[go: up one dir, main page]

PE20010116A1 - Derivados de 6-alquenil-, 6-alquinil- y 6-epoxi-epotilona, procedimientos para su preparacion - Google Patents

Derivados de 6-alquenil-, 6-alquinil- y 6-epoxi-epotilona, procedimientos para su preparacion

Info

Publication number
PE20010116A1
PE20010116A1 PE2000000403A PE0004032000A PE20010116A1 PE 20010116 A1 PE20010116 A1 PE 20010116A1 PE 2000000403 A PE2000000403 A PE 2000000403A PE 0004032000 A PE0004032000 A PE 0004032000A PE 20010116 A1 PE20010116 A1 PE 20010116A1
Authority
PE
Peru
Prior art keywords
alkyl
aryl
aralkyl
derivatives
hal
Prior art date
Application number
PE2000000403A
Other languages
English (en)
Inventor
Bernd Buchmann
Jens Hoffmann
Werner Skuballa
Rosemarie Lichtner
Wolfgang Schwede
Ulrich Klar
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19921086A external-priority patent/DE19921086A1/de
Priority claimed from DE19954228A external-priority patent/DE19954228A1/de
Priority claimed from DE10015836A external-priority patent/DE10015836A1/de
Application filed by Schering Ag filed Critical Schering Ag
Publication of PE20010116A1 publication Critical patent/PE20010116A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE REFIERE A DERIVADOS DE EPOTILONA DE FORMULA I DONDE R1a, R1b SON H, ALQUILO C1-C10, ARILO, ARALQUILO C7-C20, O JUNTOS SON -(CH2)m, -(CH2)-O-(CH2)-; m ES 1-5; R2a ES H, ALQUILO C1-C10, ARILO, ENTRE OTROS; R2b ES (CH2)rb-C­C-(CH2)pb-R26, GRUPO b; n ES 0-5; ra, rb SON 0-4; pa, pb SON 0-3; R3a ES H, ALQUILO C1-C10, ARILO, ARALQUILO C7-C20; R14 ES H, OR14a, HAL; R3b ES OPG14; R4 ES H, ALQUILO C1-C10, ARILO, ARALQUILO C7-C20, HAL, OR25, CN; R25 ES H, UN GRUPO PROTECTOR PG5; R26a, R26b SON H, ALQUILO C1-C10, ARILO, ARALQUILO C7-C20, ENTRE OTROS; R5 ES H, ALQUILO C1-C10, ARILO, ARALQUILO C7-C20, (CH2)s-T; s ES 1-4; T ES OR22, HAL; R22 ES H, PG4; R6 Y R7 SON H, JUNTOS SON UN ENLACE, O; G ES X=CR8, ALQUILO BI O TRICICLICO; R8 ES H, HALOGENO, CN, ALQUILO C1-C10, ARILO, ARALQUILO C7-C20; X ES O, ALCOXI OR23, ENTRE OTROS; R23 ES ALQUILO C1-C20; D-E ES -CH2-CH2-, -O-CH2-; A-Y ES O-C=O, O-CH2, CH2C(=O), ENTRE OTROS; Z ES O, H/OR12; R12 ES H, UN GRUPO PROTECTOR. UN COMPUESTO PREFERIDO (4S,7R,8S,9S,13E/Z,16S(E))-4,8-DIHIDROXI-16-(1-METIL-2-(2-PIRIDIL)ETENIL)-1-OXA-5,5,9,13-TETRAMETIL-7-(BUT-3-IN-IL)-CICLOHEXADEC-13-EN-2,6-DIONA, ENTRE OTROS. LOS COMPUESTOS I INTERACTUAN CON LA TUBULINA, ESTABILIZANDO LA MICROTUBULINA FORMADA PUEDEN SER UTILES EN EL TRATAMIENTO DE TUMORES, ANGIOGENESIS, ENFERMEDADES INFLAMATORIAS
PE2000000403A 1999-04-30 2000-04-28 Derivados de 6-alquenil-, 6-alquinil- y 6-epoxi-epotilona, procedimientos para su preparacion PE20010116A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19921086A DE19921086A1 (de) 1999-04-30 1999-04-30 6-Alkenyl- und 6-Alkinyl-Epothilon Derivate, Verfahren zu deren Herstellung sowie ihre Verwendung in pharmazeutischen Präparaten
DE19954228A DE19954228A1 (de) 1999-11-04 1999-11-04 6-Alkenyl-und 6-Alkinyl-Epothilon-Derivate, Verfahren zu deren Herstellung sowie ihre Verwendung in pharmazeutischen Präparaten
DE10015836A DE10015836A1 (de) 2000-03-27 2000-03-27 6-Alkenyl- und 6-Alkinyl-Epothilon-Derivate, Verfahren zu deren Herstellung sowie ihre Verwendung in pharmazeutischen Präparaten

Publications (1)

Publication Number Publication Date
PE20010116A1 true PE20010116A1 (es) 2001-02-15

Family

ID=27213767

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2000000403A PE20010116A1 (es) 1999-04-30 2000-04-28 Derivados de 6-alquenil-, 6-alquinil- y 6-epoxi-epotilona, procedimientos para su preparacion

Country Status (33)

Country Link
EP (1) EP1173441B1 (es)
JP (2) JP4024003B2 (es)
KR (1) KR100721488B1 (es)
CN (1) CN100368415C (es)
AR (1) AR023792A1 (es)
AT (1) ATE440847T1 (es)
BG (1) BG65601B1 (es)
BR (1) BR0010190A (es)
CA (2) CA2651653C (es)
CY (1) CY1109768T1 (es)
CZ (1) CZ299653B6 (es)
DE (1) DE60042821D1 (es)
DK (1) DK1173441T3 (es)
EA (1) EA011502B1 (es)
EE (1) EE05292B1 (es)
ES (1) ES2331506T3 (es)
HK (1) HK1046681B (es)
HR (1) HRP20010892A2 (es)
HU (1) HUP0201010A3 (es)
IL (1) IL145938A0 (es)
ME (1) MEP13908A (es)
MX (1) MXPA01011039A (es)
NO (1) NO328149B1 (es)
NZ (1) NZ514989A (es)
PE (1) PE20010116A1 (es)
PL (1) PL210762B1 (es)
PT (1) PT1173441E (es)
RS (1) RS51023B (es)
SI (1) SI1173441T1 (es)
SK (1) SK286858B6 (es)
TW (2) TWI280962B (es)
WO (1) WO2000066589A1 (es)
ZA (1) ZA200109859B (es)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0873341T3 (da) 1995-11-17 2004-01-19 Biotechnolog Forschung Gmbh Epothilonderivater, fremstilling og anvendelse
WO1998022461A1 (de) 1996-11-18 1998-05-28 GESELLSCHAFT FüR BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF) Epothilone c, d, e und f, deren herstellung und deren verwendung als cytostatische mittel bzw. als pflanzenschutzmittel
US6204388B1 (en) 1996-12-03 2001-03-20 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
WO1999001124A1 (en) 1996-12-03 1999-01-14 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto, analogues and uses thereof
US6605599B1 (en) 1997-07-08 2003-08-12 Bristol-Myers Squibb Company Epothilone derivatives
US6365749B1 (en) 1997-12-04 2002-04-02 Bristol-Myers Squibb Company Process for the preparation of ring-opened epothilone intermediates which are useful for the preparation of epothilone analogs
US6498257B1 (en) 1998-04-21 2002-12-24 Bristol-Myers Squibb Company 2,3-olefinic epothilone derivatives
US6399638B1 (en) 1998-04-21 2002-06-04 Bristol-Myers Squibb Company 12,13-modified epothilone derivatives
US6518421B1 (en) 2000-03-20 2003-02-11 Bristol-Myers Squibb Company Process for the preparation of epothilone analogs
US6593115B2 (en) 2000-03-24 2003-07-15 Bristol-Myers Squibb Co. Preparation of epothilone intermediates
DE10020899A1 (de) * 2000-04-20 2001-10-25 Schering Ag 9-Oxa-Epothilon-Derivate, Verfahren zu deren Herstellung sowie ihre Verwendung in pharmazeutischen Präparaten
UA75365C2 (en) * 2000-08-16 2006-04-17 Bristol Myers Squibb Co Epothilone analog polymorph modifications, a method for obtaining thereof (variants), a pharmaceutical composition based thereon
BRPI0206509B8 (pt) 2001-01-25 2021-05-25 R Pharm Us Operating Llc processo para formular, para administração parenteral, um análogo de epotilona, preparação farmacêutica, processo para formar uma composição farmacêutica para administração parental, composição farmacêutica e uso de um análogo de epotilona na preparação de uma composição farmacêutica para o tratamento de câncer
NZ526871A (en) 2001-01-25 2006-01-27 Bristol Myers Squibb Co Pharmaceutical dosage forms of epothilones for oral administration
CA2434566A1 (en) 2001-01-25 2002-08-15 Timothy M. Malloy Parenteral formulation containing epothilone analogs
PL363363A1 (en) 2001-02-20 2004-11-15 Bristol-Myers Squibb Company Epothilone derivatives for the treatment of refractory tumors
PL363362A1 (en) 2001-02-20 2004-11-15 Bristol-Myers Squibb Company Treatment of refractory tumors using epothilone derivatives
EP1383490B1 (en) 2001-03-14 2012-04-25 Bristol-Myers Squibb Company Combination of an epothilone analog and chemotherapeutic agents for the treatment of proliferative diseases
US6800653B2 (en) 2001-06-01 2004-10-05 Bristol-Myers Squibb Compnay Epothilone derivatives
EP1340498A1 (en) * 2002-03-01 2003-09-03 Schering Aktiengesellschaft Use of epothilones in the treatment of brain diseases associated with proliferative processes
WO2003077903A1 (en) 2002-03-12 2003-09-25 Bristol-Myers Squibb Company C12-cyano epothilone derivatives
DK1483251T3 (da) 2002-03-12 2010-04-12 Bristol Myers Squibb Co C3-cyano-epothilon-derivater
TW200403994A (en) 2002-04-04 2004-03-16 Bristol Myers Squibb Co Oral administration of EPOTHILONES
TW200400191A (en) 2002-05-15 2004-01-01 Bristol Myers Squibb Co Pharmaceutical compositions and methods of using C-21 modified epothilone derivatives
AU2003243561A1 (en) 2002-06-14 2003-12-31 Bristol-Myers Squibb Company Combination of epothilone analogs and chemotherapeutic agents for the treatment of proliferative diseases
PL375902A1 (en) 2002-09-23 2005-12-12 Bristol-Myers Squibb Company Methods for the preparation, isolation and purification of epothilone b, and x-ray crystal structures of epothilone b
DE10361794B3 (de) * 2003-12-31 2005-10-06 Schering Ag Optisch aktive heteroaromatische ß-Hydroxy-Ester und Verfahren zu deren Herstellung sowie deren Verwendung als Zwischenprodukte bei der Epothilon-Totalsynthese
EP1559447A1 (en) 2004-01-30 2005-08-03 Institut National De La Sante Et De La Recherche Medicale (Inserm) Use of epothilones in the treatment of neuronal connectivity defects such as schizophrenia and autism
EP1640004A1 (en) * 2004-09-24 2006-03-29 Schering Aktiengesellschaft Use of epothilones in the treatment of bone metastases and bone tumors or cancers
US20060121511A1 (en) 2004-11-30 2006-06-08 Hyerim Lee Biomarkers and methods for determining sensitivity to microtubule-stabilizing agents
EP1674098A1 (en) * 2004-12-23 2006-06-28 Schering Aktiengesellschaft Stable and tolerable parental formulations of highly reactive organic drug substances with low or no solubility in water
CN100384419C (zh) * 2005-12-02 2008-04-30 菏泽睿鹰制药集团有限公司 一种埃坡霉素缓释植入组合物及应用
DE102007016046A1 (de) 2007-03-30 2008-10-23 Bayer Schering Pharma Aktiengesellschaft Verfahren zur Herstellung von Epothilonderivaten durch selektive katalytische Epoxidierung
EP2065054A1 (en) 2007-11-29 2009-06-03 Bayer Schering Pharma Aktiengesellschaft Combinations comprising a prostaglandin and uses thereof
EP2070521A1 (en) 2007-12-10 2009-06-17 Bayer Schering Pharma Aktiengesellschaft Surface-modified nanoparticles
DE102007059752A1 (de) 2007-12-10 2009-06-18 Bayer Schering Pharma Aktiengesellschaft Funktionalisierte, feste Polymernanopartikel enthaltend Epothilone
EP2210584A1 (en) 2009-01-27 2010-07-28 Bayer Schering Pharma Aktiengesellschaft Stable polymeric composition comprising an epothilone and an amphiphilic block copolymer
JP5881254B2 (ja) 2010-05-18 2016-03-09 セルリアン・ファーマ・インコーポレイテッド 自己免疫疾患およびその他の疾患の治療のための組成物および方法
EP2793949B1 (en) 2011-12-23 2018-08-22 Innate Pharma Enzymatic conjugation of antibodies
WO2014009426A2 (en) 2012-07-13 2014-01-16 Innate Pharma Screening of conjugated antibodies
EP2916872B1 (en) 2012-11-09 2019-02-27 Innate Pharma Recognition tags for tgase-mediated conjugation
WO2014140300A1 (en) 2013-03-15 2014-09-18 Innate Pharma Solid phase tgase-mediated conjugation of antibodies
WO2014202773A1 (en) 2013-06-20 2014-12-24 Innate Pharma Enzymatic conjugation of polypeptides
CA2914189C (en) 2013-06-21 2023-03-14 Innate Pharma Enzymatic conjugation of polypeptides
WO2019092148A1 (en) 2017-11-10 2019-05-16 Innate Pharma Antibodies with functionalized glutamine residues

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54115320A (en) * 1978-02-28 1979-09-07 Soda Aromatic Novel unsaturated keto acid and its manufacture
JP2653663B2 (ja) * 1988-02-15 1997-09-17 財団法人微生物化学研究会 １．３―ジヒドロキシ―８―デセン―５―オンを含む免疫賦活剤及び制癌剤
EP0469480A3 (en) * 1990-08-01 1993-03-10 Hoechst Aktiengesellschaft Process for stereoselective preparation of 5-substituted delta-lactones and their use
DE59805110D1 (de) * 1997-02-25 2002-09-12 Biotechnolog Forschung Gmbh Seitenkettenmodifizierte epothilone
CA2299608A1 (en) * 1997-08-09 1999-02-18 Schering Aktiengesellschaft New epothilone derivatives, method for producing same and their pharmaceutical use

Also Published As

Publication number Publication date
HUP0201010A2 (en) 2002-08-28
AR023792A1 (es) 2002-09-04
YU77601A (sh) 2005-07-19
EE200100568A (et) 2003-02-17
EA200101025A1 (ru) 2002-06-27
HK1046681B (zh) 2008-08-29
EA011502B1 (ru) 2009-04-28
BG106053A (en) 2002-05-31
CA2651653C (en) 2012-02-14
MXPA01011039A (es) 2003-06-30
DK1173441T3 (da) 2009-12-07
KR100721488B1 (ko) 2007-05-23
JP4886578B2 (ja) 2012-02-29
ES2331506T3 (es) 2010-01-07
BR0010190A (pt) 2002-01-08
PL210762B1 (pl) 2012-02-29
SI1173441T1 (sl) 2010-01-29
NO20015278L (no) 2001-12-21
WO2000066589A1 (en) 2000-11-09
TWI280962B (en) 2007-05-11
JP2002543203A (ja) 2002-12-17
PT1173441E (pt) 2009-11-06
NO20015278D0 (no) 2001-10-29
MEP13908A (en) 2010-06-10
CA2371226A1 (en) 2000-11-09
TWI294292B (en) 2008-03-11
DE60042821D1 (de) 2009-10-08
ZA200109859B (en) 2003-02-28
EP1173441A1 (en) 2002-01-23
JP4024003B2 (ja) 2007-12-19
IL145938A0 (en) 2002-07-25
CN1349534A (zh) 2002-05-15
PL351491A1 (en) 2003-04-22
CZ299653B6 (cs) 2008-10-08
KR20020005737A (ko) 2002-01-17
SK15512001A3 (sk) 2002-05-09
CY1109768T1 (el) 2014-09-10
BG65601B1 (bg) 2009-02-27
CA2371226C (en) 2011-11-29
EE05292B1 (et) 2010-04-15
CN100368415C (zh) 2008-02-13
SK286858B6 (sk) 2009-06-05
NZ514989A (en) 2004-02-27
TW200711679A (en) 2007-04-01
HK1046681A1 (zh) 2003-01-24
ATE440847T1 (de) 2009-09-15
HRP20010892A2 (hr) 2008-06-30
CA2651653A1 (en) 2000-11-09
NO328149B1 (no) 2009-12-21
CZ20013885A3 (cs) 2002-04-17
HUP0201010A3 (en) 2005-02-28
JP2007224038A (ja) 2007-09-06
EP1173441B1 (en) 2009-08-26
RS51023B (sr) 2010-10-31

