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PE20020179A1 - DERIVADOS DE (6S,9R,10S,11S,13S,16R, 17R)-9-CLORO-6-FLUORO-11-HIDROXI-10,13,16-TRIMETIL-3-OXO-6,7,8,9,10,11,12,13,14,15,16,17-DODECAHIDRO-3H-CICLOPENTA[a]FENANTRENO CARBOXILICO - Google Patents

DERIVADOS DE (6S,9R,10S,11S,13S,16R, 17R)-9-CLORO-6-FLUORO-11-HIDROXI-10,13,16-TRIMETIL-3-OXO-6,7,8,9,10,11,12,13,14,15,16,17-DODECAHIDRO-3H-CICLOPENTA[a]FENANTRENO CARBOXILICO

Info

Publication number
PE20020179A1
PE20020179A1 PE2001000620A PE2001000620A PE20020179A1 PE 20020179 A1 PE20020179 A1 PE 20020179A1 PE 2001000620 A PE2001000620 A PE 2001000620A PE 2001000620 A PE2001000620 A PE 2001000620A PE 20020179 A1 PE20020179 A1 PE 20020179A1
Authority
PE
Peru
Prior art keywords
carboxyl
dodecahydro
cyclopenta
trimethyl
oxo
Prior art date
Application number
PE2001000620A
Other languages
English (en)
Inventor
David Beattie
David Andrew Sandham
Bernard Cuenoud
Thomas Hugo Keller
Gaynor Elizabeth Pilgrim
Simon James Watson
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PE20020179A1 publication Critical patent/PE20020179A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0038—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 with an androstane skeleton, including 18- or 19-substituted derivatives, 18-nor derivatives and also derivatives where position 17-beta is substituted by a carbon atom not directly bonded to a further carbon atom and not being part of an amide group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J33/00—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J33/002—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C07J71/0015—Oxiranes at position 9(11)

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Toxicology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

SE REFIERE A COMPUESTOS DE FORMULA I DONDE R ES UN GRUPO ORGANICO CICLICO MONOVALENTE DE 3-15 ATOMOS EN EL ANILLO SELECCIONADO DE: CICLOALQUILO C3-C6, UN GRUPO HETEROCICLICO PARCIALMENTE SATURADO DE C5-C10 ATOMOS DEL ANILLO CON HETEROATOMOS, UN GRUPO HETEROCICLICO DE 5 MIEMBROS CON UN HETEROATOMO; FENILO O NAFTILO CON HALOGENO, OH, ACILOXILO C1-C4, CIANO, ENTRE OTROS. UN COMPUESTO PREFERIDO ES (6S,9R,10s,11s,13s,16R, 17R)-9-CLORO-6-FLUORO-11-HIDROXI-17-METOXICARBONILO-10,13,16-TRIMETIL-3-OXO-6,7,8,9,10,11,12,13,14,15,16,17-DODECAHIDRO-3H-CICLOPENTA[a]FENANTREN-17-ILESTER DEL ACIDO 4-METIL-[1,2,3]TIADIAZOL-5-CARBOXILICO ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO PARA LA PREPARACION QUE COMPRENDE: a) LA CONVERSION DE UN ACIDO CARBOXILICO DE FORMULA II DONDE R ES UN GRUPO CICLICO MONOVALENTE; b) CLORHIDRATACION DE UNA COMPUESTO DE FORMULA III DONDE R ES UN GRUPO ORGANICO CICLICO.
PE2001000620A 2000-06-28 2001-06-26 DERIVADOS DE (6S,9R,10S,11S,13S,16R, 17R)-9-CLORO-6-FLUORO-11-HIDROXI-10,13,16-TRIMETIL-3-OXO-6,7,8,9,10,11,12,13,14,15,16,17-DODECAHIDRO-3H-CICLOPENTA[a]FENANTRENO CARBOXILICO PE20020179A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0015876.6A GB0015876D0 (en) 2000-06-28 2000-06-28 Organic compounds

Publications (1)

Publication Number Publication Date
PE20020179A1 true PE20020179A1 (es) 2002-04-10

Family

ID=9894607

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2001000620A PE20020179A1 (es) 2000-06-28 2001-06-26 DERIVADOS DE (6S,9R,10S,11S,13S,16R, 17R)-9-CLORO-6-FLUORO-11-HIDROXI-10,13,16-TRIMETIL-3-OXO-6,7,8,9,10,11,12,13,14,15,16,17-DODECAHIDRO-3H-CICLOPENTA[a]FENANTRENO CARBOXILICO

Country Status (29)

Country Link
US (1) US6921757B2 (es)
EP (1) EP1299409B1 (es)
JP (1) JP4065399B2 (es)
KR (1) KR100483865B1 (es)
CN (1) CN1214038C (es)
AR (1) AR030707A1 (es)
AT (1) ATE292639T1 (es)
AU (2) AU8389101A (es)
BR (1) BR0112068A (es)
CA (1) CA2412541C (es)
CZ (1) CZ302513B6 (es)
DE (1) DE60109931T2 (es)
EC (1) ECSP014101A (es)
ES (1) ES2240499T3 (es)
GB (1) GB0015876D0 (es)
HU (1) HUP0300783A3 (es)
IL (2) IL153703A0 (es)
MX (1) MXPA02012830A (es)
MY (1) MY129523A (es)
NO (1) NO324055B1 (es)
NZ (1) NZ523194A (es)
PE (1) PE20020179A1 (es)
PL (1) PL207722B1 (es)
PT (1) PT1299409E (es)
RU (1) RU2277100C2 (es)
SK (1) SK286690B6 (es)
TW (1) TWI232868B (es)
WO (1) WO2002000679A2 (es)
ZA (1) ZA200300202B (es)

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