AU2001279754A1 - Indoloquinazolinones - Google Patents

Indoloquinazolinones

Info

Publication number: AU2001279754A1
Authority: AU; Australia
Prior art keywords: indoloquinazolinones
Prior art date: 2000-07-17
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

AU2001279754A

Inventor

Robert Portmann

Dean Franklin Rigel

Kaspar Zimmermann

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Novartis AG

Original Assignee

Novartis AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-07-17

Filing date

2001-07-16

Publication date

2002-01-30

2001-07-16 Application filed by Novartis AG filed Critical Novartis AG

2002-01-30 Publication of AU2001279754A1 publication Critical patent/AU2001279754A1/en

Status Abandoned legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Immunology (AREA)
Diabetes (AREA)
Rheumatology (AREA)
Hospice & Palliative Care (AREA)
Urology & Nephrology (AREA)
Toxicology (AREA)
Hematology (AREA)
Psychiatry (AREA)
Psychology (AREA)
Virology (AREA)
Pain & Pain Management (AREA)
Vascular Medicine (AREA)
Dermatology (AREA)
Molecular Biology (AREA)
Ophthalmology & Optometry (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Endocrinology (AREA)

AU2001279754A 2000-07-17 2001-07-16 Indoloquinazolinones Abandoned AU2001279754A1 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GBGB0017508.3A GB0017508D0 (en)	2000-07-17	2000-07-17	Antimicrobials
GB0017508		2000-07-17
PCT/EP2001/008192 WO2002006284A1 (en)	2000-07-17	2001-07-16	Indoloquinazolinones

Publications (1)

Publication Number	Publication Date
AU2001279754A1 true AU2001279754A1 (en)	2002-01-30

Family

ID=9895801

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AU2001279754A Abandoned AU2001279754A1 (en)	2000-07-17	2001-07-16	Indoloquinazolinones

Country Status (18)

Country	Link
US (1)	US6964960B2 (en)
EP (1)	EP1303517B1 (en)
JP (1)	JP3939246B2 (en)
CN (1)	CN1183136C (en)
AR (1)	AR031379A1 (en)
AT (1)	ATE262530T1 (en)
AU (1)	AU2001279754A1 (en)
BR (1)	BR0112521A (en)
CA (1)	CA2415683C (en)
DE (1)	DE60102473T2 (en)
DK (1)	DK1303517T3 (en)
ES (1)	ES2218439T3 (en)
GB (1)	GB0017508D0 (en)
MY (1)	MY133969A (en)
PE (1)	PE20020210A1 (en)
PT (1)	PT1303517E (en)
TR (1)	TR200401026T4 (en)
WO (1)	WO2002006284A1 (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6956035B2 (en)	2001-08-31	2005-10-18	Inotek Pharmaceuticals Corporation	Isoquinoline derivatives and methods of use thereof
AU2004258801A1 (en)	2003-02-28	2005-02-03	Inotek Pharmaceuticals Corporation	Tetracyclic Benzamide Derivatives and methods of use thereof
KR20070116011A (en)	2005-02-25	2007-12-06	이노텍 파마슈티컬스 코포레이션	Tetracyclic Amino and Carboxamido Compounds and Methods of Use thereof
WO2007025009A2 (en)	2005-08-24	2007-03-01	Inotek Pharmaceuticals Corporation	Indenoisoquinolinone analogs and methods of use thereof
MX2008016339A (en) *	2006-06-20	2009-01-16	Abbott Lab	Pyrazoloquinazolinones as parp inhibitors.
GB0615809D0 (en) *	2006-08-09	2006-09-20	Istituto Di Ricerche D Biolog	Therapeutic compounds
GB0701273D0 (en) *	2007-01-24	2007-02-28	Angeletti P Ist Richerche Bio	New compounds
WO2008106619A2 (en)	2007-02-28	2008-09-04	Inotek Pharmaceuticals Corporation	Indenoisoquinolinone analogs and methods of use thereof
WO2008140724A1 (en)	2007-05-08	2008-11-20	Schering Corporation	Methods of treatment using intravenous formulations comprising temozolomide
CN103703002B (en) *	2011-07-13	2016-05-11	参天制药株式会社	There is PARP and suppress active new compound
CN102766144B (en) *	2012-07-10	2014-04-23	浙江大学	Preparation method of indolo[1,2-]quinazoline compound
EP3594343B1 (en)	2015-07-23	2021-04-21	Institut Curie	Use of a combination of dbait molecule and parp inhibitors to treat cancer
GB201519573D0 (en)	2015-11-05	2015-12-23	King S College London	Combination
WO2018162439A1 (en)	2017-03-08	2018-09-13	Onxeo	New predictive biomarker for the sensitivity to a treatment of cancer with a dbait molecule
JP7534218B2 (en)	2018-03-13	2024-08-14	ヴァレリオ・セラピューティクス	DBAIT molecules combating acquired resistance in cancer treatment
WO2020109524A1 (en) *	2018-11-30	2020-06-04	Merck Patent Gmbh	Compounds for electronic devices
WO2020182779A1 (en) *	2019-03-12	2020-09-17	Merck Patent Gmbh	Materials for organic electroluminescent devices
CN110357892B (en) *	2019-07-10	2022-06-07	云南大学	Tetrahydropyrimidino [1,2-a ] indole derivative and synthesis method and application thereof
WO2021148581A1 (en)	2020-01-22	2021-07-29	Onxeo	Novel dbait molecule and its use
CN114195789B (en) *	2021-12-15	2022-09-09	广东海洋大学	Preparation method of polycyclic indole derivative without participation of metal
CN121398822A (en)	2023-06-21	2026-01-23	四方生物科学有限公司	Combinations comprising deoxycytidine derivatives and PARP inhibitors for use in methods of treating cancers with normal heart rate function.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3635966A (en)	1969-10-22	1972-01-18	Robins Co Inc A H	6-substituted-indolo(1 2-c)quinazolines
DE2237372C3 (en)	1972-07-29	1981-07-09	Basf Ag, 6700 Ludwigshafen	Heterocyclic dyes, their preparation and their use
US5441955A (en)	1993-11-19	1995-08-15	Pathogenesis Corporation	Indolo[2,1-biquinazoline-6,12-dione antibacterial compounds and methods of use thereof
GB9404485D0 (en) *	1994-03-09	1994-04-20	Cancer Res Campaign Tech	Benzamide analogues

2000
- 2000-07-17 GB GBGB0017508.3A patent/GB0017508D0/en not_active Ceased
2001
- 2001-07-12 PE PE2001000700A patent/PE20020210A1/en not_active Application Discontinuation
- 2001-07-13 AR ARP010103339A patent/AR031379A1/en not_active Application Discontinuation
- 2001-07-13 MY MYPI20013343 patent/MY133969A/en unknown
- 2001-07-16 US US10/333,186 patent/US6964960B2/en not_active Expired - Fee Related
- 2001-07-16 PT PT01957972T patent/PT1303517E/en unknown
- 2001-07-16 CA CA002415683A patent/CA2415683C/en not_active Expired - Fee Related
- 2001-07-16 TR TR2004/01026T patent/TR200401026T4/en unknown
- 2001-07-16 AU AU2001279754A patent/AU2001279754A1/en not_active Abandoned
- 2001-07-16 BR BR0112521-4A patent/BR0112521A/en not_active Application Discontinuation
- 2001-07-16 WO PCT/EP2001/008192 patent/WO2002006284A1/en not_active Ceased
- 2001-07-16 JP JP2002512186A patent/JP3939246B2/en not_active Expired - Fee Related
- 2001-07-16 EP EP01957972A patent/EP1303517B1/en not_active Expired - Lifetime
- 2001-07-16 CN CNB018126995A patent/CN1183136C/en not_active Expired - Fee Related
- 2001-07-16 DE DE60102473T patent/DE60102473T2/en not_active Expired - Lifetime
- 2001-07-16 AT AT01957972T patent/ATE262530T1/en not_active IP Right Cessation
- 2001-07-16 ES ES01957972T patent/ES2218439T3/en not_active Expired - Lifetime
- 2001-07-16 DK DK01957972T patent/DK1303517T3/en active

Also Published As

Publication number	Publication date
DE60102473D1 (en)	2004-04-29
CA2415683A1 (en)	2002-01-24
CN1441803A (en)	2003-09-10
ES2218439T3 (en)	2004-11-16
JP2004504323A (en)	2004-02-12
BR0112521A (en)	2003-07-01
DE60102473T2 (en)	2005-02-03
PT1303517E (en)	2004-07-30
US6964960B2 (en)	2005-11-15
ATE262530T1 (en)	2004-04-15
JP3939246B2 (en)	2007-07-04
GB0017508D0 (en)	2000-08-30
WO2002006284A1 (en)	2002-01-24
TR200401026T4 (en)	2004-07-21
MY133969A (en)	2007-11-30
EP1303517A1 (en)	2003-04-23
HK1055426A1 (en)	2004-01-09
CA2415683C (en)	2009-12-29
PE20020210A1 (en)	2002-04-04
AR031379A1 (en)	2003-09-24
HK1056872A1 (en)	2004-03-05
DK1303517T3 (en)	2004-06-21
US20030199502A1 (en)	2003-10-23
CN1183136C (en)	2005-01-05
EP1303517B1 (en)	2004-03-24

Publication	Publication Date	Title
AU6419701A (en)	2001-12-11	Electropancreatography
AU2001262847A1 (en)	2001-12-11	Language-understanding
AU2001292739A1 (en)	2002-04-08	1-oxorapamycins
AU2002211620A1 (en)	2002-04-22	Autoanastomosis
AU2001254546A1 (en)	2001-11-07	Aminopiperidines
AU2000267458A1 (en)	2001-10-15	Hypercomputer
AU2001220246A1 (en)	2001-12-11	Neckphone
AU2001239310A1 (en)	2001-10-03	Decahydro-isoquinolines
AU2001296577A1 (en)	2002-04-15	Chlorophyllases
AU2001258349A1 (en)	2001-11-26	Bisacylguanidine
AU2001279754A1 (en)	2002-01-30	Indoloquinazolinones
AU2002211128A1 (en)	2002-04-22	Step-bike
AU2001290931A1 (en)	2002-03-26	Ski-snowboard
AU2001285886A1 (en)	2002-03-22	2-guanidino-4-aryl-quinazoline
AU2001258924A1 (en)	2001-11-26	Microsatellite-aflp
AU2001293852A1 (en)	2002-06-27	Sulfonylguanidine
AU2002226346A1 (en)	2002-06-03	2-aryl-5-trifluoromethylpyridines
AU2001281921A1 (en)	2002-01-08	Bdellosomes
AU2001291876A1 (en)	2002-06-20	Triazolo-epothilones
AU2001246864A1 (en)	2002-01-10	Hypotensors
AU2002214354A1 (en)	2002-05-15	Neck-phone
AU2001226668A1 (en)	2001-09-12	Crankshaft-starter-generator
AU2001262711A1 (en)	2001-12-17	Cytoprotectors
AU2001284173A1 (en)	2002-03-04	Calycins
AU2001260192A1 (en)	2001-12-11	Glycinamides