PE20021045A1 - Inhibidores de pcp basados en acidos 3-heterociclilpropanohidroxamicos - Google Patents
Inhibidores de pcp basados en acidos 3-heterociclilpropanohidroxamicosInfo
- Publication number
- PE20021045A1 PE20021045A1 PE2002000235A PE2002000235A PE20021045A1 PE 20021045 A1 PE20021045 A1 PE 20021045A1 PE 2002000235 A PE2002000235 A PE 2002000235A PE 2002000235 A PE2002000235 A PE 2002000235A PE 20021045 A1 PE20021045 A1 PE 20021045A1
- Authority
- PE
- Peru
- Prior art keywords
- het
- heterociclylpropanohydroxamic
- alkyl
- cyclohexil
- oxadiazol
- Prior art date
Links
- 239000002253 acid Substances 0.000 title abstract 2
- 150000007513 acids Chemical class 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- TWBYWOBDOCUKOW-UHFFFAOYSA-N isonicotinic acid Chemical compound OC(=O)C1=CC=NC=C1 TWBYWOBDOCUKOW-UHFFFAOYSA-N 0.000 abstract 2
- -1 2,4-DIOXO-1,2,3,4-TETRAHYDRO-5-PYRIMIDINYL Chemical class 0.000 abstract 1
- 208000032544 Cicatrix Diseases 0.000 abstract 1
- AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 231100000241 scar Toxicity 0.000 abstract 1
- 230000037387 scars Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SE REFIERE A ACIDOS 3-HETEROCICLILPROPANOHIDROXAMICOS DE FORMULA HONH-C(=O)-CH2-CH-(X-R)-[HET]-Y; DONDE: X ES ALQUILENO C1-C6, ALQUENILENO C2-C6 OPCIONALMENTE SUSTITUIDO CON F; R ES ARILO, CICLOALQUENILO C5-C8, CICLOALQUILO C3-C8; HET ES UN HETEROCICLO COMO GRUPO a, b, c; Z ES H, ALQUILO C1-C4; Y ES UN SISTEMA ANULAR INSATURADO BICICLICO DE 5-10 MIEMBROS OPCIONALMENTE SUSTITUIDO CON =O, ALQUILO C1-C4, NR1R2, SO2NR1R2, CO2R1, HET1; R1 Y R2 SON H, ALQUILO C1-C4 OPCIONALMENTE SUSTITUIDO CON ALCOXI C1-C4; HET 1 ES UN HETEROCICLO DE 4-6 MIEMBROS. TAMBIEN SE REFIERE A PROCEDIMIENTO PARA LA PREPARACION. SON COMPUESTOS PREFERIDOS (3R)-6-CICLOHEXIL-3-[3-(2,4-DIOXO-1,2,3,4-TETRAHIDRO-5-PIRIMIDINIL)-1,2,4-OXADIAZOL-5-IL]-N-HIDROXIHEXANAMIDA; ACIDO 2-(5-{(1R)-4-CICLOHEXIL-1-[2-(HIDROXIAMINO)-2-OXOETIL]-BUTIL)-1,2,4-OXADIAZOL-3-IL)ISONICOTINICO, ENTRE OTROS. LOS COMPUESTOS SON INHIBIDORES DE PROCOLAGENO C PROTEINASA PCP Y PUEDEN SER UTILES PARA EL TRATAMIENTO DE DEFORMACIONES DE CICATRICES
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0108102.5A GB0108102D0 (en) | 2001-03-30 | 2001-03-30 | Compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20021045A1 true PE20021045A1 (es) | 2002-11-19 |
Family
ID=9911984
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2002000235A PE20021045A1 (es) | 2001-03-30 | 2002-03-25 | Inhibidores de pcp basados en acidos 3-heterociclilpropanohidroxamicos |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP1373264B1 (es) |
| JP (1) | JP2004524365A (es) |
| AP (1) | AP2002002466A0 (es) |
| AT (1) | ATE285409T1 (es) |
| BR (1) | BR0208499A (es) |
| CA (1) | CA2442481A1 (es) |
| DE (1) | DE60202358T2 (es) |
| ES (1) | ES2232740T3 (es) |
| GB (1) | GB0108102D0 (es) |
| GT (1) | GT200200062A (es) |
| MX (1) | MXPA03008944A (es) |
| PA (1) | PA8542201A1 (es) |
| PE (1) | PE20021045A1 (es) |
| TN (1) | TNSN02036A1 (es) |
| UY (1) | UY27236A1 (es) |
| WO (1) | WO2002079200A1 (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE047569T2 (hu) | 2003-04-11 | 2020-04-28 | Ptc Therapeutics Inc | 1,2,4-oxadiazol-benzoesav vegyület és nonszensz szupresszióra történõ alkalmazása |
| US20080194574A1 (en) * | 2003-12-16 | 2008-08-14 | Axxima Pharmaceuticals Ag | Pyrazine Derivatives As Effective Compounds Against Infectious Diseases |
| US7319108B2 (en) | 2004-01-25 | 2008-01-15 | Sanofi-Aventis Deutschland Gmbh | Aryl-substituted heterocycles, process for their preparation and their use as medicaments |
| DE102004003812A1 (de) * | 2004-01-25 | 2005-08-11 | Aventis Pharma Deutschland Gmbh | Arylsubstituierte Heterozyklen, Verfahren ihrer Herstellung und ihre Verwendung als Arzneimittel |
| AU2005252160A1 (en) | 2004-04-13 | 2005-12-22 | Astellas Pharma Inc. | Polycyclic pyrazines as potassium ion channel modulators |
| PL1879573T3 (pl) | 2005-05-10 | 2013-05-31 | Incyte Holdings Corp | Modulatory 2,3-dioksygenazy indoloaminy i sposoby ich zastosowania |
| ES2540561T3 (es) | 2005-12-20 | 2015-07-10 | Incyte Corporation | N-hidroxiamidinoheterociclos como moduladores de indolamina 2,3-dioxigenasa |
| US20080125470A1 (en) | 2006-09-19 | 2008-05-29 | Incyte Corporation | N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase |
| CL2007002650A1 (es) * | 2006-09-19 | 2008-02-08 | Incyte Corp | Compuestos derivados de heterociclo n-hidroxiamino; composicion farmaceutica, util para tratar cancer, infecciones virales y desordenes neurodegenerativos entre otras. |
| DE102007025718A1 (de) | 2007-06-01 | 2008-12-04 | Merck Patent Gmbh | Pyridazinonderivate |
| HRP20141094T1 (hr) | 2008-07-08 | 2015-01-16 | Incyte Corporation | 1,2,5-oksadiazoli kao inhibitori indolamin 2,3-dioksigenaze |
| AR075781A1 (es) | 2009-03-03 | 2011-04-27 | Merck Serono Sa | Derivados de oxadiazol piridina como agonistas del receptor s1p1/edg1 y un metodo para su preparacion. |
| JP6461953B2 (ja) | 2013-11-08 | 2019-01-30 | インサイト・ホールディングス・コーポレイションＩｎｃｙｔｅ Ｈｏｌｄｉｎｇｓ Ｃｏｒｐｏｒａｔｉｏｎ | インドールアミン２，３−ジオキシゲナーゼ阻害剤の合成のためのプロセス |
| EA031654B1 (ru) * | 2014-01-10 | 2019-02-28 | Глэксосмитклайн Интеллекчуал Проперти (No.2) Лимитед | Гидроксиформамидные производные и их применение |
| CN106455571A (zh) | 2014-03-06 | 2017-02-22 | Ptc医疗公司 | 1,2,4‑噁二唑苯甲酸的药物组合物和盐 |
| WO2017075312A1 (en) | 2015-10-30 | 2017-05-04 | Ptc Therapeutics, Inc. | Methods for treating epilepsy |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9725782D0 (en) * | 1997-12-05 | 1998-02-04 | Pfizer Ltd | Therapeutic agents |
| WO2000058278A1 (fr) * | 1999-03-26 | 2000-10-05 | Shionogi & Co., Ltd. | Derives d'acides amines $g(b) |
| GB9930570D0 (en) * | 1999-12-23 | 2000-02-16 | Pfizer Ltd | Therapy |
-
2001
- 2001-03-30 GB GBGB0108102.5A patent/GB0108102D0/en not_active Ceased
-
2002
- 2002-03-08 EP EP02713078A patent/EP1373264B1/en not_active Expired - Lifetime
- 2002-03-08 BR BR0208499-6A patent/BR0208499A/pt not_active IP Right Cessation
- 2002-03-08 ES ES02713078T patent/ES2232740T3/es not_active Expired - Lifetime
- 2002-03-08 MX MXPA03008944A patent/MXPA03008944A/es active IP Right Grant
- 2002-03-08 JP JP2002577825A patent/JP2004524365A/ja not_active Ceased
- 2002-03-08 DE DE60202358T patent/DE60202358T2/de not_active Expired - Fee Related
- 2002-03-08 WO PCT/IB2002/000699 patent/WO2002079200A1/en not_active Ceased
- 2002-03-08 CA CA002442481A patent/CA2442481A1/en not_active Abandoned
- 2002-03-08 AT AT02713078T patent/ATE285409T1/de not_active IP Right Cessation
- 2002-03-25 PE PE2002000235A patent/PE20021045A1/es not_active Application Discontinuation
- 2002-03-26 GT GT200200062A patent/GT200200062A/es unknown
- 2002-03-27 UY UY27236A patent/UY27236A1/es not_active Application Discontinuation
- 2002-03-27 PA PA20028542201A patent/PA8542201A1/es unknown
- 2002-03-28 AP APAP/P/2002/002466A patent/AP2002002466A0/en unknown
- 2002-03-29 TN TNTNSN02036A patent/TNSN02036A1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE60202358T2 (de) | 2005-12-08 |
| PA8542201A1 (es) | 2002-10-28 |
| EP1373264A1 (en) | 2004-01-02 |
| GB0108102D0 (en) | 2001-05-23 |
| JP2004524365A (ja) | 2004-08-12 |
| GT200200062A (es) | 2003-11-15 |
| ATE285409T1 (de) | 2005-01-15 |
| UY27236A1 (es) | 2002-11-29 |
| EP1373264B1 (en) | 2004-12-22 |
| ES2232740T3 (es) | 2005-06-01 |
| TNSN02036A1 (fr) | 2005-12-23 |
| CA2442481A1 (en) | 2002-10-10 |
| AP2002002466A0 (en) | 2002-06-30 |
| BR0208499A (pt) | 2004-04-20 |
| DE60202358D1 (en) | 2005-01-27 |
| WO2002079200A1 (en) | 2002-10-10 |
| MXPA03008944A (es) | 2003-12-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |