PE20000710A1 - Derivados de triazolo-piridazina como ligandos para receptores de gaba - Google Patents
Derivados de triazolo-piridazina como ligandos para receptores de gabaInfo
- Publication number
- PE20000710A1 PE20000710A1 PE1999000557A PE00055799A PE20000710A1 PE 20000710 A1 PE20000710 A1 PE 20000710A1 PE 1999000557 A PE1999000557 A PE 1999000557A PE 00055799 A PE00055799 A PE 00055799A PE 20000710 A1 PE20000710 A1 PE 20000710A1
- Authority
- PE
- Peru
- Prior art keywords
- triazolo
- ligands
- pyridazine
- pyridazine derivatives
- gaba receptors
- Prior art date
Links
- CBHTTYDJRXOHHL-UHFFFAOYSA-N 2h-triazolo[4,5-c]pyridazine Chemical class N1=NC=CC2=C1N=NN2 CBHTTYDJRXOHHL-UHFFFAOYSA-N 0.000 title 1
- 102000005915 GABA Receptors Human genes 0.000 title 1
- 108010005551 GABA Receptors Proteins 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- -1 1,1-DIMETHYLETHYL Chemical class 0.000 abstract 1
- KXRSWXZVHQRQTP-UHFFFAOYSA-N 7-tert-butyl-6-chloro-3-(2-fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazine Chemical compound N12N=C(Cl)C(C(C)(C)C)=CC2=NN=C1C1=CC=CC=C1F KXRSWXZVHQRQTP-UHFFFAOYSA-N 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 102000004300 GABA-A Receptors Human genes 0.000 abstract 1
- 108090000839 GABA-A Receptors Proteins 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurosurgery (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
SE REFIERE A UN COMPUESTO 7-(1,1-DIMETILETIL)-6-(2-ETIL-2H-1,2,4-TRIAZOL-3-ILMETOXI)-3-(2-FLUOROFENIL)-1,2,4-TRIAZOLO[4,3-b]-PIRIDAZINA, POLIMORFO A. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION QUE COMPRENDE HACER REACCIONAR 6-CLORO-7-(1,1-DIMETILETIL)-3-(2-FLUOROFENIL)-1,2,4-TRIAZOLO[4,3-b]PIRIDAZINA EN 1-METIL-2-PIRROLIDINONA, EN PRESENCIA DE HIDROXIDO DE SODIO A UNA TEMPERATURA DE 0°C. TAMBIEN SE REFIERE A 7-CICLOBUTIL-3-(2,6-DIFLUOROFENIL)-6-(2-METIL-2H-1,2,4-TRIAZOL-3-ILMETOXI)-1,2,4-TRIAZOLO[4,3-b]PIRIDAZINA. EL COMPUESTO ES AGONISTA DEL RECEPTOR GABA A POR LO QUE PUEDE SER UTIL PARA EL TRATAMIENTO O LA PREVENCION DE LA ANSIEDAD
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9813576.7A GB9813576D0 (en) | 1998-06-24 | 1998-06-24 | Therapeutic agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20000710A1 true PE20000710A1 (es) | 2000-08-14 |
Family
ID=10834265
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1999000557A PE20000710A1 (es) | 1998-06-24 | 1999-06-22 | Derivados de triazolo-piridazina como ligandos para receptores de gaba |
Country Status (35)
| Country | Link |
|---|---|
| US (1) | US6630471B1 (es) |
| EP (1) | EP1090004B1 (es) |
| JP (1) | JP4749545B2 (es) |
| KR (1) | KR100604108B1 (es) |
| CN (1) | CN1138779C (es) |
| AR (1) | AR018925A1 (es) |
| AT (1) | ATE239730T1 (es) |
| AU (1) | AU757315B2 (es) |
| BG (1) | BG64989B1 (es) |
| BR (1) | BR9911563A (es) |
| CA (1) | CA2335328C (es) |
| CO (1) | CO5031239A1 (es) |
| CZ (1) | CZ291409B6 (es) |
| DE (1) | DE69907675T2 (es) |
| EA (1) | EA003332B1 (es) |
| EE (1) | EE200000767A (es) |
| ES (1) | ES2196824T3 (es) |
| GB (1) | GB9813576D0 (es) |
| GE (1) | GEP20033143B (es) |
| HR (1) | HRP20000879A2 (es) |
| HU (1) | HUP0102894A3 (es) |
| ID (1) | ID27771A (es) |
| IL (2) | IL139775A0 (es) |
| IS (1) | IS2258B (es) |
| MY (1) | MY124341A (es) |
| NO (1) | NO317992B1 (es) |
| NZ (1) | NZ508290A (es) |
| PE (1) | PE20000710A1 (es) |
| PL (1) | PL204650B1 (es) |
| RS (1) | RS49746B (es) |
| SK (1) | SK285307B6 (es) |
| TR (1) | TR200003789T2 (es) |
| TW (1) | TWI222449B (es) |
| WO (1) | WO1999067245A1 (es) |
| ZA (1) | ZA200007485B (es) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2345443A (en) * | 1999-01-08 | 2000-07-12 | Merck Sharp & Dohme | Use of triazolo-pyridazines for treating premenstrual syndrome |
| US20050042194A1 (en) | 2000-05-11 | 2005-02-24 | A.P. Pharma, Inc. | Semi-solid delivery vehicle and pharmaceutical compositions |
| GB0111191D0 (en) * | 2001-05-08 | 2001-06-27 | Merck Sharp & Dohme | Therapeutic agents |
| US7268136B2 (en) | 2002-12-18 | 2007-09-11 | Vertex Pharmaceuticals Incorporated | Compositions useful as inhibitors of protein kinases |
| WO2006061428A2 (en) * | 2004-12-10 | 2006-06-15 | Universität Zürich | Gaba-a alpha 2 and alpha 3 receptor agonists for treating neuropathic, inflammatory and migraine associated pain |
| EP2454259A1 (en) | 2009-06-23 | 2012-05-23 | Concert Pharmaceuticals Inc. | Deuterium-modified triazolo-pyridazine derivatives as gaba-a receptor modulators |
| EP2456311A4 (en) * | 2009-07-24 | 2013-01-23 | Concert Pharmaceuticals Inc | SUBSTITUTED IMIDASOTRIAZINES |
| WO2011047315A1 (en) | 2009-10-15 | 2011-04-21 | Concert Pharmaceuticals, Inc. | Subsitituted benzimidazoles |
| PH12012501361A1 (en) | 2009-12-31 | 2012-10-22 | Centro Nac De Investigaciones Oncologicas Cnio | Tricyclic compounds for use as kinase inhibitors |
| WO2012098387A1 (en) * | 2011-01-18 | 2012-07-26 | Centro Nacional De Investigaciones Oncológicas (Cnio) | 6, 7-ring-fused triazolo [4, 3 - b] pyridazine derivatives as pim inhibitors |
| BR112014006924B1 (pt) | 2011-09-27 | 2020-10-06 | Genfit | Derivados de triazolopiridazinas 6-substituídas como agonistas de rev-erb |
| CN108697694B (zh) | 2016-01-27 | 2022-12-09 | 苏黎世大学 | Gabaa受体调节剂用于治疗发痒的用途 |
| JP7449272B2 (ja) | 2018-04-18 | 2024-03-13 | ニューロサイクル・セラピューティクス・インコーポレイテッド | Ｇａｂａａ陽性アロステリックモジュレーター化合物、その作製の方法および使用 |
| HRP20230067T1 (hr) * | 2018-09-13 | 2023-03-17 | Saniona A/S | Ligand gaba receptora |
| HU231223B1 (hu) | 2018-09-28 | 2022-01-28 | Richter Gedeon Nyrt. | GABAA A5 receptor modulátor hatású biciklusos vegyületek |
| US20240043418A1 (en) | 2020-03-26 | 2024-02-08 | Richter Gedeon Nyrt. | 1,3-dihydro-2h-pyrrolo[3,4-c]pyridine derivatives as gabaa a5 receptor modulators |
