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ES8402580A1 - Procedimiento para preparar un derivado de guanidina - Google Patents

Procedimiento para preparar un derivado de guanidina

Info

Publication number
ES8402580A1
ES8402580A1 ES518707A ES518707A ES8402580A1 ES 8402580 A1 ES8402580 A1 ES 8402580A1 ES 518707 A ES518707 A ES 518707A ES 518707 A ES518707 A ES 518707A ES 8402580 A1 ES8402580 A1 ES 8402580A1
Authority
ES
Spain
Prior art keywords
formula
compound
pharmaceutically acceptable
free base
acid addition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES518707A
Other languages
English (en)
Other versions
ES518707A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imperial Chemical Industries Ltd
Zeneca Inc
Original Assignee
Imperial Chemical Industries Ltd
ICI Americas Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial Chemical Industries Ltd, ICI Americas Inc filed Critical Imperial Chemical Industries Ltd
Publication of ES8402580A1 publication Critical patent/ES8402580A1/es
Publication of ES518707A0 publication Critical patent/ES518707A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/76—Nitrogen atoms to which a second hetero atom is attached
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • C07D231/40—Acylated on said nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/20—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • C07D249/06—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/14—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/14—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom
    • C07D251/16—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR UN DERIVADO DE GUANIDINA, DE FORMULA GENERAL (I), Y SUS SALES DE ADICION DE ACIDO FARMACEUTICAMENTE ACEPTABLES.CONSISTE EN HIDROLIZAR UN COMPUESTO DE FORMULA (II) PARA OBTENER UN COMPUESTO DE FORMULA (I), EN FORMA DE BASE LIBRE. CUANDO SE REQUIERE UNA SAL DE ADICION DE ACIDO, SE HACE REACCIONAR EL COMPUESTO DE FORMULA (I), EN FORMA DE BASE LIBRE, CON UN ACIDO QUE PORPORCIONA UNA UNION FARMACEUTICAMENTE ACEPTABLE.DE APLICACION EN EL TRATAMIENTO DE ULCERAS PEPTICAS Y OTROS ESTADOS CAUSADOS O EXACERBADOS POR LA ACIDEZ GASTRICA, INCLUYENDO LASULCERAS POR STRESS Y LA HEMORRAGIA GASTROINTESTINAL DEBIDA A TRAUMAS.
ES518707A 1981-03-09 1982-12-30 Procedimiento para preparar un derivado de guanidina Granted ES518707A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8107273 1981-03-09
GB8128179 1981-09-17

Publications (2)

Publication Number Publication Date
ES8402580A1 true ES8402580A1 (es) 1984-02-01
ES518707A0 ES518707A0 (es) 1984-02-01

Family

ID=26278698

Family Applications (5)

Application Number Title Priority Date Filing Date
ES510258A Granted ES510258A0 (es) 1981-03-09 1982-03-09 Procedimiento para preparar derivados de quanadina.
ES518705A Granted ES518705A0 (es) 1981-03-09 1982-12-30 Procedimiento para preparar derivados de guanidina.
ES518707A Granted ES518707A0 (es) 1981-03-09 1982-12-30 Procedimiento para preparar un derivado de guanidina
ES518706A Granted ES518706A0 (es) 1981-03-09 1982-12-30 Procedimiento para preparar derivados de guanidina.
ES518704A Expired ES8402561A1 (es) 1981-03-09 1982-12-30 Procedimiento para preparar derivados de guanidina.

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES510258A Granted ES510258A0 (es) 1981-03-09 1982-03-09 Procedimiento para preparar derivados de quanadina.
ES518705A Granted ES518705A0 (es) 1981-03-09 1982-12-30 Procedimiento para preparar derivados de guanidina.

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES518706A Granted ES518706A0 (es) 1981-03-09 1982-12-30 Procedimiento para preparar derivados de guanidina.
ES518704A Expired ES8402561A1 (es) 1981-03-09 1982-12-30 Procedimiento para preparar derivados de guanidina.

Country Status (19)

