PE20010132A1 - Amidas sustituidas del acido fenilciclohexanocarboxilico y su uso como inhibidores de la incorporacion de adenosina - Google Patents
Amidas sustituidas del acido fenilciclohexanocarboxilico y su uso como inhibidores de la incorporacion de adenosinaInfo
- Publication number
- PE20010132A1 PE20010132A1 PE2000000505A PE0005052000A PE20010132A1 PE 20010132 A1 PE20010132 A1 PE 20010132A1 PE 2000000505 A PE2000000505 A PE 2000000505A PE 0005052000 A PE0005052000 A PE 0005052000A PE 20010132 A1 PE20010132 A1 PE 20010132A1
- Authority
- PE
- Peru
- Prior art keywords
- phenyl
- alkyl
- cycloalkyl
- inhibitors
- acid
- Prior art date
Links
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 title abstract 4
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 title abstract 3
- 239000002126 C01EB10 - Adenosine Substances 0.000 title abstract 2
- 239000002253 acid Substances 0.000 title abstract 2
- 229960005305 adenosine Drugs 0.000 title abstract 2
- 150000001408 amides Chemical class 0.000 title abstract 2
- 238000010348 incorporation Methods 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- -1 CARBOXYL Chemical class 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 3
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 abstract 2
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 abstract 2
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 2
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- WZKSXHQDXQKIQJ-UHFFFAOYSA-N F[C](F)F Chemical class F[C](F)F WZKSXHQDXQKIQJ-UHFFFAOYSA-N 0.000 abstract 1
- RAXXELZNTBOGNW-UHFFFAOYSA-O Imidazolium Chemical compound C1=C[NH+]=CN1 RAXXELZNTBOGNW-UHFFFAOYSA-O 0.000 abstract 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical class O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- BEBCJVAWIBVWNZ-UHFFFAOYSA-N glycinamide Chemical compound NCC(N)=O BEBCJVAWIBVWNZ-UHFFFAOYSA-N 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
- 230000000302 ischemic effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/08—Radicals containing only hydrogen and carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/14—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
SE REFIERE A AMIDAS SUSTITUIDAS DEL ACIDO FENILCICLOHEXANOCARBOXILICO DE FORMULA I DONDE A, D, E, G, SON CH, N; L1 Y L2 SON H, HALOGENO, OH, CARBOXILO, CIANO, NITRO, TRIFLUOROMETILO, TRIFLUOROMETOXI, ALQUILO C1-C6, ENTRE OTROS; R1 ES CH2-OH, CO-NR4R5, R4 Y R5 SON H, ALQUILO C1-C6; R2 ES CICLOALQUILO C3-C8, HETEROCICLO CON 4-8 MIEMBROS UNIDO POR N AL IMIDAZOL, HETEROCICLO DE 4-8 MIEMBROS; R6 Y R7 SON H, ALQUILO C1-C6, HIDROXIALQUILO C1-C6, CICLOALQUILO C3-C7; R8 Y R9 SON H, ALQUILO C1-C6, CICLOALQUILO C3-C7; R8 Y R9 JUNTO A N FORMAN UN HETEROCICLO DE 4-8 MIEMBROS CON O, S, NR1O; R10 ES H, ALQUILO C1-C6, CICLOALQUILO C3-C7; R3 ES FENILO, NAFTILO, PIRIMIDINILO, PIRIDILO, FURILO, TIENILO ENTRE OTROS. SON COMPUESTOS PREFERIDOS (S)-N-{[(1R,2R)-2-{4-{[2-(HIDROXIMETIL)-1H-BENCIMIDAZOL-1-IL]METIL}FENIL}CICLOHEX-1-IL]CARBONIL}-(4-FLUOROFENIL)GLICINAMIDA, (S)-N-{[(1R,2R)-2-{4-{[2-(2-HIDROXIETIL)-1H-BENCIMIDAZOL-1-IL]METIL}FENIL}CICLOHEX-1-IL]CARBONIL}-FENILGLICINAMIDA, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO PARA LA PREPARACION Y A COMPUESTOS INTERMEDIOS. LOS COMPUESTOS I SON INHIBIDORES DE LA INCORPORACION DE ADENOSINA Y PUEDEN SER UTILES PARA EL TRATAMIENTO DE ENFERMEDADES CARDIOVASCULARES, ENFERMEDADES ISQUEMICAS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19924819A DE19924819A1 (de) | 1999-05-29 | 1999-05-29 | Substituierte Phenylcyclohexancarbonsäurebenzylamid (Adenosinaufnahmeinhibitoren) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20010132A1 true PE20010132A1 (es) | 2001-04-12 |
Family
ID=7909713
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2000000505A PE20010132A1 (es) | 1999-05-29 | 2000-05-26 | Amidas sustituidas del acido fenilciclohexanocarboxilico y su uso como inhibidores de la incorporacion de adenosina |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US6984642B1 (es) |
| EP (1) | EP1187812B1 (es) |
| JP (1) | JP2003500474A (es) |
| KR (1) | KR20020000814A (es) |
| CN (1) | CN1165526C (es) |
| AR (1) | AR029639A1 (es) |
| AT (1) | ATE303995T1 (es) |
| AU (1) | AU766140B2 (es) |
| BR (1) | BR0011049A (es) |
| CA (1) | CA2375188A1 (es) |
| CO (1) | CO5170503A1 (es) |
| DE (2) | DE19924819A1 (es) |
| DK (1) | DK1187812T3 (es) |
| ES (1) | ES2248071T3 (es) |
| GT (1) | GT200000085A (es) |
| HK (1) | HK1047107B (es) |
| HN (1) | HN2000000078A (es) |
| IL (1) | IL146231A0 (es) |
| MX (1) | MXPA01012240A (es) |
| PE (1) | PE20010132A1 (es) |
| PL (1) | PL365960A1 (es) |
| TR (1) | TR200103398T2 (es) |
| UY (1) | UY26179A1 (es) |
| WO (1) | WO2000073274A2 (es) |
| ZA (1) | ZA200108894B (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10150310A1 (de) * | 2001-10-11 | 2003-04-24 | Bayer Ag | Substituierte Piperazincyclohexancarbonsäureamide und ihre Verwendung |
| KR100762858B1 (ko) * | 2005-03-07 | 2007-10-02 | 김기완 | Ｐｅ시트를 이용한 저수조의 방수 공법 |
| KR100762857B1 (ko) * | 2005-03-07 | 2007-10-02 | 김기완 | Ｐｅ시트를 이용한 저수조의 방수 공법 |
| KR100745024B1 (ko) * | 2005-05-09 | 2007-08-01 | 김준 | 거푸집 수평조절장치 |
| WO2010009068A2 (en) * | 2008-07-16 | 2010-01-21 | Bristol-Myers Squibb Company | Cyclohexenyl modulators of chemokine receptor activity |
| EP2380595A1 (en) | 2010-04-19 | 2011-10-26 | Nlife Therapeutics S.L. | Compositions and methods for selective delivery of oligonucleotide molecules to specific neuron types |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69322707T2 (de) * | 1992-07-31 | 1999-08-19 | Bristol-Myers Squibb Company | Diphenyl Oxazole-, Thiazole- und Imidazole-Derivate als Inhibitoren der Wiederaufnahme des Adenosins |
| DE4304455A1 (de) * | 1993-02-15 | 1994-08-18 | Bayer Ag | Heterocyclisch substituierte Phenyl-cyclohexan-carbonsäurederivate |
| DE19503160A1 (de) * | 1995-02-01 | 1996-08-08 | Bayer Ag | Verwendung von Phenylcyclohexylcarbonsäureamiden |
| KR19990044698A (ko) * | 1995-09-22 | 1999-06-25 | 고사이 아끼오 | 피라진-2-온 유도체, 그의 용도 및 그를 제조하기 위한 중간물 |
| US5723313A (en) * | 1995-09-27 | 1998-03-03 | St. Jude Children's Research Hospital | ARF-p19, a novel regulator of the mammalian cell cycle |
-
1999
- 1999-05-29 DE DE19924819A patent/DE19924819A1/de not_active Withdrawn
-
2000
- 2000-05-16 BR BR0011049-3A patent/BR0011049A/pt not_active IP Right Cessation
- 2000-05-16 HK HK02108818.1A patent/HK1047107B/zh not_active IP Right Cessation
- 2000-05-16 PL PL00365960A patent/PL365960A1/xx not_active Application Discontinuation
- 2000-05-16 EP EP00925290A patent/EP1187812B1/de not_active Expired - Lifetime
- 2000-05-16 WO PCT/EP2000/004431 patent/WO2000073274A2/de not_active Ceased
- 2000-05-16 MX MXPA01012240A patent/MXPA01012240A/es active IP Right Grant
- 2000-05-16 AU AU44057/00A patent/AU766140B2/en not_active Ceased
- 2000-05-16 AT AT00925290T patent/ATE303995T1/de not_active IP Right Cessation
- 2000-05-16 CN CNB008082170A patent/CN1165526C/zh not_active Expired - Fee Related
- 2000-05-16 TR TR2001/03398T patent/TR200103398T2/xx unknown
- 2000-05-16 IL IL14623100A patent/IL146231A0/xx unknown
- 2000-05-16 US US09/980,242 patent/US6984642B1/en not_active Expired - Fee Related
- 2000-05-16 CA CA002375188A patent/CA2375188A1/en not_active Abandoned
- 2000-05-16 KR KR1020017015253A patent/KR20020000814A/ko not_active Ceased
- 2000-05-16 DK DK00925290T patent/DK1187812T3/da active
- 2000-05-16 JP JP2000621340A patent/JP2003500474A/ja active Pending
- 2000-05-16 ES ES00925290T patent/ES2248071T3/es not_active Expired - Lifetime
- 2000-05-16 DE DE50011122T patent/DE50011122D1/de not_active Expired - Fee Related
- 2000-05-17 HN HN2000000078A patent/HN2000000078A/es unknown
- 2000-05-24 CO CO00038312A patent/CO5170503A1/es not_active Application Discontinuation
- 2000-05-26 PE PE2000000505A patent/PE20010132A1/es not_active Application Discontinuation
- 2000-05-26 GT GT200000085A patent/GT200000085A/es unknown
- 2000-05-29 UY UY26179A patent/UY26179A1/es not_active Application Discontinuation
- 2000-05-29 AR ARP000102649A patent/AR029639A1/es not_active Application Discontinuation
-
2001
- 2001-10-29 ZA ZA200108894A patent/ZA200108894B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AR029639A1 (es) | 2003-07-10 |
| KR20020000814A (ko) | 2002-01-05 |
| ES2248071T3 (es) | 2006-03-16 |
| HK1047107B (zh) | 2005-05-20 |
| US6984642B1 (en) | 2006-01-10 |
| CA2375188A1 (en) | 2000-12-07 |
| DE50011122D1 (de) | 2005-10-13 |
| HN2000000078A (es) | 2001-02-02 |
| EP1187812B1 (de) | 2005-09-07 |
| UY26179A1 (es) | 2000-12-29 |
| CN1165526C (zh) | 2004-09-08 |
| JP2003500474A (ja) | 2003-01-07 |
| HK1047107A1 (en) | 2003-02-07 |
| IL146231A0 (en) | 2002-07-25 |
| BR0011049A (pt) | 2002-03-19 |
| PL365960A1 (en) | 2005-01-24 |
| DK1187812T3 (da) | 2005-12-12 |
| DE19924819A1 (de) | 2000-11-30 |
| CN1353693A (zh) | 2002-06-12 |
| WO2000073274A2 (de) | 2000-12-07 |
| MXPA01012240A (es) | 2002-08-12 |
| AU4405700A (en) | 2000-12-18 |
| ZA200108894B (en) | 2003-01-29 |
| CO5170503A1 (es) | 2002-06-27 |
| EP1187812A2 (de) | 2002-03-20 |
| ATE303995T1 (de) | 2005-09-15 |
| TR200103398T2 (tr) | 2002-03-21 |
| WO2000073274A3 (de) | 2001-04-19 |
| AU766140B2 (en) | 2003-10-09 |
| GT200000085A (es) | 2001-11-17 |
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