PE20030859A1 - Composiciones de medicamentos sobre la base de agentes anticolinergicos y de agentes inhibidores de la cinasa del egfr - Google Patents
Composiciones de medicamentos sobre la base de agentes anticolinergicos y de agentes inhibidores de la cinasa del egfrInfo
- Publication number
- PE20030859A1 PE20030859A1 PE2003000163A PE2003000163A PE20030859A1 PE 20030859 A1 PE20030859 A1 PE 20030859A1 PE 2003000163 A PE2003000163 A PE 2003000163A PE 2003000163 A PE2003000163 A PE 2003000163A PE 20030859 A1 PE20030859 A1 PE 20030859A1
- Authority
- PE
- Peru
- Prior art keywords
- amino
- egfr
- agents
- etoxy
- vinylcarbonyl
- Prior art date
Links
- 229940121948 Muscarinic receptor antagonist Drugs 0.000 title abstract 2
- 239000003795 chemical substances by application Substances 0.000 title abstract 2
- 239000000812 cholinergic antagonist Substances 0.000 title abstract 2
- 229940079593 drug Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 title 1
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- -1 FLUORO-PHENYL Chemical class 0.000 abstract 5
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 abstract 3
- NNPPMTNAJDCUHE-UHFFFAOYSA-N isobutane Chemical compound CC(C)C NNPPMTNAJDCUHE-UHFFFAOYSA-N 0.000 abstract 2
- 102000001301 EGF receptor Human genes 0.000 abstract 1
- 108060006698 EGF receptor Proteins 0.000 abstract 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 abstract 1
- 239000004698 Polyethylene Substances 0.000 abstract 1
- 239000000443 aerosol Substances 0.000 abstract 1
- 150000002016 disaccharides Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 150000008282 halocarbons Chemical class 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 150000002430 hydrocarbons Chemical class 0.000 abstract 1
- 239000001282 iso-butane Substances 0.000 abstract 1
- 229940126601 medicinal product Drugs 0.000 abstract 1
- 150000002772 monosaccharides Chemical class 0.000 abstract 1
- 229910017604 nitric acid Inorganic materials 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 230000002085 persistent effect Effects 0.000 abstract 1
- 229920000573 polyethylene Polymers 0.000 abstract 1
- 239000003380 propellant Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 150000005846 sugar alcohols Polymers 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
SE REFIERE A UN MEDICAMENTO QUE CONTIENE i)AGENTES ANTICOLINERGICOS TAL COMO SALES TIOTROPIO, OXITROPIO, IPRATROPIO EN COMBINACION CON ii)AGENTES INHIBIDORES DE CINASA DEL RECEPTOR DEL FACTOR DE CRECIMIENTO EPIDERMICO (EGFR) DE PREFERENCIA 4-[(3-CLORO-4-FLUORO-FENIL)AMINO]-7-(2-{4-(S)-(2-OXO-TETRAHIDROFURAN-5-IL)-CARBONIL]-PIPERAZIN-1-IL}-ETOXI)-6-[(VINILCARBONIL)AMINO]QUINAZOLINA; 4-[(3-CLORO-4-FLUORO-FENIL)AMINO]-7-(2-{4-(S)-(2-OXO-TETRAHIDROFURAN-5-IL)-CARBONIL]-PIPERAZIN-1-IL}-ETOXI)-6-[(VINILCARBONIL)AMINO]QUINAZOLINA; ENTRE OTROS, iii)SUSTANCIAS AUXILIARES DE PREFERENCIA MONOSACARIDOS, DISACARIDOS, POLIALCOHOLES CON UN TAMANO DE PARTICULA DE 250µm. LA RELACION DE i) A ii) ES DE 1:800 A 20:1. TAMBIEN SE REFIERE A i)UN AEROSOL PARA INHALACION CON UN CONTENIDO DE UN GAS PROPULSOR TAL COMO HIDROCARBUROS COMO N-PROPANOS, ISOBUTANO, ENTRE OTROS O HIDROCARBUROSHALOGENADOS; ii)SOLUCION O SUSPENSION PARA INHALACION DE pH ES DE 2-7 EL QUE SE AJUSTA ADICIONANDO ACIDO NITRICO, SULFURICO, ENTRE OTROS, CODISOLVENTES COMO ALCOHOL ISOPROPILICO, POLIETILENGLICOL. EL MEDICAMENTO TIENE UNA RAPIDA INICIACION DEL EFCTO ASI COO UNA DURACION DEL EFECTO PERSISTENTE
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10206505A DE10206505A1 (de) | 2002-02-16 | 2002-02-16 | Neue Arzneimittelkompositionen auf der Basis von Anticholinergika und EGFR-Kinase-Hemmern |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20030859A1 true PE20030859A1 (es) | 2003-11-18 |
Family
ID=27635037
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2003000163A PE20030859A1 (es) | 2002-02-16 | 2003-02-14 | Composiciones de medicamentos sobre la base de agentes anticolinergicos y de agentes inhibidores de la cinasa del egfr |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP1478398B1 (es) |
| JP (1) | JP2005517039A (es) |
| KR (1) | KR20040083519A (es) |
| CN (1) | CN1633305A (es) |
| AR (1) | AR038494A1 (es) |
| AT (1) | ATE430581T1 (es) |
| AU (1) | AU2003206881B2 (es) |
| BR (1) | BR0307703A (es) |
| CA (1) | CA2476127C (es) |
| CO (1) | CO5611134A2 (es) |
| DE (2) | DE10206505A1 (es) |
| ES (1) | ES2326968T3 (es) |
| MX (1) | MXPA04007813A (es) |
| NZ (1) | NZ535166A (es) |
| PE (1) | PE20030859A1 (es) |
| PL (1) | PL369736A1 (es) |
| RU (1) | RU2004127869A (es) |
| TW (1) | TW200400036A (es) |
| UY (1) | UY27670A1 (es) |
| WO (1) | WO2003068264A1 (es) |
| ZA (1) | ZA200404787B (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10230751A1 (de) * | 2002-07-09 | 2004-01-22 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Arzneimittelkompositionen auf der Basis neuer Anticholinergika und EGFR-Kinase-Hemmern |
| MXPA06002964A (es) | 2003-09-16 | 2006-06-14 | Astrazeneca Ab | Derivados de quinazolina como inhibidores de cinasa de tirosina. |
| DE102004001607A1 (de) * | 2004-01-09 | 2005-08-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Arzneimittelkombinationen auf der Basis von Scopin- oder Tropensäureestern mit EGFR-Kinase-Hemmern |
| US20060035893A1 (en) * | 2004-08-07 | 2006-02-16 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders |
| AU2006288716A1 (en) * | 2005-09-06 | 2007-03-15 | T.K. Signal Ltd. | Polyalkylene glycol derivatives of 4- (phenylamino)quinazolines useful as irreversible inhibitors of epidermal growth factor receptor tyrosine kinase |
| KR100832594B1 (ko) | 2005-11-08 | 2008-05-27 | 한미약품 주식회사 | 다중저해제로서의 퀴나졸린 유도체 및 이의 제조방법 |
| JP5781934B2 (ja) | 2008-11-10 | 2015-09-24 | ナショナル ヘルス リサーチ インスティテューツ | チロシンキナーゼ阻害剤としての融合２環および３環ピリミジン化合物 |
| US20120220557A1 (en) * | 2011-02-17 | 2012-08-30 | Chiesi Farmaceutici S.P.A. | Liquid propellant-free formulation comprising an antimuscarinic drug |
| US10710968B2 (en) | 2016-01-13 | 2020-07-14 | Hadasit Medical Research Services And Development Ltd. | Radiolabeled erlotinib analogs and uses thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9508538D0 (en) * | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivatives |
| GB9622363D0 (en) * | 1996-10-28 | 1997-01-08 | Celltech Therapeutics Ltd | Chemical compounds |
| DE19921693A1 (de) * | 1999-05-12 | 2000-11-16 | Boehringer Ingelheim Pharma | Neuartige Arzneimittelkompositionen auf der Basis von anticholinergisch wirksamen Verbindungen und ß-Mimetika |
| DE19911509A1 (de) * | 1999-03-15 | 2000-09-21 | Boehringer Ingelheim Pharma | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
| DE10042062A1 (de) * | 2000-08-26 | 2002-03-07 | Boehringer Ingelheim Pharma | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Hertellung |
-
2002
- 2002-02-16 DE DE10206505A patent/DE10206505A1/de not_active Withdrawn
-
2003
- 2003-02-12 WO PCT/EP2003/001357 patent/WO2003068264A1/de not_active Ceased
- 2003-02-12 EP EP03704593A patent/EP1478398B1/de not_active Expired - Lifetime
- 2003-02-12 ES ES03704593T patent/ES2326968T3/es not_active Expired - Lifetime
- 2003-02-12 PL PL03369736A patent/PL369736A1/xx not_active Application Discontinuation
- 2003-02-12 NZ NZ535166A patent/NZ535166A/en unknown
- 2003-02-12 RU RU2004127869/15A patent/RU2004127869A/ru unknown
- 2003-02-12 DE DE50311496T patent/DE50311496D1/de not_active Expired - Lifetime
- 2003-02-12 AT AT03704593T patent/ATE430581T1/de active
- 2003-02-12 KR KR10-2004-7012713A patent/KR20040083519A/ko not_active Ceased
- 2003-02-12 MX MXPA04007813A patent/MXPA04007813A/es not_active Application Discontinuation
- 2003-02-12 AR ARP030100439A patent/AR038494A1/es not_active Application Discontinuation
- 2003-02-12 AU AU2003206881A patent/AU2003206881B2/en not_active Ceased
- 2003-02-12 CA CA2476127A patent/CA2476127C/en not_active Expired - Fee Related
- 2003-02-12 CN CNA038039427A patent/CN1633305A/zh active Pending
- 2003-02-12 BR BR0307703-9A patent/BR0307703A/pt not_active IP Right Cessation
- 2003-02-12 JP JP2003567444A patent/JP2005517039A/ja active Pending
- 2003-02-14 UY UY27670A patent/UY27670A1/es not_active Application Discontinuation
- 2003-02-14 PE PE2003000163A patent/PE20030859A1/es not_active Application Discontinuation
- 2003-02-14 TW TW092103090A patent/TW200400036A/zh unknown
-
2004
- 2004-06-17 ZA ZA200404787A patent/ZA200404787B/en unknown
- 2004-09-13 CO CO04090723A patent/CO5611134A2/es active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| ATE430581T1 (de) | 2009-05-15 |
| AR038494A1 (es) | 2005-01-19 |
| AU2003206881B2 (en) | 2009-02-26 |
| CN1633305A (zh) | 2005-06-29 |
| UY27670A1 (es) | 2003-09-30 |
| ZA200404787B (en) | 2005-08-11 |
| JP2005517039A (ja) | 2005-06-09 |
| ES2326968T3 (es) | 2009-10-22 |
| DE50311496D1 (de) | 2009-06-18 |
| CO5611134A2 (es) | 2006-02-28 |
| TW200400036A (en) | 2004-01-01 |
| NZ535166A (en) | 2007-01-26 |
| EP1478398A1 (de) | 2004-11-24 |
| AU2003206881A1 (en) | 2003-09-04 |
| MXPA04007813A (es) | 2004-10-15 |
| KR20040083519A (ko) | 2004-10-02 |
| CA2476127C (en) | 2011-06-14 |
| BR0307703A (pt) | 2005-01-04 |
| DE10206505A1 (de) | 2003-08-28 |
| WO2003068264A1 (de) | 2003-08-21 |
| EP1478398B1 (de) | 2009-05-06 |
| RU2004127869A (ru) | 2005-08-27 |
| PL369736A1 (en) | 2005-05-02 |
| CA2476127A1 (en) | 2003-08-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application declared void or lapsed |