PE106299A1 - Derivados del 2-(4-aril o heteroaril-piperazin-1-ilmetil)-1h-indol - Google Patents

Derivados del 2-(4-aril o heteroaril-piperazin-1-ilmetil)-1h-indol

Info

Publication number: PE106299A1
Authority: PE; Peru
Prior art keywords: compound; disorders; trifluoromethyl; chlorine; fluorine
Prior art date: 1997-08-15

Application number

PE1998000717A

Other languages

English (en)

Spanish (es)

Inventor

Anton Franz Josef Fliri

Mark Jerome Majchrzak

Stevin Howard Zorn

Hans Rollema

Patricia Ann Seymour

Original Assignee

Pfizer Prod Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-08-15

Filing date

1998-08-10

Publication date

1999-11-02

1998-08-10 Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc

1999-11-02 Publication of PE106299A1 publication Critical patent/PE106299A1/es

Links

KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 3
WZKSXHQDXQKIQJ-UHFFFAOYSA-N F[C](F)F Chemical class F[C](F)F WZKSXHQDXQKIQJ-UHFFFAOYSA-N 0.000 abstract 3
PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 3
229910052801 chlorine Inorganic materials 0.000 abstract 3
239000000460 chlorine Substances 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 3
229910052731 fluorine Inorganic materials 0.000 abstract 3
239000011737 fluorine Substances 0.000 abstract 3
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 abstract 2
101100495911 Arabidopsis thaliana CHR10 gene Proteins 0.000 abstract 1
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
102100020802 D(1A) dopamine receptor Human genes 0.000 abstract 1
229940099567 Dopamine D4 receptor agonist Drugs 0.000 abstract 1
101000931925 Homo sapiens D(1A) dopamine receptor Proteins 0.000 abstract 1
208000016285 Movement disease Diseases 0.000 abstract 1
208000028017 Psychotic disease Diseases 0.000 abstract 1
239000000556 agonist Substances 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
229960003638 dopamine Drugs 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1
LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Addiction (AREA)
Anesthesiology (AREA)
Ophthalmology & Optometry (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)

PE1998000717A 1997-08-15 1998-08-10 Derivados del 2-(4-aril o heteroaril-piperazin-1-ilmetil)-1h-indol PE106299A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US5576497P	1997-08-15	1997-08-15

Publications (1)

Publication Number	Publication Date
PE106299A1 true PE106299A1 (es)	1999-11-02

Family

ID=22000003

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PE1998000717A PE106299A1 (es)	1997-08-15	1998-08-10	Derivados del 2-(4-aril o heteroaril-piperazin-1-ilmetil)-1h-indol

Country Status (30)

Country	Link
EP (1)	EP1003739A2 (no)
JP (1)	JP2002536291A (no)
KR (1)	KR20010022507A (no)
CN (1)	CN1265660A (no)
AP (1)	AP9801321A0 (no)
AR (1)	AR017019A1 (no)
AU (1)	AU8457298A (no)
BG (1)	BG104069A (no)
BR (1)	BR9811557A (no)
CA (1)	CA2297486C (no)
CO (1)	CO4960656A1 (no)
DZ (1)	DZ2583A1 (no)
EA (1)	EA200000023A1 (no)
HR (1)	HRP980441A2 (no)
HU (1)	HUP0003425A3 (no)
ID (1)	ID23803A (no)
IL (1)	IL133960A0 (no)
IS (1)	IS5336A (no)
MA (1)	MA24632A1 (no)
NO (1)	NO20000722D0 (no)
OA (1)	OA11286A (no)
PA (1)	PA8457001A1 (no)
PE (1)	PE106299A1 (no)
PL (1)	PL338947A1 (no)
SK (1)	SK1352000A3 (no)
TN (1)	TNSN98151A1 (no)
TR (1)	TR200000414T2 (no)
UY (1)	UY25144A1 (no)
WO (1)	WO1999009025A2 (no)
ZA (1)	ZA987304B (no)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EE04588B1 (et) *	1997-10-27	2006-02-15	Neurosearch A/S	Heteroarüüldiasatsükloalkaanid kui atsetüülkoliini nikotiinretseptorite kolinergilised ligandid, nende kasutamine ravimitena ning neid sisaldav farmatseutiline kompositsioon
EP0953567A3 (en) *	1998-04-29	2003-04-02	Pfizer Products Inc.	Bicyclic substituted piperazine-, piperidine- and tetrahydropyridine derivatives, their preparation and their use as agents with central dopaminergic (dopamine D4 receptor) activity
DE60011817T2 (de)	1999-12-30	2005-07-14	H. Lundbeck A/S	4-phenyl-1-piperazinyl, -piperidinyl und -tetrahydropyridyl-derivate
GB0017952D0 (en) *	2000-07-22	2000-09-13	Univ Manchester	Treatment of dyskinesia
EP1177792A3 (en)	2000-07-27	2002-10-23	Pfizer Products Inc.	Dopamine D4 Ligands for the treatment of novelty-seeking disorders
US6803362B2 (en)	2001-03-09	2004-10-12	Ortho-Mcneil Pharmaceutical Inc.	Heterocyclic compounds
PL377087A1 (pl)	2002-09-06	2006-01-23	Janssen Pharmaceutica, N.V.	Związki heterocykliczne
WO2004108671A1 (en) *	2003-06-06	2004-12-16	Suven Life Sciences Limited	Substituted indoles with serotonin receptor affinity, process for their preparation and pharmaceutical compositions containing them
EP1731505B1 (en)	2004-03-30	2015-01-14	Takeda Pharmaceutical Company Limited	Alkoxyphenylpropanoic acid derivatives
US7618980B2 (en)	2004-07-14	2009-11-17	Bristol-Myers Squibb Company	Pyrrolo(oxo)quinolines as 5HT ligands
US7572805B2 (en)	2004-07-14	2009-08-11	Bristol-Myers Squibb Company	Pyrrolo(oxo)isoquinolines as 5HT ligands
JO2769B1 (en)	2005-10-26	2014-03-15	جانسين فارماسوتيكا ان. في	Rapid decomposition of physiologically antagonistic agents of the 2-dopamine receptor
JO2642B1 (en) *	2006-12-08	2012-06-17	جانسين فارماسوتيكا ان. في	Dopamine 2 receptor antagonists are rapidly hydrolyzed
JO2849B1 (en) *	2007-02-13	2015-03-15	جانسين فارماسوتيكا ان. في	Dopamine 2 receptor antagonists are rapidly hydrolyzed
MX2009011416A (es)	2007-04-23	2009-11-05	Janssen Pharmaceutica Nv	Tia(di)azoles como antagonistas del receptor de dopamina 2 de disociacion rapida.
CN101663292A (zh)	2007-04-23	2010-03-03	詹森药业有限公司	作为快速解离的多巴胺2受体拮抗剂的4-烷氧基哒嗪衍生物
BRPI0915834A2 (pt)	2008-07-03	2015-11-03	Janssen Pharmaceutica Nv	6-(1-piperazinil)-piridazinas substituídas como antagonistas do receptor de 5-ht6
AU2009275887B2 (en)	2008-07-31	2013-06-20	Janssen Pharmaceutica Nv	Piperazin-1-yl-trifluoromethyl-substituted-pyridines as fast dissociating dopamine 2 receptor antagonists
CN109843872B (zh) *	2017-09-20	2022-08-30	杭州英创医药科技有限公司	作为ido抑制剂和/或ido-hdac双重抑制剂的多环化合物
WO2021216665A1 (en) *	2020-04-22	2021-10-28	Anima Biotech Inc.	Collagen 1 translation inhibitors and methods of use thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB944443A (no) *	1959-09-25	1900-01-01
ATE148464T1 (de) *	1991-07-03	1997-02-15	Upjohn Co	Substituierte indole als anti-aids pharmaceutische zubereitungen
JPH05255089A (ja) *	1991-12-18	1993-10-05	Sanwa Kagaku Kenkyusho Co Ltd	抗ウイルス剤
JPH08502958A (ja) *	1992-10-23	1996-04-02	メルクシヤープエンドドームリミテツド	ドーパミンレセプターサブタイプリガンド
GB9305644D0 (en) *	1993-03-18	1993-05-05	Merck Sharp & Dohme	Therapeutic agents
US5576336A (en) *	1993-03-18	1996-11-19	Merck Sharp & Dohme Limited	Indole derivatives as dopamine D4 antagonists
US5814644A (en) *	1993-04-15	1998-09-29	Merck Sharp & Dohme, Ltd.	Indole derivatives as dopamine D4 antagonists
DE4414113A1 (de) *	1994-04-22	1995-10-26	Merck Patent Gmbh	3-Indolylpiperidine
TW406075B (en) *	1994-12-13	2000-09-21	Upjohn Co	Alkyl substituted piperidinyl and piperazinyl anti-AIDS compounds
ZA968661B (en) *	1995-11-17	1998-04-14	Upjohn Co	Oxazolidinone antibacterial agent with tricyclic substituents.
TW504510B (en) *	1996-05-10	2002-10-01	Janssen Pharmaceutica Nv	2,4-diaminopyrimidine derivatives