Similar Documents

Publication Publication Date Title
PE20010116A1 (es) Derivados de 6-alquenil-, 6-alquinil- y 6-epoxi-epotilona, procedimientos para su preparacion
PE20010219A1 (es) AGONISTAS ß-ADRENORRECEPTORES
CA2338504A1 (en) Oxazolo, thiazolo and selenazolo [4,5-c]-quinolin-4-amines and analogs thereof
JP2006516143A5 (es)
PE79699A1 (es) Derivados de 9-desoxo-9a-aza-9a-homoeritromicina a c-4" sustituidos
PE20001467A1 (es) Derivados de 4-fenilpiridina como antagonistas del receptor de neuroquinina
PE20091371A1 (es) Inhibidores de hsp90
JP6746605B2 (ja) オキサチアジン様化合物を作製する方法
HUP0202810A2 (hu) Szubsztituált 2-tio-3.5-diciano-4-aril-6-aminopiridinek és eljárás az előállításukra, valamint ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
KR960014121A (ko) 아로일-피페리딘 유도체
PE69298A1 (es) Inhibidores de metaloproteinasas, composiciones farmaceuticas que los contienen y sus usos farmaceuticos y los metodos e intermedios utiles para su preparacion
CY1109449T1 (el) Ενωσεις ουριας δραστικες ως ανταγωνιστες βανιλλοειδων υποδοχεων για την αντιμετωπιση του πονου
ATE286026T1 (de) Amid-derivate und deren medizinische verwendung
AR035668A1 (es) Imidazoquinolinas y 6,7,8,9-tetrahidroimidazoquinolinas, composiciones farmaceuticas que las comprenden, uso de dichos compuestos en la preparacion de medicamentos, e intermediarios utiles en la sintesis de dichos compuestos
AR022860A1 (es) Derivados de camptotecina que poseen actividad antitumoral
AR045161A1 (es) Derivados de quinazolina
YU55603A (sh) Derivati purina kao antagonisti purinergiskog receptora
PE20061333A1 (es) Derivados de ciclopentapiridina y tetrahidroquinolina como ligandos del receptor 5-ht
PE20040747A1 (es) Nuevos conjugados de efectores y procedimientos para su preparacion
ES2032570T3 (es) Derivados antiparkinson de ergolina. (reserva del art. 167.2 cpe).
ES2287256T3 (es) Indolinas y tetrahidroquinolina como profarmacos para el tratamiento de tumores.
PT95646A (pt) Processo para a preparacao de derivados de isotiazolo-quinolina e de composicoes farmaceuticas que os contem
PE20010149A1 (es) Derivados del indol como agentes melatoninergicos
AR038479A1 (es) Compuestos hidrosolubles de platino con porfirina con alta selectividad tumoral y su uso para preparar medicamentos para el tratamiento de enfermedades tumorales benignas y malignas
PE20020411A1 (es) Compuestos derivados de la triptamina y sus analogos que interactuan con el sistema melatoninergico

Legal Events

Date Code Title Description
FG Grant, registration
FD Application declared void or lapsed