| WO2025141131A1 (en) | 2023-12-27 | 2025-07-03 | Saniona A/S | A gabaa receptor ligand and the use thereof in medicine, in particular in the treatment of epilepsy |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| YU2899A (sh) * | 1996-07-25 | 2000-03-21 | Merck Sharp & Dohme Limited | Supstituisani triazolo-piridazin derivati kao ligandi za gaba receptore |
-
1998
- 1998-06-24 GB GBGB9813576.7A patent/GB9813576D0/en not_active Ceased
-
1999
- 1999-06-15 HR HR20000879A patent/HRP20000879A2/hr not_active Application Discontinuation
- 1999-06-15 EA EA200100071A patent/EA003332B1/ru not_active IP Right Cessation
- 1999-06-15 ID IDW20002717A patent/ID27771A/id unknown
- 1999-06-15 US US09/719,184 patent/US6630471B1/en not_active Expired - Lifetime
- 1999-06-15 DE DE69907675T patent/DE69907675T2/de not_active Expired - Lifetime
- 1999-06-15 TR TR2000/03789T patent/TR200003789T2/xx unknown
- 1999-06-15 JP JP2000555898A patent/JP4749545B2/ja not_active Expired - Fee Related
- 1999-06-15 CZ CZ20004872A patent/CZ291409B6/cs not_active IP Right Cessation
- 1999-06-15 AU AU46301/99A patent/AU757315B2/en not_active Ceased
- 1999-06-15 WO PCT/GB1999/001897 patent/WO1999067245A1/en not_active Ceased
- 1999-06-15 IL IL13977599A patent/IL139775A0/xx active IP Right Grant
- 1999-06-15 NZ NZ508290A patent/NZ508290A/en unknown
- 1999-06-15 CA CA002335328A patent/CA2335328C/en not_active Expired - Fee Related
- 1999-06-15 PL PL345332A patent/PL204650B1/pl not_active IP Right Cessation
- 1999-06-15 GE GEAP19995726A patent/GEP20033143B/en unknown
- 1999-06-15 RS YUP-778/00A patent/RS49746B/sr unknown
- 1999-06-15 EP EP99929508A patent/EP1090004B1/en not_active Expired - Lifetime
- 1999-06-15 SK SK1955-2000A patent/SK285307B6/sk not_active IP Right Cessation
- 1999-06-15 AT AT99929508T patent/ATE239730T1/de not_active IP Right Cessation
- 1999-06-15 BR BR9911563-8A patent/BR9911563A/pt not_active Application Discontinuation
- 1999-06-15 EE EEP200000767A patent/EE200000767A/xx unknown
- 1999-06-15 HU HU0102894A patent/HUP0102894A3/hu unknown
- 1999-06-15 ES ES99929508T patent/ES2196824T3/es not_active Expired - Lifetime
- 1999-06-15 KR KR1020007014680A patent/KR100604108B1/ko not_active Expired - Fee Related
- 1999-06-15 CN CNB998078352A patent/CN1138779C/zh not_active Expired - Fee Related
- 1999-06-16 MY MYPI99002465A patent/MY124341A/en unknown
- 1999-06-18 CO CO99038282A patent/CO5031239A1/es unknown
- 1999-06-22 PE PE1999000557A patent/PE20000710A1/es not_active Application Discontinuation
- 1999-06-23 AR ARP990103008A patent/AR018925A1/es active IP Right Grant
- 1999-06-28 TW TW088110866A patent/TWI222449B/zh active
-
2000
- 2000-11-20 IL IL139775A patent/IL139775A/en not_active IP Right Cessation
- 2000-11-24 IS IS5730A patent/IS2258B/is unknown
- 2000-12-14 ZA ZA200007485A patent/ZA200007485B/en unknown
- 2000-12-21 NO NO20006576A patent/NO317992B1/no not_active IP Right Cessation
-
2001
- 2001-01-15 BG BG105152A patent/BG64989B1/bg unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |