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PE20021154A1 - Derivados de 4-aminopirimidina como antagonistas del receptor metabotropico de glutamato - Google Patents

Derivados de 4-aminopirimidina como antagonistas del receptor metabotropico de glutamato

Info

Publication number
PE20021154A1
PE20021154A1 PE2002000429A PE2002000429A PE20021154A1 PE 20021154 A1 PE20021154 A1 PE 20021154A1 PE 2002000429 A PE2002000429 A PE 2002000429A PE 2002000429 A PE2002000429 A PE 2002000429A PE 20021154 A1 PE20021154 A1 PE 20021154A1
Authority
PE
Peru
Prior art keywords
alkyl
ilsulfanil
pyrimidin
amino
antagonists
Prior art date
Application number
PE2002000429A
Other languages
English (en)
Inventor
Vincent Mutel
Juergen Wichmann
Jens-Uwe Peters
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PE20021154A1 publication Critical patent/PE20021154A1/es

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
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    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
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    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
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    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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    • A61P25/16—Anti-Parkinson drugs
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
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    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
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    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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Abstract

SE REFIERE A DERIVADOS DE 4-AMINOPIRIDINA DE FORMULA I DONDE R1 ES ALQUENILO C2-C6, ALQUINILO C2-C6, CICLOALQUILO C3-C6, COO-ALQUILO C1-C6, COO-ALQUENILO C2-C6, ENTRE OTROS; R2 ES H, ALQUILO C1-C6, R3 ES ARILO OPCIONALMENTE SUSTITUIDO CON ALQUILO C1-C6, ALQUENILO C2-C6, ALQUINILO C2-C6, ENTRE OTROS; R4 ES H, ALQUILO C1-C6; m ES 0-2. SON COMPUESTOS PREFERIDOS ESTER ETILICO DEL ACIDO (4-AMINO-5-BENCIL-PIRIMIDIN-2-ILSULFANIL)-ACETICO; ESTER ALILICO DEL ACIDO (4-AMINO-5-(4-BROMO-BENCIL)-PIRIMIDIN-2-ILSULFANIL)-ACETICO; ESTER ETILICO DEL ACIDO (4-AMINO-5-FURAN-3-ILMETIL-PIRIMIDIN-2-ILSULFANIL)-ACETICO, ESTER ALILICO DEL ACIDO (4-AMINO-5-BENCIL-PIRIMIDIN-2-ILSULFANIL)-ACETICO; TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. LOS COMPUESTOS SON ANTAGONISTAS DE RECEPTORES METABOTROPICOS DE GLUTAMATO mGLUR5 Y PUEDEN SER UTILES PARA EL TRATAMIENTO DE TRASTORNOS NEUROLOGICOS, ANSIEDAD, TRATAMIENTO DE DOLOR
PE2002000429A 2001-05-23 2002-05-21 Derivados de 4-aminopirimidina como antagonistas del receptor metabotropico de glutamato PE20021154A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP01112564 2001-05-23

Publications (1)

Publication Number Publication Date
PE20021154A1 true PE20021154A1 (es) 2002-12-17

Family

ID=8177521

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2002000429A PE20021154A1 (es) 2001-05-23 2002-05-21 Derivados de 4-aminopirimidina como antagonistas del receptor metabotropico de glutamato

Country Status (10)

Country Link
US (1) US7138404B2 (es)
EP (1) EP1395568B1 (es)
JP (1) JP4098095B2 (es)
CA (1) CA2447020A1 (es)
DE (1) DE60215804T2 (es)
ES (1) ES2274038T3 (es)
GT (1) GT200200096A (es)
PA (1) PA8545601A1 (es)
PE (1) PE20021154A1 (es)
WO (1) WO2002094795A1 (es)

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US6566372B1 (en) * 1999-08-27 2003-05-20 Ligand Pharmaceuticals Incorporated Bicyclic androgen and progesterone receptor modulator compounds and methods
GB0128996D0 (en) 2001-12-04 2002-01-23 Novartis Ag Organic compounds
ITMI20030151A1 (it) * 2003-01-30 2004-07-31 Recordati Ind Chimica E Farma Ceutica S P A Uso di antagonisti selettivi del recettore mglu5 per il trattamento di disfunzioni neuromuscolari del tratto urinario inferiore.
DE102005025161A1 (de) * 2005-06-01 2006-12-07 Phenion Gmbh & Co. Kg Derivate des Pyrimidins und Triazins und deren Verwendung
DE102006012251A1 (de) * 2006-03-15 2007-11-08 Grünenthal GmbH Substituierte 4-Amino-chinazolin-Derivate und ihre Verwendung zur Herstellung von Arzneimitteln
AR076601A1 (es) 2009-05-21 2011-06-22 Chlorion Pharma Inc Pirimidinas como agentes terapeuticos
KR20250048143A (ko) 2017-07-31 2025-04-07 노파르티스 아게 코카인 사용 감소 또는 코카인 사용 재발 예방에 있어서 마보글루란트의 용도
JP7651590B2 (ja) * 2020-03-27 2025-03-26 ドン－ア エスティ カンパニー リミテッド アミノピリミジン誘導体およびアリール炭化水素受容体モジュレーターとしてのその使用

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FR1013704A (fr) 1948-09-09 1952-08-04 Wellcome Found Composés pyrimidiques et procédé de préparation de ces corps
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Also Published As

Publication number Publication date
GT200200096A (es) 2003-06-17
DE60215804D1 (de) 2006-12-14
EP1395568A1 (en) 2004-03-10
WO2002094795A1 (en) 2002-11-28
PA8545601A1 (es) 2003-01-24
ES2274038T3 (es) 2007-05-16
US7138404B2 (en) 2006-11-21
US20030022907A1 (en) 2003-01-30
EP1395568B1 (en) 2006-11-02
DE60215804T2 (de) 2007-09-06
JP4098095B2 (ja) 2008-06-11
CA2447020A1 (en) 2002-11-28
JP2004530701A (ja) 2004-10-07

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