PE20010809A1 - Formulaciones para administracion por via oral de compuestos anti-tumorales - Google Patents
Formulaciones para administracion por via oral de compuestos anti-tumoralesInfo
- Publication number
- PE20010809A1 PE20010809A1 PE2000001113A PE0011132000A PE20010809A1 PE 20010809 A1 PE20010809 A1 PE 20010809A1 PE 2000001113 A PE2000001113 A PE 2000001113A PE 0011132000 A PE0011132000 A PE 0011132000A PE 20010809 A1 PE20010809 A1 PE 20010809A1
- Authority
- PE
- Peru
- Prior art keywords
- inhibitors
- composition
- camptotecin
- agent
- agents
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 5
- 230000000259 anti-tumor effect Effects 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title 1
- 239000003795 chemical substances by application Substances 0.000 abstract 3
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- NKANXQFJJICGDU-QPLCGJKRSA-N Tamoxifen Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCN(C)C)=CC=1)/C1=CC=CC=C1 NKANXQFJJICGDU-QPLCGJKRSA-N 0.000 abstract 2
- 239000003112 inhibitor Substances 0.000 abstract 2
- DEQANNDTNATYII-OULOTJBUSA-N (4r,7s,10s,13r,16s,19r)-10-(4-aminobutyl)-19-[[(2r)-2-amino-3-phenylpropanoyl]amino]-16-benzyl-n-[(2r,3r)-1,3-dihydroxybutan-2-yl]-7-[(1r)-1-hydroxyethyl]-13-(1h-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxa Chemical compound C([C@@H](N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC=2C3=CC=CC=C3NC=2)NC(=O)[C@H](CC=2C=CC=CC=2)NC1=O)C(=O)N[C@H](CO)[C@H](O)C)C1=CC=CC=C1 DEQANNDTNATYII-OULOTJBUSA-N 0.000 abstract 1
- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 abstract 1
- JLPULHDHAOZNQI-ZTIMHPMXSA-N 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC JLPULHDHAOZNQI-ZTIMHPMXSA-N 0.000 abstract 1
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 abstract 1
- UEJJHQNACJXSKW-UHFFFAOYSA-N 2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione Chemical compound O=C1C2=CC=CC=C2C(=O)N1C1CCC(=O)NC1=O UEJJHQNACJXSKW-UHFFFAOYSA-N 0.000 abstract 1
- 190000008236 CARBOPLATIN Chemical compound 0.000 abstract 1
- GAGWJHPBXLXJQN-UORFTKCHSA-N Capecitabine Chemical compound C1=C(F)C(NC(=O)OCCCCC)=NC(=O)N1[C@H]1[C@H](O)[C@H](O)[C@@H](C)O1 GAGWJHPBXLXJQN-UORFTKCHSA-N 0.000 abstract 1
- 102000001301 EGF receptor Human genes 0.000 abstract 1
- 108060006698 EGF receptor Proteins 0.000 abstract 1
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 abstract 1
- 108010016076 Octreotide Proteins 0.000 abstract 1
- 239000002202 Polyethylene glycol Substances 0.000 abstract 1
- 229940124532 absorption promoter Drugs 0.000 abstract 1
- 229940100198 alkylating agent Drugs 0.000 abstract 1
- 239000002168 alkylating agent Substances 0.000 abstract 1
- 239000004037 angiogenesis inhibitor Substances 0.000 abstract 1
- 229940121369 angiogenesis inhibitor Drugs 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 230000001946 anti-microtubular Effects 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- 229940100197 antimetabolite Drugs 0.000 abstract 1
- 239000002256 antimetabolite Substances 0.000 abstract 1
- 239000003963 antioxidant agent Substances 0.000 abstract 1
- 230000003078 antioxidant effect Effects 0.000 abstract 1
- 239000003886 aromatase inhibitor Substances 0.000 abstract 1
- 229940046844 aromatase inhibitors Drugs 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 229960004562 carboplatin Drugs 0.000 abstract 1
- 229960000590 celecoxib Drugs 0.000 abstract 1
- RZEKVGVHFLEQIL-UHFFFAOYSA-N celecoxib Chemical compound C1=CC(C)=CC=C1C1=CC(C(F)(F)F)=NN1C1=CC=C(S(N)(=O)=O)C=C1 RZEKVGVHFLEQIL-UHFFFAOYSA-N 0.000 abstract 1
- 239000002738 chelating agent Substances 0.000 abstract 1
- 229960004316 cisplatin Drugs 0.000 abstract 1
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 abstract 1
- 239000003255 cyclooxygenase 2 inhibitor Substances 0.000 abstract 1
- 239000002270 dispersing agent Substances 0.000 abstract 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 abstract 1
- 229960002743 glutamine Drugs 0.000 abstract 1
- 229940125697 hormonal agent Drugs 0.000 abstract 1
- UWKQSNNFCGGAFS-XIFFEERXSA-N irinotecan Chemical compound C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 UWKQSNNFCGGAFS-XIFFEERXSA-N 0.000 abstract 1
- 239000000787 lecithin Substances 0.000 abstract 1
- 229940067606 lecithin Drugs 0.000 abstract 1
- 235000010445 lecithin Nutrition 0.000 abstract 1
- 239000011159 matrix material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229960002700 octreotide Drugs 0.000 abstract 1
- 229960004662 parecoxib Drugs 0.000 abstract 1
- TZRHLKRLEZJVIJ-UHFFFAOYSA-N parecoxib Chemical compound C1=CC(S(=O)(=O)NC(=O)CC)=CC=C1C1=C(C)ON=C1C1=CC=CC=C1 TZRHLKRLEZJVIJ-UHFFFAOYSA-N 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 abstract 1
- 150000003904 phospholipids Chemical class 0.000 abstract 1
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical class [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 abstract 1
- 229920001223 polyethylene glycol Polymers 0.000 abstract 1
- 229960000371 rofecoxib Drugs 0.000 abstract 1
- RZJQGNCSTQAWON-UHFFFAOYSA-N rofecoxib Chemical compound C1=CC(S(=O)(=O)C)=CC=C1C1=C(C=2C=CC=CC=2)C(=O)OC1 RZJQGNCSTQAWON-UHFFFAOYSA-N 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 229940083466 soybean lecithin Drugs 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 239000004094 surface-active agent Substances 0.000 abstract 1
- 229960001603 tamoxifen Drugs 0.000 abstract 1
- 229960003433 thalidomide Drugs 0.000 abstract 1
- UCFGDBYHRUNTLO-QHCPKHFHSA-N topotecan Chemical compound C1=C(O)C(CN(C)C)=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 UCFGDBYHRUNTLO-QHCPKHFHSA-N 0.000 abstract 1
- 229960002190 topotecan hydrochloride Drugs 0.000 abstract 1
- 229960002004 valdecoxib Drugs 0.000 abstract 1
- LNPDTQAFDNKSHK-UHFFFAOYSA-N valdecoxib Chemical compound CC=1ON=C(C=2C=CC=CC=2)C=1C1=CC=C(S(N)(=O)=O)C=C1 LNPDTQAFDNKSHK-UHFFFAOYSA-N 0.000 abstract 1
- 239000004034 viscosity adjusting agent Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SE REFIERE A UNA COMPOSICION QUE COMPRENDE a)UN DERIVADO DE CAMPTOTECINA COMO CPT-11, CLORHIDRATO DE TOPOTECAN, 9-AMINO-20(S)CAMPTOTECINA, 9-NITRO-20(S)CAMPTOTECINA; b)UNA MATRIZ QUE COMPRENDE UN GLICERIDO POLIGLICOLIZADO; Y AL MENOS UN EXCIPIENTE TAL COMO LECITINA (LECITINA DE SOYA CON UN CONTENIDO DE FOSFATIDILCOLINA ENRIQUECIDO), UN FOSFOLIPIDO, UN ACEITE, POLIETILENGLICOL, MONOGLICERIDO; UN AGENTE DISPERSANTE, UN AGENTE SOLUBILIZANTE, UN TENSIOACTIVO, UN MODIFICADOR DE LA VISCOSIDAD, UN PROMOTOR DE LA ABSORCION ORAL, UN AGENTE DE ESTABILIZACION-PROMOCION QUIMICA (UN ANTIOXIDANTE, UN AGENTE QUELANTE). LA COMPOSICION COMPRENDE ADEMAS ANTIBIOTICOS ANTITUMORALES TAL COMO ANTRACICLINAS, INHIBIDORES DE TIMIDILATO SINTASA TAL COMO CAPECITABINA; INHIBIDORES DEL RECEPTOR DEL FACTOR DE CRECIMIENTO EPIDERMICO; AGENTES ANTIMICROTUBULARES TAL COMO TAXANOS; INHIBIDORES DE LA ANGIOGENESIS TAL COMO TALIDOMIDA; INHIBIDORES DE CICLOOXIGENASA-2 TAL COMO CELECOXIB, VALDECOXIB, PARECOXIB, ROFECOXIB; INHIBIDORES DE AROMATASA, AGENTES DE ALQUILACION TAL COMO ESTRAMUSTINA; ANTIMETABOLITOS; AGENTES HORMONALES TAL COMO TAMOXIFEN; ANALOGOS DE PLATINO TAL COMO CISPLATINO, CARBOPLATINO, OCTREOTIDO, GLUTAMINA. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PRODUCCION DE LA COMPOSICION. LA COMPOSICION PUEDE SER UTIL PARA EL TRATAMIENTO DE CANCER, TUMORES
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9925127.4A GB9925127D0 (en) | 1999-10-22 | 1999-10-22 | Oral formulations for anti-tumor compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20010809A1 true PE20010809A1 (es) | 2001-08-01 |
Family
ID=10863264
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2000001113A PE20010809A1 (es) | 1999-10-22 | 2000-10-19 | Formulaciones para administracion por via oral de compuestos anti-tumorales |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US7201913B1 (es) |
| EP (1) | EP1223936A1 (es) |
| JP (1) | JP2003512430A (es) |
| KR (1) | KR100838097B1 (es) |
| CN (1) | CN1198616C (es) |
| AR (1) | AR031834A1 (es) |
| AU (1) | AU784201B2 (es) |
| BR (1) | BR0014902A (es) |
| CA (1) | CA2387648A1 (es) |
| CO (1) | CO5251471A1 (es) |
| CZ (1) | CZ20021372A3 (es) |
| EA (1) | EA008284B1 (es) |
| GB (1) | GB9925127D0 (es) |
| HK (1) | HK1048253B (es) |
| HU (1) | HUP0202850A3 (es) |
| IL (2) | IL149044A0 (es) |
| MX (1) | MXPA02003904A (es) |
| MY (1) | MY138106A (es) |
| NO (1) | NO322782B1 (es) |
| NZ (1) | NZ518398A (es) |
| PE (1) | PE20010809A1 (es) |
| PL (1) | PL356236A1 (es) |
| SK (1) | SK5102002A3 (es) |
| TW (1) | TWI233355B (es) |
| WO (1) | WO2001030351A1 (es) |
