PE20010993A1 - Bases de mannich indolicas, procedimiento para su preparacion, medicamentos que contienen estos compuestos y su uso para la preparacion de medicamentos - Google Patents
Bases de mannich indolicas, procedimiento para su preparacion, medicamentos que contienen estos compuestos y su uso para la preparacion de medicamentosInfo
- Publication number
- PE20010993A1 PE20010993A1 PE2000001397A PE0013972000A PE20010993A1 PE 20010993 A1 PE20010993 A1 PE 20010993A1 PE 2000001397 A PE2000001397 A PE 2000001397A PE 0013972000 A PE0013972000 A PE 0013972000A PE 20010993 A1 PE20010993 A1 PE 20010993A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- preparation
- aryl
- compounds
- indolic
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- RREANTFLPGEWEN-MBLPBCRHSA-N 7-[4-[[(3z)-3-[4-amino-5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidin-2-yl]imino-5-fluoro-2-oxoindol-1-yl]methyl]piperazin-1-yl]-1-cyclopropyl-6-fluoro-4-oxoquinoline-3-carboxylic acid Chemical compound COC1=C(OC)C(OC)=CC(CC=2C(=NC(\N=C/3C4=CC(F)=CC=C4N(CN4CCN(CC4)C=4C(=CC=5C(=O)C(C(O)=O)=CN(C=5C=4)C4CC4)F)C\3=O)=NC=2)N)=C1 RREANTFLPGEWEN-MBLPBCRHSA-N 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title 2
- 229940079593 drug Drugs 0.000 title 2
- 206010020751 Hypersensitivity Diseases 0.000 abstract 2
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical group [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 2
- SLRMQYXOBQWXCR-UHFFFAOYSA-N 2154-56-5 Chemical class [CH2]C1=CC=CC=C1 SLRMQYXOBQWXCR-UHFFFAOYSA-N 0.000 abstract 1
- 101100516572 Caenorhabditis elegans nhr-8 gene Proteins 0.000 abstract 1
- 206010012735 Diarrhoea Diseases 0.000 abstract 1
- 206010013654 Drug abuse Diseases 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 208000007882 Gastritis Diseases 0.000 abstract 1
- 208000010412 Glaucoma Diseases 0.000 abstract 1
- 208000025865 Ulcer Diseases 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- LXDIIORCAOTLRS-UHFFFAOYSA-N ethyl 3-[dimethylamino(phenyl)methyl]-1h-indole-2-carboxylate Chemical compound CCOC(=O)C=1NC2=CC=CC=C2C=1C(N(C)C)C1=CC=CC=C1 LXDIIORCAOTLRS-UHFFFAOYSA-N 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
- 208000011117 substance-related disease Diseases 0.000 abstract 1
- 231100000397 ulcer Toxicity 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Pulmonology (AREA)
- Ophthalmology & Optometry (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
SE REFIERE A BASES INDOLICAS MANNICH SUSTITUIDAS DE FORMULA I DONDE R1 ES H, ALQUILO C1-C10, ARILO, HETEROARILO; R2 ES H, F, Cl, Br, CF3, CN, NO2NHR8, SR9, OR10, CO(OR11), ENTRE OTROS; R3 ES CH(R13)N(R14)(R15); R4, R5, R6, R7 SON H, F, Cl, Br, CF3, CN, NO2, NHR8, ENTRE OTROS; R8 ES H, COR16, ALQUILO C1-C10, ARILO; R9 ES H, ALQUILO C1-C10, ARILO; R10 ES H, COR17, ALQUILO C1-C10, ENTRE OTROS; R11 Y R12 SON H, ALQUILO C1-C10, ARILO; R13 ES FENILO; R14 Y R15 SON ALQUILO C1-C6, JUNTOS FORMAN (CH2)n; n ES 3-6; (CH2)2O(CH2)2; R16 ES ALQUILO C1-C10, ARILO, HETEROARILO; EXCEPTO LOS COMPUESTOS CUANDO R3 ES CH(R13)N(R14(R15) O R4-R7 SON H; R13 ES FENILO; R14 Y R15 FORMAN (CH2)5; R1 ES H, CH3, BENCILO, ENTRE OTROS; SON COMPUESTOS PREFERIDOS 3-(DIMETILAMINOFENILMETIL)-1H-INDOL-2-CARBOXILATO DE ETILO; [(5-FLUORO-1H-INDOL-3-IL)-FENILMETIL]-DIMETILAMINA, ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. EL COMPUESTO I PUEDE SER UTIL PARA COMBATIR DOLORES, REACCIONES INFLAMATORIAS, REACCIONES ALERGICAS, ABUSO DE DROGAS, ALCOHOL, DIARREA, GASTRITIS, ULCERA, REACCIONES ALERGICAS, GLAUCOMA, ASMA
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19963178A DE19963178A1 (de) | 1999-12-27 | 1999-12-27 | Substituierte Indol-Mannichbasen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20010993A1 true PE20010993A1 (es) | 2001-10-06 |
Family
ID=7934622
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2000001397A PE20010993A1 (es) | 1999-12-27 | 2000-12-26 | Bases de mannich indolicas, procedimiento para su preparacion, medicamentos que contienen estos compuestos y su uso para la preparacion de medicamentos |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US7091220B2 (es) |
| EP (1) | EP1261585B1 (es) |
| JP (1) | JP2003519124A (es) |
| KR (1) | KR20020062314A (es) |
| CN (1) | CN1219763C (es) |
| AR (2) | AR027059A1 (es) |
| AT (1) | ATE374184T1 (es) |
| AU (1) | AU782585B2 (es) |
| BR (1) | BR0016747A (es) |
| CA (1) | CA2392866A1 (es) |
| CO (1) | CO5251383A1 (es) |
| CY (1) | CY1107080T1 (es) |
| CZ (1) | CZ20021708A3 (es) |
| DE (2) | DE19963178A1 (es) |
| DK (1) | DK1261585T3 (es) |
| ES (1) | ES2293935T3 (es) |
| HU (1) | HUP0203873A3 (es) |
| IL (1) | IL149426A0 (es) |
| NO (1) | NO20022803D0 (es) |
| NZ (1) | NZ518876A (es) |
| PE (1) | PE20010993A1 (es) |
| PL (1) | PL355446A1 (es) |
| PT (1) | PT1261585E (es) |
| RU (1) | RU2265594C2 (es) |
| SK (1) | SK8522002A3 (es) |
| UY (1) | UY26511A1 (es) |
| WO (1) | WO2001047885A1 (es) |
| ZA (1) | ZA200203444B (es) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI224101B (en) * | 2001-06-20 | 2004-11-21 | Wyeth Corp | Substituted naphthyl indole derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1) |
| PT1397130E (pt) | 2001-06-20 | 2007-11-13 | Wyeth Corp | Derivados ácidos de indole substituído como inibidores de inibidor 1 do activador de plasminogénio (pai-1) |
| US7005445B2 (en) | 2001-10-22 | 2006-02-28 | The Research Foundation Of State University Of New York | Protein kinase and phosphatase inhibitors and methods for designing them |
| DE10153346A1 (de) * | 2001-10-29 | 2004-04-22 | Grünenthal GmbH | Substituierte Indole |
| MXPA05006288A (es) * | 2002-12-10 | 2005-08-19 | Wyeth Corp | Derivados del acido 3-carbonil-1h-indol-1-ilacetico sustituidos como inhibidores del inhibidor del activador de plasminogeno 1 (pai-1). |
| JP2006514640A (ja) * | 2002-12-10 | 2006-05-11 | ワイス | プラスミノゲンアクティベータインヒビターのインヒビターとしての置換３−アルキル及び３−アリールアルキル１ｈ−イル酢酸誘導体 |
| CA2509222A1 (en) * | 2002-12-10 | 2004-06-24 | Wyeth | Substituted indole oxo-acetyl amino acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1) |
| UA80453C2 (en) * | 2002-12-10 | 2007-09-25 | Derivatives of substituted dyhydropyranoindol-3,4-dion as inhibitors of plasminogen activator inhibitor-1 (pai-1) | |
| EP1569901B1 (en) * | 2002-12-10 | 2008-10-15 | Wyeth | ARYL, ARYLOXY, AND ALKYLOXY SUBSTITUTED i 1H /i -INDOL-3-YL GLYOXYLIC ACID DERIVATIVES AS INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR-1 (PAI-1) |
| US7141592B2 (en) * | 2003-09-25 | 2006-11-28 | Wyeth | Substituted oxadiazolidinediones |
| US7332521B2 (en) | 2003-09-25 | 2008-02-19 | Wyeth | Substituted indoles |
| US7582773B2 (en) * | 2003-09-25 | 2009-09-01 | Wyeth | Substituted phenyl indoles |
| US7342039B2 (en) * | 2003-09-25 | 2008-03-11 | Wyeth | Substituted indole oximes |
| US7420083B2 (en) | 2003-09-25 | 2008-09-02 | Wyeth | Substituted aryloximes |
| US7411083B2 (en) * | 2003-09-25 | 2008-08-12 | Wyeth | Substituted acetic acid derivatives |
| US7265148B2 (en) | 2003-09-25 | 2007-09-04 | Wyeth | Substituted pyrrole-indoles |
| US7268159B2 (en) | 2003-09-25 | 2007-09-11 | Wyeth | Substituted indoles |
| US7446201B2 (en) * | 2003-09-25 | 2008-11-04 | Wyeth | Substituted heteroaryl benzofuran acids |
| US7442805B2 (en) * | 2003-09-25 | 2008-10-28 | Wyeth | Substituted sulfonamide-indoles |
| US7534894B2 (en) * | 2003-09-25 | 2009-05-19 | Wyeth | Biphenyloxy-acids |
| US7351726B2 (en) * | 2003-09-25 | 2008-04-01 | Wyeth | Substituted oxadiazolidinediones |
| US7163954B2 (en) * | 2003-09-25 | 2007-01-16 | Wyeth | Substituted naphthyl benzothiophene acids |
| WO2006023866A2 (en) * | 2004-08-23 | 2006-03-02 | Wyeth | Thiazolo-naphthyl acids as inhibitors of plasminogen activator inhibitor-1 |
| BRPI0514549A (pt) * | 2004-08-23 | 2008-06-17 | Wyeth Corp | ácidos de pirrol-naftila como inibidores de pai-1 |
| JP2008510815A (ja) * | 2004-08-23 | 2008-04-10 | ワイス | 血栓症および心臓血管疾患の治療にて有用な調節剤であるプラスミノゲン活性化因子阻害剤１型（ｐａｉ−１）としてのオキサゾロ−ナフチル酸 |
| CN101263115A (zh) | 2005-08-17 | 2008-09-10 | 惠氏公司 | 经取代吲哚和其用途 |
| US7838542B2 (en) | 2006-06-29 | 2010-11-23 | Kinex Pharmaceuticals, Llc | Bicyclic compositions and methods for modulating a kinase cascade |
| DE102006033109A1 (de) * | 2006-07-18 | 2008-01-31 | Grünenthal GmbH | Substituierte Heteroaryl-Derivate |
| CN102686635B (zh) * | 2009-05-01 | 2014-10-22 | 汉高公司 | 用于厌氧可固化组合物的固化促进剂 |
| US9416104B2 (en) | 2011-08-26 | 2016-08-16 | Uwm Research Foundation, Inc. | Vitamin D receptor-coregulator inhibitors |
| CN102687719A (zh) * | 2012-06-04 | 2012-09-26 | 陕西海安实业有限责任公司 | 一种新型高效油田用杀菌剂及其制备方法 |
| WO2015143020A1 (en) * | 2014-03-18 | 2015-09-24 | The Board Of Regents For Oklahoma State University | Systems and methods for production of artificial eumelanin |
| KR102729280B1 (ko) * | 2016-10-28 | 2024-11-12 | 서울대학교병원 | 3-아미노알킬레이티드 인돌 유도체, 이의 제조 방법 및 이를 포함하는 약학적 조성물 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3296072A (en) * | 1962-06-11 | 1967-01-03 | Upjohn Co | Method of treating mental depression |
| FR2181559A1 (en) | 1972-04-28 | 1973-12-07 | Aec Chimie Organique Bio | N-Phenylalkyl-N-3-indolylalkyl-alkylamines - with sedative, neuroleptic, analgesic, hypotensive, antiserotonin, adrenolytic activity |
| GB1374414A (en) * | 1972-06-12 | 1974-11-20 | Sterling Drug Inc | 1-acyl-3-amino-alkyl-indoles and their preparation |
| GB1456208A (en) * | 1972-12-28 | 1976-11-24 | Agfa Gevaert | Thermographic processes and recording material for use therein |
| DE2724809A1 (de) | 1977-06-02 | 1978-08-31 | Dieter P Philippen | Urinflaschen-spuelgeraet |
| US4341402A (en) * | 1980-03-06 | 1982-07-27 | Sterling Drug Inc. | Systems employing indole color formers |
| DE3209305A1 (de) | 1982-03-15 | 1983-09-22 | SIC AG, 4020 Basel | Verfahren zur automatischen entleerung und reinigung von hygienegefaessen unter optimaler zufuehrung des spuelwassers bei minimalem wasserverbrauch |
| GB2168973B (en) * | 1984-12-04 | 1988-02-03 | Glaxo Group Ltd | Indole derivatives |
| SE449483B (sv) | 1986-03-12 | 1987-05-04 | Juhani Jervinen | Anordning for att avlegsna urin fran en flexibel urinuppsamlingspase |
| US4855448A (en) * | 1986-08-26 | 1989-08-08 | A. H. Robins Company, Incorporated | 2-Amino-3-aroyl-γ-oxobenzenebutanoic acids and esters |
| DE3723891A1 (de) * | 1987-07-18 | 1989-01-26 | Huels Chemische Werke Ag | Verfahren zur herstellung von dicyclopentenolestern |
| GB9226532D0 (en) | 1992-12-21 | 1993-02-17 | Smithkline Beecham Plc | Compounds |
| GB9226537D0 (en) | 1992-12-21 | 1993-02-17 | Smithkline Beecham Plc | Compounds |
| TW270114B (es) * | 1993-10-22 | 1996-02-11 | Hoffmann La Roche | |
| CA2130294A1 (en) | 1994-08-17 | 1996-02-18 | F. W. Arthur Morrow | Method of cleaning an ostomy pouch |
| US5942536A (en) * | 1995-10-10 | 1999-08-24 | Eli Lilly And Company | N- 2-substituted-3-(2-aminoethyl)-1H-indol-5-YL!-Amides: new 5-HT1F agonists |
| US5735301A (en) * | 1996-02-22 | 1998-04-07 | Rower; Gary | Urostomy patient equipment irrigation system |
| CN1310706A (zh) | 1998-02-25 | 2001-08-29 | 遗传研究所有限公司 | 磷脂酶抑制剂 |
| DE19823326A1 (de) | 1998-05-26 | 1999-12-02 | Volker Fesser | Einrichtung zum Entleeren und Desinfizieren von Urin- und Sekretbeuteln |
| DE19963177A1 (de) * | 1999-12-27 | 2001-07-12 | Gruenenthal Gmbh | Substanzbibliothek |
| US6263887B1 (en) | 2000-01-14 | 2001-07-24 | Dornoch Medical Systems, Inc. | Liquid waste disposal and canister flushing system and method |
-
1999
- 1999-12-27 DE DE19963178A patent/DE19963178A1/de not_active Ceased
-
2000
- 2000-12-20 ES ES00991219T patent/ES2293935T3/es not_active Expired - Lifetime
- 2000-12-20 JP JP2001549357A patent/JP2003519124A/ja not_active Withdrawn
- 2000-12-20 DE DE50014679T patent/DE50014679D1/de not_active Expired - Lifetime
- 2000-12-20 AU AU31610/01A patent/AU782585B2/en not_active Ceased
- 2000-12-20 EP EP00991219A patent/EP1261585B1/de not_active Expired - Lifetime
- 2000-12-20 CA CA002392866A patent/CA2392866A1/en not_active Abandoned
- 2000-12-20 RU RU2002120478/04A patent/RU2265594C2/ru not_active IP Right Cessation
- 2000-12-20 SK SK852-2002A patent/SK8522002A3/sk unknown
- 2000-12-20 CZ CZ20021708A patent/CZ20021708A3/cs unknown
- 2000-12-20 PL PL00355446A patent/PL355446A1/xx not_active Application Discontinuation
- 2000-12-20 AT AT00991219T patent/ATE374184T1/de active
- 2000-12-20 WO PCT/EP2000/012974 patent/WO2001047885A1/de not_active Ceased
- 2000-12-20 PT PT00991219T patent/PT1261585E/pt unknown
- 2000-12-20 HU HU0203873A patent/HUP0203873A3/hu unknown
- 2000-12-20 CN CNB008177317A patent/CN1219763C/zh not_active Expired - Fee Related
- 2000-12-20 IL IL14942600A patent/IL149426A0/xx unknown
- 2000-12-20 US US10/168,985 patent/US7091220B2/en not_active Expired - Fee Related
- 2000-12-20 NZ NZ518876A patent/NZ518876A/en unknown
- 2000-12-20 DK DK00991219T patent/DK1261585T3/da active
- 2000-12-20 BR BR0016747-9A patent/BR0016747A/pt not_active IP Right Cessation
- 2000-12-20 KR KR1020027007032A patent/KR20020062314A/ko not_active Ceased
- 2000-12-21 AR ARP000106840A patent/AR027059A1/es not_active Application Discontinuation
- 2000-12-21 AR ARP000106841A patent/AR027060A1/es unknown
- 2000-12-22 CO CO00097385A patent/CO5251383A1/es not_active Application Discontinuation
- 2000-12-26 PE PE2000001397A patent/PE20010993A1/es not_active Application Discontinuation
- 2000-12-27 UY UY26511A patent/UY26511A1/es not_active Application Discontinuation
-
2002
- 2002-04-30 ZA ZA200203444A patent/ZA200203444B/xx unknown
- 2002-06-12 NO NO20022803A patent/NO20022803D0/no not_active Application Discontinuation
-
2007
- 2007-12-10 CY CY20071101569T patent/CY1107080T1/el unknown
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