1998
- 1998-08-05 IL IL13396098A patent/IL133960A0/xx unknown
- 1998-08-05 AU AU84572/98A patent/AU8457298A/en not_active Abandoned
- 1998-08-05 CN CN98807831A patent/CN1265660A/zh active Pending
- 1998-08-05 BR BR9811557-0A patent/BR9811557A/pt not_active IP Right Cessation
- 1998-08-05 JP JP2000509706A patent/JP2002536291A/ja active Pending
- 1998-08-05 EA EA200000023A patent/EA200000023A1/ru unknown
- 1998-08-05 AP APAP/P/1998/001321A patent/AP9801321A0/en unknown
- 1998-08-05 EP EP98935229A patent/EP1003739A2/en not_active Withdrawn
- 1998-08-05 PL PL98338947A patent/PL338947A1/xx unknown
- 1998-08-05 KR KR1020007001093A patent/KR20010022507A/ko not_active Ceased
- 1998-08-05 HU HU0003425A patent/HUP0003425A3/hu unknown
- 1998-08-05 WO PCT/IB1998/001198 patent/WO1999009025A2/en not_active Ceased
- 1998-08-05 CA CA002297486A patent/CA2297486C/en not_active Expired - Fee Related
- 1998-08-05 SK SK135-2000A patent/SK1352000A3/sk unknown
- 1998-08-05 ID IDW20000197A patent/ID23803A/id unknown
- 1998-08-05 TR TR2000/00414T patent/TR200000414T2/xx unknown
- 1998-08-10 PE PE1998000717A patent/PE106299A1/es not_active Application Discontinuation
- 1998-08-10 PA PA19988457001A patent/PA8457001A1/es unknown
- 1998-08-12 MA MA25210A patent/MA24632A1/fr unknown
- 1998-08-12 DZ DZ980193A patent/DZ2583A1/xx active
- 1998-08-12 TN TNTNSN98151A patent/TNSN98151A1/fr unknown
- 1998-08-13 AR ARP980104021A patent/AR017019A1/es unknown
- 1998-08-14 CO CO98046788A patent/CO4960656A1/es unknown
- 1998-08-14 HR HR60/055,764A patent/HRP980441A2/hr not_active Application Discontinuation
- 1998-08-14 ZA ZA9807304A patent/ZA987304B/xx unknown
- 1998-08-17 UY UY25144A patent/UY25144A1/es not_active Application Discontinuation
2000
- 2000-01-10 BG BG104069A patent/BG104069A/xx unknown
- 2000-01-11 IS IS5336A patent/IS5336A/is unknown
- 2000-02-08 OA OA1200000030A patent/OA11286A/en unknown
- 2000-02-14 NO NO20000722A patent/NO20000722D0/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
HRP980441A2 (en)	1999-04-30
UY25144A1 (es)	2000-12-29
WO1999009025A3 (en)	1999-04-15
IL133960A0 (en)	2001-04-30
NO20000722L (no)	2000-02-14
SK1352000A3 (en)	2000-08-14
AR017019A1 (es)	2001-08-22
CN1265660A (zh)	2000-09-06
IS5336A (is)	2000-01-11
ZA987304B (en)	2000-02-14
OA11286A (en)	2003-10-22
HUP0003425A2 (hu)	2001-10-28
JP2002536291A (ja)	2002-10-29
EP1003739A2 (en)	2000-05-31
CO4960656A1 (es)	2000-09-25
EA200000023A1 (ru)	2000-08-28
NO20000722D0 (no)	2000-02-14
DZ2583A1 (fr)	2003-02-22
AU8457298A (en)	1999-03-08
BR9811557A (pt)	2000-08-22
PL338947A1 (en)	2000-12-04
TR200000414T2 (tr)	2000-08-21
CA2297486C (en)	2005-05-03
KR20010022507A (ko)	2001-03-15
AP9801321A0 (en)	2000-02-14
WO1999009025A2 (en)	1999-02-25
ID23803A (id)	2000-05-11
MA24632A1 (fr)	1999-04-01
HUP0003425A3 (en)	2002-02-28
PA8457001A1 (es)	2000-09-29
TNSN98151A1 (fr)	2005-03-15
BG104069A (en)	2001-05-31
CA2297486A1 (en)	1999-02-25

Publication	Publication Date	Title
PE106299A1 (es)	1999-11-02	Derivados del 2-(4-aril o heteroaril-piperazin-1-ilmetil)-1h-indol
PE2799A1 (es)	1999-02-04	Lactamas e imidas heterociclicas de aralquilo y aralquilideno
PE20020753A1 (es)	2002-08-27	Heteroaromaticos fusionados como activadores de la glucoquinasa
PE16299A1 (es)	1999-03-12	Compuestos de 2-imidazolinilaminoindol utiles como agonistas de alfa-2 adrenoreceptores
PE20040720A1 (es)	2004-10-12	Derivados de benzodioxol
PE20000947A1 (es)	2000-09-22	ACTIVADORES DE hPPARþ Y hPPARO
PE20030610A1 (es)	2003-07-12	Derivados de 3-azabiciclo[3.1.0]hexano con afinidad a los receptores opioides
PE20030565A1 (es)	2003-08-14	Compuestos heterociclicos como agonistas de receptores activados por proliferador de peroxisoma
PE20020637A1 (es)	2002-07-18	Derivados de 5-oxo-pirrolidina como agonistas de prostaglandinas
PE20010854A1 (es)	2001-08-28	USO DE DERIVADOS DE PIRIMIDINA 4 SUSTITUIDOS COMO ANTAGONISTAS DE LOS RECEPTORES DE GLUTAMATO mGluR1
PE68799A1 (es)	1999-09-26	Derivados de tetrahidroisoquinolina como moduladores del receptor de d3 de dopamina
PE69398A1 (es)	1998-12-02	Antagonistas de receptor de benzoxazinona dopamina d4
CO4930274A1 (es)	2000-06-27	Tiazol bencenosulfonamidas como agonistas b3 para el trata- miento de la diabetes y la obesidad
PE20030707A1 (es)	2003-08-21	Agonistas muscarinicos
PE20001234A1 (es)	2000-11-07	Compuestos azabiciclicos sustituidos de heteroaril-aminoetil/benzisoxazol como antagonistas serotonergicos 5-ht1
PE20080540A1 (es)	2008-06-08	Compuestos 4-fenil-2-piridinil-metil sustituidos como moduladores de los canales de sodio con apertura por voltaje
PE20030943A1 (es)	2003-11-08	Agonistas del receptor b3-adrenergico
PE20050862A1 (es)	2005-12-17	Derivados de indano heterociclicos sustituidos como antagonistas de los receptores de dopamina d2 y serotonina 2a
PE20060734A1 (es)	2006-09-05	Derivado de pirrol sustituido como antagonistas del receptor de androgenos
TR200101808T2 (tr)	2001-10-22	Psikotik hastalıkların tedavisi için 3-tetrahidropiridin-4-il indoller
ES2188509T3 (es)	2003-07-01	N-oxidos triciclicos de piridina como agonistas de la vasopresina.
PE20001057A1 (es)	2001-01-03	Nuevos bis-benzimidazoles
PE20061092A1 (es)	2006-12-05	COMPUESTOS HETEROCICLICOS COMO AGONISTAS SELECTIVOS PARA EL RECEPTOR-ß DE ESTROGENO
PE16499A1 (es)	1999-03-12	Compuestos heterociclicos de guanidinilamino utiles como agonistas de alfa-2 adrenoreceptores
DE60233982D1 (de)	2009-11-19	8-Chlor-11-(4-(2'-hydroxyethyl)piperazin-1-yl)-dibenzoÄb,f ÜÄ1,4Üoxazepin mit atypisch antipsychotischer Wirkung und geringer Affinität zum Dopamin-D2-Rezeptor

Legal Events

Date	Code	Title	Description
2002-03-13	FD	Application declared void or lapsed