| ZA (1) | ZA200203042B (es) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EE200200471A (et) * | 2000-02-28 | 2003-12-15 | Aventis Pharma S.A. | Farmatseutiline kompositsioon, mis sisaldab kamptotetsiini või selle derivaati kombinatsioonis pürimidiini derivaadiga ning on ette nähtud vähktõve raviks |
| GB0011903D0 (en) * | 2000-05-18 | 2000-07-05 | Astrazeneca Ab | Combination chemotherapy |
| ITRM20030074A1 (it) * | 2003-02-21 | 2004-08-22 | Pharmacia Italia Spa | Formulazioni semisolide a rilascio immediato intese |
| US7871632B2 (en) | 2004-07-12 | 2011-01-18 | Adventrx Pharmaceuticals, Inc. | Compositions for delivering highly water soluble drugs |
| GT200500310A (es) | 2004-11-19 | 2006-06-19 | Compuestos organicos | |
| SA06270147B1 (ar) | 2005-06-09 | 2009-12-22 | نوفارتيس ايه جي | عملية لتخليق 5-(مثيل–1h–إيميدازول–1-يل )–3-(ثلاثي فلـورو مثيل)–بنزامـين |
| US20070053869A1 (en) * | 2005-09-02 | 2007-03-08 | Yuichi Sugiyama | Formulation and method for enhancement of gastrointestinal absorption of pharmaceutical agents |
| US8168661B2 (en) * | 2006-11-06 | 2012-05-01 | Poniard Pharmaceuticals, Inc. | Use of picoplatin to treat colorectal cancer |
| US8178564B2 (en) * | 2006-11-06 | 2012-05-15 | Poniard Pharmaceuticals, Inc. | Use of picoplatin to treat colorectal cancer |
| US8173686B2 (en) | 2006-11-06 | 2012-05-08 | Poniard Pharmaceuticals, Inc. | Use of picoplatin to treat colorectal cancer |
| US8168662B1 (en) | 2006-11-06 | 2012-05-01 | Poniard Pharmaceuticals, Inc. | Use of picoplatin to treat colorectal cancer |
| WO2008090732A1 (ja) | 2007-01-26 | 2008-07-31 | Pola Pharma Inc. | 医薬組成物 |
| US20110033528A1 (en) * | 2009-08-05 | 2011-02-10 | Poniard Pharmaceuticals, Inc. | Stabilized picoplatin oral dosage form |
| TW200916094A (en) * | 2007-06-27 | 2009-04-16 | Poniard Pharmaceuticals Inc | Stabilized picoplatin dosage form |
| US20100260832A1 (en) * | 2007-06-27 | 2010-10-14 | Poniard Pharmaceuticals, Inc. | Combination therapy for ovarian cancer |
| CN101809024A (zh) * | 2007-07-16 | 2010-08-18 | 铂雅制药公司 | 吡铂的口服制剂 |
| CN102006875A (zh) * | 2008-02-08 | 2011-04-06 | 帕纳德制药公司 | 吡铂和贝伐单抗治疗结直肠癌的用途 |
| HUP0900614A2 (en) * | 2009-09-29 | 2011-05-30 | Mate Dr Hidvegi | Preparation comprising dehydrated, fermented material with amorphous crystaline structure and process for its production |
| US20120322752A1 (en) * | 2009-12-08 | 2012-12-20 | Sung Kyun Lee | SOLID DISPERSIONS CONTAINING 20-O-beta-D-GLUCOPYRANOSYL-20(S)-PROTOPANAXADIOL |
| WO2014123899A1 (en) | 2013-02-05 | 2014-08-14 | Purdue Pharma L.P. | Tamper resistant pharmaceutical formulations |
| JP6704345B2 (ja) * | 2014-01-17 | 2020-06-03 | オンコラル ファーマ エーピーエス | 癌治療のためのイリノテカンの固体経口剤形 |
| CN110448533B (zh) * | 2014-12-05 | 2022-03-29 | 天津键凯科技有限公司 | 一种聚乙二醇修饰的喜树碱类衍生物的药物组合物及其制备方法 |
| KR102293907B1 (ko) | 2015-06-30 | 2021-08-26 | 한미약품 주식회사 | 이리노테칸 함유 경구용 고형제제 및 그 제조방법 |
| TWI795381B (zh) | 2016-12-21 | 2023-03-11 | 比利時商健生藥品公司 | 作為ｍａｌｔ１抑制劑之吡唑衍生物 |
| KR102066402B1 (ko) * | 2017-12-22 | 2020-01-15 | 대화제약 주식회사 | 이리노테칸 또는 그의 약제학적으로 허용가능한 염을 포함하는 경구투여용 약제학적 조성물 |
| ES2949871T3 (es) | 2019-04-11 | 2023-10-03 | Janssen Pharmaceutica Nv | Anillos de piridina que contienen derivados como inhibidores de MALT1 |
| KR102185475B1 (ko) | 2019-06-20 | 2020-12-02 | 대화제약 주식회사 | 이리노테칸 자유 염기를 포함하는 경구투여용 약학 조성물 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ236393A (en) * | 1989-12-13 | 1992-05-26 | Lilly Co Eli | N-alkylated glycopeptide derivatives prepared from antibiotics a82846 series and pa-42867-a; pharmaceutical compositions |
| US5552156A (en) | 1992-10-23 | 1996-09-03 | Ohio State University | Liposomal and micellular stabilization of camptothecin drugs |
| FR2697752B1 (fr) * | 1992-11-10 | 1995-04-14 | Rhone Poulenc Rorer Sa | Compositions antitumorales contenant des dérivés du taxane. |
| US5433951A (en) | 1993-10-13 | 1995-07-18 | Bristol-Myers Squibb Company | Sustained release formulation containing captopril and method |
| IL115099A (en) * | 1994-10-14 | 1999-04-11 | Upjohn Co | Lyophilizate of phospholipid complex of water insoluble camptothecins |
| IL116674A (en) * | 1995-01-09 | 2003-05-29 | Mendell Co Inc Edward | Microcrystalline cellulose-based excipient having improved compressibility, pharmaceutical compositions containing the same and methods for the preparation of said excipient and of solid dosage form thereof |
| US5954998A (en) * | 1995-05-25 | 1999-09-21 | The Clorox Company | Liquid peracid precursor colloidal dispersions: oil-core vesicles |
| WO1998038984A2 (en) * | 1997-03-05 | 1998-09-11 | Sugen, Inc. | Formulations for hydrophobic pharmaceutical agents |
| GB9711962D0 (en) * | 1997-06-10 | 1997-08-06 | Reckitt & Colmann Prod Ltd | Therapeutically active compositions |
| BR9810866B1 (pt) * | 1997-07-29 | 2010-07-13 | composição farmacêutica em uma forma de formulação auto-emulsificante para compostos lipofìlicos. | |
| AR013261A1 (es) * | 1997-08-01 | 2000-12-13 | Smithkline Beecham Corp | Formulaciones farmaceuticas para analogos de camptotecina en capsula de gelatina |
| FR2775188B1 (fr) | 1998-02-23 | 2001-03-09 | Lipha | Forme galenique a liberation immediate ou liberation prolongee administrable par voie orale comprenant un agent promoteur d'absorption et utilisation de cet agent promoteur d'absorption |
| EP1178795A1 (en) * | 1999-05-17 | 2002-02-13 | Ilex Oncology, Inc. | Dfmo and celecoxib in combination for cancer chemoprevention and therapy |
| GB9918885D0 (en) * | 1999-08-10 | 1999-10-13 | Pharmacia & Upjohn Spa | Pharmaceutical formulations in hydroxypropymethycellulose capsules |
-
1999
- 1999-10-22 GB GBGB9925127.4A patent/GB9925127D0/en not_active Ceased
-
2000
- 2000-10-02 IL IL14904400A patent/IL149044A0/xx active IP Right Grant
- 2000-10-02 HK HK03100370.7A patent/HK1048253B/zh not_active IP Right Cessation
- 2000-10-02 NZ NZ518398A patent/NZ518398A/en unknown
- 2000-10-02 EA EA200200480A patent/EA008284B1/ru not_active IP Right Cessation
