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PE20020100A1 - DERIVADOS DE 2-SULFONIL AMINO-1,3-TIAZOL COMO INHIBIDORES DE 11-ß-HIDROXI ESTEROIDE DESHIDROGENASA TIPO 1 (11ßHSD1) - Google Patents

DERIVADOS DE 2-SULFONIL AMINO-1,3-TIAZOL COMO INHIBIDORES DE 11-ß-HIDROXI ESTEROIDE DESHIDROGENASA TIPO 1 (11ßHSD1)

Info

Publication number
PE20020100A1
PE20020100A1 PE2001000450A PE2001000450A PE20020100A1 PE 20020100 A1 PE20020100 A1 PE 20020100A1 PE 2001000450 A PE2001000450 A PE 2001000450A PE 2001000450 A PE2001000450 A PE 2001000450A PE 20020100 A1 PE20020100 A1 PE 20020100A1
Authority
PE
Peru
Prior art keywords
amino
sulfonil
thiazol
derivatives
11ßhsd1
Prior art date
Application number
PE2001000450A
Other languages
English (en)
Inventor
Tjeerd Barf
Rikard Emond
Guido Kurz
Marianne Nilsson
Jerk Vallgarda
Original Assignee
Biovitrum Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biovitrum Ab filed Critical Biovitrum Ab
Publication of PE20020100A1 publication Critical patent/PE20020100A1/es

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    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
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    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
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    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
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    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

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Abstract

SE REFIERE A DERIVADOS DE 2-SULFONIL AMINO -1,3-TIAZOL DE FORMULA I DONDE T ES UN ANILLO ARILO, HETEROARILO, ARILALQUENILO CON [R]n, DONDE n ES 0-5 Y R ES H, ARILO, HETEROARILO, HETEROCICLICO OPCIONALMENTE HALOGENADO, ENTRE OTROS, CON LA CONDICION QUE CUANDO R1 SEA H, X SEA CH2, Y SEA CO, R2 SEA ETO Y B SEA H ENTONCES T NO SEA 2,4-DICLORO-5-METILFENILO, 4-CLOROFENILO, 4-CLORO-2,5-DIMETILFENILO, 2,4-DIFLUORFENILO, 3-NITROFENIL Y FENILO; R1 ES H, ALQUILO C1-C6; X ES CH2, CO; Y ES CH2, CO, ENLACE SENCILLO; B ES H, ALQUILO C1-C6, DIMETILAMINOMETILO; R2 ES ALQUILO C1-C6, AZIDO, ARILTIO, HETEROARILTIO, HALOGENO, HIDROXIMETILO, 2-HIDROXIETILAMINOMETILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS 2-(2-(((4-METILFENIL)SULFONIL)AMINO)-1,3-TIAZOL-4-IL)ACETATO DE ETILO, 2-HIDROXIETILAMINOMETILO, 2-(2-{[(2,5-DICLORO-3-TIENIL)SULFONIL)AMINO)-1,3-TIAZOL-4-IL)ACETATO DE ETILO, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO PARA LA PREPARACION. LOS DERIVADOS DE 2-SULFONIL AMINO -1,3-TIAZOL SON INHIBIDORES DE 11-ß-HIDROXI ESTEROIDE DESHIDROGENASA TIPO 1 (11ßHSD1) Y SON UTILES PARA EL TRATAMIENTO DE DIABETES, OBESIDAD, GLAUCOMA, OSTEOPOROSIS
PE2001000450A 2000-05-22 2001-05-18 DERIVADOS DE 2-SULFONIL AMINO-1,3-TIAZOL COMO INHIBIDORES DE 11-ß-HIDROXI ESTEROIDE DESHIDROGENASA TIPO 1 (11ßHSD1) PE20020100A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE0001899A SE0001899D0 (sv) 2000-05-22 2000-05-22 New compounds

Publications (1)

Publication Number Publication Date
PE20020100A1 true PE20020100A1 (es) 2002-02-13

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Application Number Title Priority Date Filing Date
PE2001000450A PE20020100A1 (es) 2000-05-22 2001-05-18 DERIVADOS DE 2-SULFONIL AMINO-1,3-TIAZOL COMO INHIBIDORES DE 11-ß-HIDROXI ESTEROIDE DESHIDROGENASA TIPO 1 (11ßHSD1)

Country Status (23)

Country Link
US (7) US7618961B2 (es)
EP (4) EP1283831A1 (es)
JP (4) JP2003534338A (es)
KR (4) KR20030016272A (es)
CN (4) CN1430614A (es)
AR (1) AR033534A1 (es)
AT (2) ATE443055T1 (es)
AU (6) AU6093101A (es)
BR (1) BR0111099A (es)
CA (4) CA2409697C (es)
DE (3) DE60143293D1 (es)
EA (1) EA005274B1 (es)
ES (1) ES2333846T3 (es)
HU (1) HUP0302435A3 (es)
IL (4) IL152670A0 (es)
MX (1) MXPA02011632A (es)
NO (4) NO323832B1 (es)
NZ (4) NZ522507A (es)
PE (1) PE20020100A1 (es)
PL (1) PL360137A1 (es)
SE (1) SE0001899D0 (es)
WO (5) WO2001090093A1 (es)
ZA (4) ZA200209359B (es)

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SE0001899D0 (sv) * 2000-05-22 2000-05-22 Pharmacia & Upjohn Ab New compounds
JP2004502432A (ja) * 2000-07-05 2004-01-29 バイエル　アクチェンゲゼルシャフト ヒト１１β−ヒドロキシステロイドデヒドロゲナーゼ１様酵素の調節
GB0107383D0 (en) * 2001-03-23 2001-05-16 Univ Edinburgh Lipid profile modulation
IL160630A0 (en) * 2001-11-22 2004-07-25 Biovitrum Ab Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
EA200400709A1 (ru) * 2001-11-22 2004-12-30 Биовитрум Аб Ингибиторы 11-бета-гидроксистероиддегидрогеназы типа 1
AU2007205749B2 (en) * 2001-11-22 2009-04-23 Biovitrum Ab Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
EA200400708A1 (ru) * 2001-11-22 2004-10-28 Биовитрум Аб Ингибиторы 11-бета-гидроксистероиддегидрогеназы типа 1
WO2003043999A1 (en) 2001-11-22 2003-05-30 Biovitrum Ab Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
EA200400707A1 (ru) 2001-11-22 2004-10-28 Биовитрум Аб Ингибиторы 11-бета-гидроксистероиддегидрогеназы типа 1
WO2003061655A1 (en) 2002-01-16 2003-07-31 University Of Virginia Patent Foundation 2-aminothiazole allosteric enhancers of a1 adenosine receptors
EP1474139B1 (en) * 2002-02-01 2007-11-21 Merck & Co., Inc. 11-beta-hydroxysteroid dehydrogenase 1 inhibitors useful for the treatment of diabetes, obesity and dyslipidemia
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