PE20030921A1 - Derivados de nicotinamida y una sal de tiotropio en combinacion para el tratamiento de enfermedades - Google Patents
Derivados de nicotinamida y una sal de tiotropio en combinacion para el tratamiento de enfermedadesInfo
- Publication number
- PE20030921A1 PE20030921A1 PE2003000148A PE2003000148A PE20030921A1 PE 20030921 A1 PE20030921 A1 PE 20030921A1 PE 2003000148 A PE2003000148 A PE 2003000148A PE 2003000148 A PE2003000148 A PE 2003000148A PE 20030921 A1 PE20030921 A1 PE 20030921A1
- Authority
- PE
- Peru
- Prior art keywords
- nicotinamide
- methyl
- diseases
- salt
- treatment
- Prior art date
Links
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical class NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 title abstract 2
- 201000010099 disease Diseases 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 title abstract 2
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical group [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 2
- QDKWLJJOYIFEBS-UHFFFAOYSA-N 1-fluoro-4-$l^{1}-oxidanylbenzene Chemical class [O]C1=CC=C(F)C=C1 QDKWLJJOYIFEBS-UHFFFAOYSA-N 0.000 abstract 1
- SEQNJEWIPZQXAG-UHFFFAOYSA-N 2-(4-fluorophenoxy)-n-[[4-[[(2-hydroxy-3-methylbenzoyl)amino]methyl]phenyl]methyl]pyridine-3-carboxamide Chemical compound CC1=CC=CC(C(=O)NCC=2C=CC(CNC(=O)C=3C(=NC=CC=3)OC=3C=CC(F)=CC=3)=CC=2)=C1O SEQNJEWIPZQXAG-UHFFFAOYSA-N 0.000 abstract 1
- DHNYGSKZXMZJIA-UHFFFAOYSA-N 2-fluoro-6-hydroxybenzamide Chemical compound NC(=O)C1=C(O)C=CC=C1F DHNYGSKZXMZJIA-UHFFFAOYSA-N 0.000 abstract 1
- SLRMQYXOBQWXCR-UHFFFAOYSA-N 2154-56-5 Chemical compound [CH2]C1=CC=CC=C1 SLRMQYXOBQWXCR-UHFFFAOYSA-N 0.000 abstract 1
- NGMMGKYJUWYIIG-UHFFFAOYSA-N 3-hydroxybenzamide Chemical compound NC(=O)C1=CC=CC(O)=C1 NGMMGKYJUWYIIG-UHFFFAOYSA-N 0.000 abstract 1
- 206010006482 Bronchospasm Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 230000007885 bronchoconstriction Effects 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 230000000414 obstructive effect Effects 0.000 abstract 1
- 210000002345 respiratory system Anatomy 0.000 abstract 1
- LERNTVKEWCAPOY-DZZGSBJMSA-N tiotropium Chemical compound O([C@H]1C[C@@H]2[N+]([C@H](C1)[C@@H]1[C@H]2O1)(C)C)C(=O)C(O)(C=1SC=CC=1)C1=CC=CS1 LERNTVKEWCAPOY-DZZGSBJMSA-N 0.000 abstract 1
- 229940110309 tiotropium Drugs 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
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- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4433—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Virology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
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- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
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- Pulmonology (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
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- Urology & Nephrology (AREA)
- Psychiatry (AREA)
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Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0203193.8A GB0203193D0 (en) | 2002-02-11 | 2002-02-11 | Nicotinamide derivatives useful as pde4 inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20030921A1 true PE20030921A1 (es) | 2003-11-05 |
Family
ID=9930842
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2003000148A PE20030921A1 (es) | 2002-02-11 | 2003-02-11 | Derivados de nicotinamida y una sal de tiotropio en combinacion para el tratamiento de enfermedades |
| PE2003000149A PE20030860A1 (es) | 2002-02-11 | 2003-02-11 | Derivados de nicotamida utiles como inhibidores de pde4 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2003000149A PE20030860A1 (es) | 2002-02-11 | 2003-02-11 | Derivados de nicotamida utiles como inhibidores de pde4 |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP1476157A1 (fr) |
| JP (1) | JP2005522449A (fr) |
| AR (1) | AR038404A1 (fr) |
| AU (2) | AU2003245812A1 (fr) |
| BR (1) | BR0307574A (fr) |
| CA (1) | CA2475708A1 (fr) |
| GB (1) | GB0203193D0 (fr) |
| GT (2) | GT200300034A (fr) |
| HN (1) | HN2003000062A (fr) |
| MX (1) | MXPA04007736A (fr) |
| PA (2) | PA8566601A1 (fr) |
| PE (2) | PE20030921A1 (fr) |
| SV (1) | SV2004001481A (fr) |
| TW (2) | TW200307545A (fr) |
| UY (2) | UY27657A1 (fr) |
| WO (2) | WO2003068234A1 (fr) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7105682B2 (en) | 2001-01-12 | 2006-09-12 | Amgen Inc. | Substituted amine derivatives and methods of use |
| US6878714B2 (en) | 2001-01-12 | 2005-04-12 | Amgen Inc. | Substituted alkylamine derivatives and methods of use |
| US6995162B2 (en) | 2001-01-12 | 2006-02-07 | Amgen Inc. | Substituted alkylamine derivatives and methods of use |
| US7102009B2 (en) | 2001-01-12 | 2006-09-05 | Amgen Inc. | Substituted amine derivatives and methods of use |
| AU2003245711A1 (en) | 2002-02-11 | 2003-09-04 | Pfizer Inc. | Nicotinamide derivatives useful as pde4 inhibitors |
| US7307088B2 (en) | 2002-07-09 | 2007-12-11 | Amgen Inc. | Substituted anthranilic amide derivatives and methods of use |
| GB0317516D0 (en) * | 2003-07-25 | 2003-08-27 | Pfizer Ltd | Nicotinamide derivatives useful as PDE4 inhibitors |
| GB0317484D0 (en) * | 2003-07-25 | 2003-08-27 | Pfizer Ltd | Nicotinamide derivatives useful as pde4 inhibitors |
| GB0317482D0 (en) * | 2003-07-25 | 2003-08-27 | Pfizer Ltd | Nicotinamide derivatives useful as pde4 inhibitors |
| US7153870B2 (en) | 2003-07-25 | 2006-12-26 | Pfizer Inc. | Nicotinamide derivatives useful as PDE4 inhibitors |
| GB0317509D0 (en) * | 2003-07-25 | 2003-08-27 | Pfizer Ltd | Nicotinamide derivatives useful as PDE4 inhibitors |
| JPWO2005026132A1 (ja) * | 2003-09-17 | 2007-11-08 | 日本新薬株式会社 | ホスホジエステラーゼのｃＡＭＰ基質特異的阻害剤 |
| US8686148B2 (en) | 2003-11-03 | 2014-04-01 | Boehringer Ingelheim International Gmbh | Process for preparing new tiotropium salts, new tiotropium salts as such and pharmaceutical compositions thereof |
| CA2547394A1 (fr) * | 2004-01-09 | 2005-07-28 | Boehringer Ingelheim International Gmbh | Nouvelles compositions pharmaceutiques a base de derives de scopineester et de nicotinamide |
| US7829585B2 (en) * | 2005-03-30 | 2010-11-09 | Eisai R&D Management Co., Ltd. | Antifungal agent containing pyridine derivative |
| CA2617101A1 (fr) * | 2005-08-08 | 2007-02-15 | Boehringer Ingelheim International Gmbh | Methode de protection contre le risque de troubles cardiaques consistant a administrer des sels de tiotropium |
| DE102005049429A1 (de) | 2005-10-15 | 2007-04-19 | Cognis Ip Management Gmbh | Verfahren zur Ausrüstung von Textilien |
| US20090054382A1 (en) * | 2005-10-19 | 2009-02-26 | Abhijit Ray | Compositions of phosphodiesterase type iv inhibitors |
| US8247556B2 (en) | 2005-10-21 | 2012-08-21 | Amgen Inc. | Method for preparing 6-substituted-7-aza-indoles |
| TWI385169B (zh) | 2005-10-31 | 2013-02-11 | Eisai R&D Man Co Ltd | 經雜環取代之吡啶衍生物及含有彼之抗真菌劑 |
| EP2068873B1 (fr) * | 2006-09-14 | 2011-11-09 | Bridge BioResearch Rights (Jersey) Limited | Guérison des blessures et des ulcères sous la médiation de l'isoniazide |
| US8513287B2 (en) | 2007-12-27 | 2013-08-20 | Eisai R&D Management Co., Ltd. | Heterocyclic ring and phosphonoxymethyl group substituted pyridine derivatives and antifungal agent containing same |
| CN109020825B (zh) * | 2017-06-12 | 2021-03-19 | 重庆医科大学 | 抗流感病毒化合物及其制备方法 |
| WO2022132679A1 (fr) * | 2020-12-18 | 2022-06-23 | Merck Sharp & Dohme Corp. | Composés pyrimidine amido-substitués et procédés d'utilisation associée pour traiter les virus herpétiques |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3931041C2 (de) * | 1989-09-16 | 2000-04-06 | Boehringer Ingelheim Kg | Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel |
| TR200001847T2 (tr) * | 1997-04-04 | 2002-06-21 | Pfizer Products Inc. | Nikotinamid Türevleri |
-
2002
- 2002-02-11 GB GBGB0203193.8A patent/GB0203193D0/en not_active Ceased
-
2003
- 2003-02-03 WO PCT/IB2003/000379 patent/WO2003068234A1/fr not_active Ceased
- 2003-02-03 BR BR0307574-5A patent/BR0307574A/pt not_active IP Right Cessation
- 2003-02-03 AU AU2003245812A patent/AU2003245812A1/en not_active Abandoned
- 2003-02-03 MX MXPA04007736A patent/MXPA04007736A/es active IP Right Grant
- 2003-02-03 WO PCT/IB2003/000377 patent/WO2003068232A1/fr not_active Ceased
- 2003-02-03 AU AU2003202116A patent/AU2003202116A1/en not_active Abandoned
- 2003-02-03 EP EP03700974A patent/EP1476157A1/fr not_active Withdrawn
- 2003-02-03 CA CA002475708A patent/CA2475708A1/fr not_active Abandoned
- 2003-02-03 JP JP2003567414A patent/JP2005522449A/ja not_active Withdrawn
- 2003-02-06 TW TW092102422A patent/TW200307545A/zh unknown
- 2003-02-06 TW TW092102415A patent/TW200304824A/zh unknown
- 2003-02-10 AR ARP030100406A patent/AR038404A1/es not_active Application Discontinuation
- 2003-02-10 GT GT200300034A patent/GT200300034A/es unknown
- 2003-02-10 SV SV2003001481A patent/SV2004001481A/es not_active Application Discontinuation
- 2003-02-10 GT GT200300033A patent/GT200300033A/es unknown
- 2003-02-10 HN HN2003000062A patent/HN2003000062A/es unknown
- 2003-02-11 PE PE2003000148A patent/PE20030921A1/es not_active Application Discontinuation
- 2003-02-11 PA PA20038566601A patent/PA8566601A1/es unknown
- 2003-02-11 UY UY27657A patent/UY27657A1/es not_active Application Discontinuation
- 2003-02-11 PA PA20038566501A patent/PA8566501A1/es unknown
- 2003-02-11 UY UY27658A patent/UY27658A1/es not_active Application Discontinuation
- 2003-02-11 PE PE2003000149A patent/PE20030860A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| GB0203193D0 (en) | 2002-03-27 |
| PE20030860A1 (es) | 2003-10-25 |
| GT200300033A (es) | 2003-10-11 |
| AU2003245812A1 (en) | 2003-09-04 |
| PA8566501A1 (es) | 2003-11-12 |
| WO2003068232A1 (fr) | 2003-08-21 |
| GT200300034A (es) | 2003-09-11 |
| UY27658A1 (es) | 2003-09-30 |
| UY27657A1 (es) | 2003-09-30 |
| TW200304824A (en) | 2003-10-16 |
| WO2003068234A1 (fr) | 2003-08-21 |
| BR0307574A (pt) | 2004-12-21 |
| EP1476157A1 (fr) | 2004-11-17 |
| TW200307545A (en) | 2003-12-16 |
| JP2005522449A (ja) | 2005-07-28 |
| SV2004001481A (es) | 2004-05-07 |
| AU2003202116A1 (en) | 2003-09-04 |
| PA8566601A1 (es) | 2003-11-12 |
| AR038404A1 (es) | 2005-01-12 |
| CA2475708A1 (fr) | 2003-08-21 |
| HN2003000062A (es) | 2003-09-24 |
| MXPA04007736A (es) | 2004-10-15 |
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Legal Events
| Date | Code | Title | Description |
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| FD | Application declared void or lapsed |