PE20020857A1 - Proteinas de fusion cuya parte del n-terminal es un derivado de hirudina para la produccion de proteinas recombinantes a traves de la secresion por levaduras - Google Patents
Proteinas de fusion cuya parte del n-terminal es un derivado de hirudina para la produccion de proteinas recombinantes a traves de la secresion por levadurasInfo
- Publication number
- PE20020857A1 PE20020857A1 PE2002000082A PE2002000082A PE20020857A1 PE 20020857 A1 PE20020857 A1 PE 20020857A1 PE 2002000082 A PE2002000082 A PE 2002000082A PE 2002000082 A PE2002000082 A PE 2002000082A PE 20020857 A1 PE20020857 A1 PE 20020857A1
- Authority
- PE
- Peru
- Prior art keywords
- hirudin
- protein
- yeast
- dna
- sequence
- Prior art date
Links
- WQPDUTSPKFMPDP-OUMQNGNKSA-N hirudin Chemical class C([C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC(OS(O)(=O)=O)=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]1NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H]2CSSC[C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@H](C(NCC(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N2)=O)CSSC1)C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=2C=CC(O)=CC=2)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)C(C)C)[C@@H](C)O)CSSC1)C(C)C)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 WQPDUTSPKFMPDP-OUMQNGNKSA-N 0.000 title abstract 4
- 240000004808 Saccharomyces cerevisiae Species 0.000 title abstract 3
- 108020001507 fusion proteins Proteins 0.000 title abstract 2
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 title 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 title 1
- 102000037865 fusion proteins Human genes 0.000 title 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 4
- 108020004414 DNA Proteins 0.000 abstract 3
- 150000001413 amino acids Chemical class 0.000 abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- 102000004169 proteins and genes Human genes 0.000 abstract 3
- 239000000126 substance Substances 0.000 abstract 3
- 108020004705 Codon Proteins 0.000 abstract 2
- 102000007625 Hirudins Human genes 0.000 abstract 2
- 108010007267 Hirudins Proteins 0.000 abstract 2
- 210000004027 cell Anatomy 0.000 abstract 2
- 229940006607 hirudin Drugs 0.000 abstract 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 2
- 102000053602 DNA Human genes 0.000 abstract 1
- 102000004877 Insulin Human genes 0.000 abstract 1
- 108090001061 Insulin Proteins 0.000 abstract 1
- 241001138401 Kluyveromyces lactis Species 0.000 abstract 1
- 241000235058 Komagataella pastoris Species 0.000 abstract 1
- 210000000349 chromosome Anatomy 0.000 abstract 1
- 229940125396 insulin Drugs 0.000 abstract 1
- 108010013359 miniproinsulin Proteins 0.000 abstract 1
- 239000013612 plasmid Substances 0.000 abstract 1
- 230000001737 promoting effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Mycology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SE REFIERE A UNA MOLECULA DE DNA DE FORMA Px-Sx-Bn-(ZR)-Hir(ASmR)-proteina(Y)-T DONDE Px ES UNA SECUENCIA DE DNA PROMOTORA SELECCIONADA DE MODO TAL QUE SE PUEDE CONSEGUIR RENDIMIENTOS OPTIMOS DE LA PROTEINA DE INTERES; Sx ES DNA QUE CODIFICA UNA SECUENCIA O SENAL O SECUENCIA LIDER; Bn ES 1-15 CODONES DE AMINOACIDOS O UN ENLACE QUIMICO; Z ES EL CODON DE UN AMINOACIDO SELECCIONADO DEL GRUPO QUE COMPRENDE Lys Y Arg; R ES UN CODON Arg O UN ENLACE QUIMICO; Asm ES UN ENLACE QUIMCO O m CODONES DE AMINOACIDOS DONDE m ES 1-10; Hir ES UNA SECUENCIA DE DNA QUE CODIFICA HIRUDINA O UN DERIVADO DE HIRUDINA QUE TIENE COMO MINIMO 40% DE HOMOLOGIA CON LA HIRUDINA NATURAL; LA PROTEINA y ES UNA SECUENCIA DE DNA QUE CODIFICA CUALQUIER PROTEINA QUE PUEDE SER PRODUCIDA Y SEGREGADA POR UNA LEVADURA COMO UNA MINI-PROINSULINA O SUS DERIVADOS, INTERLEUQUINA, INTERFERON, ENTRE OTROS. T ES UNA SECUENCIA DE DNA. SE REFIERE TAMBIEN A UNA CELULA HOSPEDERA QUE COMPRENDE UNA MOLECULA DE DNA, UN VECTOR DE COPIA MULTIPLE Y/O UN PLASMIDO COMO UNA PARTE DE SU CROMOSOMA. LA CELULA HOSPEDERA ES UNA LEVADURA Y SE SELECCIONA DE S. cerevisiae, K. lactis, p. pastoris. SE REFIERE ADEMAS A UN PROCEDIMIENTO FERMENTAR UNA PROTEINA DE FUSION Y UN PROCEDIMIENTO PARA PREPARAR INSULINA
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10108211A DE10108211A1 (de) | 2001-02-20 | 2001-02-20 | Verwendung von Fusionsproteinen, deren N-terminaler Anteil aus einem Hirudinderivat besteht, zur Herstellung rekombinanter Proteine über Sekretion durch Hefen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20020857A1 true PE20020857A1 (es) | 2002-11-04 |
Family
ID=7674912
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2002000082A PE20020857A1 (es) | 2001-02-20 | 2002-02-06 | Proteinas de fusion cuya parte del n-terminal es un derivado de hirudina para la produccion de proteinas recombinantes a traves de la secresion por levaduras |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US20030176673A1 (es) |
| EP (1) | EP1364032B1 (es) |
| JP (1) | JP4199543B2 (es) |
| KR (1) | KR100858833B1 (es) |
| CN (1) | CN1279171C (es) |
| AT (1) | ATE342367T1 (es) |
| AU (1) | AU2002250903B2 (es) |
| BR (1) | BR0207379A (es) |
| CA (1) | CA2439042C (es) |
| CY (1) | CY1106274T1 (es) |
| DE (2) | DE10108211A1 (es) |
| DK (1) | DK1364032T3 (es) |
| ES (1) | ES2272696T3 (es) |
| IL (2) | IL157416A0 (es) |
| MX (1) | MXPA03007116A (es) |
| NO (1) | NO331376B1 (es) |
| NZ (1) | NZ527642A (es) |
| PE (1) | PE20020857A1 (es) |
| PT (1) | PT1364032E (es) |
| WO (1) | WO2002070722A1 (es) |
| ZA (1) | ZA200305868B (es) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7638618B2 (en) * | 2001-02-20 | 2009-12-29 | Sanofi-Aventis Deutschland Gmbh | Nucleic acids encoding a hirudin and pro-insulin as superscretable peptides and for parallel improvement of the exported forms of one or more polypeptides of interest |
| DE102006031962A1 (de) | 2006-07-11 | 2008-01-17 | Sanofi-Aventis Deutschland Gmbh | Amidiertes Insulin Glargin |
| DE102006031955A1 (de) | 2006-07-11 | 2008-01-17 | Sanofi-Aventis Deutschland Gmbh | Verfahren zur Herstellung von Insulinanaloga mit dibasischem B-Kettenende |
| DE102008003566A1 (de) | 2008-01-09 | 2009-07-16 | Sanofi-Aventis Deutschland Gmbh | Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil |
| WO2009087082A2 (de) | 2008-01-09 | 2009-07-16 | Sanofi-Aventis Deutschland Gmbh | Neue insulinderivate mit extrem verzögertem zeit- / wirkungsprofil |
| WO2009087081A2 (de) | 2008-01-09 | 2009-07-16 | Sanofi-Aventis Deutschland Gmbh | Neue insulinderivate mit extrem verzögertem zeit-/wirkungsprofil |
| DE102008025007A1 (de) | 2008-05-24 | 2009-11-26 | Sanofi-Aventis Deutschland Gmbh | Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil |
| DK2349324T3 (en) | 2008-10-17 | 2017-12-11 | Sanofi Aventis Deutschland | COMBINATION OF AN INSULIN AND A GLP-1 AGONIST |
| KR101836070B1 (ko) | 2009-11-13 | 2018-03-09 | 사노피-아벤티스 도이칠란트 게엠베하 | Ｇｌｐ－１ 작용제, 인슐린 및 메티오닌을 포함하는 약제학적 조성물 |
| ES2965209T3 (es) | 2009-11-13 | 2024-04-11 | Sanofi Aventis Deutschland | Composición farmacéutica que comprende desPro36exendina-4(1-39)-Lys6-NH2 y metionina |
| CN103179978A (zh) | 2010-08-30 | 2013-06-26 | 赛诺菲-安万特德国有限公司 | Ave0010用于制造供治疗2型糖尿病用的药物的用途 |
| US9821032B2 (en) | 2011-05-13 | 2017-11-21 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin |
| ES2550357T3 (es) | 2011-08-29 | 2015-11-06 | Sanofi-Aventis Deutschland Gmbh | Combinación farmacéutica para su uso en el control glucémico en pacientes de diabetes de tipo 2 |
| TWI559929B (en) | 2011-09-01 | 2016-12-01 | Sanofi Aventis Deutschland | Pharmaceutical composition for use in the treatment of a neurodegenerative disease |
| HRP20230470T1 (hr) | 2014-12-12 | 2023-07-21 | Sanofi-Aventis Deutschland Gmbh | Formulacija fiksnog omjera inzulin glargin/liksisenatid |
| TWI748945B (zh) | 2015-03-13 | 2021-12-11 | 德商賽諾菲阿凡提斯德意志有限公司 | 第２型糖尿病病患治療 |
| TW201705975A (zh) | 2015-03-18 | 2017-02-16 | 賽諾菲阿凡提斯德意志有限公司 | 第２型糖尿病病患之治療 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3586333T2 (de) * | 1984-03-27 | 1992-12-10 | Transgene Sa | Expressionsvektoren fuer hirudin, transformierte zellen und verfahren zur herstellung von hirudin. |
| US5705355A (en) * | 1984-03-27 | 1998-01-06 | Transgene, S.A. | Hirudin, pharmaceutical compositions comprising it and their use |
| DE3738541A1 (de) * | 1987-11-13 | 1989-05-24 | Hoechst Ag | Verfahren zur isolierung und reinigung von hirudin |
| US6875589B1 (en) * | 1988-06-23 | 2005-04-05 | Hoechst Aktiengesellschaft | Mini-proinsulin, its preparation and use |
| GB8927722D0 (en) * | 1989-12-07 | 1990-02-07 | British Bio Technology | Proteins and nucleic acids |
| DE4009268A1 (de) * | 1990-03-22 | 1991-09-26 | Consortium Elektrochem Ind | Sekretion von hirudinderivaten |
| DK0511393T3 (da) * | 1990-11-08 | 1996-12-09 | Japan Energy Corp | Hirudin-mutant, fremstilling af denne, antikoagulant, sekretorisk vektor, mikroorganisme transformeret af vektoren og fremstilling af produkt ud fra mikroorganismen |
| FI92601C (fi) * | 1992-03-11 | 1994-12-12 | Marja Makarow | Menetelmä hyötyproteiinien erittämiseksi hiivoista |
| DE19543737A1 (de) * | 1995-11-24 | 1997-05-28 | Hoechst Ag | Verfahren zur Ultrafiltration von Peptide oder Proteine enthaltender biologischer Matrices |
| DE19544233A1 (de) * | 1995-11-28 | 1997-06-05 | Hoechst Ag | Verfahren zur Nutzung des Hefe-ADH II-Promotorsystems zur biotechnologischen Produktion heterologer Proteine in hohen Ausbeuten |
| KR100447374B1 (ko) * | 1996-03-13 | 2004-11-03 | 델타 바이오테크놀로지 리미티드 | 발효조절방법 |
| DE10033195A1 (de) * | 2000-07-07 | 2002-03-21 | Aventis Pharma Gmbh | Bifunktionale Fusionsproteine aus Hirudin und TAP |
| US7202059B2 (en) * | 2001-02-20 | 2007-04-10 | Sanofi-Aventis Deutschland Gmbh | Fusion proteins capable of being secreted into a fermentation medium |
-
2001
- 2001-02-20 DE DE10108211A patent/DE10108211A1/de not_active Withdrawn
-
2002
- 2002-02-06 PE PE2002000082A patent/PE20020857A1/es not_active Application Discontinuation
- 2002-02-08 AU AU2002250903A patent/AU2002250903B2/en not_active Ceased
- 2002-02-08 NZ NZ527642A patent/NZ527642A/en not_active IP Right Cessation
- 2002-02-08 CN CNB028068491A patent/CN1279171C/zh not_active Expired - Fee Related
- 2002-02-08 EP EP02719782A patent/EP1364032B1/en not_active Expired - Lifetime
- 2002-02-08 BR BR0207379-0A patent/BR0207379A/pt not_active Application Discontinuation
- 2002-02-08 KR KR1020037010932A patent/KR100858833B1/ko not_active Expired - Fee Related
- 2002-02-08 CA CA2439042A patent/CA2439042C/en not_active Expired - Fee Related
- 2002-02-08 JP JP2002570745A patent/JP4199543B2/ja not_active Expired - Fee Related
- 2002-02-08 WO PCT/EP2002/001308 patent/WO2002070722A1/en not_active Ceased
- 2002-02-08 AT AT02719782T patent/ATE342367T1/de active
- 2002-02-08 IL IL15741602A patent/IL157416A0/xx unknown
- 2002-02-08 ES ES02719782T patent/ES2272696T3/es not_active Expired - Lifetime
- 2002-02-08 PT PT02719782T patent/PT1364032E/pt unknown
- 2002-02-08 DE DE60215315T patent/DE60215315T2/de not_active Expired - Lifetime
- 2002-02-08 DK DK02719782T patent/DK1364032T3/da active
- 2002-02-08 MX MXPA03007116A patent/MXPA03007116A/es active IP Right Grant
- 2002-02-19 US US10/076,632 patent/US20030176673A1/en not_active Abandoned
-
2003
- 2003-07-30 ZA ZA2003/05868A patent/ZA200305868B/en unknown
- 2003-08-14 IL IL157416A patent/IL157416A/en not_active IP Right Cessation
- 2003-08-19 NO NO20033672A patent/NO331376B1/no not_active IP Right Cessation
-
2006
- 2006-11-30 CY CY20061101726T patent/CY1106274T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2002250903B2 (en) | 2006-12-07 |
| IL157416A0 (en) | 2004-03-28 |
| MXPA03007116A (es) | 2003-11-18 |
| CN1526021A (zh) | 2004-09-01 |
| ES2272696T3 (es) | 2007-05-01 |
| PT1364032E (pt) | 2007-01-31 |
| NO20033672L (no) | 2003-10-17 |
| US20030176673A1 (en) | 2003-09-18 |
| WO2002070722A1 (en) | 2002-09-12 |
| JP4199543B2 (ja) | 2008-12-17 |
| DE10108211A1 (de) | 2002-08-22 |
| NZ527642A (en) | 2005-03-24 |
| DK1364032T3 (da) | 2007-02-19 |
| CN1279171C (zh) | 2006-10-11 |
| KR20030074841A (ko) | 2003-09-19 |
| DE60215315D1 (de) | 2006-11-23 |
| CA2439042C (en) | 2013-06-18 |
| ATE342367T1 (de) | 2006-11-15 |
| HK1065068A1 (en) | 2005-02-08 |
| CY1106274T1 (el) | 2011-10-12 |
| EP1364032A1 (en) | 2003-11-26 |
| JP2004518446A (ja) | 2004-06-24 |
| EP1364032B1 (en) | 2006-10-11 |
| NO331376B1 (no) | 2011-12-12 |
| BR0207379A (pt) | 2004-06-15 |
| IL157416A (en) | 2009-08-03 |
| CA2439042A1 (en) | 2002-09-12 |
| DE60215315T2 (de) | 2007-05-24 |
| KR100858833B1 (ko) | 2008-09-17 |
| NO20033672D0 (no) | 2003-08-19 |
| ZA200305868B (en) | 2005-02-23 |
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