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DE602005017159D1 - Oxysteroid-dehydrogenase-inhibitoren - Google Patents

Oxysteroid-dehydrogenase-inhibitoren

Info

Publication number
DE602005017159D1
DE602005017159D1 DE602005017159T DE602005017159T DE602005017159D1 DE 602005017159 D1 DE602005017159 D1 DE 602005017159D1 DE 602005017159 T DE602005017159 T DE 602005017159T DE 602005017159 T DE602005017159 T DE 602005017159T DE 602005017159 D1 DE602005017159 D1 DE 602005017159D1
Authority
DE
Germany
Prior art keywords
oxysteroid
dehydrogenase inhibitors
dehydrogenase
inhibitors
oxysteroid dehydrogenase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE602005017159T
Other languages
English (en)
Inventor
Libuse Jaroskova
Joannes T M Linders
Der Veken L J Van
G H M Willemsens
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Priority claimed from PCT/EP2005/054198 external-priority patent/WO2006024628A1/en
Publication of DE602005017159D1 publication Critical patent/DE602005017159D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/62—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles
    • C07D209/64—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles with an oxygen atom in position 1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE602005017159T 2004-08-30 2005-08-26 Oxysteroid-dehydrogenase-inhibitoren Expired - Lifetime DE602005017159D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP04104147 2004-08-30
US60784004P 2004-09-08 2004-09-08
PCT/EP2005/054198 WO2006024628A1 (en) 2004-08-30 2005-08-26 Tricyclic lactam derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors

Publications (1)

Publication Number Publication Date
DE602005017159D1 true DE602005017159D1 (de) 2009-11-26

Family

ID=35432565

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602005017159T Expired - Lifetime DE602005017159D1 (de) 2004-08-30 2005-08-26 Oxysteroid-dehydrogenase-inhibitoren

Country Status (3)

Country Link
US (3) US9150512B2 (de)
DE (1) DE602005017159D1 (de)
NO (1) NO20071685L (de)

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2510945A (en) 1945-04-24 1950-06-13 Us Agriculture Nu-cyclohexyl nicotinamide
US2524643A (en) 1947-12-04 1950-10-03 Maltbie Lab Inc 3-phenyl-2-piperidones
FR1399615A (fr) 1963-03-08 1965-05-21 Chemical Investors Sa Nouveaux composés chimiques et composition herbicide contenant ceux-ci
US3201466A (en) 1963-03-08 1965-08-17 Gulf Oil Corp Substituted cyclopropanecarboxanilide herbicides
US3526656A (en) 1967-05-25 1970-09-01 Parke Davis & Co (1-arylcyclobutyl)carbonyl carbamic acid derivatives
US3622567A (en) 1968-05-13 1971-11-23 Little Inc A Norcamphane derivatives
NL6917600A (de) 1968-11-29 1970-06-02
US3919313A (en) 1973-07-23 1975-11-11 Schering Corp Novel 1-N-({60 -aminoacetyl) aminoadamantanes
HU177576B (en) 1975-06-02 1981-11-28 Chinoin Gyogyszer Es Vegyeszet Process for preparing 2-amino-cyclohexane carboxylic acid,its amides and similar compounds
EP0117462A3 (de) 1983-02-28 1986-08-20 American Cyanamid Company N-(2-4-(1H-Imidazol-1-yl)alkyl)arylamide
CH655103A5 (de) 1983-03-11 1986-03-27 Sandoz Ag Azolderivate, verfahren zu ihrer herstellung und ihre verwendung.
JPH0386853A (ja) 1989-05-23 1991-04-11 Sankyo Co Ltd 置換フェノール誘導体およびその用途
CA2017287A1 (en) 1989-05-23 1990-11-23 Shunji Naruto Substituted phenol derivatives and their use
FR2653123B1 (fr) 1989-10-17 1992-01-17 Roussel Uclaf Nouveaux derives de la pyridone, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant.
CA2053340C (en) 1990-10-18 2002-04-02 Timothy P. Burkholder Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
DE4035961A1 (de) 1990-11-02 1992-05-07 Thomae Gmbh Dr K Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
GB9312893D0 (en) 1993-06-22 1993-08-04 Boots Co Plc Therapeutic agents
FR2714291B1 (fr) 1993-12-24 1996-03-01 Roussel Uclaf Application des dérivés de la pyridone à titre de médicaments anesthésiques.
JPH10504545A (ja) 1994-07-29 1998-05-06 藤沢薬品工業株式会社 ベンゾジアゼピン誘導体
US5776959A (en) 1995-06-05 1998-07-07 Washington University Anticonvulsant and anxiolytic lactam and thiolactam derivatives
US6211199B1 (en) 1995-11-17 2001-04-03 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl-amino)piperidines useful for the treatment of allergic diseases
PT920425E (pt) 1995-11-17 2003-07-31 Aventis Pharma Inc 4-(1h-benzimidazol-2-il-amino)piperidinas substituidas uteis para o tratamento de doencas alergicas
JP3230818B2 (ja) 1995-12-14 2001-11-19 メルク エンド カンパニー インコーポレーテッド ゴナドトロピン放出ホルモン拮抗剤
US6423704B2 (en) 1995-12-20 2002-07-23 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic diseases
CA2241827C (en) 1995-12-20 2002-04-30 Hoechst Marion Roussel, Inc. Novel substituted 4-(1h-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic diseases
US6194406B1 (en) 1995-12-20 2001-02-27 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic disease
CA2262786A1 (en) 1996-09-10 1998-03-19 Pharmacia & Upjohn Company 8-hydroxy-7-substituted quinolines as anti-viral agents
IL136250A0 (en) 1997-11-21 2001-05-20 Nps Pharma Inc Metabotropic glutamate receptor antagonist compounds
CO5180581A1 (es) 1999-09-30 2002-07-30 Pfizer Prod Inc Compuestos para el tratamiento de la isquemia ciones farmaceuticas que los contienen para el tratamiento de la isquemia
US6867299B2 (en) 2000-02-24 2005-03-15 Hoffmann-La Roche Inc. Oxamide IMPDH inhibitors
CA2402384A1 (en) 2000-03-16 2001-09-20 Inflazyme Pharmaceuticals Ltd. Benzylated pde4 inhibitors
SE0001899D0 (sv) 2000-05-22 2000-05-22 Pharmacia & Upjohn Ab New compounds
AU2001296961A1 (en) 2000-09-29 2002-04-08 Bayer Pharmaceuticals Corporation 17-beta-hydroxysteroid dehydrogenase-ii inhibitors
DE60317631T2 (de) 2002-02-01 2008-09-25 Merck & Co., Inc. 11-beta-hydroxysteroid-dehydrogenase-1-hemmer zur behandlung von diabetes, adipositas und dyslipidämie
AR040241A1 (es) 2002-06-10 2005-03-23 Merck & Co Inc Inhibidores de la 11-beta-hidroxiesteroide deshidrogrenasa 1 para el tratamiento de la diabetes obesidad y dislipidemia
WO2004056744A1 (en) 2002-12-23 2004-07-08 Janssen Pharmaceutica N.V. Adamantyl acetamides as hydroxysteroid dehydrogenase inhibitors
TW200503994A (en) 2003-01-24 2005-02-01 Novartis Ag Organic compounds
WO2004075847A2 (en) 2003-02-21 2004-09-10 Message Pharmaceuticals, Inc. METHODS AND COMPOUNDS FOR THE TREATMENT OF Aß­ ASSOCIATED DISEASES, DISORDERS, AND CONDITIONS
WO2004089416A2 (en) 2003-04-11 2004-10-21 Novo Nordisk A/S Combination of an 11beta-hydroxysteroid dehydrogenase type 1 inhibitor and an antihypertensive agent
EP1615667A2 (de) 2003-04-11 2006-01-18 Novo Nordisk A/S Kombinationspräparate welche einen 11-beta-hydroxysteroid-dehydrogenas typ-3 hemmer und einen glucocorticoid rezeptor agonist enthalten
EP2239012A3 (de) 2003-04-11 2011-06-15 High Point Pharmaceuticals, LLC Substituierte amide Derivate und deren pharmazeutische Verwendungen
US20050245534A1 (en) 2004-04-29 2005-11-03 Link James T Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme
US9012494B2 (en) 2004-05-07 2015-04-21 Janssen Pharmaceutica N.V. Pyrrolidin-2-one and piperidin-2-one derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors
PL1747198T3 (pl) 2004-05-07 2008-11-28 Janssen Pharmaceutica Nv Pochodne adamantylopirolidyn-2-onu jako inhibitory 11ß-dehydrogenazy hydroksysteroidowej
DE602005018509D1 (de) 2004-08-30 2010-02-04 Janssen Pharmaceutica Nv N-2-adamantanyl-2-phenoxy-acetamid-derivate als 11-betahydroxysteroid-dehydrogenase-hemmer
CA2576850C (en) 2004-08-30 2013-06-25 Janssen Pharmaceutica N.V. Tricyclic lactam derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors

Also Published As

Publication number Publication date
NO20071685L (no) 2007-03-30
US20160318865A1 (en) 2016-11-03
US9422284B2 (en) 2016-08-23
US20140179732A1 (en) 2014-06-26
US9630921B2 (en) 2017-04-25
US9150512B2 (en) 2015-10-06
US20160002229A1 (en) 2016-01-07

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Legal Events

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8364 No opposition during term of opposition