-30 |
| KR20050067433A (ko) | 2005-07-01 |
| WO2004041823A1 (en) | 2004-05-21 |
| GT200300240A (es) | 2004-09-02 |
| KR100755770B1 (ko) | 2007-09-05 |
| CA2502477A1 (en) | 2004-05-21 |
| US20040087600A1 (en) | 2004-05-06 |
| MXPA05004212A (es) | 2005-06-08 |
| EP1560831A1 (en) | 2005-08-10 |
| JP2006506408A (ja) | 2006-02-23 |
| AR041740A1 (es) | 2005-05-26 |
| TW200413381A (en) | 2004-08-01 |
| US7091345B2 (en) | 2006-08-15 |
| CN1711265A (zh) | 2005-12-21 |
| PL377239A1 (pl) | 2006-01-23 |
| PA8587101A1 (es) | 2004-09-16 |
| AU2003287982A1 (en) | 2004-06-07 |
| RU2005117342A (ru) | 2006-01-20 |
| BR0315988A (pt) | 2005-09-20 |
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