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PE20030921A1 - DERIVATIVES OF NICOTINAMIDE AND A TIOTROPE SALT IN COMBINATION FOR THE TREATMENT OF DISEASES - Google Patents

DERIVATIVES OF NICOTINAMIDE AND A TIOTROPE SALT IN COMBINATION FOR THE TREATMENT OF DISEASES

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Publication number
PE20030921A1
PE20030921A1 PE2003000148A PE2003000148A PE20030921A1 PE 20030921 A1 PE20030921 A1 PE 20030921A1 PE 2003000148 A PE2003000148 A PE 2003000148A PE 2003000148 A PE2003000148 A PE 2003000148A PE 20030921 A1 PE20030921 A1 PE 20030921A1
Authority
PE
Peru
Prior art keywords
nicotinamide
methyl
diseases
salt
treatment
Prior art date
Application number
PE2003000148A
Other languages
Spanish (es)
Inventor
Thomas Victor Magee
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of PE20030921A1 publication Critical patent/PE20030921A1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine

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Abstract

SE REFIERE A UNA COMBINACION DE DERIVADOS DE NICOTINAMIDA DE FORMULA I DONDE m ES 0-3, n ES 0-3; R1 Y R2 SON H, HALO, CIANO , ALQUILO C1-C4, ENTRE OTROS; X ES -O-, -S-, -NH-; R3 ES FENILO, NAFTILO, CICLOALQUILO C3-C8, GRUPOS BICICLICOS; Y ES *-(C=O)-**, *-(C=O)-NH-**, ENTRE OTROS DONDE * INDICA EL PUNTO DE UNION DE CADA FORMULA PARCIAL; R4 ES FENILO, NAFTILO, HETEROARILO, ALQUILO C1-C4, ENTRE OTROS. SON COMPUESTOS PREFERIDOS ESTER ETILICO DE ACIDO 3-(3-{4-[(3-HIDROXIBENZOILAMINO)METIL]BENCILCARBAMOIL}PIRIDIN-2-ILOXIBENZOICO, 2-(4-FLUOROFENOXI)-N-{4-[(2-HIDROXI-3-METILBENZOILAMINO)METIL]BENCIL}-NICOTINAMIDA, 2-(4-FLUOROFENOXI)-N-{4-[(6-FLUORO-2-HIDROXIBENZOILAMINO)METIL]BENCIL}-NICOTINAMIDA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA QUE INCLUYE EL COMPUESTO DE FORMULA I Y UNA SAL DE TIOTROPIO O DERIVADO DEL MISMO UTIL PARA EL TRATAMIENTO DE ASMA, BRONCOCONSTRICCION, ENFERMEDADES INFLAMATORIAS, OBSTRUCTIVAS DE LAS VIAS RESPIRATORIASREFERS TO A COMBINATION OF NICOTINAMIDE DERIVATIVES OF FORMULA I WHERE m IS 0-3, n IS 0-3; R1 AND R2 ARE H, HALO, CYANE, C1-C4 ALKYL, AMONG OTHERS; X IS -O-, -S-, -NH-; R3 IS PHENYL, NAPHTHYL, C3-C8 CYCLOALKYL, BICYCLE GROUPS; AND IS * - (C = O) - **, * - (C = O) -NH - **, AMONG OTHERS WHERE * INDICATES THE JOINT POINT OF EACH PARTIAL FORMULA; R4 IS PHENYL, NAPHTHYLL, HETEROARYL, C1-C4 ALKYL, AMONG OTHERS. PREFERRED COMPOUNDS ARE 3- (3- {4 - [(3-HYDROXYBENZOYLAMINE) METHYL] BENZYLCARBAMOYL} PYRIDIN-2-ILOXIBENZOIC ACID, 2- (4-FLUOROPHENOXY) -N- {4 - [(2-HYDROXY- 3-METHYLBENZOYLAMINO) METHYL] BENZYL} -NICOTINAMIDE, 2- (4-FLUOROPHENOXY) -N- {4 - [(6-FLUORO-2-HYDROXYBENZOYLAMINE) METHYL] BENZYL} -NICOTINAMIDE, AMONG OTHERS ALSO REFERRED TO. PHARMACEUTICAL THAT INCLUDES THE COMPOUND OF FORMULA I AND A SALT OF TIOTROPIUM OR A DERIVATIVE OF THE SAME USEFUL FOR THE TREATMENT OF ASTHMA, BRONCHOCONSTRICTION, INFLAMMATORY DISEASES, OBSTRUCTIVE DISEASES OF THE RESPIRATORY TRACT

PE2003000148A 2002-02-11 2003-02-11 DERIVATIVES OF NICOTINAMIDE AND A TIOTROPE SALT IN COMBINATION FOR THE TREATMENT OF DISEASES PE20030921A1 (en)

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US6995162B2 (en) 2001-01-12 2006-02-07 Amgen Inc. Substituted alkylamine derivatives and methods of use
US7102009B2 (en) 2001-01-12 2006-09-05 Amgen Inc. Substituted amine derivatives and methods of use
AU2003245711A1 (en) 2002-02-11 2003-09-04 Pfizer Inc. Nicotinamide derivatives useful as pde4 inhibitors
US7307088B2 (en) 2002-07-09 2007-12-11 Amgen Inc. Substituted anthranilic amide derivatives and methods of use
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US7153870B2 (en) 2003-07-25 2006-12-26 Pfizer Inc. Nicotinamide derivatives useful as PDE4 inhibitors
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JPWO2005026132A1 (en) * 2003-09-17 2007-11-08 日本新薬株式会社 CAMP substrate-specific inhibitors of phosphodiesterase
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