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PE20010208A1 - Derivados de indolilpiperidina como agentes antihistaminicos y antialergicos - Google Patents

Derivados de indolilpiperidina como agentes antihistaminicos y antialergicos

Info

Publication number
PE20010208A1
PE20010208A1 PE2000000524A PE0005242000A PE20010208A1 PE 20010208 A1 PE20010208 A1 PE 20010208A1 PE 2000000524 A PE2000000524 A PE 2000000524A PE 0005242000 A PE0005242000 A PE 0005242000A PE 20010208 A1 PE20010208 A1 PE 20010208A1
Authority
PE
Peru
Prior art keywords
alkylene
antihistamine
allergic
alcoxialkyl
alcoxy
Prior art date
Application number
PE2000000524A
Other languages
English (en)
Inventor
Duran Carles Puig
Forner Dolors Fernandez
Santacana Lluis Pages
Pou Silvia Fonquerna
Original Assignee
Almirall Prodesfarma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Almirall Prodesfarma Sa filed Critical Almirall Prodesfarma Sa
Publication of PE20010208A1 publication Critical patent/PE20010208A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Otolaryngology (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE REFIERE A DERIVADOS DE INDOLILPIPERIDINA DE FORMULA I, DONDE: A1 ES ALQUILENO, ALQUILENOXI, ALQUILENTIO, ALCANOIL, HIDROXIALQUILENO; A2 ES UN ENLACE, ALQUILENO, ALQUENILENO; W ES UN ENLACE, FENILENO, FURANILENO OPCIONALMENTE SUSTITUIDO CON HALOGENO, ALCOXI, ALQUILO; R1 ES H, ALQUILO, ALQUENILO, ALQUINILO, ALCOXIALQUILO, ALQUENILOXIALQUILO, ALCOXI-ALCOXIALQUILO, FENILALQUILO, ENTRE OTROS; R2 ES H, HALOGENO, ALQUILO, ALCOXI; R3 ES CARBOXILO, TETRAZOLILO. SON COMPUESTOS PREFERIDOS ACIDO 2-(2-{4-[1-(4-FLUOROBENCIL)-1H-INDOL-3-IL]PIPERIDIN-1-IL}ETOXI)BENZOICO; ACIDO 2-{2-[4-(1-PENTIL-1H-INDOL-3-IL)PIPERIDIN-1-IL]ETOXI}BENZOICO, ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. EL COMPUESTO I ES UN AGENTE ANTIHISTAMINICO Y ANTIALERGICO Y PUEDEN SER UTILES PARA EL TRATAMIENTO DE ENFERMEDADES ALERGICAS, ASMA BRONQUIAL, RINITIS ALERGICA, CONJUNTIVITIS, DERMATOSIS, URTICARIA
PE2000000524A 1999-06-04 2000-05-31 Derivados de indolilpiperidina como agentes antihistaminicos y antialergicos PE20010208A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES009901232A ES2165274B1 (es) 1999-06-04 1999-06-04 Nuevos derivados de indolilpiperidina como agentes antihistaminicos y antialergicos.

Publications (1)

Publication Number Publication Date
PE20010208A1 true PE20010208A1 (es) 2001-03-19

Family

ID=8308707

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2000000524A PE20010208A1 (es) 1999-06-04 2000-05-31 Derivados de indolilpiperidina como agentes antihistaminicos y antialergicos

Country Status (35)

Country Link
US (1) US6683096B2 (es)
EP (1) EP1183251B1 (es)
JP (1) JP2003501424A (es)
KR (1) KR100683454B1 (es)
CN (1) CN1191246C (es)
AR (1) AR029640A1 (es)
AT (1) ATE259362T1 (es)
AU (1) AU773164B2 (es)
BG (1) BG106168A (es)
BR (1) BR0011340A (es)
CA (1) CA2375985A1 (es)
CO (1) CO5180556A1 (es)
CZ (1) CZ20014334A3 (es)
DE (1) DE60008239T2 (es)
DK (1) DK1183251T3 (es)
EE (1) EE04717B1 (es)
ES (2) ES2165274B1 (es)
HK (1) HK1040990A1 (es)
HU (1) HUP0203320A3 (es)
IL (1) IL146629A0 (es)
MX (1) MXPA01012425A (es)
MY (1) MY127033A (es)
NO (1) NO20015897D0 (es)
NZ (1) NZ515649A (es)
PE (1) PE20010208A1 (es)
PL (1) PL196774B1 (es)
PT (1) PT1183251E (es)
RU (1) RU2246493C2 (es)
SI (1) SI1183251T1 (es)
SK (1) SK17042001A3 (es)
TR (1) TR200103490T2 (es)
TW (1) TWI226889B (es)
UA (1) UA72517C2 (es)
WO (1) WO2000075130A1 (es)
ZA (1) ZA200109676B (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0107624A (pt) 2000-01-17 2002-11-12 Bayer Ag Arilcetonas substituìdas
ES2172436B1 (es) 2000-10-31 2004-01-16 Almirall Prodesfarma Sa Derivados de indolilpiperidina como agentes antihistaminicos y antialergicos.
AU2002243394A1 (en) * 2000-11-16 2002-06-24 Wyeth Aryloxy piperidinyl derivatives for the treatment of depression
ES2201899B1 (es) 2002-04-01 2005-06-01 Almirall Prodesfarma, S.A. Derivados de la azaindolilpiperidina como agentes antihistaminicos y antialergicos.
ES2201907B1 (es) 2002-05-29 2005-06-01 Almirall Prodesfarma, S.A. Nuevos derivados de indolilpiperidina como potentes agentes antihistaminicos y antialergicos.
EP1687294B1 (en) 2003-11-17 2014-05-21 Boehringer Ingelheim International GmbH Novel piperidine-substituted indoles-or hetero-derivatives thereof and their use as modulators of chemokine receptor (ccr-3)
US20050245540A1 (en) * 2003-12-09 2005-11-03 Fujisawa Pharmaceutical Co., Ltd. New methods
KR101235090B1 (ko) 2004-04-13 2013-02-20 인사이트 코포레이션 케모킨 수용체 길항제로서의 피페라지닐피페리딘 유도체
US20060009491A1 (en) * 2004-06-24 2006-01-12 Incyte Corporation Amido compounds and their use as pharmaceuticals
EP1758580A4 (en) 2004-06-24 2008-01-16 Incyte Corp N-SUBSTITUTED PIPERIDINE AND ITS USE AS A MEDICAMENT
EP1877390B1 (en) * 2005-04-26 2010-03-24 Hypnion, Inc. Benzisoxazole piperazine compounds and methods of use thereof
WO2006117314A2 (en) 2005-04-30 2006-11-09 Boehringer Ingelheim International Gmbh Novel piperidin- substituted indoles and their use as ccr-3 modulators
US20060275516A1 (en) * 2005-06-02 2006-12-07 Ram A N S Compositions and methods for the treatment of allergic rhinitis
US20080108586A1 (en) * 2006-09-06 2008-05-08 Incyte Corporation Combination therapy for human immunodeficiency virus infection
WO2008049874A1 (en) 2006-10-27 2008-05-02 Boehringer Ingelheim International Gmbh Piperidyl-propane-thiol ccr3 modulators
JP5550352B2 (ja) 2007-03-15 2014-07-16 ノバルティス アーゲー 有機化合物およびその使用
US20100041663A1 (en) 2008-07-18 2010-02-18 Novartis Ag Organic Compounds as Smo Inhibitors
CN101560179B (zh) * 2009-05-25 2012-04-18 浙江大学 具有h3受体亲和能力的含氮吲哚衍生物和用途
CN101747321B (zh) * 2009-12-22 2013-01-02 浙江大学 吲哚-3-苄胺衍生物及制备方法和用途
EP3040334A1 (en) * 2014-12-29 2016-07-06 Faes Farma, S.A. New benzimidazole derivatives as antihistamine agents
PE20241304A1 (es) * 2021-07-30 2024-06-24 Confo Therapeutics N V Compuestos para el tratamiento del dolor, en particular el dolor neuropatico, y/u otras enfermedades o trastornos que se asocian con at2r y/o senalizacion mediada por at2r

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4742057A (en) * 1985-12-05 1988-05-03 Fujisawa Pharmaceutical Co., Ltd. Antiallergic thiazole compounds
JPS63301881A (ja) * 1987-06-01 1988-12-08 Fujisawa Pharmaceut Co Ltd インドリルピペリジン誘導体
DK733788A (da) * 1988-01-14 1989-07-15 Fujisawa Pharmaceutical Co Indolylpiperidinderivater og fremgangsmaade til fremstilling deraf
GB8800795D0 (en) * 1988-01-14 1988-02-17 Fujisawa Pharmaceutical Co New indolylpiperidine compounds processes for preparations thereof & pharmaceutical composition comprising same
GB8900382D0 (en) * 1989-01-09 1989-03-08 Janssen Pharmaceutica Nv 2-aminopyrimidinone derivatives
PH30434A (en) * 1989-04-07 1997-05-09 Janssen Pharmaceutica Nv Hydroxyalkylfuranyl derivatives
EP0626968B1 (en) * 1992-02-13 2001-09-26 Merrell Pharmaceuticals Inc. Piperidinyl thiacyclic derivatives
IT1271417B (it) * 1993-10-15 1997-05-28 Erregierre Ind Chim Composti ad attivita' antiistaminica procedimento per la loro preperazione e composizioni farmaceutiche che li contengono.
DE19500689A1 (de) 1995-01-12 1996-07-18 Merck Patent Gmbh Indolpiperidin-Derivate
DE19707628A1 (de) 1997-02-26 1998-08-27 Merck Patent Gmbh Oxazolidinone
AR013669A1 (es) * 1997-10-07 2001-01-10 Smithkline Beecham Corp Compuestos y metodos
AR028685A1 (es) * 2000-06-14 2003-05-21 Lundbeck & Co As H Derivados de indol

Also Published As

Publication number Publication date
JP2003501424A (ja) 2003-01-14
CZ20014334A3 (cs) 2002-03-13
NO20015897L (no) 2001-12-03
RU2246493C2 (ru) 2005-02-20
DE60008239T2 (de) 2004-11-18
AU5527600A (en) 2000-12-28
PL196774B1 (pl) 2008-01-31
HK1040990A1 (zh) 2002-06-28
US6683096B2 (en) 2004-01-27
CA2375985A1 (en) 2000-12-14
SI1183251T1 (en) 2004-06-30
US20020147344A1 (en) 2002-10-10
ES2211559T3 (es) 2004-07-16
MXPA01012425A (es) 2002-06-04
DK1183251T3 (da) 2004-06-07
ES2165274A1 (es) 2002-03-01
NZ515649A (en) 2003-08-29
CO5180556A1 (es) 2002-07-30
TR200103490T2 (tr) 2002-04-22
PT1183251E (pt) 2004-05-31
ATE259362T1 (de) 2004-02-15
RU2002100073A (ru) 2004-01-10
AR029640A1 (es) 2003-07-10
EE200100653A (et) 2003-02-17
HUP0203320A3 (en) 2004-01-28
KR20020020721A (ko) 2002-03-15
SK17042001A3 (sk) 2002-04-04
NO20015897D0 (no) 2001-12-03
EP1183251A1 (en) 2002-03-06
ES2165274B1 (es) 2003-04-01
HUP0203320A2 (hu) 2003-02-28
ZA200109676B (en) 2003-02-24
EE04717B1 (et) 2006-10-16
DE60008239D1 (de) 2004-03-18
KR100683454B1 (ko) 2007-02-20
UA72517C2 (uk) 2005-03-15
MY127033A (en) 2006-11-30
CN1191246C (zh) 2005-03-02
BR0011340A (pt) 2002-03-05
AU773164B2 (en) 2004-05-20
BG106168A (bg) 2002-07-31
IL146629A0 (en) 2002-07-25
WO2000075130A1 (en) 2000-12-14
PL353164A1 (en) 2003-10-20
CN1368969A (zh) 2002-09-11
TWI226889B (en) 2005-01-21
EP1183251B1 (en) 2004-02-11

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Legal Events

Date Code Title Description
FG Grant, registration
FD Application declared void or lapsed