PE20021159A1 - Forma de dosificacion farmaceutica del mesilato de nelfinavir amorfo - Google Patents
Forma de dosificacion farmaceutica del mesilato de nelfinavir amorfoInfo
- Publication number
- PE20021159A1 PE20021159A1 PE2002000369A PE2002000369A PE20021159A1 PE 20021159 A1 PE20021159 A1 PE 20021159A1 PE 2002000369 A PE2002000369 A PE 2002000369A PE 2002000369 A PE2002000369 A PE 2002000369A PE 20021159 A1 PE20021159 A1 PE 20021159A1
- Authority
- PE
- Peru
- Prior art keywords
- nelfinavir
- dosage form
- fusion
- pharmaceutical dosage
- amorphous
- Prior art date
Links
- 239000002552 dosage form Substances 0.000 title abstract 3
- QAGYKUNXZHXKMR-UHFFFAOYSA-N CPD000469186 Natural products CC1=C(O)C=CC=C1C(=O)NC(C(O)CN1C(CC2CCCCC2C1)C(=O)NC(C)(C)C)CSC1=CC=CC=C1 QAGYKUNXZHXKMR-UHFFFAOYSA-N 0.000 title abstract 2
- 229960000884 nelfinavir Drugs 0.000 title abstract 2
- QAGYKUNXZHXKMR-HKWSIXNMSA-N nelfinavir Chemical compound CC1=C(O)C=CC=C1C(=O)N[C@H]([C@H](O)CN1[C@@H](C[C@@H]2CCCC[C@@H]2C1)C(=O)NC(C)(C)C)CSC1=CC=CC=C1 QAGYKUNXZHXKMR-HKWSIXNMSA-N 0.000 title abstract 2
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 title 1
- 230000004927 fusion Effects 0.000 abstract 3
- NQHXCOAXSHGTIA-SKXNDZRYSA-N nelfinavir mesylate Chemical compound CS(O)(=O)=O.CC1=C(O)C=CC=C1C(=O)N[C@H]([C@H](O)CN1[C@@H](C[C@@H]2CCCC[C@@H]2C1)C(=O)NC(C)(C)C)CSC1=CC=CC=C1 NQHXCOAXSHGTIA-SKXNDZRYSA-N 0.000 abstract 3
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 abstract 2
- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 abstract 2
- 230000000903 blocking effect Effects 0.000 abstract 2
- 229920001577 copolymer Polymers 0.000 abstract 2
- 239000008187 granular material Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 229910000497 Amalgam Inorganic materials 0.000 abstract 1
- 239000011230 binding agent Substances 0.000 abstract 1
- 238000004090 dissolution Methods 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 239000000314 lubricant Substances 0.000 abstract 1
- 229960005230 nelfinavir mesylate Drugs 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 239000003381 stabilizer Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
- 239000000080 wetting agent Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
SE REFIERE A UNA FORMA DE DOSIFICACION FARMACEUTICA ORAL SOLIDA QUE COMPRENDE MESILATO DE NELFINAVIR AMORFO UTILIZANDO DE 400mg A 700mg Y UN COPOLIMERO DE BLOQUEO DE OXIDO DE ETILENO Y OXIDO DE PROPILENO, SINTETICO, NO IONICO, SOLUBLE EN AGUA, PUNTO DE FUSION DE 40°C, VALOR DE HLB A 25°C DE 14 A 29; EXCIPIENTES TAL COMO ESTABILIZANTES, AGENTES HUMECTANTES, AGLUTINANTES, DISGREGANTES, DILUYENTES, SOLUBILIZANTES, LUBRICANTES. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION QUE COMPRENDE CALENTAR UNA MEZCLA DE MESILATO DE NELFINAVIR AMORFO Y EL POLIMERO DE BLOQUEO DE OXIDO DE ETILENO Y OXIDO DE PROPILENO SINTETICO NO IONICO, SOLUBLE EN AGUA; MEZCLAR LA AMALGAMA PARA FORMAR UN GRANULADO DE FUSION; PROCESAR EL GRANULADO DE FUSION EN DICHA FORMA DE DOSIFICACION DE MESILATO DE NELFINAVIR AMORFO. EL COPOLIMERO PROPORCIONA A LA FORMULACION DE NELFINAVIR MEJOR DISOLUCION Y BIODISPONIBILIDAD
