CO5200762A1 - Preparacion de piperidin-4-onas sustituidas - Google Patents
Preparacion de piperidin-4-onas sustituidasInfo
- Publication number
- CO5200762A1 CO5200762A1 CO00048059A CO00048059A CO5200762A1 CO 5200762 A1 CO5200762 A1 CO 5200762A1 CO 00048059 A CO00048059 A CO 00048059A CO 00048059 A CO00048059 A CO 00048059A CO 5200762 A1 CO5200762 A1 CO 5200762A1
- Authority
- CO
- Colombia
- Prior art keywords
- phenyl
- alkyl
- jpeg
- compound
- formula
- Prior art date
Links
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 7
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 abstract 3
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- -1 halo (C1-C6) alkyl Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/02—Preparation by ring-closure or hydrogenation
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Un procedimiento para la preparación de un compuesto de fórmula I:<EMI FILE="00048059_1" ID="1" IMF=JPEG >en la que R es hidrógeno, alquilo C1-C6, haloalquilo(C1-C6), fenilo, bencilo, o fenilo sustituido con 1 a 3 sustituyentes seleccionados entre el grupo constituido por F, CI, Br, I, alquilo C1-C6, alcoxi C1-C6, haloalquilo C1-C6, fenilo, NO2, y CN; R1, R2, R3, R4, R5 y R6 son cada uno independientemente hidrógeno, alquilo C1-C6, haloalquilo C1-C6, fenilo, o fenilo sustituido con 1 a 3 sustituyentes seleccionados entre el grupo constituido por F, CI, Br, I, alquilo C1-C6, alcoxi C1-C6, -S(alquilo C1-C6), -S(fenilo), haloalquilo C1-C6, fenilo, NO2, y CN;o las sales farmacéuticamente aceptables de los mismos;que comprende combinar un compuesto de fórmula II:<EMI FILE="00048059_2" ID="2" IMF=JPEG >en la que R1, R2, R3 y R4 se definen como anteriormente, un compuesto de fórmula III:<EMI FILE="00048059_3" ID="3" IMF=JPEG >en la que R5 se define como anteriormente, y un compuesto de fórmula IV:<EMI FILE="00048059_4" ID="4" IMF=JPEG >en la que R se define como anteriormente, en presencia de un ácido adecuado; seguido de adición de una base adecuada y un compuesto de fórmula V:<EMI FILE="00048059_5" ID="5" IMF=JPEG >en la que R6 se define como anteriormente.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14147899P | 1999-06-29 | 1999-06-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5200762A1 true CO5200762A1 (es) | 2002-09-27 |
Family
ID=22495854
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO00048059A CO5200762A1 (es) | 1999-06-29 | 2000-06-27 | Preparacion de piperidin-4-onas sustituidas |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US6538136B1 (es) |
| EP (1) | EP1196382A2 (es) |
| JP (1) | JP2003522122A (es) |
| KR (1) | KR20020015068A (es) |
| CN (1) | CN1356982A (es) |
| AU (1) | AU770759B2 (es) |
| BR (1) | BR0011996A (es) |
| CA (1) | CA2370491A1 (es) |
| CO (1) | CO5200762A1 (es) |
| CZ (1) | CZ20014548A3 (es) |
| EA (1) | EA200200101A1 (es) |
| EG (1) | EG22530A (es) |
| HK (1) | HK1045309A1 (es) |
| HU (1) | HUP0201642A3 (es) |
| IL (1) | IL146339A0 (es) |
| MX (1) | MXPA01012727A (es) |
| NO (1) | NO20016151D0 (es) |
| PE (1) | PE20010300A1 (es) |
| PL (1) | PL364868A1 (es) |
| SK (1) | SK19012001A3 (es) |
| SV (1) | SV2002000111A (es) |
| WO (1) | WO2001000577A2 (es) |
| ZA (1) | ZA200109206B (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7608630B2 (en) | 2004-01-30 | 2009-10-27 | Hainan Yangpu New Special Pharmaceutical Co., Ltd. | Marasmius androsaceus L.es Fr extract, piperidone derivative, and their use for the preparation of hypertensives |
| US7821428B2 (en) | 2004-06-03 | 2010-10-26 | Silicon Laboratories Inc. | MCU with integrated voltage isolator and integrated galvanically isolated asynchronous serial data link |
| US7460604B2 (en) | 2004-06-03 | 2008-12-02 | Silicon Laboratories Inc. | RF isolator for isolating voltage sensing and gate drivers |
| US7738568B2 (en) | 2004-06-03 | 2010-06-15 | Silicon Laboratories Inc. | Multiplexed RF isolator |
| US8198951B2 (en) | 2004-06-03 | 2012-06-12 | Silicon Laboratories Inc. | Capacitive isolation circuitry |
| US7447492B2 (en) | 2004-06-03 | 2008-11-04 | Silicon Laboratories Inc. | On chip transformer isolator |
| US7902627B2 (en) | 2004-06-03 | 2011-03-08 | Silicon Laboratories Inc. | Capacitive isolation circuitry with improved common mode detector |
| US8049573B2 (en) | 2004-06-03 | 2011-11-01 | Silicon Laboratories Inc. | Bidirectional multiplexed RF isolator |
| US8441325B2 (en) | 2004-06-03 | 2013-05-14 | Silicon Laboratories Inc. | Isolator with complementary configurable memory |
| US7302247B2 (en) * | 2004-06-03 | 2007-11-27 | Silicon Laboratories Inc. | Spread spectrum isolator |
| US7577223B2 (en) | 2004-06-03 | 2009-08-18 | Silicon Laboratories Inc. | Multiplexed RF isolator circuit |
| US8451032B2 (en) | 2010-12-22 | 2013-05-28 | Silicon Laboratories Inc. | Capacitive isolator with schmitt trigger |
| EP3293888B1 (en) | 2016-09-13 | 2020-08-26 | Allegro MicroSystems, LLC | Signal isolator having bidirectional communication between die |
| US11115244B2 (en) | 2019-09-17 | 2021-09-07 | Allegro Microsystems, Llc | Signal isolator with three state data transmission |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2883387A (en) * | 1959-04-21 | Chjch | ||
| DE510184C (de) | 1927-06-03 | 1930-10-16 | Carl Mannich Dr | Verfahren zur Darstellung von 2, 6-Dimethyl-4-ketopiperidin-3, 5-dicarbonsaeureestern |
| FR2717803B1 (fr) | 1994-03-25 | 1996-06-21 | Meram Lab | Dérivés substitués d'hétérocycles azotés et leurs isomères, actifs sur le système nerveux central, procédé d'obtention et compositions pharmaceutiques les contenant. |
| ES2181366T3 (es) * | 1998-06-30 | 2003-02-16 | Lilly Co Eli | Derivados de piperidina que tienen efectos sobre sistemas relacionados con serotonina. |
-
2000
- 2000-06-13 AU AU54535/00A patent/AU770759B2/en not_active Ceased
- 2000-06-13 HU HU0201642A patent/HUP0201642A3/hu unknown
- 2000-06-13 PL PL00364868A patent/PL364868A1/xx not_active Application Discontinuation
- 2000-06-13 IL IL14633900A patent/IL146339A0/xx unknown
- 2000-06-13 EA EA200200101A patent/EA200200101A1/ru unknown
- 2000-06-13 JP JP2001506987A patent/JP2003522122A/ja not_active Withdrawn
- 2000-06-13 EP EP00939451A patent/EP1196382A2/en not_active Withdrawn
- 2000-06-13 KR KR1020017016848A patent/KR20020015068A/ko not_active Withdrawn
- 2000-06-13 SK SK1901-2001A patent/SK19012001A3/sk unknown
- 2000-06-13 MX MXPA01012727A patent/MXPA01012727A/es not_active Application Discontinuation
- 2000-06-13 CZ CZ20014548A patent/CZ20014548A3/cs unknown
- 2000-06-13 WO PCT/US2000/015029 patent/WO2001000577A2/en not_active Ceased
- 2000-06-13 BR BR0011996-2A patent/BR0011996A/pt not_active IP Right Cessation
- 2000-06-13 CN CN00809338A patent/CN1356982A/zh active Pending
- 2000-06-13 CA CA002370491A patent/CA2370491A1/en not_active Abandoned
- 2000-06-13 HK HK02106801.4A patent/HK1045309A1/zh unknown
- 2000-06-13 US US10/018,036 patent/US6538136B1/en not_active Expired - Fee Related
- 2000-06-26 EG EG20000822A patent/EG22530A/xx active
- 2000-06-27 PE PE2000000647A patent/PE20010300A1/es not_active Application Discontinuation
- 2000-06-27 CO CO00048059A patent/CO5200762A1/es unknown
- 2000-06-28 SV SV2000000111A patent/SV2002000111A/es unknown
-
2001
- 2001-11-07 ZA ZA200109206A patent/ZA200109206B/xx unknown
- 2001-12-17 NO NO20016151A patent/NO20016151D0/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| HK1045309A1 (zh) | 2002-11-22 |
| KR20020015068A (ko) | 2002-02-27 |
| NO20016151L (no) | 2001-12-17 |
| WO2001000577A2 (en) | 2001-01-04 |
| ZA200109206B (en) | 2003-05-28 |
| PE20010300A1 (es) | 2001-03-07 |
| AU770759B2 (en) | 2004-03-04 |
| CN1356982A (zh) | 2002-07-03 |
| EA200200101A1 (ru) | 2002-06-27 |
| BR0011996A (pt) | 2002-03-05 |
| SK19012001A3 (sk) | 2002-06-04 |
| WO2001000577A3 (en) | 2002-01-24 |
| CZ20014548A3 (cs) | 2002-04-17 |
| AU5453500A (en) | 2001-01-31 |
| IL146339A0 (en) | 2002-07-25 |
| JP2003522122A (ja) | 2003-07-22 |
| MXPA01012727A (es) | 2002-07-02 |
| CA2370491A1 (en) | 2001-01-04 |
| HUP0201642A2 (en) | 2002-09-28 |
| SV2002000111A (es) | 2002-01-23 |
| PL364868A1 (en) | 2004-12-27 |
| HUP0201642A3 (en) | 2002-11-28 |
| NO20016151D0 (no) | 2001-12-17 |
| US6538136B1 (en) | 2003-03-25 |
| EP1196382A2 (en) | 2002-04-17 |
| EG22530A (en) | 2003-03-31 |
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