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PE20030332A1 - Terapia de combinacion para el tratamiento del cancer - Google Patents

Terapia de combinacion para el tratamiento del cancer

Info

Publication number
PE20030332A1
PE20030332A1 PE2002000737A PE2002000737A PE20030332A1 PE 20030332 A1 PE20030332 A1 PE 20030332A1 PE 2002000737 A PE2002000737 A PE 2002000737A PE 2002000737 A PE2002000737 A PE 2002000737A PE 20030332 A1 PE20030332 A1 PE 20030332A1
Authority
PE
Peru
Prior art keywords
alkyl
aryl
alcoxyl
hydroxyl
nr13r14
Prior art date
Application number
PE2002000737A
Other languages
English (en)
Inventor
Julie Cherrington
Jaime Massferrer
Parul Doshi
Original Assignee
Pharmacia Corp
Sugen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Corp, Sugen Inc filed Critical Pharmacia Corp
Publication of PE20030332A1 publication Critical patent/PE20030332A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE REFIERE A METODOS PARA EL TRATAMIENTO DE CANCER, TRASTORNOS NEOPLASICOS ADMINISTRANDO COMPUESTOS INHIBIDORES DE PROTEINQUINASA, CICLOOXIGENASA-2 DE FORMULA I DONDE R ES H, PIPERAZIN-1-ILMETILO, 4-METILPIPERAZIN-1-ILMETILO, PIPERIDIN-1-ILMETILO, ENTRE OTROS; R1 ES H, HALO, ALQUILO, CICLOALQUILO, ARILO CONR8R9, NR13R14, COR15, (CH2)R16; R2 ES H, HALO, ALQUILO, TRIHALOMETILO, HIDROXILO, ALCOXILO, ENTRE OTROS; R3 ES H, HALOGENO, ALQUILO, TRIHALOMETILO, HIDROXILO, ALCOXILO, ARILO, ENTRE OTROS; R4 ES H, HALOGENO, ALQUILO, HIDROXILO, ALCOXILO, NR13R14, ENTRE OTROS; R5 Y R6 SON H, ALQUILO, COR10; R7 ES H, ALQUILO, ARILO, HETEROARILO, COR17, COR10, ENTRE OTROS; R6 Y R7 FORMAN (CH2)4, (CH2)5, (CH2)6; R8 Y R9 SON H, ALQUILO, ARILO; R10 ES HIDROXILO, ALCOXILO, ARILOXILO, ENTRE OTROS; R11 ES H, ALQUILO; R12 ES NR13R14, OH, COR15, ARILO, HETEROARILO, N(OH)R13; R13 Y R14 SON H, ALQUILO, CIANOALQUILO, ARILO, HETEROARILO; n Y r SON 1-4. SON COMPUESTOS PREFERIDOS ACIDO 6-CLORO-2-TRIFLUOROMETIL-2H-1-BENZOPIRAN-3-CARBOXILICO; ACIDO 6-CLORO-7-METIL-2-TRIFLUOROMETIL-2H-1-BENZOPIRAN-3-CARBOXILICO, ACIDO 8-(1-METILETIL)-2-TRIFLUOROMETIL-2H-1-BENZOPIRAN-3-CARBOXILICO
PE2002000737A 2001-08-15 2002-08-15 Terapia de combinacion para el tratamiento del cancer PE20030332A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US31241301P 2001-08-15 2001-08-15

Publications (1)

Publication Number Publication Date
PE20030332A1 true PE20030332A1 (es) 2003-04-05

Family

ID=23211320

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2002000737A PE20030332A1 (es) 2001-08-15 2002-08-15 Terapia de combinacion para el tratamiento del cancer

Country Status (36)

Country Link
US (1) US7320996B2 (es)
EP (1) EP1427326B1 (es)
JP (1) JP2005501843A (es)
KR (1) KR100656004B1 (es)
CN (1) CN1541098A (es)
AP (1) AP2004002995A0 (es)
AR (1) AR038957A1 (es)
AT (1) ATE414512T1 (es)
AU (1) AU2002329744B2 (es)
BG (1) BG108622A (es)
BR (1) BR0211978A (es)
CA (1) CA2457745A1 (es)
CO (1) CO5560544A2 (es)
CZ (1) CZ2004356A3 (es)
DE (1) DE60229959D1 (es)
EA (1) EA008137B1 (es)
EC (1) ECSP045021A (es)
GE (1) GEP20063868B (es)
HR (1) HRP20040170A2 (es)
HU (1) HUP0500424A3 (es)
IL (1) IL159887A0 (es)
IS (1) IS7137A (es)
MA (1) MA27060A1 (es)
MX (1) MXPA04001464A (es)
NO (1) NO20040516L (es)
NZ (1) NZ530792A (es)
OA (1) OA12651A (es)
PE (1) PE20030332A1 (es)
PL (1) PL368921A1 (es)
RS (1) RS13204A (es)
SK (1) SK1412004A3 (es)
TN (1) TNSN04015A1 (es)
TW (1) TWI230609B (es)
UA (1) UA77002C2 (es)
WO (1) WO2003015608A2 (es)
ZA (1) ZA200400849B (es)

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CN101500578A (zh) * 2005-07-08 2009-08-05 约翰·P·福德 用于全身抗癌治疗的计量剂量的以及安全和顺应性包装
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RU2495628C1 (ru) * 2012-04-18 2013-10-20 Государственное бюджетное учреждение здравоохранения Московской области "Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского" (ГБУЗ МО МОНИКИ им. М.Ф. Владимирского) Способ выбора тактики лечения актинического кератоза
TWI646091B (zh) * 2012-12-28 2019-01-01 日商衛斯克慧特股份有限公司 鹽類及晶形
KR20150127249A (ko) * 2013-03-13 2015-11-16 보스톤 바이오메디칼, 인크. 암 치료를 위한 암 줄기세포 경로 키나아제의 저해제로서 3-(아릴 또는 헤테로아릴)메틸렌인돌린-2-온 유도체
CN103923014A (zh) * 2014-05-05 2014-07-16 宁夏宝马药业有限公司 环肌酸制备方法
JP6942726B2 (ja) 2016-01-08 2021-09-29 ユークリセス ファーマシューティカルズ，インコーポレイテッド クロメン化合物および第２活性薬剤の併用薬
CN111759883B (zh) * 2020-07-23 2021-09-17 浙江农林大学 山核桃内果皮提取物在制备抗卵巢癌产品中的应用
CN114853736B (zh) * 2022-07-06 2022-10-21 北京鑫开元医药科技有限公司 具有trk抑制活性的化合物、制备方法、组合物及其用途

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