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28841001P | 2001-05-03 | 2001-05-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20021159A1 true PE20021159A1 (es) | 2002-12-20 |
Family
ID=23106974
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2002000369A PE20021159A1 (es) | 2001-05-03 | 2002-04-30 | Forma de dosificacion farmaceutica del mesilato de nelfinavir amorfo |
Country Status (36)
| Country | Link |
|---|---|
| US (1) | US7014866B2 (es) |
| EP (1) | EP1390063B1 (es) |
| JP (1) | JP4101661B2 (es) |
| KR (1) | KR100554816B1 (es) |
| CN (1) | CN1255185C (es) |
| AR (1) | AR034320A1 (es) |
| AT (1) | ATE282428T1 (es) |
| BG (1) | BG108311A (es) |
| BR (1) | BR0209325A (es) |
| CA (1) | CA2444116C (es) |
| CZ (1) | CZ20033211A3 (es) |
| DE (1) | DE60201988T2 (es) |
| EA (1) | EA006627B1 (es) |
| EC (1) | ECSP034827A (es) |
| ES (1) | ES2231717T3 (es) |
| GE (1) | GEP20053466B (es) |
| GT (1) | GT200200079A (es) |
| HR (1) | HRP20030873B1 (es) |
| HU (1) | HU229938B1 (es) |
| IL (2) | IL158306A0 (es) |
| IS (1) | IS7010A (es) |
| JO (1) | JO2401B1 (es) |
| MA (1) | MA27018A1 (es) |
| MX (1) | MXPA03009971A (es) |
| MY (1) | MY128509A (es) |
| NO (1) | NO20034689D0 (es) |
| NZ (1) | NZ528689A (es) |
| PA (1) | PA8544501A1 (es) |
| PE (1) | PE20021159A1 (es) |
| PL (1) | PL366998A1 (es) |
| PT (1) | PT1390063E (es) |
| RS (1) | RS83503A (es) |
| SK (1) | SK14572003A3 (es) |
| TW (1) | TWI234461B (es) |
| UA (1) | UA76463C2 (es) |
| WO (1) | WO2002089835A2 (es) |
Families Citing this family (114)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1175205B1 (en) | 1999-11-12 | 2006-06-14 | Abbott Laboratories | Solid dispersion comprising ritonavir, fenofibrate or griseofulvin |
| DE10026698A1 (de) | 2000-05-30 | 2001-12-06 | Basf Ag | Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung |
| CA2398226A1 (en) * | 2002-01-28 | 2003-07-28 | Pfizer Inc. | Increased-dosage nelfinavir tablet and method of making same |
| CN100475209C (zh) * | 2003-07-15 | 2009-04-08 | 阿利健制药有限公司 | 抗冠状病毒剂 |
| US8377952B2 (en) * | 2003-08-28 | 2013-02-19 | Abbott Laboratories | Solid pharmaceutical dosage formulation |
| US8025899B2 (en) * | 2003-08-28 | 2011-09-27 | Abbott Laboratories | Solid pharmaceutical dosage form |
| CA2548376A1 (en) * | 2003-12-31 | 2005-07-21 | Pfizer Products Inc. | Solid compositions of low-solubility drugs and poloxamers |
| AU2005311652B2 (en) * | 2004-12-03 | 2010-12-02 | Merck Sharp & Dohme Corp. | Pharmaceutical formulation of carboxamide HIV integrase inhibitors containing a release rate controlling composition |
| JP5523706B2 (ja) | 2005-09-23 | 2014-06-18 | エフ．ホフマン−ラ ロシュ アーゲー | 新規投薬配合物 |
| CN101330906B (zh) * | 2005-12-14 | 2010-12-29 | 弗·哈夫曼-拉罗切有限公司 | Hcv前药制剂 |
| ATE482690T1 (de) * | 2005-12-14 | 2010-10-15 | Hoffmann La Roche | Hcv-prodrug-formulierung |
| CA2660374A1 (en) * | 2006-08-10 | 2008-02-14 | Cipla Limited | Antiretroviral solid oral composition |
| RU2454220C2 (ru) | 2006-08-16 | 2012-06-27 | Новартис Аг | Способ получения твердых дисперсий высококристаллических терапевтических соединений |
| US20080181948A1 (en) * | 2006-11-15 | 2008-07-31 | Abbott Laboratories | Solid pharmaceutical dosage formulations |
| EP2136637B1 (en) | 2007-03-16 | 2015-11-11 | Concert Pharmaceuticals, Inc. | Inhibitors of cholesterol ester transfer protein |
| BRPI0810362A2 (pt) * | 2007-04-19 | 2014-10-29 | Concert Pharmaceuticals Inc | Compostos de morfolinila deuterados |
| ES2401914T3 (es) | 2007-04-25 | 2013-04-25 | Concert Pharmaceuticals Inc. | Análogos de Cilostazol |
| US9194512B2 (en) | 2007-04-30 | 2015-11-24 | Mark Andreychuk | Coiled tubing with heat resistant conduit |
| US8567657B2 (en) * | 2007-04-30 | 2013-10-29 | Mtj Consulting Services Inc. | Coiled tubing with retainer for conduit |
| WO2008137461A1 (en) | 2007-05-01 | 2008-11-13 | Concert Pharmaceuticals Inc. | Naphthyl(ethyl) acetamides |
| PT2345653E (pt) | 2007-05-01 | 2013-04-01 | Concert Pharmaceuticals Inc | Compostos de morfinano |
| CA3056205C (en) | 2007-05-01 | 2023-09-26 | Concert Pharmaceuticals Inc. | Morphinan compounds |
| EP4183787A1 (en) | 2007-05-01 | 2023-05-24 | Concert Pharmaceuticals Inc. | Morphinan compounds |
| RS51226B (sr) | 2007-06-12 | 2010-12-31 | Concert Pharmaceuticals Inc. | Derivati azapeptida kao inhibitori hiv proteaze |
| WO2009051782A1 (en) * | 2007-10-18 | 2009-04-23 | Concert Pharmaceuticals Inc. | Deuterated etravirine |
| WO2009052391A1 (en) * | 2007-10-19 | 2009-04-23 | Purdue Research Foundation | Solid formulations of crystalline compounds |
| ITMI20080227A1 (it) * | 2008-02-13 | 2009-08-14 | Felice Vinati | '' dispositivo di sicurezza per apparati di sollevamento a fune '' |
| WO2009108383A2 (en) | 2008-02-29 | 2009-09-03 | Concert Pharmaceuticals, Inc. | Substituted xanthine derivatives |
| WO2009146310A1 (en) * | 2008-05-28 | 2009-12-03 | Concert Pharmaceuticals Inc. | Deuterated tizanidine |
| WO2010019557A1 (en) * | 2008-08-12 | 2010-02-18 | Concert Pharmaceuticals Inc. | N-phenyl-2-pyrimidineamine derivatives |
| SI2334678T1 (sl) | 2008-09-19 | 2013-05-31 | Concert Pharmaceuticals Inc. | Spojine morfinana |
| WO2010062690A1 (en) | 2008-10-30 | 2010-06-03 | Concert Pharmaceuticals Inc. | Combination of morphinan compounds and antidepressant for the treatment of pseudobulbar affect, neurological diseases, intractable and chronic pain and brain injury |
| SI2397158T1 (sl) | 2008-10-30 | 2016-07-29 | Concert Pharmaceuticals Inc. | Kombinacija spojin morfinana in antidepresivov za zdravljenje psevdobulbarnih vplivov |
| AU2009311645C1 (en) | 2008-11-04 | 2014-10-02 | Acer Therapeutics Inc. | CXCR4 receptor compounds |
| WO2010065755A1 (en) | 2008-12-04 | 2010-06-10 | Concert Pharmaceuticals, Inc. | Deuterated pyridinones |
| US20110053961A1 (en) | 2009-02-27 | 2011-03-03 | Concert Pharmaceuticals, Inc. | Substituted xanthine derivatives |
| US8563554B2 (en) | 2009-03-17 | 2013-10-22 | Concert Pharmaceuticals, Inc. | Deuterated pyrazinoisoquinoline compounds |
| US20120244122A1 (en) | 2009-05-28 | 2012-09-27 | Masse Craig E | Peptides for the Treatment of HCV Infections |
| EP2454259A1 (en) | 2009-06-23 | 2012-05-23 | Concert Pharmaceuticals Inc. | Deuterium-modified triazolo-pyridazine derivatives as gaba-a receptor modulators |
| US20110015154A1 (en) * | 2009-07-20 | 2011-01-20 | Kellermann Gottfried H | Supporting acetylcholine function |
| US8278460B2 (en) | 2009-10-15 | 2012-10-02 | Concert Pharmaceuticals, Inc. | Substituted benzimidazoles |