- 2000-10-02 BR BR0014902-0A patent/BR0014902A/pt not_active Application Discontinuation
- 2000-10-02 MX MXPA02003904A patent/MXPA02003904A/es active IP Right Grant
- 2000-10-02 JP JP2001532771A patent/JP2003512430A/ja not_active Withdrawn
- 2000-10-02 US US10/110,225 patent/US7201913B1/en not_active Expired - Fee Related
- 2000-10-02 HU HU0202850A patent/HUP0202850A3/hu unknown
- 2000-10-02 PL PL00356236A patent/PL356236A1/xx not_active IP Right Cessation
- 2000-10-02 SK SK510-2002A patent/SK5102002A3/sk unknown
- 2000-10-02 KR KR1020027005068A patent/KR100838097B1/ko not_active Expired - Fee Related
- 2000-10-02 AU AU76613/00A patent/AU784201B2/en not_active Ceased
- 2000-10-02 CZ CZ20021372A patent/CZ20021372A3/cs unknown
- 2000-10-02 WO PCT/EP2000/009647 patent/WO2001030351A1/en not_active Ceased
- 2000-10-02 CA CA002387648A patent/CA2387648A1/en not_active Abandoned
- 2000-10-02 CN CNB008146594A patent/CN1198616C/zh not_active Expired - Fee Related
- 2000-10-02 EP EP00966102A patent/EP1223936A1/en not_active Withdrawn
- 2000-10-07 TW TW089121016A patent/TWI233355B/zh not_active IP Right Cessation
- 2000-10-19 AR ARP000105495A patent/AR031834A1/es unknown
- 2000-10-19 PE PE2000001113A patent/PE20010809A1/es not_active Application Discontinuation
- 2000-10-19 CO CO00079673A patent/CO5251471A1/es not_active Application Discontinuation
- 2000-10-19 MY MYPI20004934A patent/MY138106A/en unknown
-
2002
- 2002-04-09 IL IL149044A patent/IL149044A/en not_active IP Right Cessation
- 2002-04-17 ZA ZA200203042A patent/ZA200203042B/en unknown
- 2002-04-18 NO NO20021834A patent/NO322782B1/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL149044A (en) | 2007-03-08 |
| EP1223936A1 (en) | 2002-07-24 |
| BR0014902A (pt) | 2002-06-11 |
| JP2003512430A (ja) | 2003-04-02 |
| MXPA02003904A (es) | 2003-07-14 |
| HUP0202850A2 (hu) | 2003-01-28 |
| KR100838097B1 (ko) | 2008-06-13 |
| NO20021834L (no) | 2002-04-18 |
| WO2001030351A1 (en) | 2001-05-03 |
| CN1198616C (zh) | 2005-04-27 |
| CA2387648A1 (en) | 2001-05-03 |
| CN1382050A (zh) | 2002-11-27 |
| SK5102002A3 (en) | 2002-11-06 |
| HK1048253B (zh) | 2005-12-02 |
| CO5251471A1 (es) | 2003-02-28 |
| HK1048253A1 (en) | 2003-03-28 |
| CZ20021372A3 (cs) | 2002-09-11 |
| AU784201B2 (en) | 2006-02-23 |
| KR20020045613A (ko) | 2002-06-19 |
| NO322782B1 (no) | 2006-12-11 |
| HUP0202850A3 (en) | 2004-12-28 |
| MY138106A (en) | 2009-04-30 |
| AR031834A1 (es) | 2003-10-08 |
| EA200200480A1 (ru) | 2002-10-31 |
| PL356236A1 (en) | 2004-06-28 |
| NZ518398A (en) | 2004-01-30 |
| GB9925127D0 (en) | 1999-12-22 |
| US7201913B1 (en) | 2007-04-10 |
| ZA200203042B (en) | 2003-04-17 |
| AU7661300A (en) | 2001-05-08 |
| EA008284B1 (ru) | 2007-04-27 |
| TWI233355B (en) | 2005-06-01 |
| NO20021834D0 (no) | 2002-04-18 |
| IL149044A0 (en) | 2002-11-10 |
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| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |