PE20020421A1 - Produccion de terpenoides ciclicos - Google Patents
Produccion de terpenoides ciclicosInfo
- Publication number
- PE20020421A1 PE20020421A1 PE2001000881A PE2001000881A PE20020421A1 PE 20020421 A1 PE20020421 A1 PE 20020421A1 PE 2001000881 A PE2001000881 A PE 2001000881A PE 2001000881 A PE2001000881 A PE 2001000881A PE 20020421 A1 PE20020421 A1 PE 20020421A1
- Authority
- PE
- Peru
- Prior art keywords
- methylobacter
- encoding gene
- production
- cyclic
- substrate
- Prior art date
Links
- 150000003505 terpenes Chemical class 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- BDAGIHXWWSANSR-UHFFFAOYSA-N Formic acid Chemical compound OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 abstract 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- 241000589350 Methylobacter Species 0.000 abstract 3
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical class O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 abstract 2
- 102000001390 Fructose-Bisphosphate Aldolase Human genes 0.000 abstract 2
- 108010068561 Fructose-Bisphosphate Aldolase Proteins 0.000 abstract 2
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- NDVASEGYNIMXJL-UHFFFAOYSA-N sabinene Chemical compound C=C1CCC2(C(C)C)C1C2 NDVASEGYNIMXJL-UHFFFAOYSA-N 0.000 abstract 2
- 239000000758 substrate Substances 0.000 abstract 2
- NDVASEGYNIMXJL-NXEZZACHSA-N (+)-sabinene Natural products C=C1CC[C@@]2(C(C)C)[C@@H]1C2 NDVASEGYNIMXJL-NXEZZACHSA-N 0.000 abstract 1
- NFBQIWJDUKFHJP-SQOUGZDYSA-N (2r,3s,4r,5r)-3,4,5,6-tetrahydroxy-2-phosphonooxyhexanoic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](C(O)=O)OP(O)(O)=O NFBQIWJDUKFHJP-SQOUGZDYSA-N 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- WEEGYLXZBRQIMU-UHFFFAOYSA-N Eucalyptol Chemical compound C1CC2CCC1(C)OC2(C)C WEEGYLXZBRQIMU-UHFFFAOYSA-N 0.000 abstract 1
- 241000589344 Methylomonas Species 0.000 abstract 1
- KQAZVFVOEIRWHN-UHFFFAOYSA-N alpha-thujene Natural products CC1=CCC2(C(C)C)C1C2 KQAZVFVOEIRWHN-UHFFFAOYSA-N 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- RNBGYGVWRKECFJ-ARQDHWQXSA-N beta-D-fructofuranose 1,6-bisphosphate Chemical compound O[C@H]1[C@H](O)[C@@](O)(COP(O)(O)=O)O[C@@H]1COP(O)(O)=O RNBGYGVWRKECFJ-ARQDHWQXSA-N 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 239000001569 carbon dioxide Chemical class 0.000 abstract 1
- 229910002092 carbon dioxide Inorganic materials 0.000 abstract 1
- RFFOTVCVTJUTAD-UHFFFAOYSA-N cineole Natural products C1CC2(C)CCC1(C(C)C)O2 RFFOTVCVTJUTAD-UHFFFAOYSA-N 0.000 abstract 1
- 229960005233 cineole Drugs 0.000 abstract 1
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 abstract 1
- 235000011180 diphosphates Nutrition 0.000 abstract 1
- 239000000796 flavoring agent Substances 0.000 abstract 1
- 235000019634 flavors Nutrition 0.000 abstract 1
- 235000019253 formic acid Nutrition 0.000 abstract 1
- 239000003205 fragrance Substances 0.000 abstract 1
- 239000004434 industrial solvent Substances 0.000 abstract 1
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 abstract 1
- 230000000813 microbial effect Effects 0.000 abstract 1
- 108010071062 pinene cyclase I Proteins 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
- 229930006696 sabinene Natural products 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 108010087432 terpene synthase Proteins 0.000 abstract 1
- 235000007586 terpenes Nutrition 0.000 abstract 1
- 150000003573 thiols Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P23/00—Preparation of compounds containing a cyclohexene ring having an unsaturated side chain containing at least ten carbon atoms bound by conjugated double bonds, e.g. carotenes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E50/00—Technologies for the production of fuel of non-fossil origin
- Y02E50/30—Fuel from waste, e.g. synthetic alcohol or diesel
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Medicinal Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
SE REFIERE A UN METODO PARA LA PRODUCCION DE TERPENOS CICLICO A PARTIR DE GERANIL PIROFOSFATO EN UN HUESPED MICROBIANO METILOTROPICO O METANOTROPICO TRANSFORMADO COMO METHYLOMONAS 16a (ATTC PTA 2402), METHYLOBACTER, METHYLOCOCCUS, METHYLOSINUS, METHYLOCICTIS, METHYLOMICROBIUM, METHAMONAS, METHYLOPHILUS; QUE UTILIZAN LA VIA ISOPRENOIDE SIENDO EL SUSTRATO METANO, METANOL, FORMALDEHIDO, ACIDO FORMICO, AMINAS METILADAS, TIOLES METILADOS, DIOXIDO DE CARBONO; LA VIA EMBDEN MEYERHOF; VIA ENTNER DOUDEROFF Y ADEMAS CONTIENEN UN GEN CODIFICADOR DE TERPENO CICLICO SINTASA COMO SINTASA DE LIMONENO, PINENO, BORNIL, PELANDRENO, CINEOLE, SABINENO; BAJO EL CONTROL DE SECUENCIAS REGULADORAS; O UN GEN CODIFICADOR DE LA ENZIMA BISFOSFATO FRUCTOSA ALDOLASA; CETODEOXI FOSFOGLUCONATO ALDOLASA; MANTENIENDO A LAS CELULAS HUESPED EN CONDICIONES DE DESARROLLO CON UN SUSTRATO DE CARBONO. LOS MONOTERPENOS PROPORCIONAN SABOR Y FRAGANCIA Y SE UTILIZAN COMO COMPONENTES EN DISOLVENTES INDUSTRIALES SIENDO OBTENIDOS POR FUENTES NATURALES O SINTESIS QUIMICA, AMBOS PROCEDIMIENTOS CONSUMEN TIEMPO Y SON COSTOSOS
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22990700P | 2000-09-01 | 2000-09-01 | |
| US22985800P | 2000-09-01 | 2000-09-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20020421A1 true PE20020421A1 (es) | 2002-06-25 |
Family
ID=26923677
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2001000881A PE20020421A1 (es) | 2000-09-01 | 2001-09-03 | Produccion de terpenoides ciclicos |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US6818424B2 (es) |
| EP (2) | EP1313841A2 (es) |
| JP (2) | JP2005500805A (es) |
| KR (1) | KR20030034160A (es) |
| AU (2) | AU2001288477A1 (es) |
| CA (2) | CA2417246A1 (es) |
| IL (1) | IL154090A0 (es) |
| MX (1) | MXPA03001822A (es) |
| NO (2) | NO20030343L (es) |
| PE (1) | PE20020421A1 (es) |
| WO (2) | WO2002020815A2 (es) |
Families Citing this family (95)
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| US7105634B2 (en) * | 2002-02-11 | 2006-09-12 | E. I. Du Pont De Nemours And Company | Genetic constructs encoding carotenoid biosynthetic enzymes |
| US7186523B2 (en) * | 2002-05-06 | 2007-03-06 | E. I. Du Pont De Nemours And Company | Method for synthesis of aryl-carotenoids |
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| EP1313841A2 (en) | 2003-05-28 |
| KR20030034160A (ko) | 2003-05-01 |
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| US6969595B2 (en) | 2005-11-29 |
| US20020142408A1 (en) | 2002-10-03 |
| WO2002020815A2 (en) | 2002-03-14 |
| JP2005503103A (ja) | 2005-02-03 |
| CA2417261A1 (en) | 2002-03-07 |
| EP1328639A2 (en) | 2003-07-23 |
| NO20030343L (no) | 2003-04-03 |
| WO2002020815A3 (en) | 2003-02-06 |
| NO20030960D0 (no) | 2003-02-28 |
| MXPA03001822A (es) | 2003-09-10 |
| IL154090A0 (en) | 2003-07-31 |
| WO2002018617A2 (en) | 2002-03-07 |
| NO20030960L (no) | 2003-04-09 |
| US20030003528A1 (en) | 2003-01-02 |
| JP2005500805A (ja) | 2005-01-13 |
| WO2002018617A3 (en) | 2003-05-22 |
| AU2001288477A1 (en) | 2002-03-22 |
| US6818424B2 (en) | 2004-11-16 |
| AU2001288699A1 (en) | 2002-03-13 |
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