| US20110098265A1 (en) * | 2009-10-28 | 2011-04-28 | Neuroscience, Inc. | Methods for reducing cravings and impulses associated with addictive and compulsive behaviors |
| WO2011060216A1 (en) | 2009-11-12 | 2011-05-19 | Concert Pharmaceuticals Inc. | Substituted azaindoles |
| WO2011103457A1 (en) | 2010-02-18 | 2011-08-25 | Concert Pharmaceuticals Inc. | Pyrimidine derivatives |
| EP2566494B1 (en) | 2010-02-26 | 2017-11-29 | Acer Therapeutics, Inc. | Cxcr4 receptor compounds |
| US8513434B2 (en) | 2010-03-02 | 2013-08-20 | Concert Pharmaceuticals Inc. | Tetrahydronaphthalene derivatives |
| US8575361B2 (en) | 2010-03-02 | 2013-11-05 | Concert Pharmaceuticals Inc. | Tetrahydronaphthalene derivatives |
| US20130116239A1 (en) | 2010-06-14 | 2013-05-09 | ratiopharm GnbH | Ivabradine-containing pharmaceutical composition with modified release |
| US20120208837A1 (en) | 2010-09-13 | 2012-08-16 | Roger Tung | Substituted azaindoles |
| EP2455068A1 (en) * | 2010-11-09 | 2012-05-23 | F. Hoffmann-La Roche AG | Pharmaceutical composition for treating HCV infections |
| WO2012065028A2 (en) | 2010-11-11 | 2012-05-18 | Concert Pharmaceuticals Inc. | Substituted tetracyclines |
| WO2012079075A1 (en) | 2010-12-10 | 2012-06-14 | Concert Pharmaceuticals, Inc. | Deuterated phthalimide derivatives |
| US8447329B2 (en) | 2011-02-08 | 2013-05-21 | Longsand Limited | Method for spatially-accurate location of a device using audio-visual information |
| CA2828251A1 (en) | 2011-02-25 | 2012-08-30 | Concert Pharmaceuticals, Inc. | 2-amino-naphthyridine derivatives |
| WO2012129381A1 (en) | 2011-03-22 | 2012-09-27 | Concert Pharmaceuticals Inc. | Deuterated preladenant |
| WO2012151361A1 (en) | 2011-05-03 | 2012-11-08 | Concert Pharmaceuticals Inc. | Carbamoylpyridone derivatives |
| WO2012154728A1 (en) | 2011-05-10 | 2012-11-15 | Concert Pharmaceuticals Inc. | Deuterated n-butyl bumetanide |
| PL3235812T3 (pl) | 2011-05-18 | 2020-04-30 | Vertex Pharmaceuticals (Europe) Limited | Deuterowane pochodne iwakaftoru |
| WO2013013052A1 (en) | 2011-07-19 | 2013-01-24 | Concert Pharmaceuticals, Inc. | Substituted xanthine derivatives |
| FR2985177B1 (fr) * | 2012-01-02 | 2016-04-01 | Oreal | Composition cosmetique solide aqueuse comprenant de l'alkylcellulose, au moins deux huiles non volatiles et au moins deux agents tensioactifs |
| WO2013106437A1 (en) | 2012-01-09 | 2013-07-18 | Anchor Therapeutics, Inc. | Apj receptor compounds |
| WO2013130849A1 (en) | 2012-02-29 | 2013-09-06 | Concert Pharmaceuticals, Inc. | Substituted dioxopiperidinyl phthalimide derivatives |
| EP2836492B1 (en) | 2012-04-13 | 2018-03-14 | Concert Pharmaceuticals Inc. | Substituted xanthine derivatives |
| US9249093B2 (en) | 2012-04-20 | 2016-02-02 | Concert Pharmaceuticals, Inc. | Deuterated rigosertib |
| BR122023027277A2 (pt) | 2012-06-15 | 2024-01-23 | Concert Pharmaceuticals, Inc. | Derivados deuterados de ruxolitinib e composição farmacêutica |
| ES2694202T3 (es) | 2012-07-12 | 2018-12-19 | Concert Pharmaceuticals, Inc. | Idebenona deuterada |
| ES2717279T3 (es) | 2012-08-17 | 2019-06-20 | Concert Pharmaceuticals Inc | Baricitinib deuterada |
| WO2014078842A1 (en) | 2012-11-19 | 2014-05-22 | Concert Pharmaceuticals, Inc. | Deuterated cftr potentiators |
| US20150299166A1 (en) | 2012-12-20 | 2015-10-22 | Concert Pharmaceuticals, Inc. | Deuterated alk inhibitors |
| ES2700989T3 (es) | 2012-12-21 | 2019-02-20 | Mayo Found Medical Education & Res | Métodos y materiales para tratar estenosis de la válvula aórtica calcificada |
| WO2014110322A2 (en) | 2013-01-11 | 2014-07-17 | Concert Pharmaceuticals, Inc. | Substituted dioxopiperidinyl phthalimide derivatives |
| EP2968268B1 (en) | 2013-03-15 | 2020-07-29 | Concert Pharmaceuticals Inc. | Inhibitors of the enzyme udp-glucose: n-acyl-sphingosine glucosyltransferase |
| EA201892726A1 (ru) | 2013-03-15 | 2019-04-30 | Консерт Фармасьютикалс, Инк. | Дейтерированный палбоциклиб |
| HU231191B1 (hu) | 2013-04-15 | 2021-08-30 | Szegedi Tudományegyetem | Izotóp tartalmú morfin molekulák |
| US20160159861A1 (en) | 2013-07-18 | 2016-06-09 | Anchor Therapeutics, Inc. | APJ Receptor Compounds |
| WO2015009889A1 (en) | 2013-07-18 | 2015-01-22 | Concert Pharmaceuticals, Inc. | Deuterated intedanib derivatives and their use for the treatment of proliferative disorders |
| WO2015031741A1 (en) | 2013-08-30 | 2015-03-05 | Concert Pharmaceuticals, Inc. | Deuterated derivatives of a thienotriazolodiazapine bromodomain-containing protein inhibitor |
| EP3105232B1 (en) | 2014-02-10 | 2019-08-28 | Concert Pharmaceuticals Inc. | Substituted triazolobenzodiazepines |
| US20170216296A1 (en) | 2014-04-18 | 2017-08-03 | Concert Pharmaceuticals, Inc. | Methods of treating hyperglycemia |
| WO2015179772A1 (en) | 2014-05-23 | 2015-11-26 | Concert Pharmaceuticals, Inc. | Deuterated phenylquinazolinone and phenylisoquinolinone compounds |
| WO2015188073A1 (en) | 2014-06-06 | 2015-12-10 | Research Triangle Institute | Apelin receptor (apj) agonists and uses thereof |
| EP3177292B1 (en) | 2014-08-07 | 2020-11-25 | Mayo Foundation for Medical Education and Research | Compounds and methods for treating cancer |
| WO2016061488A1 (en) | 2014-10-17 | 2016-04-21 | Concert Pharmaceuticals, Inc. | Amine reuptake inhibitors |
| WO2016073545A1 (en) | 2014-11-06 | 2016-05-12 | Concert Pharmaceuticals, Inc. | Phenyloxadiazole benzoic acids |
| WO2016089814A1 (en) | 2014-12-02 | 2016-06-09 | Concert Pharmaceuticals, Inc. | Deuterated analogues of daclatasvir |
| US10301281B2 (en) | 2014-12-11 | 2019-05-28 | Merck Sharp & Dohme Corp. | Crystal forms of a CCR5 antagonist |
| CN105769809A (zh) * | 2014-12-23 | 2016-07-20 | 上海星泰医药科技有限公司 | 提高生物利用度的雷尼司他及其制备方法 |
| WO2016105547A1 (en) | 2014-12-24 | 2016-06-30 | Concert Pharmaceuticals, Inc. | Deuterated dasabuvir |
| WO2016109795A1 (en) | 2014-12-31 | 2016-07-07 | Concert Pharmaceuticals, Inc. | Deuterated funapide and difluorofunapide |
| US20180044375A1 (en) | 2015-03-06 | 2018-02-15 | Concert Pharmaceuticals, Inc. | Deuterated emricasan |
| HK1249893A1 (zh) | 2015-03-31 | 2018-11-16 | Vertex Pharmaceuticals (Europe) Limited | 氘代vx-661 |
| US10683305B2 (en) | 2015-04-27 | 2020-06-16 | Concert Pharmaceuticals, Inc. | Deuterated OTX-015 |
| WO2017020005A1 (en) | 2015-07-30 | 2017-02-02 | Concert Pharmaceuticals, Inc. | Morphinan compounds for use in treating agitation |
| WO2017020002A1 (en) | 2015-07-30 | 2017-02-02 | Concert Pharmaceuticals, Inc. | Deuterated morphinan compounds for use in treating agitation |
| JP6849686B2 (ja) | 2015-09-21 | 2021-03-24 | バーテックス ファーマシューティカルズ （ヨーロッパ） リミテッド | 重水素化されたｃｆｔｒ増強剤の投与 |
| US11267777B2 (en) | 2015-11-19 | 2022-03-08 | Concert Pharmaceuticals, Inc. | Deuterated EPI-743 |
| BR112018011784A2 (pt) | 2015-12-09 | 2018-12-04 | Res Triangle Inst | agonistas aprimorados do receptor de apelina (apj) e usos dos mesmos |
| WO2017147003A1 (en) | 2016-02-26 | 2017-08-31 | Novobiotic Pharmaceuticals, Llc | Novel macrocyclic antibiotics and uses thereof |
| AU2017261286B2 (en) | 2016-05-04 | 2023-03-23 | Sun Pharmaceutical Industries, Inc. | Treatment of hair loss disorders with deuterated JAK inhibitors |
| PT3478664T (pt) | 2016-07-04 | 2020-12-28 | Avanir Pharmaceuticals Inc | Métodos para a síntese de dextrometorfano deuterado |
| WO2018026833A1 (en) | 2016-08-01 | 2018-02-08 | The Brigham And Women's Hospital, Inc. | Particles for delivery of proteins and peptides |
| WO2018119076A1 (en) | 2016-12-21 | 2018-06-28 | Research Triangle Institute | Diaryl purine derivatives with improved bioavailability |
| US11596629B2 (en) | 2017-02-28 | 2023-03-07 | Mayo Foundation For Medical Education And Research | Compounds and methods for treating cancer |
| US11278025B2 (en) | 2017-05-17 | 2022-03-22 | The General Hospital Corporation | Antibiotic compounds |
| US11274099B2 (en) | 2017-05-19 | 2022-03-15 | Superb Wisdom Limited | Derivatives of Resiquimod |
| MX2020005336A (es) | 2017-11-22 | 2020-08-13 | Concert Pharmaceuticals Inc | Analogos de d-serina deuterados y usos de los mismos. |
| US11243207B2 (en) | 2018-03-29 | 2022-02-08 | Mayo Foundation For Medical Education And Research | Assessing and treating cancer |
| CA3136550A1 (en) | 2019-04-10 | 2020-10-15 | Mayo Foundation For Medical Education And Research | Methods and materials for gender-dependent treatment of cardiovascular dysfunction |
| WO2021236139A1 (en) | 2020-05-21 | 2021-11-25 | Concert Pharmaceuticals, Inc. | Novel deuterated jak inhibitor and uses thereof |
| EP4157265A4 (en) | 2020-05-27 | 2023-11-22 | The Penn State Research Foundation | ANTIBACTERIAL COMPOUNDS |
| WO2022094133A1 (en) | 2020-10-28 | 2022-05-05 | Concert Pharmaceuticals, Inc. | Regimens for the treatment of hair loss disorders with deuterated jak inhibitors |
| JP2024531188A (ja) | 2021-08-11 | 2024-08-29 | サン ファーマシューティカル インダストリーズ，インコーポレイテッド | 重水素化ｊａｋ阻害剤による脱毛障害の治療 |
| CA3228509A1 (en) | 2021-08-12 | 2023-02-16 | Sun Pharmaceutical Industries, Inc. | Treatment of jak-inhibition-responsive disorders with prodrugs of jak inhibitors |
| JP2025515051A (ja) | 2022-05-04 | 2025-05-13 | サン ファーマシューティカル インダストリーズ，インコーポレイテッド | 重水素化ｊａｋ阻害剤による治療のための投与レジメン |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5281420A (en) * | 1992-05-19 | 1994-01-25 | The Procter & Gamble Company | Solid dispersion compositions of tebufelone |
| IE80467B1 (en) * | 1995-07-03 | 1998-07-29 | Elan Corp Plc | Controlled release formulations for poorly soluble drugs |
| US5834472A (en) * | 1996-05-24 | 1998-11-10 | Schering Corporation | Antifungal composition with enhanced bioavailability |
| US6232333B1 (en) * | 1996-11-21 | 2001-05-15 | Abbott Laboratories | Pharmaceutical composition |
