PE20020193A1 - Pirroloquinolonas como agentes antivirales - Google Patents
Pirroloquinolonas como agentes antiviralesInfo
- Publication number
- PE20020193A1 PE20020193A1 PE2001000659A PE2001000659A PE20020193A1 PE 20020193 A1 PE20020193 A1 PE 20020193A1 PE 2001000659 A PE2001000659 A PE 2001000659A PE 2001000659 A PE2001000659 A PE 2001000659A PE 20020193 A1 PE20020193 A1 PE 20020193A1
- Authority
- PE
- Peru
- Prior art keywords
- cycloalkyl
- aryl
- alkyl
- pyroloquinolones
- halogen
- Prior art date
Links
- 239000003443 antiviral agent Substances 0.000 title abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- CIEWGZJDEDBECJ-UHFFFAOYSA-N 1-chloro-4-methylbenzene Chemical class [CH2]C1=CC=C(Cl)C=C1 CIEWGZJDEDBECJ-UHFFFAOYSA-N 0.000 abstract 2
- -1 2-HYDROXYETHYL Chemical class 0.000 abstract 2
- 101100440695 Dictyostelium discoideum corB gene Proteins 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- XNMYNYSCEJBRPZ-UHFFFAOYSA-N 2-[(3-butyl-1-isoquinolinyl)oxy]-N,N-dimethylethanamine Chemical compound C1=CC=C2C(OCCN(C)C)=NC(CCCC)=CC2=C1 XNMYNYSCEJBRPZ-UHFFFAOYSA-N 0.000 abstract 1
- 229940127399 DNA Polymerase Inhibitors Drugs 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
SE REFIERE A PIRROLOQUINOLONAS DONDE R1 ES F, Cl, Br, CN, NO2: R2 Y R3 SON H, HALOGENO, OR11, COR7, COOR11, CICLOALQUILO C3-C8, ALQUILO C1-C7; R4 Y R5 SON H, HALOGENO, ARILO, SOmR7, COR7, ENTRE OTROS; R6 ES H, HALOGENO, CICLOALQUILO C3-C8, ALQUILO C1-C4; R7 ES ALQUILO C1-C7, CICLOALQUILO C3-C5, NR8R9, ARILO, HETEROCICLO; R8 Y R9 SON H, ARILO, CICLOALQUILO C3-C8; R11 ES H, CICLOALQUILO C3-C8, ALQUILO C1-C7, ARILO. SON COMPUESTOS PREFERIDOS N-(4-CLOROBENCIL)-2-(2-HIDROXIETIL)-6-OXO-8-(TETRAHIDRO-2H-PIRAN-4-ILMETIL)-6H-PIRROLO[3,2,1-ij]QUINOLEINA-5-CARBOXAMIDA; N-(4-CLOROBENCIL)-2-(HIDROXIMETIL)-8-(4-MORFOLINILMETIL)-6-OXO-6H-PIRROLO[3,2,1-ij]QUINOLEINA-5-CARBOXAMIDA. LOS COMPUESTOS SON INHIBIDORES DE ADN POLIMERASA UTILES COMO AGENTES ANTIVIRALES
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21598600P | 2000-07-05 | 2000-07-05 | |
| US27701201P | 2001-03-19 | 2001-03-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20020193A1 true PE20020193A1 (es) | 2002-03-02 |
Family
ID=26910543
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2001000659A PE20020193A1 (es) | 2000-07-05 | 2001-07-03 | Pirroloquinolonas como agentes antivirales |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US6525049B2 (es) |
| EP (1) | EP1299386A1 (es) |
| JP (1) | JP2004502689A (es) |
| KR (1) | KR20030014320A (es) |
| CN (1) | CN1437600A (es) |
| AR (1) | AR031857A1 (es) |
| AU (1) | AU2001271258A1 (es) |
| CA (1) | CA2410658A1 (es) |
| MX (1) | MXPA03000107A (es) |
| MY (1) | MY117789A (es) |
| NZ (1) | NZ523449A (es) |
| PE (1) | PE20020193A1 (es) |
| TW (1) | TW593316B (es) |
| WO (1) | WO2002002558A1 (es) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004019939A1 (en) * | 2002-08-30 | 2004-03-11 | Pharmacia & Upjohn Company | Method of preventing or treating atherosclerosis or restenosis |
| ATE433974T1 (de) | 2003-09-19 | 2009-07-15 | Gilead Sciences Inc | Azachinolinolphosphonatverbindungen als integraseinhibitoren |
| ES2315922T3 (es) * | 2004-04-14 | 2009-04-01 | Gilead Sciences, Inc. | Analogos de fosfonato de compuestos inhibidores de la integrasa del vih. |
| DE102006005861A1 (de) * | 2006-02-09 | 2007-08-23 | Aicuris Gmbh & Co. Kg | Substituierte Chinolone III |
| AU2008240764C1 (en) * | 2007-04-20 | 2011-10-20 | Glaxo Group Limited | Tricyclic nitrogen containing compounds as antibacterial agents |
| WO2014062655A1 (en) | 2012-10-16 | 2014-04-24 | Janssen Pharmaceutica Nv | HETEROARYL LINKED QUINOLINYL MODULATORS OF RORyt |
| ES2628365T3 (es) | 2012-10-16 | 2017-08-02 | Janssen Pharmaceutica N.V. | Moduladores de quinolinilo unidos a fenilo de ROR-GAMA-T |
| SG11201502369XA (en) | 2012-10-16 | 2015-05-28 | Janssen Pharmaceutica Nv | Methylene linked quinolinyl modulators of ror-gamma-t |
| US10555941B2 (en) | 2013-10-15 | 2020-02-11 | Janssen Pharmaceutica Nv | Alkyl linked quinolinyl modulators of RORγt |
| KR20160070133A (ko) | 2013-10-15 | 2016-06-17 | 얀센 파마슈티카 엔.브이. | RORyt의 알킬 결합 퀴놀리닐 조절제 |
| US9328095B2 (en) | 2013-10-15 | 2016-05-03 | Janssen Pharmaceutica Nv | Heteroaryl linked quinolinyl modulators of RORgammat |
| US9221804B2 (en) | 2013-10-15 | 2015-12-29 | Janssen Pharmaceutica Nv | Secondary alcohol quinolinyl modulators of RORγt |
| US9284308B2 (en) | 2013-10-15 | 2016-03-15 | Janssen Pharmaceutica Nv | Methylene linked quinolinyl modulators of RORγt |
| KR20160068956A (ko) | 2013-10-15 | 2016-06-15 | 얀센 파마슈티카 엔.브이. | RORyT의 퀴놀리닐 조절제 |
| US9403816B2 (en) | 2013-10-15 | 2016-08-02 | Janssen Pharmaceutica Nv | Phenyl linked quinolinyl modulators of RORγt |
| US11072610B2 (en) | 2018-09-12 | 2021-07-27 | Novartis Ag | Antiviral pyridopyrazinedione compounds |
| CN120842223A (zh) | 2019-09-26 | 2025-10-28 | 诺华股份有限公司 | 抗病毒吡唑并吡啶酮化合物 |
| CN111349094B (zh) * | 2020-04-23 | 2021-02-02 | 杭州师范大学 | 一种6H-咪唑[4,5,1-ij]并喹诺酮及其合成方法和应用 |
| CN112349961B (zh) * | 2020-11-12 | 2021-09-24 | 宁德新能源科技有限公司 | 电解液及包含其的电化学装置和电子设备 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3917609A (en) | 1973-06-27 | 1975-11-04 | Minnesota Mining & Mfg | Pyrroloquinoline carboxylic acids and derivatives |
| DE2914218C2 (de) | 1978-04-12 | 1985-10-24 | Otsuka Pharmaceutical Co. Ltd., Tokio/Tokyo | N-Acylderivate des Ampicillins und Amoxicillins, Verfahren zu deren Herstellung und pharmazeutische Zubereitungen, welche die Verbindungen enthalten |
| JPS55145612A (en) | 1979-05-02 | 1980-11-13 | Otsuka Pharmaceut Co Ltd | Anti-bacterial agent |
| JPS55153792A (en) | 1979-05-18 | 1980-11-29 | Otsuka Pharmaceut Co Ltd | Cephalosporanic acid derivative |
| IE52670B1 (en) | 1981-03-03 | 1988-01-20 | Leo Ab | Heterocyclic carboxamides,compositions containing such compounds,and processes for their preparation |
| JPH0262875A (ja) | 1988-05-23 | 1990-03-02 | Wakunaga Pharmaceut Co Ltd | 新規イソインドリン誘導体 |
| GB2236751B (en) | 1989-10-14 | 1993-04-28 | Wyeth John & Brother Ltd | Heterocyclic compounds |
| GB9108547D0 (en) | 1991-04-22 | 1991-06-05 | Fujisawa Pharmaceutical Co | Quinoline derivatives |
| NZ290946A (en) | 1994-08-12 | 1997-12-19 | Toyama Chemical Co Ltd | Quinolone- or naphthyridone-carboxylic acid derivatives |
| JP2000505451A (ja) | 1996-02-21 | 2000-05-09 | ダーウィン・ディスカバリー・リミテッド | キノロン類およびこれらの治療的使用 |
| US5792774A (en) * | 1996-02-21 | 1998-08-11 | Chiroscience Limited | Quinolones and their therapeutic use |
| WO1997030999A1 (en) | 1996-02-21 | 1997-08-28 | Darwin Discovery Limited | Quinolones and their therapeutic use |
| WO1999032450A1 (en) | 1997-12-22 | 1999-07-01 | Pharmacia & Upjohn Company | 4-hydroxyquinoline-3-carboxamides and hydrazides as antiviral agents |
| ITMI981670A1 (it) * | 1998-07-21 | 2000-01-21 | Zambon Spa | Derivati ftalazinici inibitori della fosfodiesterasi 4 |
| US6248739B1 (en) | 1999-01-08 | 2001-06-19 | Pharmacia & Upjohn Company | Quinolinecarboxamides as antiviral agents |
-
2001
- 2001-06-22 US US09/888,283 patent/US6525049B2/en not_active Expired - Fee Related
- 2001-06-25 KR KR10-2003-7000127A patent/KR20030014320A/ko not_active Withdrawn
- 2001-06-25 AU AU2001271258A patent/AU2001271258A1/en not_active Abandoned
- 2001-06-25 NZ NZ523449A patent/NZ523449A/en unknown
- 2001-06-25 JP JP2002507810A patent/JP2004502689A/ja active Pending
- 2001-06-25 MX MXPA03000107A patent/MXPA03000107A/es not_active Application Discontinuation
- 2001-06-25 CN CN01811360A patent/CN1437600A/zh active Pending
- 2001-06-25 EP EP01950235A patent/EP1299386A1/en not_active Withdrawn
- 2001-06-25 WO PCT/US2001/016493 patent/WO2002002558A1/en not_active Ceased
- 2001-06-25 CA CA002410658A patent/CA2410658A1/en not_active Abandoned
- 2001-06-26 MY MYPI20013011A patent/MY117789A/en unknown
- 2001-07-03 PE PE2001000659A patent/PE20020193A1/es not_active Application Discontinuation
- 2001-07-05 TW TW090116504A patent/TW593316B/zh not_active IP Right Cessation
- 2001-07-05 AR ARP010103208A patent/AR031857A1/es not_active Application Discontinuation
-
2002
- 2002-11-05 US US10/288,117 patent/US6683181B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| TW593316B (en) | 2004-06-21 |
| KR20030014320A (ko) | 2003-02-15 |
| CA2410658A1 (en) | 2002-01-10 |
| US6525049B2 (en) | 2003-02-25 |
| AR031857A1 (es) | 2003-10-08 |
| AU2001271258A1 (en) | 2002-01-14 |
| MY117789A (en) | 2004-08-30 |
| EP1299386A1 (en) | 2003-04-09 |
| US6683181B2 (en) | 2004-01-27 |
| WO2002002558A1 (en) | 2002-01-10 |
| US20020055636A1 (en) | 2002-05-09 |
| JP2004502689A (ja) | 2004-01-29 |
| MXPA03000107A (es) | 2003-08-19 |
| NZ523449A (en) | 2004-09-24 |
| US20030153561A1 (en) | 2003-08-14 |
| CN1437600A (zh) | 2003-08-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FX | Voluntary withdrawal |