PE20000953A1 - Composiciones farmaceuticas que contienen un inhibidor de lipasas gastrointestinales - Google Patents
Composiciones farmaceuticas que contienen un inhibidor de lipasas gastrointestinalesInfo
- Publication number
- PE20000953A1 PE20000953A1 PE1999000820A PE00082099A PE20000953A1 PE 20000953 A1 PE20000953 A1 PE 20000953A1 PE 1999000820 A PE1999000820 A PE 1999000820A PE 00082099 A PE00082099 A PE 00082099A PE 20000953 A1 PE20000953 A1 PE 20000953A1
- Authority
- PE
- Peru
- Prior art keywords
- lipase inhibitor
- orlistat
- gastrointestinal lipase
- gum
- absorbable
- Prior art date
Links
- 229940086609 Lipase inhibitor Drugs 0.000 title abstract 4
- 230000002496 gastric effect Effects 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- AHLBNYSZXLDEJQ-FWEHEUNISA-N orlistat Chemical compound CCCCCCCCCCC[C@H](OC(=O)[C@H](CC(C)C)NC=O)C[C@@H]1OC(=O)[C@H]1CCCCCC AHLBNYSZXLDEJQ-FWEHEUNISA-N 0.000 abstract 3
- 229960001243 orlistat Drugs 0.000 abstract 3
- 239000003995 emulsifying agent Substances 0.000 abstract 2
- 235000013305 food Nutrition 0.000 abstract 2
- 239000003921 oil Substances 0.000 abstract 2
- 239000002562 thickening agent Substances 0.000 abstract 2
- 229920000569 Gum karaya Polymers 0.000 abstract 1
- 244000134552 Plantago ovata Species 0.000 abstract 1
- 235000003421 Plantago ovata Nutrition 0.000 abstract 1
- 241000934878 Sterculia Species 0.000 abstract 1
- 238000010521 absorption reaction Methods 0.000 abstract 1
- 239000000654 additive Substances 0.000 abstract 1
- 239000007910 chewable tablet Substances 0.000 abstract 1
- 229940068682 chewable tablet Drugs 0.000 abstract 1
- 230000037213 diet Effects 0.000 abstract 1
- 235000005911 diet Nutrition 0.000 abstract 1
- 235000019621 digestibility Nutrition 0.000 abstract 1
- 230000037406 food intake Effects 0.000 abstract 1
- 239000000231 karaya gum Substances 0.000 abstract 1
- 229940039371 karaya gum Drugs 0.000 abstract 1
- 235000010494 karaya gum Nutrition 0.000 abstract 1
- 229920000609 methyl cellulose Polymers 0.000 abstract 1
- 239000001923 methylcellulose Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008203 oral pharmaceutical composition Substances 0.000 abstract 1
- 229920000728 polyester Polymers 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Zoology (AREA)
- Child & Adolescent Psychology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Jellies, Jams, And Syrups (AREA)
- General Preparation And Processing Of Foods (AREA)
Abstract
SE REFIERE A UNA COMPOSICION FARMACEUTICA ORAL TAL COMO UN COMPRIMIDO MASTICABLE QUE COMPRENDE: a)UN INHIBIDOR DE LIPASAS GASTROINTESTINALES TAL COMO ORLISTAT, UTILIZANDOSE DE 50mg A 150 mg; b)UNO O MAS ADITIVOS COMO: i)ESPESANTES TALES COMO GOMA DE XANTANO, GOMA KARAYA, SEMILLA DE PSILIO, CASCARA DE ISPAGULA, SEMILLAS DE PLANTAGO OVATA, METILCELULOSA; ii)UN EMULSIFICANTE TAL COMO POLIESTER DE SACAROSA; CARACTERIZADOS POR SER DE BAJA DIGESTIBILIDAD, POCA FERMENTABILIDAD, HIDROFILOS, HIDROCOLOIDES DE GRADO ALIMENTARIO. LA PROPORCION ES DE UNA PARTE EN PESO DE INHIBIDOR DE LIPASAS Y DE 1-300 PARTES EN PESO DE ESPESANTES O EMULSIFICANTES, DE PREFERENCIA DE 3 A 30 PARTES DE GOMA KARAYA O GOMA XANTANO POR UNA PARTE DE ORLISTAT. EL ORLISTAT REDUCE LA ABSORCION DE GRASAS DE LA DIETA Y LA COMPOSICION PUEDE SER UTIL PARA LA PREVENCION DEL SINDROME DE LA PERDIDA ANAL DE ACEITE QUE SE PRODUCE POR LA ADMINISTRACION DE UN INHIBIDOR DE LIPASA GASTROINTESTINAL O POR LA INGESTION DE ALIMENTOS CONTENIENDO GRASAS O ACEITES POCO ABSORBIBLES O NO ABSORBIBLES
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98115311 | 1998-08-14 | ||
| EP99109516 | 1999-05-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20000953A1 true PE20000953A1 (es) | 2000-09-26 |
Family
ID=26149537
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1999000820A PE20000953A1 (es) | 1998-08-14 | 1999-08-12 | Composiciones farmaceuticas que contienen un inhibidor de lipasas gastrointestinales |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US6358522B1 (es) |
| EP (1) | EP1105122B1 (es) |
| JP (1) | JP3774118B2 (es) |
| KR (1) | KR20010079635A (es) |
| CN (1) | CN1170534C (es) |
| AR (1) | AR035001A1 (es) |
| AT (1) | ATE293970T1 (es) |
| AU (1) | AU761351B2 (es) |
| BR (1) | BR9912980B1 (es) |
| CA (1) | CA2340056C (es) |
| CO (1) | CO5130009A1 (es) |
| DE (1) | DE69924999T2 (es) |
| DK (1) | DK1105122T3 (es) |
| ES (1) | ES2242413T3 (es) |
| MA (1) | MA26671A1 (es) |
| PE (1) | PE20000953A1 (es) |
| PT (1) | PT1105122E (es) |
| TR (1) | TR200100471T2 (es) |
| WO (1) | WO2000009122A1 (es) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7048917B1 (en) | 1998-01-09 | 2006-05-23 | Genzyme Corporation | Fat-binding polymers |
| US6299868B1 (en) | 1999-07-14 | 2001-10-09 | Geltex Pharmaceuticals, Inc. | Fat-binding polymers |
| US6264937B1 (en) * | 1998-01-09 | 2001-07-24 | Geltex Pharmaceuticals, Inc. | Fat-binding polymers |
| CA2342625A1 (en) | 1998-09-08 | 2000-03-16 | Smithkline Beecham Corporation | Lipstatin derivative-soluble fiber tablets |
| AR025587A1 (es) | 1999-09-13 | 2002-12-04 | Hoffmann La Roche | Formulaciones en dispersion que contienen inhibidores de lipasa |
| AR025609A1 (es) | 1999-09-13 | 2002-12-04 | Hoffmann La Roche | Formulaciones lipidas solidas |
| EP1132389A1 (en) | 2000-03-06 | 2001-09-12 | Vernalis Research Limited | New aza-indolyl derivatives for the treatment of obesity |
| MXPA02012583A (es) * | 2000-06-27 | 2003-04-10 | Hoffmann La Roche | Metodo para preparacion de una composicion. |
| ATE293477T1 (de) * | 2000-07-28 | 2005-05-15 | Hoffmann La Roche | Neue verwendung von lipase-inhibitoren |
| JP4265911B2 (ja) * | 2000-07-28 | 2009-05-20 | エフ．ホフマン−ラ ロシュ アーゲー | 新規医薬組成物 |
| DE60133470T2 (de) | 2000-08-09 | 2009-05-07 | F. Hoffmann-La Roche Ag | Lipase inhibitoren zur behandlung von dyspepsia |
| JP4047723B2 (ja) | 2000-10-16 | 2008-02-13 | エフ．ホフマン−ラ ロシュ アーゲー | インドリン誘導体、および５−ｈｔ２受容体リガンドとしてのその使用 |
| GB0030710D0 (en) | 2000-12-15 | 2001-01-31 | Hoffmann La Roche | Piperazine derivatives |
| US6610685B2 (en) | 2000-12-27 | 2003-08-26 | Hoffmann-La Roche Inc. | Fused indole derivatives |
| GB0106177D0 (en) | 2001-03-13 | 2001-05-02 | Hoffmann La Roche | Piperazine derivatives |
| AU2002338896B2 (en) | 2001-05-21 | 2006-04-27 | F.Hoffman-La Roche Ag | Quinoline derivatives as ligands for the neuropeptide Y receptor |
| US6730319B2 (en) * | 2001-06-06 | 2004-05-04 | Hoffmann-La Roche Inc. | Pharmaceutical compositions having depressed melting points |
| US20030027786A1 (en) * | 2001-06-06 | 2003-02-06 | Karsten Maeder | Lipase inhibiting composition |
| US7049345B2 (en) * | 2001-06-29 | 2006-05-23 | Genzyme Corporation | Fat-binding polymers |
| US7041280B2 (en) * | 2001-06-29 | 2006-05-09 | Genzyme Corporation | Aryl boronate functionalized polymers for treating obesity |
| US6787558B2 (en) | 2001-09-28 | 2004-09-07 | Hoffmann-La Roche Inc. | Quinoline derivatives |
| GB0202015D0 (en) | 2002-01-29 | 2002-03-13 | Hoffmann La Roche | Piperazine Derivatives |
| CN100383124C (zh) | 2002-02-04 | 2008-04-23 | 霍夫曼-拉罗奇有限公司 | 作为npy拮抗剂的喹啉衍生物 |
| PL372463A1 (en) | 2002-02-28 | 2005-07-25 | F.Hoffmann-La Roche Ag | Thiazole derivatives as npy receptor antagonists |
| CN1325050C (zh) | 2002-04-26 | 2007-07-11 | 霍夫曼-拉罗奇有限公司 | 包含脂肪酶抑制剂和葡甘露聚糖的药物组合物 |
| CN1665791A (zh) | 2002-07-05 | 2005-09-07 | 霍夫曼-拉罗奇有限公司 | 喹唑啉衍生物 |
| RU2324685C2 (ru) | 2002-08-07 | 2008-05-20 | Ф.Хоффманн-Ля Рош Аг | Производные тиазола, способ их получения и применение, фармацевтическая композиция, обладающая свойствами антагонистов рецепторов npy |
| PL375878A1 (en) | 2002-09-12 | 2005-12-12 | F.Hoffmann-La Roche Ag | N-substituted-1h-indol-5-propionic acid compounds as ppar agonists useful for the treatment of diabetes |
| BR0316556A (pt) | 2002-11-25 | 2005-10-04 | Hoffmann La Roche | Compostos, processo para a preparação de um composto, composição farmacêutica que compreende esse composto, sua utilização e método para o tratamento e/ou profilaxia de enfermidades que são moduladas por agonistas ppar(alfa) e/ou ppary |
| US8372430B2 (en) * | 2002-12-17 | 2013-02-12 | The Procter & Gamble Company | Compositions, methods, and kits useful for the alleviation of gastrointestinal effects |
| GB0314967D0 (en) | 2003-06-26 | 2003-07-30 | Hoffmann La Roche | Piperazine derivatives |
| KR20060037435A (ko) | 2003-08-12 | 2006-05-03 | 에프. 호프만-라 로슈 아게 | 2-아미노-5-벤조일싸이아졸 ｎｐｙ 길항물질 |
| DE602004019939D1 (de) | 2003-08-12 | 2009-04-23 | Hoffmann La Roche | Thiazolderivate als npy-antagonisten |
| CA2609634C (en) | 2005-05-03 | 2011-02-01 | F. Hoffmann-La Roche Ag | Tetracyclic azapyrazinoindolines as 5-ht2 ligands |
| US20090208584A1 (en) | 2005-06-09 | 2009-08-20 | Tomohiro Yoshinari | Solid preparation |
| EP1945635B1 (en) | 2005-08-18 | 2009-05-06 | F.Hoffmann-La Roche Ag | Thiazolyl piperidine derivatives useful as h3 receptor modulators |
| BRPI0619268A2 (pt) | 2005-11-30 | 2011-09-20 | Hoffmann La Roche | compostos, processo para a sua manufatura, composições farmacêuticas, método para o tratamento e/ou prevenção de enfermidades que estão associadas com a modulação de receptores de h3, uso dos compostos e método para o tratamento ou prevenção de obesidade e de diabetes do tipo ii em um ser humano ou animal |
| RU2412182C2 (ru) | 2005-11-30 | 2011-02-20 | Ф.Хоффманн-Ля Рош Аг | Производные 1,1-диоксотиоморфолинилиндолилметанона для применения в качестве модуляторов гистамина 3 (н3) |
| CA2630270A1 (en) | 2005-11-30 | 2007-06-07 | F. Hoffmann-La Roche Ag | 5-substituted indole-2-carboxamide derivatives |
| CA2631128A1 (en) | 2005-12-09 | 2007-06-14 | F. Hoffmann-La Roche Ag | Tricyclic amide derivatives useful for treating obesity |
| DE602006010738D1 (de) | 2005-12-15 | 2010-01-07 | Hoffmann La Roche | Pyrroloä2,3-cüpyridinderivate |
| WO2007068641A1 (en) | 2005-12-16 | 2007-06-21 | F. Hoffmann-La Roche Ag | Pyrrolo [2 , 3-b] pyridine derivatives as h3 receptor modulators |
| US7432255B2 (en) | 2006-05-16 | 2008-10-07 | Hoffmann-La Roche Inc. | 1H-indol-5-yl-piperazin-1-yl-methanone derivatives |
| MX2008014532A (es) | 2006-05-30 | 2008-11-27 | Hoffmann La Roche | Derivados de piperidinil pirimidinas. |
| US7514433B2 (en) | 2006-08-03 | 2009-04-07 | Hoffmann-La Roche Inc. | 1H-indole-6-yl-piperazin-1-yl-methanone derivatives |
| US20080146559A1 (en) | 2006-12-08 | 2008-06-19 | Li Chen | 4,5,6,7-Tetrahydro-Thieno [2,3-C] Pyridine Derivatives |
| US7862688B2 (en) * | 2007-05-16 | 2011-01-04 | Buckman Laboratories International, Inc. | Methods to control organic contaminants in fibers |
| WO2009013195A1 (en) | 2007-07-25 | 2009-01-29 | F. Hoffmann-La Roche Ag | Benzofuran- and benzo[b]thiophene-2-carboxylic acid amide derivatives and use thereof as histamine 3 receptor modulators |
| WO2009044380A2 (en) | 2007-10-05 | 2009-04-09 | Ranbaxy Laboratories Limited | Formulations containing orlistat particles having controlled particle size |
| EP2219614A1 (en) * | 2007-10-15 | 2010-08-25 | Inventis DDS Pvt Limited | Pharmaceutical composition of orlistat |
| PL216542B1 (pl) | 2008-03-20 | 2014-04-30 | Zakłady Farmaceutyczne POLPHARMA Spółka Akcyjna | Sposób wytwarzania stabilnej kompozycji orlistatu w postaci kapsułkowanego proszku |
| US8309107B2 (en) | 2008-10-06 | 2012-11-13 | Banner Pharmacaps, Inc. | Stable solutions of orlistat for pharmaceutical dosage forms |
| GB201122213D0 (en) * | 2011-12-23 | 2012-02-01 | Norgine Bv | Compositions |
| CN104546768B (zh) * | 2014-12-30 | 2017-06-16 | 重庆植恩药业有限公司 | 含有脂肪酶抑制剂的咀嚼片组合物及其制备方法 |
| BR112018075415A2 (pt) * | 2016-06-17 | 2019-03-12 | The Procter & Gamble Company | composição mastigável macia compreendendo plantago |
| CN112220831A (zh) * | 2020-08-07 | 2021-01-15 | 天津盛实百草中药科技有限公司 | 圆苞车前子壳粉在缓解奥利司他副作用中的应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4005195A (en) * | 1976-02-12 | 1977-01-25 | The Procter & Gamble Company | Compositions for treating hypercholesterolemia |
| CA1247547A (en) | 1983-06-22 | 1988-12-28 | Paul Hadvary | Leucine derivatives |
| US5294451A (en) * | 1991-03-29 | 1994-03-15 | Curtice-Burns, Inc. | Fat substitute compositions having reduced laxative effects |
| CA2098167C (en) * | 1992-06-24 | 2006-12-19 | Dorothea Isler | Foodstuffs and feedstuffs containing a lipase inhibitor |
| CA2128044C (en) * | 1993-08-05 | 2007-02-20 | Klaus-Dieter Bremer | Pharmaceutical compositions comprising a glucosidase and/or amylase inhibitor, and a lipase inhibitor |
| JPH09252746A (ja) * | 1996-03-22 | 1997-09-30 | Nippon Kankyo Yakuhin Kk | 栄養補助食品 |
| JP4202439B2 (ja) * | 1996-10-01 | 2008-12-24 | 江崎グリコ株式会社 | フラボノイド可溶化法、その糖転移法及び高濃度フラボノイド溶液 |
| US6004996A (en) * | 1997-02-05 | 1999-12-21 | Hoffman-La Roche Inc. | Tetrahydrolipstatin containing compositions |
-
1999
- 1999-08-02 KR KR1020017001801A patent/KR20010079635A/ko not_active Ceased
- 1999-08-02 TR TR2001/00471T patent/TR200100471T2/xx unknown
- 1999-08-02 CA CA002340056A patent/CA2340056C/en not_active Expired - Lifetime
- 1999-08-02 DK DK99940127T patent/DK1105122T3/da active
- 1999-08-02 JP JP2000564625A patent/JP3774118B2/ja not_active Expired - Lifetime
- 1999-08-02 PT PT99940127T patent/PT1105122E/pt unknown
- 1999-08-02 ES ES99940127T patent/ES2242413T3/es not_active Expired - Lifetime
- 1999-08-02 CN CNB998095079A patent/CN1170534C/zh not_active Expired - Lifetime
- 1999-08-02 WO PCT/EP1999/005607 patent/WO2000009122A1/en not_active Ceased
- 1999-08-02 DE DE69924999T patent/DE69924999T2/de not_active Expired - Lifetime
- 1999-08-02 AU AU54185/99A patent/AU761351B2/en not_active Expired
- 1999-08-02 BR BRPI9912980-9B1A patent/BR9912980B1/pt not_active IP Right Cessation
- 1999-08-02 AT AT99940127T patent/ATE293970T1/de active
- 1999-08-02 EP EP99940127A patent/EP1105122B1/en not_active Expired - Lifetime
- 1999-08-10 US US09/370,846 patent/US6358522B1/en not_active Expired - Lifetime
- 1999-08-10 CO CO99050689A patent/CO5130009A1/es unknown
- 1999-08-11 MA MA25725A patent/MA26671A1/fr unknown
- 1999-08-12 AR ARP990104054A patent/AR035001A1/es not_active Application Discontinuation
- 1999-08-12 PE PE1999000820A patent/PE20000953A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CO5130009A1 (es) | 2002-02-27 |
| US6358522B1 (en) | 2002-03-19 |
| MA26671A1 (fr) | 2004-12-20 |
| DE69924999D1 (de) | 2005-06-02 |
| DE69924999T2 (de) | 2006-05-04 |
| CN1170534C (zh) | 2004-10-13 |
| CN1312713A (zh) | 2001-09-12 |
| WO2000009122A1 (en) | 2000-02-24 |
| JP3774118B2 (ja) | 2006-05-10 |
| BR9912980A (pt) | 2001-05-08 |
| PT1105122E (pt) | 2005-08-31 |
| AU5418599A (en) | 2000-03-06 |
| ATE293970T1 (de) | 2005-05-15 |
| ES2242413T3 (es) | 2005-11-01 |
| TR200100471T2 (tr) | 2001-07-23 |
| CA2340056C (en) | 2007-01-09 |
| JP2002522491A (ja) | 2002-07-23 |
| BR9912980B1 (pt) | 2013-10-22 |
| CA2340056A1 (en) | 2000-02-24 |
| EP1105122A1 (en) | 2001-06-13 |
| DK1105122T3 (da) | 2005-08-08 |
| AR035001A1 (es) | 2004-04-14 |
| EP1105122B1 (en) | 2005-04-27 |
| KR20010079635A (ko) | 2001-08-22 |
| AU761351B2 (en) | 2003-06-05 |
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