| US6045829A (en) * | 1997-02-13 | 2000-04-04 | Elan Pharma International Limited | Nanocrystalline formulations of human immunodeficiency virus (HIV) protease inhibitors using cellulosic surface stabilizers |
| US6001851A (en) * | 1997-03-13 | 1999-12-14 | Agouron Pharmaceuticals, Inc. | HIV protease inhibitors |
| CA2290624C (en) * | 1997-06-06 | 2006-12-05 | John W. Shell | Gastric-retentive oral drug dosage forms for controlled release of highly soluble drugs |
| WO1998057648A1 (en) * | 1997-06-16 | 1998-12-23 | Vertex Pharmaceuticals Incorporated | Methods of increasing the bioavailability of stable crystal polymorphs of a compound |
| US6692767B2 (en) * | 1997-09-19 | 2004-02-17 | Shire Laboratories Inc. | Solid solution beadlet |
| WO2001034118A2 (en) * | 1999-11-12 | 2001-05-17 | Abbott Laboratories | Solid dispersion pharmaceutical formulations |
| US6499984B1 (en) * | 2000-05-22 | 2002-12-31 | Warner-Lambert Company | Continuous production of pharmaceutical granulation |
-
2002
- 2002-04-29 EP EP02748680A patent/EP1390063B1/en not_active Expired - Lifetime
- 2002-04-29 NZ NZ528689A patent/NZ528689A/en unknown
- 2002-04-29 WO PCT/EP2002/004711 patent/WO2002089835A2/en not_active Ceased
- 2002-04-29 CZ CZ20033211A patent/CZ20033211A3/cs unknown
- 2002-04-29 PT PT02748680T patent/PT1390063E/pt unknown
- 2002-04-29 PL PL02366998A patent/PL366998A1/xx unknown
- 2002-04-29 CN CNB028092953A patent/CN1255185C/zh not_active Expired - Fee Related
- 2002-04-29 MX MXPA03009971A patent/MXPA03009971A/es active IP Right Grant
- 2002-04-29 IL IL15830602A patent/IL158306A0/xx unknown
- 2002-04-29 HU HU0401238A patent/HU229938B1/hu not_active IP Right Cessation
- 2002-04-29 EA EA200301166A patent/EA006627B1/ru not_active IP Right Cessation
- 2002-04-29 AT AT02748680T patent/ATE282428T1/de active
- 2002-04-29 KR KR1020037014234A patent/KR100554816B1/ko not_active Expired - Fee Related
- 2002-04-29 HR HR20030873A patent/HRP20030873B1/xx not_active IP Right Cessation
- 2002-04-29 SK SK1457-2003A patent/SK14572003A3/sk unknown
- 2002-04-29 BR BR0209325-1A patent/BR0209325A/pt not_active Application Discontinuation
- 2002-04-29 JP JP2002586967A patent/JP4101661B2/ja not_active Expired - Fee Related
- 2002-04-29 GE GE5295A patent/GEP20053466B/en unknown
- 2002-04-29 RS YU83503A patent/RS83503A/sr unknown
- 2002-04-29 CA CA002444116A patent/CA2444116C/en not_active Expired - Fee Related
- 2002-04-29 DE DE60201988T patent/DE60201988T2/de not_active Expired - Lifetime
- 2002-04-29 UA UA20031210981A patent/UA76463C2/uk unknown
- 2002-04-29 ES ES02748680T patent/ES2231717T3/es not_active Expired - Lifetime
- 2002-04-30 AR ARP020101580A patent/AR034320A1/es not_active Application Discontinuation
- 2002-04-30 MY MYPI20021591A patent/MY128509A/en unknown
- 2002-04-30 PE PE2002000369A patent/PE20021159A1/es not_active Application Discontinuation
- 2002-04-30 TW TW091108967A patent/TWI234461B/zh not_active IP Right Cessation
- 2002-04-30 PA PA20028544501A patent/PA8544501A1/es unknown
- 2002-05-01 JO JO200237A patent/JO2401B1/en active
- 2002-05-02 GT GT200200079A patent/GT200200079A/es unknown
- 2002-05-02 US US10/138,071 patent/US7014866B2/en not_active Expired - Fee Related
-
2003
- 2003-10-08 IL IL158306A patent/IL158306A/en not_active IP Right Cessation
- 2003-10-20 NO NO20034689A patent/NO20034689D0/no not_active Application Discontinuation
- 2003-10-30 IS IS7010A patent/IS7010A/is unknown
- 2003-10-31 EC EC2003004827A patent/ECSP034827A/es unknown
- 2003-11-03 BG BG108311A patent/BG108311A/bg unknown
- 2003-11-03 MA MA27379A patent/MA27018A1/fr unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PE20021159A1 (es) | Forma de dosificacion farmaceutica del mesilato de nelfinavir amorfo | |
| DK1689724T3 (da) | Quinazolinonforbindelser som anticancermidler | |
| BR0112311A (pt) | Compostos e composições para liberar agentes ativos, forma de dosagem unitária, método para preparar ditas composições e seu uso | |
| AR018143A1 (es) | Formulacion para preparar un comprimido de desintegracion rapida, comprimidos de desintegracion rapida, especialmente comprimidos de desintegracionrapida en la boca | |
| AR077411A2 (es) | Forma de dosificacion farmaceutica solida, con lopinavir y ritonavir, y proceso para su preparacion. | |
| TW200505454A (en) | Heteroaryl-fused pyrimidinyl compounds as anticancer agents | |
| WO2006103399A8 (en) | Hiv integrase inhibitors | |
| CL2007001090A1 (es) | Compuestos derivados de diazepano, antagonistas de los receptores ccr-2, ccr-5 y ccr-3; procedimiento de preparacion; composicion farmaceutica; compuesto intermediario; y uso del compuesto en el tratamiento de una enfermedad oclusiva de arterias perifericas, isquemia critica de extremidades, angina inestable, apoplejia, entre otras | |
| UY27374A1 (es) | Uso de los antagonistas del receptor nk-1 para el tratamiento de lesiones cerebrales, espinales o neuronales | |
| BR0114799A (pt) | Compostos de ácido cianofenoxi carboxìlico e composições para liberar agentes ativos | |
| ECSP088239A (es) | Composición de liberación de fármaco sostenida | |
| AR103653A1 (es) | Complejos de acetato de abiraterona, proceso para prepararlos y composiciones farmacéuticas que los contienen | |
| PT1131050E (pt) | Formulacoes galenicas que se desintegram rapidamente na boca e metodo para as preparar | |
| AR038872A1 (es) | Formulaciones de carbamazepina de dosificacion solidad de liberacion controlada | |
| WO2020118251A3 (en) | Hypoxia targeting compositions and combinations thereof with a parp inhibitor and methods of use thereof | |
| ES2150404T3 (es) | Composiciones farmaceuticas de tizoxanida y nitozoxanida. | |
| MY197663A (en) | Pharmaceutical formulation | |
| AR077884A1 (es) | (4-(5-aminometil- fenil)-piperidin-1-il)-1h-indol-3-il)-metanonas disustituidas | |
| ECSP003685A (es) | Formulaciones orales de liberacion controlada | |
| SE0000303D0 (sv) | Novel compounds | |
| CO5170463A1 (es) | Formas polimorfas de un citrato de azobiciclo [2,2,2]octan- 3-amina y sus composiciones farmaceuticas | |
| MX2022004014A (es) | Composicion liofilizada que contiene 2-((s)-2-acetamido-3-(1h-indo l-3-il)propanamido)-6-diazo-5-oxohexanoato de (s)-isopropilo para administracion intravenosa y su uso. | |
| MX2021004553A (es) | Composiciones farmaceuticas y metodos para fabricar formulaciones de dosificacion solidas bajo demanda. | |
| AR046464A1 (es) | Multiparticulas de liberacion controlada con mejoradores de la disolucion | |
| PA8577801A1 (es) | Polipeptido t1249 pegilado |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |