PE20000426A1 - Uso de dihidropirimidinas como medicamento y nuevas sustancias - Google Patents
Uso de dihidropirimidinas como medicamento y nuevas sustanciasInfo
- Publication number
- PE20000426A1 PE20000426A1 PE1999000308A PE00030899A PE20000426A1 PE 20000426 A1 PE20000426 A1 PE 20000426A1 PE 1999000308 A PE1999000308 A PE 1999000308A PE 00030899 A PE00030899 A PE 00030899A PE 20000426 A1 PE20000426 A1 PE 20000426A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- optionally substituted
- phenyl
- dihydropyrimidines
- phenyl optionally
- Prior art date
Links
- 229940126601 medicinal product Drugs 0.000 title 1
- 239000000126 substance Substances 0.000 title 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical group [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 5
- -1 CARBOXYL Chemical class 0.000 abstract 3
- WZKSXHQDXQKIQJ-UHFFFAOYSA-N F[C](F)F Chemical class F[C](F)F WZKSXHQDXQKIQJ-UHFFFAOYSA-N 0.000 abstract 2
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical class O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- TUJKJAMUKRIRHC-UHFFFAOYSA-N hydroxyl Chemical class [OH] TUJKJAMUKRIRHC-UHFFFAOYSA-N 0.000 abstract 2
- 239000000725 suspension Substances 0.000 abstract 2
- OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical class C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 abstract 1
- 239000004215 Carbon black (E152) Substances 0.000 abstract 1
- 239000003443 antiviral agent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000006454 hepatitis Diseases 0.000 abstract 1
- 231100000283 hepatitis Toxicity 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 150000002430 hydrocarbons Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical group [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 1
- CFHIDWOYWUOIHU-UHFFFAOYSA-N oxomethyl Chemical compound O=[CH] CFHIDWOYWUOIHU-UHFFFAOYSA-N 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
SE REFIERE AL USO DE DIHIDROPIRIMIDINAS DE FORMULA I COMO AGENTES ANTIVIRALES PARA EL TRATAMIENTO Y PROFILAXIS DE LA HEPATITIS B, DONDE R1 ES FENILO, FURILO, TIENILO, TRIAZOLILO, PIRIDILO, CICLOALQUILO C3-C6, GRUPO a, b, c OPCIONALMENTE SUSTITUIDO CON HALOGENO, TRIFLUOROMETILO, NITRO, CIANO, TRIFLUOROMETOXI, CARBOXILO, HIDROXILO, -S-R6, NR7R8, CONR9R10, SO2-CF3, -A-CH2-R11; R6 ES FENILO OPCIONALMENTE SUSTITUIDO POR HALOGENO; R7, R8, R9, R10 SON H, FENILO OPCIONALMENTE SUSTITUIDO POR HIDROXILO, ACILO C1-C6, ALQUILO C1-C6; A ES O, S, SO, SO2; R11 ES FENILO OPCIONALMENTE SUSTITUIDO CON HALOGENO, NITRO, TRIFLUOROMETILO, ALQUILO C1-C6, ALCOXI C1-C6; R2 ES -XR12, -NR13R14; X ES UN ENLACE, O; R12 ES H, ALCOXICARBONILO C1-C6, UN RESTO HIDROCARBONADO C1-C8; R13 Y R14 SON H, ALQUILO C1-C6, CICLOALQUILO C3-C6; R3 ES H, AMINO, -CH2-(OCH3)2, FORMILO, CIANO, ALQUILTIO C1-C6, O R3 ES FENILO OPCIONALMENTE SUSTITUIDO CON METOXI; R2 Y R3 FORMAN JUNTOS UN RESTO -O-CH2-; R4 ES H, ALQUILO C1-C4, ALQUENILO C2-C4, BENZOILO, ACILO C2-C6; R5 ES PIRIDILO, PIRIMIDILO, PIRAZINILO. TAMBIEN SE REFIERE A COMPUESTOS, ENTRE ELLOS UN COMPUESTO PREFERIDO DE FORMULA II Y A PROCEDIMIENTOS PARA LA PREPARACION
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19817265A DE19817265A1 (de) | 1998-04-18 | 1998-04-18 | Verwendung von Dihydropyrimidinen als Arzneimittel und neue Stoffe |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20000426A1 true PE20000426A1 (es) | 2000-06-25 |
Family
ID=7864973
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1999000308A PE20000426A1 (es) | 1998-04-18 | 1999-04-15 | Uso de dihidropirimidinas como medicamento y nuevas sustancias |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6436943B1 (es) |
| EP (1) | EP1073642B1 (es) |
| JP (1) | JP2002512233A (es) |
| AR (1) | AR023308A1 (es) |
| AU (1) | AU3813499A (es) |
| CA (1) | CA2328733A1 (es) |
| DE (2) | DE19817265A1 (es) |
| ES (1) | ES2186354T3 (es) |
| GT (1) | GT199900054A (es) |
| PE (1) | PE20000426A1 (es) |
| SV (1) | SV1999000048A (es) |
| WO (1) | WO1999054312A1 (es) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU4289100A (en) * | 1999-03-25 | 2000-10-16 | Bayer Aktiengesellschaft | Dihydropyrimidines and their use in the treatment of hepatitis |
| AU5568400A (en) * | 1999-06-23 | 2001-01-09 | Ajinomoto Co., Inc. | Novel dihydropyrimidine derivatives |
| WO2001045712A1 (de) * | 1999-12-22 | 2001-06-28 | Bayer Aktiengesellschaft | Arzneimittelkombinationen gegen virale erkrankungen |
| US6440860B1 (en) | 2000-01-18 | 2002-08-27 | Micron Technology, Inc. | Semiconductor processing methods of transferring patterns from patterned photoresists to materials, and structures comprising silicon nitride |
| DE10012549A1 (de) * | 2000-03-15 | 2001-09-20 | Bayer Ag | Arzneimittel gegen virale Erkrankungen |
| DE10012823A1 (de) | 2000-03-16 | 2001-09-20 | Bayer Ag | Arzneimittel gegen virale Erkrankungen |
| DE10012824A1 (de) * | 2000-03-16 | 2001-09-20 | Bayer Ag | Arzneimittel gegen virale Erkrankungen |
| DE10013126A1 (de) * | 2000-03-17 | 2001-09-20 | Bayer Ag | Arzneimittel gegen virale Erkrankungen |
| GB0017676D0 (en) | 2000-07-19 | 2000-09-06 | Angeletti P Ist Richerche Bio | Inhibitors of viral polymerase |
| GB0201179D0 (en) * | 2002-01-18 | 2002-03-06 | Angeletti P Ist Richerche Bio | Therapeutic agents |
| KR100502395B1 (ko) * | 2003-06-04 | 2005-07-19 | (주) 비엔씨바이오팜 | 4-[4-(4-모르포리노)아닐리노]피리미딘 유도체, 그제조방법 및 이를 포함하는 항바이러스용 약학적 조성물. |
| KR100502394B1 (ko) * | 2003-06-04 | 2005-07-19 | (주) 비엔씨바이오팜 | 2-[2-(4-모르포리노)에틸아미노]피리딘 유도체, 그제조방법 및 이를 포함하는 항바이러스용 약학적 조성물 |
| GB0313250D0 (en) * | 2003-06-09 | 2003-07-16 | Angeletti P Ist Richerche Bio | Therapeutic agents |
| AU2008265397C1 (en) | 2007-06-18 | 2013-08-29 | Sunshine Lake Pharma Co., Ltd. | Bromo-phenyl substituted thiazolyl dihydropyrimidines |
| CA2693609A1 (en) | 2007-07-12 | 2009-01-15 | Novartis Ag | Oral pharmaceutical solutions containing telbivudine |
| US9487534B2 (en) | 2011-08-02 | 2016-11-08 | Scripps Research Institute, A Not-For-Profit Public Benefit Corporation Of California | Modulators of virus assembly as antiviral agents |
| CA3132120C (en) | 2012-02-08 | 2023-10-24 | Sunovion Pharmaceuticals Inc. | Heteroaryl compounds and methods of use thereof |
| US20130267517A1 (en) | 2012-03-31 | 2013-10-10 | Hoffmann-La Roche Inc. | Novel 4-methyl-dihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection |
| PL2888241T3 (pl) | 2012-08-24 | 2017-12-29 | Sunshine Lake Pharma Co., Ltd. | 2,4,5,6-Podstawione pochodne 3,6-dihydropirymidyny jako inhibitory polimerazy wirusa zapalenia wątroby typu B (HBV) do leczenia np. przewlekłego zapalenia wątroby |
| BR112015004113A2 (pt) | 2012-09-10 | 2017-07-04 | Hoffmann La Roche | 6-aminoácido heteroarila diidropirimidinas para o tratamento e profilaxia da infecção pelo vírus da hepatite b |
| KR20150093685A (ko) * | 2012-11-09 | 2015-08-18 | 인디애나 유니버시티 리서치 앤드 테크놀로지 코포레이션 | Hbv 어셈블리 이펙터의 대체 용도 |
| CA2907490A1 (en) * | 2013-03-20 | 2014-09-25 | Indiana University Research And Technology Corporation | Fluorescent-hap: a diagnostic stain for hbv cores in cells |
| MX2016006564A (es) | 2013-11-19 | 2017-09-12 | Sunshine Lake Pharma Co Ltd | Compuestos dihidropirimidina y su aplicacion en productos farmaceuticos. |
| KR102284938B1 (ko) | 2013-11-27 | 2021-08-02 | 선샤인 레이크 파르마 컴퍼니 리미티드 | 다이하이드로피리미딘 유도체 및 이의 중간산물의 제조 방법 |
| MX2016012573A (es) | 2014-03-28 | 2018-02-19 | Sunshine Lake Pharma Co Ltd | Compuestos de dihidropirimidina y su aplicacion en productos farmaceuticos. |
| TW201629054A (zh) | 2015-02-07 | 2016-08-16 | 廣東東陽光藥業有限公司 | 二氫嘧啶衍生物的複合物及其在藥物中的應用 |
| JP2019523279A (ja) | 2016-07-29 | 2019-08-22 | サノビオン ファーマシューティカルズ インクＳｕｎｏｖｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． | 化合物および組成物ならびにそれらの使用 |
| SG11201900689RA (en) | 2016-07-29 | 2019-02-27 | Sunovion Pharmaceuticals Inc | Compounds and compositions and uses thereof |
| ES2895023T3 (es) * | 2017-03-31 | 2022-02-17 | Fujifilm Corp | Compuesto de 4-piridona o sal del mismo y composición farmacéutica y formulación que los incluyen |
| AU2018312559B2 (en) | 2017-08-02 | 2022-06-02 | Pgi Drug Discovery Llc | Isochroman compounds and uses thereof |
| CN108947996B (zh) * | 2018-07-12 | 2022-01-18 | 山东大学 | 二氢嘧啶-磺酰胺类衍生物及其制备方法与应用 |
| JP7703449B2 (ja) | 2019-03-14 | 2025-07-07 | スミトモ・ファーマ・アメリカ・インコーポレイテッド | イソクロマニル化合物の塩およびその結晶体、ならびにそれらの製造方法、治療用途および医薬組成物 |
| CN112778299B (zh) * | 2019-11-04 | 2023-07-14 | 江苏恒瑞医药股份有限公司 | 哌嗪脲基类衍生物、其制备方法及其在医药上的应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH550189A (de) | 1971-01-08 | 1974-06-14 | Ciba Geigy Ag | Verfahren zur herstellung von neuen dibenzo (b,f) thiepincarbonsaeuren. |
| CH569043A5 (es) | 1973-01-23 | 1975-11-14 | Ciba Geigy Ag | |
| DE3234684A1 (de) | 1982-09-18 | 1984-03-22 | Bayer Ag, 5090 Leverkusen | Neue dihydropyrimidine, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln |
| US4698340A (en) * | 1984-07-19 | 1987-10-06 | Fujisawa Pharmaceutical Co., Ltd. | Pyrimidine derivatives, processes for preparation thereof and composition containing the same |
| US4727073A (en) | 1984-10-01 | 1988-02-23 | Fujisawa Pharmaceutical Co., Ltd. | Pyrimidine derivatives and composition of the same |
| JPH07110132B2 (ja) | 1991-08-22 | 1995-11-22 | 日本モトローラ株式会社 | 電圧変換装置 |
| JP3349781B2 (ja) | 1993-08-30 | 2002-11-25 | 富士通株式会社 | スイッチングレギュレータ電源装置 |
| US5774319A (en) | 1993-10-27 | 1998-06-30 | Square D Company | Energy validation arrangement for a self-powered circuit interrupter |
| US5638264A (en) | 1993-12-27 | 1997-06-10 | Hitachi, Ltd. | Parallelized power supply system providing uninterrupted operation |
| JP3493840B2 (ja) | 1995-10-27 | 2004-02-03 | 松下電工株式会社 | 電源装置 |
| SE9702564D0 (sv) | 1997-07-02 | 1997-07-02 | Astra Ab | New compounds |
| US5929615A (en) | 1998-09-22 | 1999-07-27 | Impala Linear Corporation | Step-up/step-down voltage regulator using an MOS synchronous rectifier |
-
1998
- 1998-04-18 DE DE19817265A patent/DE19817265A1/de not_active Withdrawn
-
1999
- 1999-04-07 CA CA002328733A patent/CA2328733A1/en not_active Abandoned
- 1999-04-07 WO PCT/EP1999/002346 patent/WO1999054312A1/de not_active Ceased
- 1999-04-07 US US09/673,581 patent/US6436943B1/en not_active Expired - Fee Related
- 1999-04-07 ES ES99920604T patent/ES2186354T3/es not_active Expired - Lifetime
- 1999-04-07 DE DE59903174T patent/DE59903174D1/de not_active Expired - Fee Related
- 1999-04-07 EP EP99920604A patent/EP1073642B1/de not_active Expired - Lifetime
- 1999-04-07 JP JP2000544651A patent/JP2002512233A/ja active Pending
- 1999-04-07 AU AU38134/99A patent/AU3813499A/en not_active Abandoned
- 1999-04-15 PE PE1999000308A patent/PE20000426A1/es not_active Application Discontinuation
- 1999-04-16 AR ARP990101778A patent/AR023308A1/es unknown
- 1999-04-16 GT GT199900054A patent/GT199900054A/es unknown
- 1999-04-16 SV SV1999000048A patent/SV1999000048A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU3813499A (en) | 1999-11-08 |
| DE59903174D1 (de) | 2002-11-28 |
| EP1073642A1 (de) | 2001-02-07 |
| ES2186354T3 (es) | 2003-05-01 |
| GT199900054A (es) | 2000-10-07 |
| US6436943B1 (en) | 2002-08-20 |
| CA2328733A1 (en) | 1999-10-28 |
| DE19817265A1 (de) | 1999-10-21 |
| WO1999054312A1 (de) | 1999-10-28 |
| EP1073642B1 (de) | 2002-10-23 |
| JP2002512233A (ja) | 2002-04-23 |
| AR023308A1 (es) | 2002-09-04 |
| SV1999000048A (es) | 2000-07-04 |
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