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PE20010758A1 - DERIVADOS DE DIHIDROPIRIMIDO[4,5-d]PIRIMIDONA SUSTITUIDOS POR HETEROALQUILO COMO INHIBIDORES DE QUINASAS p38 - Google Patents

DERIVADOS DE DIHIDROPIRIMIDO[4,5-d]PIRIMIDONA SUSTITUIDOS POR HETEROALQUILO COMO INHIBIDORES DE QUINASAS p38

Info

Publication number
PE20010758A1
PE20010758A1 PE2000001104A PE0011042000A PE20010758A1 PE 20010758 A1 PE20010758 A1 PE 20010758A1 PE 2000001104 A PE2000001104 A PE 2000001104A PE 0011042000 A PE0011042000 A PE 0011042000A PE 20010758 A1 PE20010758 A1 PE 20010758A1
Authority
PE
Peru
Prior art keywords
dihydropyrimide
heteroalkyl
alkyl
rent
derivatives substituted
Prior art date
Application number
PE2000001104A
Other languages
English (en)
Inventor
James Patrick Dunn
Lawrence Emerson Fisher
David Michael Goldstein
Teresa Rosanne Welch
Christopher Huw Hill
Ian Edward David Smith
William Harris
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PE20010758A1 publication Critical patent/PE20010758A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Communicable Diseases (AREA)
  • Neurology (AREA)
  • Dermatology (AREA)
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  • Ophthalmology & Optometry (AREA)
  • Tropical Medicine & Parasitology (AREA)
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  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Molecular Biology (AREA)
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  • Urology & Nephrology (AREA)
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Abstract

SE REFIERE A DERIVADOS DIHIDROPIRIMIDO[4,5-d]PIRIMIDONA SUSTITUIDOS CON HETEROARILO, DONDE R1 ES ACILO, HETEROALQUILO, ARILHETEROALQUILO, ARILHETEROALQUILO, (ALQUILEN)-CO-R11, ENTRE OTROS; R11 ES ALQUILO, HALOALQUILO, AMINO, CICLOALQUILO; R2 ES ALQUILO, HALOGENO, HETEROALQUILO, VINILO; R3 ES H, ALQUILO, HETEROALQUILO, ARILO, ARALQUILO, ALQUILEN-COR31, ENTRE OTROS; R31 ES ALQUILO, HALOALQUILO, OH, ALCOXI, ENTRE OTROS; R4 ES H, ALQUILO, (ALQUILEN)-COR31. SON COMPUESTOS PREFERIDOS 3-(2-CLOROFENIL)-7-(TRANS-4-HIDROXICICLOHEXILAMINO)-3,4-DIHIDROPIRIMIDO[4,5-d]PIRIMIDIN-2(1H)ONA, 3-(2-CLOROFENIL)-7-(TETRAHIDROPIRAN-4-ILAMINO]-3,4-DIHIDROPIRIMIDO[4,5-d]PIRIMIDIN-2(1H)-ONA, ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. EL COMPUESTO I ES UN INHIBIDOR DE LA QUINASA p38 Y PUEDE SER UTIL PARA EL TRATAMIENTO DE ARTRITIS, ENFERMEDAD DE CROHN, SINDROME DE IRRITACION INTESTINAL, SINDROME DE INSUFICIENCIA RESPIRATORIA, OSTEOPOROSIS, ALZHEIMER
PE2000001104A 1999-10-21 2000-10-17 DERIVADOS DE DIHIDROPIRIMIDO[4,5-d]PIRIMIDONA SUSTITUIDOS POR HETEROALQUILO COMO INHIBIDORES DE QUINASAS p38 PE20010758A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16080399P 1999-10-21 1999-10-21
US21374300P 2000-06-22 2000-06-22

Publications (1)

Publication Number Publication Date
PE20010758A1 true PE20010758A1 (es) 2001-07-21

Family

ID=26857240

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2000001104A PE20010758A1 (es) 1999-10-21 2000-10-17 DERIVADOS DE DIHIDROPIRIMIDO[4,5-d]PIRIMIDONA SUSTITUIDOS POR HETEROALQUILO COMO INHIBIDORES DE QUINASAS p38

Country Status (26)

Country Link
US (1) US6451804B1 (es)
EP (1) EP1228070B1 (es)
JP (1) JP3961830B2 (es)
KR (1) KR100523120B1 (es)
CN (1) CN1171889C (es)
AR (1) AR026084A1 (es)
AT (1) ATE353329T1 (es)
AU (1) AU776250B2 (es)
BR (1) BR0015243A (es)
CA (1) CA2388142C (es)
CZ (1) CZ20021744A3 (es)
DE (1) DE60033307T2 (es)
ES (1) ES2280247T3 (es)
HR (1) HRP20020328A2 (es)
HU (1) HUP0203564A3 (es)
IL (1) IL149100A0 (es)
MA (1) MA26837A1 (es)
MX (1) MXPA02003950A (es)
NO (1) NO20021781L (es)
NZ (1) NZ518119A (es)
PE (1) PE20010758A1 (es)
PL (1) PL357502A1 (es)
RU (1) RU2265606C2 (es)
TR (1) TR200201057T2 (es)
WO (1) WO2001029042A1 (es)
YU (1) YU29102A (es)

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