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MX2017001859A - Produccion de glicosidos de esteviol en hospederos recombinantes. - Google Patents

Produccion de glicosidos de esteviol en hospederos recombinantes.

Info

Publication number
MX2017001859A
MX2017001859A MX2017001859A MX2017001859A MX2017001859A MX 2017001859 A MX2017001859 A MX 2017001859A MX 2017001859 A MX2017001859 A MX 2017001859A MX 2017001859 A MX2017001859 A MX 2017001859A MX 2017001859 A MX2017001859 A MX 2017001859A
Authority
MX
Mexico
Prior art keywords
production
steviol glycosides
recombinant hosts
steviol
recombinant
Prior art date
Application number
MX2017001859A
Other languages
English (en)
Inventor
Dalgaard Mikkelsen Michael
Douchin Veronique
Møller HANSEN Iben
Original Assignee
Evolva Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Evolva Sa filed Critical Evolva Sa
Publication of MX2017001859A publication Critical patent/MX2017001859A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/44Preparation of O-glycosides, e.g. glucosides
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L27/00Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/30Artificial sweetening agents
    • A23L27/33Artificial sweetening agents containing sugars or derivatives
    • A23L27/36Terpene glycosides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00Processes for the preparation of sugar derivatives
    • C07H1/06Separation; Purification
    • C07H1/08Separation; Purification from natural products
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14Fungi; Culture media therefor
    • C12N1/16Yeasts; Culture media therefor

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Molecular Biology (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Nutrition Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Botany (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Saccharide Compounds (AREA)

Abstract

La invención se refiere a microorganismos recombinantes y métodos para producir glicósidos de esteviol y precursores de glicósido de esteviol.
MX2017001859A 2014-08-11 2015-08-07 Produccion de glicosidos de esteviol en hospederos recombinantes. MX2017001859A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462035902P 2014-08-11 2014-08-11
PCT/EP2015/068314 WO2016023844A1 (en) 2014-08-11 2015-08-07 Production of steviol glycosides in recombinant hosts

Publications (1)

Publication Number Publication Date
MX2017001859A true MX2017001859A (es) 2017-04-11

Family

ID=53836078

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017001859A MX2017001859A (es) 2014-08-11 2015-08-07 Produccion de glicosidos de esteviol en hospederos recombinantes.

Country Status (11)

Country Link
US (3) US10421983B2 (es)
EP (1) EP3179869A1 (es)
JP (1) JP2017528125A (es)
KR (1) KR20170041209A (es)
CN (2) CN114410493A (es)
AU (1) AU2015303294A1 (es)
BR (1) BR112017002783A2 (es)
CA (1) CA2957331A1 (es)
MX (1) MX2017001859A (es)
SG (2) SG10201901007PA (es)
WO (1) WO2016023844A1 (es)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ604915A (en) 2010-06-02 2014-10-31 Evolva Nutrition Inc Recombinant production of steviol glycosides
CN103732753B (zh) 2011-08-08 2018-03-30 埃沃尔瓦公司 甜菊醇糖苷类的重组生产
EP3892728A1 (en) 2013-02-06 2021-10-13 Evolva SA Methods for improved production of rebaudioside d and rebaudioside m
SG10201705993YA (en) 2013-02-11 2017-08-30 Evolva Sa Efficient production of steviol glycosides in recombinant hosts
MX2017001859A (es) 2014-08-11 2017-04-11 Evolva Sa Produccion de glicosidos de esteviol en hospederos recombinantes.
KR20170052647A (ko) 2014-09-09 2017-05-12 에볼바 에스아 재조합 숙주에서 스테비올 글리코시드의 생성
WO2016100689A1 (en) 2014-12-17 2016-06-23 Cargill, Incorporated Steviol glycoside compounds, compositions for oral ingestion or use, and method for enhancing steviol glycoside solubility
JP2018503388A (ja) 2015-01-30 2018-02-08 エヴォルヴァ エスアー.Evolva Sa. 組み換え宿主におけるステビオールグリコシドの生産
US10604743B2 (en) 2015-03-16 2020-03-31 Dsm Ip Assets B.V. UDP-glycosyltransferases
BR112017021066B1 (pt) 2015-04-03 2022-02-08 Dsm Ip Assets B.V. Glicosídeos de esteviol, método para a produção de um glicosídeo de esteviol, composição, usos relacionados, gênero alimentício, alimento para animais e bebida
CA2995067A1 (en) 2015-08-07 2017-02-16 Evolva Sa Production of steviol glycosides in recombinant hosts
BR112018011611A2 (pt) * 2015-12-10 2018-11-27 Evolva Sa produção de glicosídeos de esteviol em hospedeiros recombinantes
CA3020671A1 (en) 2016-04-13 2017-10-19 Evolva Sa Production of steviol glycosides in recombinant hosts
WO2017198682A1 (en) 2016-05-16 2017-11-23 Evolva Sa Production of steviol glycosides in recombinant hosts
WO2017218888A1 (en) * 2016-06-17 2017-12-21 Cargill, Incorporated Steviol glycoside compositions for oral ingestion or use
ES2906310T3 (es) * 2016-08-12 2022-04-18 Amyris Inc Glicosiltransferasa dependiente de UDP para la producción de alta eficiencia de rebaudiósidos
WO2018083338A1 (en) 2016-11-07 2018-05-11 Evolva Sa Production of steviol glycosides in recombinant hosts
WO2018111194A1 (en) * 2016-12-16 2018-06-21 Temasek Life Sciences Laboratory Limited Targets for improving terpene production in rhodosporidium toruloides
CN106636133A (zh) * 2016-12-26 2017-05-10 四川农业大学 玉米低镁条件下特异性转运镁离子基因ZmMGT10及其应用
WO2018211032A1 (en) * 2017-05-17 2018-11-22 Evolva Sa Production of steviol glycosides in recombinant hosts
AU2018291372A1 (en) * 2017-06-30 2020-01-16 Zimitech, Inc. Engineered microorganisms for enhanced use of oligosaccharides
BR112020002708A2 (pt) * 2017-08-11 2020-08-25 Amyris, Inc. célula hospedeira, métodos para produzir ácido caurenoico, rebaudiosídeo d, rebaudiosídeo m e glicosídeo de esteviol, composição de fermentação, caureno oxidase de ocorrência não natural, e, ácido nucleico de ocorrência não natural
GB2566516A (en) 2017-09-15 2019-03-20 Univ Oxford Innovation Ltd Electrochemical recognition and quantification of cytochrome c oxidase expression in bacteria
EP3720968A1 (en) * 2017-12-05 2020-10-14 Evolva SA Production of steviol glycosides in recombinant hosts
WO2019211230A1 (en) 2018-04-30 2019-11-07 Dsm Ip Assets B.V. Steviol glycoside transport
EP3877519A4 (en) 2018-11-09 2022-08-24 Ginkgo Bioworks, Inc. BIOSYNTHESIS OF MOGROSIDS
AU2020211408A1 (en) 2019-01-24 2021-08-12 Amyris, Inc. ABC transporters for the high efficiency production of rebaudiosides
CN110551643A (zh) * 2019-07-19 2019-12-10 天津科技大学 通过调控脯氨酸代谢途径构建的低产高级醇酿酒酵母菌株
CN113801798B (zh) * 2021-08-02 2023-07-28 广西大学 食腺嘌呤节孢酵母a50菌株、所产胞外多糖及其应用
CN118374427B (zh) * 2024-05-07 2025-01-24 山东三元生物科技股份有限公司 一株催化甜菊糖粗糖生成莱鲍迪甙d的重组菌及其应用

Family Cites Families (143)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58149697A (ja) 1982-02-27 1983-09-06 Dainippon Ink & Chem Inc β−1,3グリコシルステビオシドの製造方法
JPS59101408A (ja) 1982-12-02 1984-06-12 Junichi Iwamura 植物生長調整剤
US5198360A (en) 1990-01-19 1993-03-30 Eli Lilly And Company Dna sequence conferring a plaque inhibition phenotype
US6946587B1 (en) 1990-01-22 2005-09-20 Dekalb Genetics Corporation Method for preparing fertile transgenic corn plants
US5484956A (en) 1990-01-22 1996-01-16 Dekalb Genetics Corporation Fertile transgenic Zea mays plant comprising heterologous DNA encoding Bacillus thuringiensis endotoxin
JPH03277275A (ja) 1990-03-28 1991-12-09 Dainippon Ink & Chem Inc 新規酵素及びその酵素を用いた配糖体の製造方法
US5204253A (en) 1990-05-29 1993-04-20 E. I. Du Pont De Nemours And Company Method and apparatus for introducing biological substances into living cells
US5306862A (en) 1990-10-12 1994-04-26 Amoco Corporation Method and composition for increasing sterol accumulation in higher plants
US5460949A (en) 1990-11-15 1995-10-24 Amoco Corporation Method and composition for increasing the accumulation of squalene and specific sterols in yeast
US5712112A (en) 1992-11-04 1998-01-27 National Science Council Of R.O.C. Gene expression system comprising the promoter region of the alpha-amylase genes
EP0785988A1 (en) 1993-07-15 1997-07-30 Neose Pharmaceuticals, Inc Method of synthesizing saccharide compositions
US7186891B1 (en) 1996-04-12 2007-03-06 University Of Kentucky, Research Foundation Plant cells and plants expressing chimeric isoprenoid synthases
JPH10117776A (ja) 1996-10-22 1998-05-12 Japan Tobacco Inc インディカイネの形質転換方法
JP2001519164A (ja) 1997-10-06 2001-10-23 ザ サーントル ナショナル ド ルシエルシュ シアンティフィク 植物脂肪酸ヒドロキシラーゼ遺伝子
US6255557B1 (en) 1998-03-31 2001-07-03 Her Majesty The Queen In Right Of Canada As Represented By The Ministerof Agriculture And Agri-Food Canada Stevia rebaudiana with altered steviol glycoside composition
US6806076B1 (en) 1998-04-14 2004-10-19 Kyowa Hakko Kogyo Co., Ltd. Process for producing isoprenoid compounds by microorganisms and a method for screening compounds with antibiotic or weeding activity
EP0955363A3 (en) 1998-05-06 2004-01-28 F. Hoffmann-La Roche Ag Dna sequences encoding enzymes involved in production of isoprenoids
TWI250210B (en) 1998-05-06 2006-03-01 Dsm Ip Assets Bv An isolated DNA sequence coding for an enzyme involved in the mevalonate pathway or the pathway from isopentenyl pyrophosphate to farnesyl pyrophosphate
EP2100963B1 (en) 1998-07-06 2011-12-14 DCV Inc. doing business as Bio-Technical Resourses Method of vitamin production
US6531303B1 (en) 1998-07-06 2003-03-11 Arkion Life Sciences Llc Method of producing geranylgeraniol
AR021636A1 (es) 1998-12-17 2002-07-31 Rubicon Forests Holdings Ltd Materiales y metodos para la modificacion del contenido, la composicion y el metabolismo de los isoprenoides
AU2594300A (en) 1998-12-23 2000-07-12 Samuel Roberts Noble Foundation, Inc., The Plant transformation process
EP1190068B1 (en) 1999-04-15 2006-01-25 Calgene LLC Nucleic acid sequences to proteins involved in tocopherol synthesis
NZ513993A (en) 1999-04-21 2001-09-28 Samuel Roberts Noble Found Inc Plant transformation process
EP1198575B1 (en) 1999-08-04 2007-09-19 Adelbert Bacher Isoprenoid biosynthesis
WO2001012828A1 (en) 1999-08-18 2001-02-22 Paradigm Genetics, Inc. Methods and apparatus for transformation of monocotyledenous plants using agrobacterium in combination with vacuum filtration
AU2001269685A1 (en) 2000-05-03 2001-11-12 The Salk Institute For Biological Studies Crystallization of 4-diphosphocytidyl-2-c-methylerythritol synthesis
DE10027821A1 (de) 2000-06-05 2001-12-06 Adelbert Bacher Der Mevalonat-unabhängige Isoprenoidbiosyntheseweg
EP2281890A1 (en) 2000-07-31 2011-02-09 Danisco US Inc. Manipulation of genes of the mevalonate and isoprenoid pathways to create novel traits in transgenic organisms
US7109033B2 (en) 2000-08-24 2006-09-19 The Scripps Research Institute Stress-regulated genes of plants, transgenic plants containing same, and methods of use
US6818424B2 (en) 2000-09-01 2004-11-16 E. I. Du Pont De Nemours And Company Production of cyclic terpenoids
US6689601B2 (en) 2000-09-01 2004-02-10 E. I. Du Pont De Nemours And Company High growth methanotropic bacterial strain
US6660507B2 (en) 2000-09-01 2003-12-09 E. I. Du Pont De Nemours And Company Genes involved in isoprenoid compound production
EP1409530A2 (en) 2000-09-19 2004-04-21 Microbia, Inc. Modulation of secondary metabolite production by zinc binuclear cluster proteins
ATE384119T1 (de) 2000-09-29 2008-02-15 Cargill Inc Isoprenoidproduktion
US6949362B2 (en) 2000-12-12 2005-09-27 E. I. Du Pont De Nemours And Company Rhodococcus cloning and expression vectors
DK1356037T3 (da) 2001-01-25 2011-06-27 Evolva Ltd Bibliotek med en samling af celler
US20050003474A1 (en) 2001-01-26 2005-01-06 Desouza Mervyn L. Carotenoid biosynthesis
US20040078846A1 (en) 2002-01-25 2004-04-22 Desouza Mervyn L. Carotenoid biosynthesis
DE10201458A1 (de) 2001-04-11 2002-10-17 Adelbert Bacher Intermediate und Enzyme des Mevalonat-unabhängigen Isoprenoidbiosyntheseweg
US7034140B2 (en) 2001-04-24 2006-04-25 E.I. Du Pont De Nemours And Company Genes involved in isoprenoid compound production
CA2449885A1 (en) 2001-06-06 2002-12-12 Roche Vitamins Ag Improved isoprenoid production
AU2002341541A1 (en) 2001-06-22 2003-03-03 Syngenta Participations Ag Abiotic stress responsive polynucleotides and polypeptides
NZ513755A (en) 2001-08-24 2001-09-28 Ann Rachel Holmes Protein expression system in yeast comprising a vector encoding a heterologous membrane protein and its application in screening for drugs
US20040072311A1 (en) 2001-08-28 2004-04-15 Dicosimo Deana J. Production of cyclic terpenoids
US20040010815A1 (en) 2001-09-26 2004-01-15 Lange B. Markus Identification and characterization of plant genes
US7172886B2 (en) 2001-12-06 2007-02-06 The Regents Of The University Of California Biosynthesis of isopentenyl pyrophosphate
JP2005185101A (ja) 2002-05-30 2005-07-14 National Institute Of Agrobiological Sciences 植物の全長cDNAおよびその利用
US7514597B2 (en) 2002-08-20 2009-04-07 Suntory Limited Glycosyltransferase gene
EP1543115B1 (en) 2002-09-27 2008-05-07 DSM IP Assets B.V. Squalene synthase (sqs) gene
US7098000B2 (en) 2003-06-04 2006-08-29 E. I. Du Pont De Nemoure And Company Method for production of C30-aldehyde carotenoids
WO2004111214A1 (en) 2003-06-12 2004-12-23 Dsm Ip Assets B.V. Feedback-resistant mevalonate kinases
US7569389B2 (en) 2004-09-30 2009-08-04 Ceres, Inc. Nucleotide sequences and polypeptides encoded thereby useful for modifying plant characteristics
BRPI0510115B1 (pt) 2004-05-21 2022-09-27 The Regents Of The University Of California Método para produzir um isoprenóide ou precursor de isoprenóide através de uma via de mevalonato em escherichia coli e célula hospedeira geneticamente modificada que os produz
AU2005321630A1 (en) 2004-07-02 2006-07-06 Metanomics Gmbh Process for the production of fine chemicals
US20060014264A1 (en) 2004-07-13 2006-01-19 Stowers Institute For Medical Research Cre/lox system with lox sites having an extended spacer region
WO2006016395A1 (ja) 2004-08-09 2006-02-16 National University Corporation Tohoku University Udp−グルクロニル基転移酵素およびその遺伝子
CN101044243B (zh) 2004-08-19 2011-12-28 帝斯曼知识产权资产管理有限公司 类异戊二烯的生产方法
US7923552B2 (en) 2004-10-18 2011-04-12 SGF Holdings, LLC High yield method of producing pure rebaudioside A
WO2006063752A1 (en) 2004-12-14 2006-06-22 Dsm Ip Assets B.V. Improved mevalonate kinase
WO2006092449A2 (en) * 2005-03-02 2006-09-08 Metanomics Gmbh Process for the production of fine chemicals
WO2006096392A2 (en) 2005-03-04 2006-09-14 Diversa Corporation Enzymes involved in astaxanthin, carotenoid and isoprenoid biosynthetic pathways, genes encoding them and methods of making and using them
WO2006093289A1 (ja) 2005-03-04 2006-09-08 National Institute Of Advanced Industrial Science And Technology Udp-キシロースの製造方法
US7989677B2 (en) 2005-08-17 2011-08-02 Nestec S. A. Nucleic acids and proteins associated with sucrose accumulation in coffee
EP1916888A4 (en) 2005-08-22 2011-05-18 Co2 Boost Llc DEVICE AND PROCESS FOR GENERATING CO2 USED FOR HARVEST PRODUCTION AND SUBMARINE GARDENING
US8293307B2 (en) 2005-10-11 2012-10-23 Purecircle Sdn Bhd Process for manufacturing a sweetener and use thereof
MX2008006583A (es) 2005-11-23 2008-05-31 Coca Cola Co Composiciones de edulcorante natural de alta potencia, con perfil de sabor y/o perfil temporal mejorado, metodos para su formulacion, y usos
KR100784261B1 (ko) 2006-01-02 2007-12-11 한국과학기술원 탄저균의 포자외막 단백질을 이용한 목적단백질의 미생물표면발현방법
US7927851B2 (en) 2006-03-21 2011-04-19 Vineland Research And Innovation Centre Compositions having ent-kaurenoic acid 13-hydroxylase activity and methods for producing same
CA2644273A1 (en) 2006-04-05 2008-03-27 Metanomics Gmbh Process for the production of a fine chemical
WO2007136847A2 (en) 2006-05-19 2007-11-29 The Regents Of The University Of California Methods for increasing isoprenoid and isoprenoid precursor production by modulating fatty acid levels
WO2007147275A1 (en) 2006-06-19 2007-12-27 Givaudan Sa Nucleic acid, polypeptide and its use
WO2008008256A2 (en) 2006-07-07 2008-01-17 The Regents Of The University Of California Methods for enhancing production of isoprenoid compounds by host cells
EP3020799B1 (en) 2006-09-26 2020-08-26 The Regents of The University of California Production of isoprenoids and isoprenoid precursors
US7741119B2 (en) 2006-09-28 2010-06-22 E. I. Du Pont De Nemours And Company Xylitol synthesis mutant of xylose-utilizing zymomonas for ethanol production
US7629156B2 (en) 2006-09-28 2009-12-08 E.I. Du Pont De Nemours And Company Ethanol production in fermentation of mixed sugars containing xylose
CN101200480B (zh) 2006-12-15 2011-03-30 成都华高药业有限公司 莱鲍迪甙a的提取方法
JP4915917B2 (ja) 2006-12-22 2012-04-11 独立行政法人農業・食品産業技術総合研究機構 ラクト−n−ビオースi及びガラクト−n−ビオースの製造方法
ATE547953T1 (de) 2007-01-22 2012-03-15 Cargill Inc Verfahren zur herstellung gereinigter rebaudiosid-a-zusammensetzungen durch solvent/antisolvent- kristallisation
JP2008237110A (ja) 2007-03-27 2008-10-09 Institute Of Physical & Chemical Research ステビオール合成酵素遺伝子及びステビオールの製造方法
WO2008144060A2 (en) 2007-05-17 2008-11-27 Tetravitae Bioscience, Inc. Methods and compositions for producing solvents
US20080292775A1 (en) 2007-05-22 2008-11-27 The Coca-Cola Company Delivery Systems for Natural High-Potency Sweetener Compositions, Methods for Their Formulation, and Uses
WO2009005704A1 (en) 2007-07-03 2009-01-08 The Regents Of The University Of California Methods of increasing isoprenoid or isoprenoid precursor production
JP2009034080A (ja) 2007-08-03 2009-02-19 Sanei Gen Ffi Inc 新規糖転移酵素、及びそれを利用した配糖体の製造
US7964232B2 (en) 2007-09-17 2011-06-21 Pepsico, Inc. Steviol glycoside isomers
EP2594646A3 (en) 2007-09-21 2013-11-06 BASF Plant Science GmbH Plant with increased yield
NZ585720A (en) 2007-12-03 2012-05-25 Dsm Ip Assets Bv Novel nutraceutical compositions containing stevia extract or stevia extract constituents and uses thereof
CA2710629C (en) 2007-12-27 2016-06-21 Mcneil Nutritionals, Llc Synergistic sweetening compositions
CA2715397A1 (en) 2008-02-20 2009-08-27 Ceres, Inc. Nucleotide sequences and corresponding polypeptides conferring improved nitrogen use efficiency characteristics in plants
TWI475963B (zh) 2008-02-25 2015-03-11 可口可樂公司 甜菊糖苷a衍生性產物以及製造彼的方法
EP2285948B1 (en) 2008-03-03 2014-01-08 Joule Unlimited Technologies, Inc. Engineered co2 fixing microorganisms producing carbon-based products of interest
CN101255432B (zh) * 2008-03-03 2011-11-30 创世纪转基因技术有限公司 人工改造合成的杀虫基因及其编码的蛋白质与应用
WO2009140394A1 (en) 2008-05-13 2009-11-19 Cargill, Incorporated Separation of rebaudioside a from stevia glycosides using chromatography
CN101314776B (zh) 2008-07-11 2010-11-03 南京农业大学 二磷酸尿核甘葡萄糖基转移酶基因及其所编码的蛋白质
WO2010021001A2 (en) 2008-08-19 2010-02-25 Kaushik Ramakrishnan S Process for preparing sweetener from stevia rebaudiana
CN102216313A (zh) 2008-10-03 2011-10-12 守田化学工业株式会社 新的甜菊醇糖苷
CN101720910B (zh) 2008-10-23 2012-07-25 大闽食品(漳州)有限公司 一种甜菊糖甙的制备方法
US8614085B2 (en) 2009-02-27 2013-12-24 Butamax(Tm) Advanced Biofuels Llc Yeast with increased butanol tolerance involving a multidrug efflux pump gene
US20100297722A1 (en) 2009-05-20 2010-11-25 Board Of Trustees Of Southern Illinois University Transgenic moss producing terpenoids
RU2517602C2 (ru) 2009-06-08 2014-05-27 Йенневайн Биотехнологи Гмбх Синтез нмо
BRPI1010766A2 (pt) 2009-06-16 2015-09-22 Epc Beeijing Natural Products Co Ltd processo para rebaudiosídeo d
US20120164083A1 (en) 2009-09-04 2012-06-28 Redpoint Bio Corporation Sweetness Enhancers Including Rebaudioside A or D
BR112012006282A2 (pt) 2009-09-22 2015-09-01 Redpoint Bio Corp Forma cristalina i de rebaudiosídeo c isolada, métodos para fabricar a mesma, para purificar rebaudiosídeo c, para intensificar um sabor doce de um adoçante de carboidrato, para diminuir a quantiddae de um adoçante de carboidrato em um produto consumível, e para aumentar a doçura de um produto consumível, e, produto consumível.
US8299224B2 (en) 2009-10-15 2012-10-30 Purecircle Sdn Bhd High-purity Rebaudioside D
CA2775732C (en) 2009-10-15 2018-10-09 Purecircle Sdn Bhd High-purity rebaudioside d and applications
US8703224B2 (en) 2009-11-04 2014-04-22 Pepsico, Inc. Method to improve water solubility of Rebaudioside D
ES2575790T3 (es) 2009-11-10 2016-07-01 Massachusetts Insitute Of Technology Ingeniería microbiana para la preparación de productos químicos y farmacéuticos a partir de la vía isoprenoide
BR112012012374A2 (pt) 2009-11-23 2015-09-15 Du Pont semente de planta com maior teor de óleo, planta, método para aumentar ainda mais o teor de óleo em uma semente de planta de alto teor de óleo, método par avaliar o teor de óleo aumentado em uma semente de planta, polinucleotídeo isolado polipeptídeo isolado
US8586363B2 (en) 2009-12-10 2013-11-19 Regents Of The University Of Minnesota TAL effector-mediated DNA modification
CN104855925B (zh) 2009-12-28 2017-04-26 可口可乐公司 甜味增强剂,其组合物,及使用方法
KR101244315B1 (ko) 2010-10-19 2013-03-14 이화여자대학교 산학협력단 에탄올―저항성 효모 유전자 및 이의 용도
US9441233B2 (en) 2010-05-06 2016-09-13 Ceres, Inc. Transgenic plants having increased biomass
WO2011146833A1 (en) 2010-05-20 2011-11-24 Evolva Inc. Method of producing isoprenoid compounds in yeast
EP2575499A2 (en) * 2010-05-31 2013-04-10 Vib Vzw The use of transporters to modulate flavor production by yeast
NZ604915A (en) 2010-06-02 2014-10-31 Evolva Nutrition Inc Recombinant production of steviol glycosides
US20120021111A1 (en) 2010-07-23 2012-01-26 Aexelon Therapeutics, Inc. Natural Low Caloric Sweetener Compositions for Use in Beverages, Foods and Pharmaceuticals, and Their Methods of Manufacture
US20120083593A1 (en) 2010-10-01 2012-04-05 Shanghai Yongyou Bioscience Inc. Separation and Purification of Stevioside and Rebaudioside A
WO2012075030A1 (en) 2010-11-30 2012-06-07 Massachusetts Institute Of Technology Microbial production of natural sweeteners, diterpenoid steviol glycosides
KR20130014227A (ko) 2011-07-29 2013-02-07 한국생명공학연구원 신규한 α-글루코실 스테비오사이드 및 이의 제조 방법
CN103732753B (zh) * 2011-08-08 2018-03-30 埃沃尔瓦公司 甜菊醇糖苷类的重组生产
HK1199286A1 (en) 2011-08-08 2015-06-26 Evolva Sa Methods and materials for recombinant production of saffron compounds
IN2014CN03557A (es) 2011-11-23 2015-10-09 Evolva Sa
CN103159808B (zh) 2011-12-09 2017-03-29 上海泓博智源医药股份有限公司 一种制备天然甜味剂的工艺方法
EP3345490B1 (en) 2011-12-19 2023-11-08 The Coca-Cola Company Beverage comprising rebaudioside x
WO2013110673A1 (en) 2012-01-23 2013-08-01 Dsm Ip Assets B.V. Diterpene production
CN102559528B (zh) 2012-02-09 2013-08-21 南京工业大学 一种产甜叶菊糖基转移酶ugt76g1的基因工程菌及其应用
EP2826861B1 (en) 2012-03-16 2020-04-29 Suntory Holdings Limited Steviol glycosyltransferase and gene encoding same
CN110358795B (zh) 2012-05-22 2024-12-03 谱赛科有限责任公司 高纯度的甜菊醇糖苷
CN103710318B (zh) 2012-09-29 2017-01-18 中国科学院上海生命科学研究院 利用微生物生产甜菊糖苷类化合物的方法
US20150342234A1 (en) 2012-12-05 2015-12-03 Evolva Sa Steviol Glycoside Compositions Sensory Properties
EP3892728A1 (en) 2013-02-06 2021-10-13 Evolva SA Methods for improved production of rebaudioside d and rebaudioside m
SG10201705993YA (en) 2013-02-11 2017-08-30 Evolva Sa Efficient production of steviol glycosides in recombinant hosts
AU2014273055A1 (en) 2013-05-31 2015-12-17 Dsm Ip Assets B.V. Microorganisms for diterpene production
BR112015029601A2 (pt) 2013-05-31 2017-09-26 Dsm Ip Assets Bv produção de diterpeno extracelular
KR101559478B1 (ko) 2013-06-24 2015-10-13 한국생명공학연구원 효소전환법을 이용한 천연 고감미료의 제조방법
EP3024941B1 (en) 2013-07-23 2019-07-03 DSM IP Assets B.V. Diterpene production in yarrowia
MX2016000825A (es) 2013-07-31 2016-05-24 Dsm Ip Assets Bv Glicosidos de esteviol.
BR112016002092B1 (pt) 2013-07-31 2020-12-15 Dsm Ip Assets B.V. Recuperação de glicosídeos de esteviol
WO2015016393A1 (ja) 2013-08-02 2015-02-05 サントリーホールディングス株式会社 ヘキセノール配糖体化酵素の利用方法
CN103397064B (zh) 2013-08-14 2015-04-15 苏州汉酶生物技术有限公司 一种酶法制备瑞鲍迪甙m的方法
MX2017001859A (es) 2014-08-11 2017-04-11 Evolva Sa Produccion de glicosidos de esteviol en hospederos recombinantes.
KR20170052647A (ko) 2014-09-09 2017-05-12 에볼바 에스아 재조합 숙주에서 스테비올 글리코시드의 생성
CA2995067A1 (en) 2015-08-07 2017-02-16 Evolva Sa Production of steviol glycosides in recombinant hosts

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