Country Link
US (2) US4447441A (es)
EP (1) EP0060094B1 (es)
AU (3) AU560043B2 (es)
CA (1) CA1233818A (es)
DD (1) DD202551A5 (es)
DE (1) DE3268615D1 (es)
DK (1) DK101882A (es)
ES (5) ES510258A0 (es)
FI (1) FI820795A7 (es)
GR (1) GR74750B (es)
IE (1) IE52719B1 (es)
IL (1) IL65216A (es)
IN (1) IN160139B (es)
NO (1) NO820726L (es)
NZ (1) NZ199941A (es)
PL (1) PL138527B1 (es)
PT (1) PT74548B (es)
YU (1) YU49482A (es)
ZW (1) ZW4182A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1233818A (en) * 1981-03-09 1988-03-08 David J. Gilman Guanidine derivatives as histamine h-2 receptor antagonists
EP0103390A3 (en) * 1982-08-13 1986-02-26 Imperial Chemical Industries Plc Guanidine-containing esters as histamine h2 receptor blockers
GB8320820D0 (en) * 1982-09-03 1983-09-01 Ici Plc Polymorphs
GB8316779D0 (en) * 1982-09-07 1983-07-27 Ici Plc Process
DE3334455A1 (de) * 1983-03-04 1984-09-06 Bayer Ag, 5090 Leverkusen Guanidin - derivate
GB8401751D0 (en) * 1984-01-24 1984-02-29 Ici Plc Guanidine derivatives
DE3532880A1 (de) * 1985-09-14 1987-03-26 Basf Ag 1,4-disubstituierte pyrazolderivate
KR900008756B1 (en) * 1987-05-27 1990-11-29 Mitsubishi Electric Corp Amplifier
GB9125970D0 (en) * 1991-12-06 1992-02-05 Fujisawa Pharmaceutical Co New compounds
AR091516A1 (es) 2012-06-22 2015-02-11 Actelion Pharmaceuticals Ltd Derivados de 1-[m-carboxamido(hetero)aril-metil]-heterociclil-carboxamida
EP4196793A1 (en) 2020-08-11 2023-06-21 Université de Strasbourg H2 blockers targeting liver macrophages for the prevention and treatment of liver disease and cancer

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4117131A (en) * 1976-12-07 1978-09-26 Warner-Lambert Company Method of inhibiting gastric acid secretions with 2-(4-pyrimidinyl)thioacetamides
US4248784A (en) * 1977-02-25 1981-02-03 Sterling Drug Inc. Pyrrole-3-acetamides
US4165378A (en) * 1977-04-20 1979-08-21 Ici Americas Inc. Guanidine derivatives of imidazoles and thiazoles
IE47044B1 (en) * 1977-04-20 1983-12-14 Ici Ltd Guanidine derivatives
JPS5444660A (en) * 1977-08-29 1979-04-09 Yamanouchi Pharmaceut Co Ltd Heterocyclic compound and its preparation
JPS54132566A (en) * 1978-01-18 1979-10-15 Ici Ltd Guanidine derivative*its manufacture and secretion controlling pharmaceutical composition containing it
EP0006679B1 (en) * 1978-05-24 1982-07-21 Imperial Chemical Industries Plc Antisecretory thiadiazole derivatives, processes for their manufacture and pharmaceutical compositions containing them
US4309435A (en) * 1978-10-16 1982-01-05 Imperial Chemical Industries Ltd. Antisecretory guanidine derivatives and pharmaceutical compositions containing them
PH16099A (en) * 1979-03-06 1983-06-24 Yamanouchi Pharma Co Ltd Guanidinothiazole compounds,process for preparing them and medical composition containing them
US4242351A (en) * 1979-05-07 1980-12-30 Imperial Chemical Industries Limited Antisecretory oxadiazoles and pharmaceutical compositions containing them
GR71929B (es) * 1979-11-13 1983-08-19 Ici Ltd
CA1233818A (en) * 1981-03-09 1988-03-08 David J. Gilman Guanidine derivatives as histamine h-2 receptor antagonists
IN158869B (es) * 1981-03-18 1987-02-07 Ici Plc
US4451463A (en) * 1981-03-24 1984-05-29 Imperial Chemical Industries Plc Alcohol derivatives

Also Published As

Publication number Publication date
EP0060094A3 (en) 1982-11-17
IL65216A (en) 1987-12-20
AU582948B2 (en) 1989-04-13
CA1233818A (en) 1988-03-08
NO820726L (no) 1982-09-10
ES8305707A1 (es) 1983-04-16
EP0060094A2 (en) 1982-09-15
PT74548B (en) 1983-11-10
PT74548A (en) 1982-04-01
ES510258A0 (es) 1983-04-16
AU8117282A (en) 1982-09-16
GR74750B (es) 1984-07-11
ES518704A0 (es) 1984-02-01
AU560043B2 (en) 1987-03-26
US4665073A (en) 1987-05-12
AU582492B2 (en) 1989-03-23
DK101882A (da) 1982-09-10
IE820518L (en) 1982-09-09
NZ199941A (en) 1985-05-31
ES8402563A1 (es) 1984-02-01
PL138527B1 (en) 1986-09-30
ZW4182A1 (en) 1983-10-26
IN160139B (es) 1987-06-27
DE3268615D1 (en) 1986-03-06
IE52719B1 (en) 1988-02-03
ES8402561A1 (es) 1984-02-01
ES8402562A1 (es) 1984-02-01
AU6889387A (en) 1987-05-14
EP0060094B1 (en) 1986-01-22
ES518705A0 (es) 1984-02-01
PL235333A1 (en) 1983-03-28
ES518706A0 (es) 1984-02-01
FI820795L (fi) 1982-09-10
DD202551A5 (de) 1983-09-21
YU49482A (en) 1985-04-30
ES518707A0 (es) 1984-02-01
AU6889487A (en) 1987-05-14
US4447441A (en) 1984-05-08
FI820795A7 (fi) 1982-09-10

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20010402