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PE20001590A1 - Compuestos heterociclicos, aromaticos utiles como secretagogos de la hormona del crecimiento - Google Patents

Compuestos heterociclicos, aromaticos utiles como secretagogos de la hormona del crecimiento

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Publication number
PE20001590A1
PE20001590A1 PE2000000217A PE0002172000A PE20001590A1 PE 20001590 A1 PE20001590 A1 PE 20001590A1 PE 2000000217 A PE2000000217 A PE 2000000217A PE 0002172000 A PE0002172000 A PE 0002172000A PE 20001590 A1 PE20001590 A1 PE 20001590A1
Authority
PE
Peru
Prior art keywords
alkyl
aryl
alkenyl
alkinyl
group
Prior art date
Application number
PE2000000217A
Other languages
English (en)
Inventor
Andres S Hernandez
James J Li
Joseph A Tino
Jeffrey A Robl
Stephen G Swartz
Jun Li
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of PE20001590A1 publication Critical patent/PE20001590A1/es

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    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A—HUMAN NECESSITIES
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    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A61P5/08—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH for decreasing, blocking or antagonising the activity of the anterior pituitary hormones
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    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
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    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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Abstract

SE REFIERE A COMPUESTOS HETEROCICLICOS, AROMATICOS (R1)(R1a)(Xa)C-N(R6)-CO-Y(Xb), DONDE R1 ES ALQUILO, ARILO, ALQUENILO, ALQUINILO, ARILALQUILO, CICLOALQUILO, HETEROARILO; R1a ES H, ALQUILO, CICLOALQUILO; Xa ES HETEROARILO, GRUPO a, b, ENTRE OTROS; A ES O, S, NH, NR5, NC(O)R2; R2 ES ALQUILO, ARILO, ALQUENILO, ALQUINILO, ENTRE OTROS; R3 ES H, HALOGENO, ALQUILO, ARILO, ALQUENILO, ALQUINILO, ENTRE OTROS; R4 Y R4a SON H, HALOGENO, CF3, ALQUILO, ARILO; R5 ES H, ALQUILO, ARILO, ALQUENILO, ENTRE OTROS; R5a Y R5b SON H, ALQUILO, ARILO, ALQUENILO, ARILALQUENILO, ALQUINILO, ENTRE OTROS; Y ES UN GRUPO c, ENTRE OTROS; x E y SON 0-3; R6 ES H, ALQUILO, CICLOALQUILO, ALQUENILO, ARILO. Xb ES N(R9)(R10), GRUPO d; R9 Y R10 SON H, ALQUILO, ENTRE OTROS; R11 ES H, ALQUILO C1-C6, CF3, ENTRE OTROS; R12 Y R13 SON H, ALQUILO C1-C6, CF3, ENTRE OTROS; CON LA CONDICION QUE Xa ES UN GRUPO a; UNO O AMBOS DE R9 Y R10 FORMAN UN ALQUILENO; R5 ES (CH2)CON(T1a)T1, AL MENOS UNO DE T1a Y T ES DIFERENTE DE H, ENTRE OTRAS. TAMBIEN SE REFIERE A LA COMBINACION CON HORMONA PARATIROIDEA, BISFOSFONATO, ESTROGENO, TESTOSTERONA. LOS COMPUESTOS ESTIMULAN LA PRODUCCION ENDOGENA Y LA LIBERACION DE LA HORMONA DE CRECIMIENTO Y PUEDE SER UTIL PARA EL TRATAMIENTO DE LA OBESIDAD, OSTEOPOROSIS, ENFERMEDAD RENAL, MIOPATIA CARDIACA, CAQUEXIA
PE2000000217A 1999-03-12 2000-03-13 Compuestos heterociclicos, aromaticos utiles como secretagogos de la hormona del crecimiento PE20001590A1 (es)

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US12413199P 1999-03-12 1999-03-12
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Publication number Priority date Publication date Assignee Title
US6518292B1 (en) * 1999-03-12 2003-02-11 Bristol-Myers Squibb Co. Heterocyclic aromatic compounds usefuls as growth hormone secretagogues
KR20010112408A (ko) * 1999-04-07 2001-12-20 모리타 다카카즈 Ｎ-치환되고-Ｎ'-치환된 우레아 유도체 및 ＴＮＦ-α 생성억제제로서의 그의 용도
WO2001085695A1 (en) 2000-05-11 2001-11-15 Bristol-Myers Squibb Co. Tetrahydroisoquinoline analogs useful as growth hormone secretagogues
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