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AR029640A1 - Derivados de indolilpiperidinas que poseen actividad antihistaminica y antialergica, procesos para preparar dichos derivados y compuestos intermediarios utilizables en dicho proceso, composiciones formuladas con dichos derivados y uso de los derivados mencionados para el tratamiento del cuerpo human - Google Patents

Derivados de indolilpiperidinas que poseen actividad antihistaminica y antialergica, procesos para preparar dichos derivados y compuestos intermediarios utilizables en dicho proceso, composiciones formuladas con dichos derivados y uso de los derivados mencionados para el tratamiento del cuerpo human

Info

Publication number
AR029640A1
AR029640A1 ARP000102755A ARP000102755A AR029640A1 AR 029640 A1 AR029640 A1 AR 029640A1 AR P000102755 A ARP000102755 A AR P000102755A AR P000102755 A ARP000102755 A AR P000102755A AR 029640 A1 AR029640 A1 AR 029640A1
Authority
AR
Argentina
Prior art keywords
derivatives
group
alkoxy
alkyl
groups
Prior art date
Application number
ARP000102755A
Other languages
English (en)
Original Assignee
Almirall Prodesfarma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Almirall Prodesfarma Sa filed Critical Almirall Prodesfarma Sa
Publication of AR029640A1 publication Critical patent/AR029640A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Otolaryngology (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Se describen y reivindican compuestos de la formula (1) en donde: A1 representa un grupo alquileno, alquilenoxi, alquilentio, alcanoil o hidroxialquileno; A2 representa un enlace sencillo, un grupo alquileno o alquenileno; W representa un enlace sencillo, un grupo fenilo o furanileno opcionalmente sustituido por uno o más átomos de halogeno, o grupos alcoxi y/o grupos alquilo; R1 representa un átomo de hidrogeno o un grupo alquilo, alquenilo, alquinilo, alcoxialquilo, alqueniloxialquilo, alquiniloxialquilo, alcoxi-alcoxialquilo, fenilalquilo en donde el anillo fenilo está opcionalmente sustituido por uno o más átomos de halogeno o grupos alquilo, alcoxi o arilalcoxi (preferentemente fenilalcoxi) o un grupo cicloalquilalquilo en donde el grupo cicloalquilo está opcionalmente sustituido por uno o más átomos de halogeno, grupos alquilo o grupos alcoxi; R2 representa un átomo de hidrogeno o halogeno, o un grupo alquilo o alcoxi; y R3 representa un grupo carboxilo o un grupo tetrazolilo; y sus sales son utiles por su actividad antihistamínica y antialérgica y pueden ser utilizados para el tratamiento de enfermedades alérgicas, incluidas asma bronquial, rinitis, conjuntivitis, dermatitis y urticarias.
ARP000102755A 1999-06-04 2000-06-02 Derivados de indolilpiperidinas que poseen actividad antihistaminica y antialergica, procesos para preparar dichos derivados y compuestos intermediarios utilizables en dicho proceso, composiciones formuladas con dichos derivados y uso de los derivados mencionados para el tratamiento del cuerpo human AR029640A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES009901232A ES2165274B1 (es) 1999-06-04 1999-06-04 Nuevos derivados de indolilpiperidina como agentes antihistaminicos y antialergicos.

Publications (1)

Publication Number Publication Date
AR029640A1 true AR029640A1 (es) 2003-07-10

Family

ID=8308707

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP000102755A AR029640A1 (es) 1999-06-04 2000-06-02 Derivados de indolilpiperidinas que poseen actividad antihistaminica y antialergica, procesos para preparar dichos derivados y compuestos intermediarios utilizables en dicho proceso, composiciones formuladas con dichos derivados y uso de los derivados mencionados para el tratamiento del cuerpo human

Country Status (35)

Country Link
US (1) US6683096B2 (es)
EP (1) EP1183251B1 (es)
JP (1) JP2003501424A (es)
KR (1) KR100683454B1 (es)
CN (1) CN1191246C (es)
AR (1) AR029640A1 (es)
AT (1) ATE259362T1 (es)
AU (1) AU773164B2 (es)
BG (1) BG106168A (es)
BR (1) BR0011340A (es)
CA (1) CA2375985A1 (es)
CO (1) CO5180556A1 (es)
CZ (1) CZ20014334A3 (es)
DE (1) DE60008239T2 (es)
DK (1) DK1183251T3 (es)
EE (1) EE04717B1 (es)
ES (2) ES2165274B1 (es)
HK (1) HK1040990A1 (es)
HU (1) HUP0203320A3 (es)
IL (1) IL146629A0 (es)
MX (1) MXPA01012425A (es)
MY (1) MY127033A (es)
NO (1) NO20015897D0 (es)
NZ (1) NZ515649A (es)
PE (1) PE20010208A1 (es)
PL (1) PL196774B1 (es)
PT (1) PT1183251E (es)
RU (1) RU2246493C2 (es)
SI (1) SI1183251T1 (es)
SK (1) SK17042001A3 (es)
TR (1) TR200103490T2 (es)
TW (1) TWI226889B (es)
UA (1) UA72517C2 (es)
WO (1) WO2000075130A1 (es)
ZA (1) ZA200109676B (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004504266A (ja) * 2000-01-17 2004-02-12 バイエル　アクチェンゲゼルシャフト 置換アリールケトン類
ES2172436B1 (es) * 2000-10-31 2004-01-16 Almirall Prodesfarma Sa Derivados de indolilpiperidina como agentes antihistaminicos y antialergicos.
WO2002048105A2 (en) * 2000-11-16 2002-06-20 Wyeth Aryloxy piperidinyl derivatives for the treatment of depression
ES2201899B1 (es) 2002-04-01 2005-06-01 Almirall Prodesfarma, S.A. Derivados de la azaindolilpiperidina como agentes antihistaminicos y antialergicos.
ES2201907B1 (es) 2002-05-29 2005-06-01 Almirall Prodesfarma, S.A. Nuevos derivados de indolilpiperidina como potentes agentes antihistaminicos y antialergicos.
CA2545261C (en) 2003-11-17 2013-07-23 Boehringer Ingelheim International Gmbh Piperidine-substituted indoles- or heteroderivatives thereof
US20050245540A1 (en) * 2003-12-09 2005-11-03 Fujisawa Pharmaceutical Co., Ltd. New methods
CA2562235C (en) 2004-04-13 2013-09-24 Incyte Corporation Piperazinylpiperidine derivatives as chemokine receptor antagonists
WO2006002350A1 (en) * 2004-06-24 2006-01-05 Incyte Corporation Amido compounds and their use as pharmaceuticals
WO2006012226A2 (en) 2004-06-24 2006-02-02 Incyte Corporation N-substituted piperidines and their use as pharmaceuticals
DK1877390T3 (da) * 2005-04-26 2010-05-31 Hypnion Inc Benzisoxazol-piperazin-forbindelser og fremgangsmåder til anvendelse deraf
JP5080450B2 (ja) 2005-04-30 2012-11-21 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規なピペリジン置換インドール
US20060275516A1 (en) * 2005-06-02 2006-12-07 Ram A N S Compositions and methods for the treatment of allergic rhinitis
US20080108586A1 (en) * 2006-09-06 2008-05-08 Incyte Corporation Combination therapy for human immunodeficiency virus infection
WO2008049874A1 (en) 2006-10-27 2008-05-02 Boehringer Ingelheim International Gmbh Piperidyl-propane-thiol ccr3 modulators
AR065718A1 (es) * 2007-03-15 2009-06-24 Novartis Ag Compuestos heterociclicos nitrogenados,utiles en el diagnostico y tratamiento de trastornos hiperproliferativos.
US20100041663A1 (en) 2008-07-18 2010-02-18 Novartis Ag Organic Compounds as Smo Inhibitors
CN101560179B (zh) * 2009-05-25 2012-04-18 浙江大学 具有h3受体亲和能力的含氮吲哚衍生物和用途
CN101747321B (zh) * 2009-12-22 2013-01-02 浙江大学 吲哚-3-苄胺衍生物及制备方法和用途
EP3040334A1 (en) * 2014-12-29 2016-07-06 Faes Farma, S.A. New benzimidazole derivatives as antihistamine agents
AU2022318349B2 (en) * 2021-07-30 2025-12-18 Confo Therapeutics N.V. Compounds for the treatment of pain, in particular neuropathic pain, and/or other diseases or disorders that are associated with at2r and/or at2r mediated signaling

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Publication number Priority date Publication date Assignee Title
US4742057A (en) * 1985-12-05 1988-05-03 Fujisawa Pharmaceutical Co., Ltd. Antiallergic thiazole compounds
JPS63301881A (ja) * 1987-06-01 1988-12-08 Fujisawa Pharmaceut Co Ltd インドリルピペリジン誘導体
GB8800795D0 (en) * 1988-01-14 1988-02-17 Fujisawa Pharmaceutical Co New indolylpiperidine compounds processes for preparations thereof & pharmaceutical composition comprising same
DK733788A (da) * 1988-01-14 1989-07-15 Fujisawa Pharmaceutical Co Indolylpiperidinderivater og fremgangsmaade til fremstilling deraf
GB8900382D0 (en) * 1989-01-09 1989-03-08 Janssen Pharmaceutica Nv 2-aminopyrimidinone derivatives
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PT626968E (pt) * 1992-02-13 2002-03-28 Merrell Pharma Inc Derivados de piperidinilo tiaciclicos
IT1271417B (it) * 1993-10-15 1997-05-28 Erregierre Ind Chim Composti ad attivita' antiistaminica procedimento per la loro preperazione e composizioni farmaceutiche che li contengono.
DE19500689A1 (de) 1995-01-12 1996-07-18 Merck Patent Gmbh Indolpiperidin-Derivate
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Also Published As

Publication number Publication date
IL146629A0 (en) 2002-07-25
UA72517C2 (uk) 2005-03-15
TWI226889B (en) 2005-01-21
MXPA01012425A (es) 2002-06-04
PE20010208A1 (es) 2001-03-19
KR100683454B1 (ko) 2007-02-20
US6683096B2 (en) 2004-01-27
WO2000075130A1 (en) 2000-12-14
HUP0203320A3 (en) 2004-01-28
PL196774B1 (pl) 2008-01-31
AU5527600A (en) 2000-12-28
CA2375985A1 (en) 2000-12-14
PL353164A1 (en) 2003-10-20
TR200103490T2 (tr) 2002-04-22
SK17042001A3 (sk) 2002-04-04
NZ515649A (en) 2003-08-29
DE60008239T2 (de) 2004-11-18
RU2246493C2 (ru) 2005-02-20
JP2003501424A (ja) 2003-01-14
NO20015897L (no) 2001-12-03
CN1368969A (zh) 2002-09-11
EE200100653A (et) 2003-02-17
BG106168A (bg) 2002-07-31
ES2165274A1 (es) 2002-03-01
HK1040990A1 (zh) 2002-06-28
MY127033A (en) 2006-11-30
SI1183251T1 (en) 2004-06-30
CZ20014334A3 (cs) 2002-03-13
BR0011340A (pt) 2002-03-05
ZA200109676B (en) 2003-02-24
RU2002100073A (ru) 2004-01-10
DE60008239D1 (de) 2004-03-18
CN1191246C (zh) 2005-03-02
NO20015897D0 (no) 2001-12-03
PT1183251E (pt) 2004-05-31
AU773164B2 (en) 2004-05-20
ATE259362T1 (de) 2004-02-15
HUP0203320A2 (hu) 2003-02-28
DK1183251T3 (da) 2004-06-07
CO5180556A1 (es) 2002-07-30
ES2165274B1 (es) 2003-04-01
KR20020020721A (ko) 2002-03-15
US20020147344A1 (en) 2002-10-10
EP1183251A1 (en) 2002-03-06
ES2211559T3 (es) 2004-07-16
EE04717B1 (et) 2006-10-16
EP1183251B1 (en) 2004-02-11

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