GT200200062A - Inhibidores de pcp basados en acidos 3-heterociclilpropanohidroxamicos - Google Patents
Inhibidores de pcp basados en acidos 3-heterociclilpropanohidroxamicosInfo
- Publication number
- GT200200062A GT200200062A GT200200062A GT200200062A GT200200062A GT 200200062 A GT200200062 A GT 200200062A GT 200200062 A GT200200062 A GT 200200062A GT 200200062 A GT200200062 A GT 200200062A GT 200200062 A GT200200062 A GT 200200062A
- Authority
- GT
- Guatemala
- Prior art keywords
- pcp
- heterociclilpropanohydroxamic
- acids
- inhibitors based
- compounds
- Prior art date
Links
- 239000002253 acid Substances 0.000 title 1
- 150000007513 acids Chemical class 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 102000008186 Collagen Human genes 0.000 abstract 1
- 108010035532 Collagen Proteins 0.000 abstract 1
- 102000035195 Peptidases Human genes 0.000 abstract 1
- 108091005804 Peptidases Proteins 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 229920001436 collagen Polymers 0.000 abstract 1
- 230000037319 collagen production Effects 0.000 abstract 1
- 230000008021 deposition Effects 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 235000019833 protease Nutrition 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
LA PRESENTE INVENCION SE REFIERE A COMPUESTOS QUE INHIBEN LA PROCOLAGENO C PROTEINASA (PCP) DEL TIPO DE ACIDOS 3HETEROCICLILPROPANOHIDROXAMICOS DE FORMULA GENERAL (I) EN DONDE X,Y,HET,R, SON GRUPOS FUNCIONALES DESCRITOS EN EL EXPEDIENTE. ESTOS COMPUESTOS POR SU CAPACIDAD DE INHIBICION DE LA PCP VAN A REGULAR, MODULAR Y/O DISMINUIR LA FORMACION Y DEPOSICION DE COLAGENO POR LO QUE SON UTILES PARA TRATAR DIVERSOS ESTADOS RELACIONADOS CON LA PRODUCCION DE COLAGENO.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0108102.5A GB0108102D0 (en) | 2001-03-30 | 2001-03-30 | Compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GT200200062A true GT200200062A (es) | 2003-11-15 |
Family
ID=9911984
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GT200200062A GT200200062A (es) | 2001-03-30 | 2002-03-26 | Inhibidores de pcp basados en acidos 3-heterociclilpropanohidroxamicos |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP1373264B1 (es) |
| JP (1) | JP2004524365A (es) |
| AP (1) | AP2002002466A0 (es) |
| AT (1) | ATE285409T1 (es) |
| BR (1) | BR0208499A (es) |
| CA (1) | CA2442481A1 (es) |
| DE (1) | DE60202358T2 (es) |
| ES (1) | ES2232740T3 (es) |
| GB (1) | GB0108102D0 (es) |
| GT (1) | GT200200062A (es) |
| MX (1) | MXPA03008944A (es) |
| PA (1) | PA8542201A1 (es) |
| PE (1) | PE20021045A1 (es) |
| TN (1) | TNSN02036A1 (es) |
| UY (1) | UY27236A1 (es) |
| WO (1) | WO2002079200A1 (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2770035T3 (es) | 2003-04-11 | 2020-06-30 | Ptc Therapeutics Inc | Compuesto de ácido 1,2,4-oxadiazol benzoico y su uso para la supresión sin sentido y el tratamiento de enfermedades |
| EP1694670A1 (en) * | 2003-12-16 | 2006-08-30 | GPC Biotech AG | Pyrazine derivatives as effective compounds against infectious diseases |
| US7319108B2 (en) | 2004-01-25 | 2008-01-15 | Sanofi-Aventis Deutschland Gmbh | Aryl-substituted heterocycles, process for their preparation and their use as medicaments |
| DE102004003812A1 (de) * | 2004-01-25 | 2005-08-11 | Aventis Pharma Deutschland Gmbh | Arylsubstituierte Heterozyklen, Verfahren ihrer Herstellung und ihre Verwendung als Arzneimittel |
| AU2005252160A1 (en) | 2004-04-13 | 2005-12-22 | Astellas Pharma Inc. | Polycyclic pyrazines as potassium ion channel modulators |
| BR122020016659B8 (pt) | 2005-05-10 | 2021-07-27 | Incyte Holdings Corp | moduladores de 2,3-dioxigenase de indolamina e métodos de modulação de atividade de inibição e de imunossupressão |
| TWI382974B (zh) | 2005-12-20 | 2013-01-21 | 英塞特公司 | 作為吲哚胺２，３-二氧化酶調節劑之ｎ-羥基甲脒基雜環化物 |
| CA2663057C (en) | 2006-09-19 | 2015-12-08 | Incyte Corporation | N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase |
| CL2007002650A1 (es) | 2006-09-19 | 2008-02-08 | Incyte Corp | Compuestos derivados de heterociclo n-hidroxiamino; composicion farmaceutica, util para tratar cancer, infecciones virales y desordenes neurodegenerativos entre otras. |
| DE102007025718A1 (de) | 2007-06-01 | 2008-12-04 | Merck Patent Gmbh | Pyridazinonderivate |
| BR122019015876B8 (pt) | 2008-07-08 | 2021-07-27 | Incyte Holdings Corp | compostos derivados de 1,2,5-oxadiazóis, composição, bem como seus usos |
| CA2752804C (en) | 2009-03-03 | 2017-04-04 | Anna Quattropani | Oxazole pyridine derivatives useful as s1p1 receptor agonists |
| DK3066085T3 (da) | 2013-11-08 | 2020-06-02 | Incyte Holdings Corp | Fremgangsmåde til syntesen af en indolamin-2,3-dioxygenaseinhibitor |
| CN106103431B (zh) * | 2014-01-10 | 2019-03-15 | 葛兰素史密斯克莱知识产权（第2 号）有限公司 | 羟基甲酰胺衍生物及其用途 |
| CA2942147C (en) | 2014-03-06 | 2022-12-13 | Ptc Therapeutics, Inc. | Pharmaceutical compositions and salts of a 1,2,4-oxadiazole benzoic acid |
| CN108348527A (zh) | 2015-10-30 | 2018-07-31 | Ptc医疗公司 | 用于治疗癫痫的方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9725782D0 (en) * | 1997-12-05 | 1998-02-04 | Pfizer Ltd | Therapeutic agents |
| WO2000058278A1 (fr) * | 1999-03-26 | 2000-10-05 | Shionogi & Co., Ltd. | Derives d'acides amines $g(b) |
| GB9930570D0 (en) * | 1999-12-23 | 2000-02-16 | Pfizer Ltd | Therapy |
-
2001
- 2001-03-30 GB GBGB0108102.5A patent/GB0108102D0/en not_active Ceased
-
2002
- 2002-03-08 MX MXPA03008944A patent/MXPA03008944A/es active IP Right Grant
- 2002-03-08 ES ES02713078T patent/ES2232740T3/es not_active Expired - Lifetime
- 2002-03-08 CA CA002442481A patent/CA2442481A1/en not_active Abandoned
- 2002-03-08 AT AT02713078T patent/ATE285409T1/de not_active IP Right Cessation
- 2002-03-08 EP EP02713078A patent/EP1373264B1/en not_active Expired - Lifetime
- 2002-03-08 BR BR0208499-6A patent/BR0208499A/pt not_active IP Right Cessation
- 2002-03-08 WO PCT/IB2002/000699 patent/WO2002079200A1/en not_active Ceased
- 2002-03-08 DE DE60202358T patent/DE60202358T2/de not_active Expired - Fee Related
- 2002-03-08 JP JP2002577825A patent/JP2004524365A/ja not_active Ceased
- 2002-03-25 PE PE2002000235A patent/PE20021045A1/es not_active Application Discontinuation
- 2002-03-26 GT GT200200062A patent/GT200200062A/es unknown
- 2002-03-27 UY UY27236A patent/UY27236A1/es not_active Application Discontinuation
- 2002-03-27 PA PA20028542201A patent/PA8542201A1/es unknown
- 2002-03-28 AP APAP/P/2002/002466A patent/AP2002002466A0/en unknown
- 2002-03-29 TN TNTNSN02036A patent/TNSN02036A1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PA8542201A1 (es) | 2002-10-28 |
| PE20021045A1 (es) | 2002-11-19 |
| MXPA03008944A (es) | 2003-12-08 |
| ES2232740T3 (es) | 2005-06-01 |
| GB0108102D0 (en) | 2001-05-23 |
| ATE285409T1 (de) | 2005-01-15 |
| WO2002079200A1 (en) | 2002-10-10 |
| CA2442481A1 (en) | 2002-10-10 |
| EP1373264B1 (en) | 2004-12-22 |
| EP1373264A1 (en) | 2004-01-02 |
| BR0208499A (pt) | 2004-04-20 |
| JP2004524365A (ja) | 2004-08-12 |
| TNSN02036A1 (fr) | 2005-12-23 |
| AP2002002466A0 (en) | 2002-06-30 |
| UY27236A1 (es) | 2002-11-29 |
| DE60202358D1 (en) | 2005-01-27 |
| DE60202358T2 (de) | 2005-12-08 |
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