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PE20020850A1 - Utilizacion de compuestos de azetidinona sustituida para tratamiento de la sitosterolemia - Google Patents

Utilizacion de compuestos de azetidinona sustituida para tratamiento de la sitosterolemia

Info

Publication number
PE20020850A1
PE20020850A1 PE2002000059A PE2002000059A PE20020850A1 PE 20020850 A1 PE20020850 A1 PE 20020850A1 PE 2002000059 A PE2002000059 A PE 2002000059A PE 2002000059 A PE2002000059 A PE 2002000059A PE 20020850 A1 PE20020850 A1 PE 20020850A1
Authority
PE
Peru
Prior art keywords
aryl
alkyl
substitute
halogen
substituted
Prior art date
Application number
PE2002000059A
Other languages
English (en)
Inventor
Harry R Davis
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23006987&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20020850(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Corp filed Critical Schering Corp
Publication of PE20020850A1 publication Critical patent/PE20020850A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE REFIERE A UN METODO PARA TRATAR SITOSTEROLEMIA O REDUCIR LA CONCENTRACION DE FITOESTEROL O 5-a-ESTANOLES QUE COMPRENDE ADMINISTRAR UN INHIBIDOR DE ABSORCION DE ESTEROLES TAL COMO COMPUESTOS DE AZETIDINONA i)DE FORMULA I; Ar1 ES ARILO R3-SUSTITUIDO; Ar2 ES ARILO R4-SUSTITUIDO; Ar3 ES ARILO R5-SUSTITUIDO CON R19, A; Y, Z SON CH2, CH-ALQUILO, C-ALQUILO; A ES O, S, SO, SO2; R1 ES OR6, OCOR6, OCOOR9, OCONR6R7; R2 ES H, ALQUILO, ARILO O R1 Y R2 JUNTOS SON =O; q ES 1-3; p ES 0-4; R5 ES OR6, OCOR6, OCOOR9, O(CH2)(1-5)OR9, OCONR6R7, NR6R7, ENTRE OTROS; R3 Y R5 SON H, ALQUILO, ARILO, NO2, CF3, HALOGENO; R6, R7 Y R8 SON H, ALQUILO, ARILO, ENTRE OTROS; R9 ES ALQUILO; ii)DE FORMULA IX DONDE R26 ES OH, OCH3, F, Cl; R1 ES H, UN GRUPO a, b, ENTRE OTROS; R, Ra, Rb SON H, OH, HALOGENO, NH2, AZIDO, ENTRE OTROS; W ES NH-CO, OCO, ENTRE OTROS; R3, R4, R3a, R4a SON H, ALQUILO C1-C6, ENTRE OTROS; R30 ES TR32, T-ALQUILO C1-C6-R32 SUSTITUIDO, ENTRE OTROS; T ES FENILO, FURILO, TIENILO, ENTRE OTROS: R32 ES H, HALOGENO, ALQUILO C1-C4, OH, ENTRE OTROS, Ar1 ES ARILO, ARILO R10 SUSTITUIDO, Ar2 ES ARILO, ARILO R11 SUSTITUIDO; Q ES (CH2)q; q ES 2-6. TAMBIEN SE REFIERE AL USO CON UN AGENTE REDUCTOR DE LIPIDOS TAL COMO UN INHIBIDOR DE HMG-CoA REDUCTASA SELECCIONADO ENTRE SIMVASTATIN, LOVASTATIN, PRAVASTATIN, FLUVASTATINA, ATORVASTATINA, ROSUVASTATIN; O UN SECUESTRANTE DE ACIDOS BILIARES TAL COMO COLESTIRAMINA, CLORHIDRATO DE COLESEVELAM, COLESTIPOL; UN INHIBIDOR DE BIOSINTESIS DE ESTEROLES EZETIMIBE.
PE2002000059A 2001-01-26 2002-01-25 Utilizacion de compuestos de azetidinona sustituida para tratamiento de la sitosterolemia PE20020850A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US26464501P 2001-01-26 2001-01-26

Publications (1)

Publication Number Publication Date
PE20020850A1 true PE20020850A1 (es) 2002-09-21

Family

ID=23006987

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2002000059A PE20020850A1 (es) 2001-01-26 2002-01-25 Utilizacion de compuestos de azetidinona sustituida para tratamiento de la sitosterolemia

Country Status (32)

Country Link
US (2) US7417039B2 (es)
EP (1) EP1355644B1 (es)
JP (2) JP4711600B2 (es)
KR (2) KR100820983B1 (es)
CN (1) CN100522159C (es)
AR (1) AR035533A1 (es)
AT (1) ATE331512T1 (es)
AU (1) AU2002243557B2 (es)
BR (1) BRPI0206641B8 (es)
CA (1) CA2434430A1 (es)
CY (1) CY1106149T1 (es)
CZ (1) CZ305202B6 (es)
DE (1) DE60212801T2 (es)
DK (1) DK1355644T3 (es)
ES (1) ES2266459T3 (es)
HU (1) HU230435B1 (es)
IL (2) IL156422A0 (es)
ME (1) ME00145B (es)
MX (1) MXPA03006729A (es)
MY (1) MY138301A (es)
NO (1) NO333695B1 (es)
NZ (1) NZ526532A (es)
PE (1) PE20020850A1 (es)
PL (1) PL205343B1 (es)
PT (1) PT1355644E (es)
RS (1) RS50406B (es)
RU (2) RU2756946C2 (es)
SI (1) SI1355644T1 (es)
SK (1) SK287746B6 (es)
TW (1) TWI337076B (es)
WO (1) WO2002058696A2 (es)
ZA (1) ZA200305691B (es)

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BR0206641A (pt) 2004-02-25
CA2434430A1 (en) 2002-08-01
EP1355644A2 (en) 2003-10-29
WO2002058696A2 (en) 2002-08-01
EP1355644B1 (en) 2006-06-28
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RU2007131955A (ru) 2009-02-27
JP4711600B2 (ja) 2011-06-29
CY1106149T1 (el) 2011-06-08
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ATE331512T1 (de) 2006-07-15
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AU2002243557B2 (en) 2006-01-05
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