PE20020210A1 - Indoloquinazolinonas como inhibidores de poli(adp-ribosa)polimerasa (parp) - Google Patents
Indoloquinazolinonas como inhibidores de poli(adp-ribosa)polimerasa (parp)Info
- Publication number
- PE20020210A1 PE20020210A1 PE2001000700A PE2001000700A PE20020210A1 PE 20020210 A1 PE20020210 A1 PE 20020210A1 PE 2001000700 A PE2001000700 A PE 2001000700A PE 2001000700 A PE2001000700 A PE 2001000700A PE 20020210 A1 PE20020210 A1 PE 20020210A1
- Authority
- PE
- Peru
- Prior art keywords
- indoloquinazolinones
- alkyl
- polymerase
- refers
- poly
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000012458 free base Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- SLRMQYXOBQWXCR-UHFFFAOYSA-N 2154-56-5 Chemical class [CH2]C1=CC=CC=C1 SLRMQYXOBQWXCR-UHFFFAOYSA-N 0.000 abstract 1
- PWJFNRJRHXWEPT-UHFFFAOYSA-N ADP ribose Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(=O)OP(O)(=O)OCC(O)C(O)C(O)C=O)C(O)C1O PWJFNRJRHXWEPT-UHFFFAOYSA-N 0.000 abstract 1
- SRNWOUGRCWSEMX-ZQSHOCFMSA-N ADP-alpha-D-ribose Chemical compound O([P@](O)(=O)O[P@](O)(=O)OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)N1C=2N=CN=C(C=2N=C1)N)C[C@H]1O[C@H](O)[C@H](O)[C@@H]1O SRNWOUGRCWSEMX-ZQSHOCFMSA-N 0.000 abstract 1
- -1 CARBOXYL Chemical class 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- 230000006907 apoptotic process Effects 0.000 abstract 1
- 230000005779 cell damage Effects 0.000 abstract 1
- 208000037887 cell injury Diseases 0.000 abstract 1
- 230000017074 necrotic cell death Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
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-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychology (AREA)
- Toxicology (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Virology (AREA)
- Psychiatry (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Tropical Medicine & Parasitology (AREA)
- Oncology (AREA)
- AIDS & HIV (AREA)
- Endocrinology (AREA)
- Molecular Biology (AREA)
- Emergency Medicine (AREA)
- Communicable Diseases (AREA)
Abstract
SE REFIERE A INDOLOQUINAZOLINONAS DE FORMULA I DONDE R ES -(CH2)n-X DONDE n ES 1-3; X ES ALQUILO C1-C4, ALCOXILO C1-C4, ALQUENILO C2-C7, ALQUINILO C2-C7, CARBOXILO, ALCOXICARBONILO, CH2CON(R1)R2, DONDE R1 Y R2 SON H, OH, ALQUILO C1-C4, BENCILO, DIALQUILAMINO C1-C4, ENTRE OTROS. EL COMPUESTO PREFERIDO ES 7-(1H-TETRAZOL-5-ILMETIL)-6H-INDOLO[1,2-ALQUINAZOLIN-5-ONA] EN FORMA DE BASE LIBRE O SAL. SE REFIERE TAMBIEN A UN PROCESO PARA LA PREPARACION QUE COMPRENDE HACER REACCIONAR EL COMPUESTO DE FORMULA II CON METOXIDO DE SODIO Y RECUPERAR EL COMPUESTO RESULTANTE EN FORMA DE BASE LIBRE O SAL. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. LAS INDOLOQUINAZOLINONAS INHIBEN LA ENZIMA NUCLEICA POLI(ADENOSINA-5'-DIFOSFO-RIBOSA)POLIMERASA Y SON UTILES PARA PREVENIR O TRATAR EL DANO CELULAR NECROSIS APOPTOSIS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0017508.3A GB0017508D0 (en) | 2000-07-17 | 2000-07-17 | Antimicrobials |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20020210A1 true PE20020210A1 (es) | 2002-04-04 |
Family
ID=9895801
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2001000700A PE20020210A1 (es) | 2000-07-17 | 2001-07-12 | Indoloquinazolinonas como inhibidores de poli(adp-ribosa)polimerasa (parp) |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6964960B2 (es) |
| EP (1) | EP1303517B1 (es) |
| JP (1) | JP3939246B2 (es) |
| CN (1) | CN1183136C (es) |
| AR (1) | AR031379A1 (es) |
| AT (1) | ATE262530T1 (es) |
| AU (1) | AU2001279754A1 (es) |
| BR (1) | BR0112521A (es) |
| CA (1) | CA2415683C (es) |
| DE (1) | DE60102473T2 (es) |
| DK (1) | DK1303517T3 (es) |
| ES (1) | ES2218439T3 (es) |
| GB (1) | GB0017508D0 (es) |
| MY (1) | MY133969A (es) |
| PE (1) | PE20020210A1 (es) |
| PT (1) | PT1303517E (es) |
| TR (1) | TR200401026T4 (es) |
| WO (1) | WO2002006284A1 (es) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6956035B2 (en) | 2001-08-31 | 2005-10-18 | Inotek Pharmaceuticals Corporation | Isoquinoline derivatives and methods of use thereof |
| JP2007501857A (ja) | 2003-02-28 | 2007-02-01 | イノテック ファーマシューティカルズ コーポレーション | 四環系ベンズアミド誘導体およびその使用方法 |
| MX2007010333A (es) | 2005-02-25 | 2007-11-06 | Inotek Pharmaceuticals Corp | Compuestos amino y carboxamido tetrac??clicos y m??todos para utilizar los mismos. |
| EP1937268A4 (en) | 2005-08-24 | 2009-07-22 | Inotek Pharmaceuticals Corp | INDENOISOCHINOLINONE ANALOGUES AND METHOD OF USE THEREOF |
| EP2069351B1 (en) * | 2006-06-20 | 2015-10-28 | AbbVie Inc. | Pyrazoloquinazolinones as parp inhibitors |
| GB0615809D0 (en) * | 2006-08-09 | 2006-09-20 | Istituto Di Ricerche D Biolog | Therapeutic compounds |
| GB0701273D0 (en) * | 2007-01-24 | 2007-02-28 | Angeletti P Ist Richerche Bio | New compounds |
| US20100121049A1 (en) | 2007-02-28 | 2010-05-13 | Inotek Pharmaceuticals Corporation | Indenoisoquinolinone analogs and methods of use thereof |
| MX2009012054A (es) | 2007-05-08 | 2009-11-19 | Schering Corp | Metodos de tratamiento que usan formulaciones intravenosas que comprenden temozolomida. |
| JP5927071B2 (ja) * | 2011-07-13 | 2016-05-25 | 参天製薬株式会社 | Ｐａｒｐ阻害活性を有する新規化合物 |
| CN102766144B (zh) * | 2012-07-10 | 2014-04-23 | 浙江大学 | 一种吲哚并[1,2-c]喹唑啉化合物的制备方法 |
| AU2016296905B2 (en) | 2015-07-23 | 2018-07-05 | Centre National De La Recherche Scientifique | Use of a combination of Dbait molecule and parp inhibitors to treat cancer |
| GB201519573D0 (en) | 2015-11-05 | 2015-12-23 | King S College London | Combination |
| WO2018162439A1 (en) | 2017-03-08 | 2018-09-13 | Onxeo | New predictive biomarker for the sensitivity to a treatment of cancer with a dbait molecule |
| US20200407720A1 (en) | 2018-03-13 | 2020-12-31 | Onxeo | A dbait molecule against acquired resistance in the treatment of cancer |
| US20220073531A1 (en) * | 2018-11-30 | 2022-03-10 | Merck Patent Gmbh | Compounds for electronic devices |
| WO2020182779A1 (de) * | 2019-03-12 | 2020-09-17 | Merck Patent Gmbh | Materialien für organische elektrolumineszenzvorrichtungen |
| CN110357892B (zh) * | 2019-07-10 | 2022-06-07 | 云南大学 | 四氢嘧啶并[1,2-a]吲哚衍生物及其合成方法与应用 |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| CN114195789B (zh) * | 2021-12-15 | 2022-09-09 | 广东海洋大学 | 一种无金属参与的多环吲哚衍生物的制备方法 |
| WO2024261243A1 (en) | 2023-06-21 | 2024-12-26 | Hemispherian As | Combination comprising a deoxycytidine derivative and a parp inhibitor for use in a method of treating hr proficient cancer |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3635966A (en) | 1969-10-22 | 1972-01-18 | Robins Co Inc A H | 6-substituted-indolo(1 2-c)quinazolines |
| DE2237372C3 (de) | 1972-07-29 | 1981-07-09 | Basf Ag, 6700 Ludwigshafen | Heterocyclische Farbstoffe, ihre Herstellung und ihre Verwendung |
| US5441955A (en) | 1993-11-19 | 1995-08-15 | Pathogenesis Corporation | Indolo[2,1-biquinazoline-6,12-dione antibacterial compounds and methods of use thereof |
| GB9404485D0 (en) * | 1994-03-09 | 1994-04-20 | Cancer Res Campaign Tech | Benzamide analogues |
-
2000
- 2000-07-17 GB GBGB0017508.3A patent/GB0017508D0/en not_active Ceased
-
2001
- 2001-07-12 PE PE2001000700A patent/PE20020210A1/es not_active Application Discontinuation
- 2001-07-13 AR ARP010103339A patent/AR031379A1/es not_active Application Discontinuation
- 2001-07-13 MY MYPI20013343 patent/MY133969A/en unknown
- 2001-07-16 AT AT01957972T patent/ATE262530T1/de not_active IP Right Cessation
- 2001-07-16 EP EP01957972A patent/EP1303517B1/en not_active Expired - Lifetime
- 2001-07-16 CN CNB018126995A patent/CN1183136C/zh not_active Expired - Fee Related
- 2001-07-16 PT PT01957972T patent/PT1303517E/pt unknown
- 2001-07-16 ES ES01957972T patent/ES2218439T3/es not_active Expired - Lifetime
- 2001-07-16 US US10/333,186 patent/US6964960B2/en not_active Expired - Fee Related
- 2001-07-16 BR BR0112521-4A patent/BR0112521A/pt not_active Application Discontinuation
- 2001-07-16 TR TR2004/01026T patent/TR200401026T4/xx unknown
- 2001-07-16 JP JP2002512186A patent/JP3939246B2/ja not_active Expired - Fee Related
- 2001-07-16 WO PCT/EP2001/008192 patent/WO2002006284A1/en not_active Ceased
- 2001-07-16 DK DK01957972T patent/DK1303517T3/da active
- 2001-07-16 DE DE60102473T patent/DE60102473T2/de not_active Expired - Lifetime
- 2001-07-16 AU AU2001279754A patent/AU2001279754A1/en not_active Abandoned
- 2001-07-16 CA CA002415683A patent/CA2415683C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ES2218439T3 (es) | 2004-11-16 |
| CA2415683C (en) | 2009-12-29 |
| JP2004504323A (ja) | 2004-02-12 |
| WO2002006284A1 (en) | 2002-01-24 |
| DK1303517T3 (da) | 2004-06-21 |
| ATE262530T1 (de) | 2004-04-15 |
| TR200401026T4 (tr) | 2004-07-21 |
| HK1056872A1 (en) | 2004-03-05 |
| DE60102473T2 (de) | 2005-02-03 |
| DE60102473D1 (de) | 2004-04-29 |
| EP1303517A1 (en) | 2003-04-23 |
| CA2415683A1 (en) | 2002-01-24 |
| US20030199502A1 (en) | 2003-10-23 |
| CN1441803A (zh) | 2003-09-10 |
| AR031379A1 (es) | 2003-09-24 |
| MY133969A (en) | 2007-11-30 |
| BR0112521A (pt) | 2003-07-01 |
| GB0017508D0 (en) | 2000-08-30 |
| JP3939246B2 (ja) | 2007-07-04 |
| HK1055426A1 (en) | 2004-01-09 |
| US6964960B2 (en) | 2005-11-15 |
| EP1303517B1 (en) | 2004-03-24 |
| AU2001279754A1 (en) | 2002-01-30 |
| PT1303517E (pt) | 2004-07-30 |
| CN1183136C (zh) | 2005-01-05 |
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