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LU91076I9 - 4"-substituted-9-deoxo-9a-aza-9a-homoerythromycin a derivatives - Google Patents

4"-substituted-9-deoxo-9a-aza-9a-homoerythromycin a derivatives

Info

Publication number
LU91076I9
LU91076I9 LU91076C LU91076C LU91076I9 LU 91076 I9 LU91076 I9 LU 91076I9 LU 91076 C LU91076 C LU 91076C LU 91076 C LU91076 C LU 91076C LU 91076 I9 LU91076 I9 LU 91076I9
Authority
LU
Luxembourg
Prior art keywords
compounds
formula
homoerythromycin
deoxo
aza
Prior art date
Application number
LU91076C
Other languages
English (en)
Other versions
LU91076I2 (fr
Inventor
Takushi Kaneko
Bingwei Vera Yang
Brian Scott Bronk
Michael Anthony Letavic
Edward Alan Glazer
Hengmiao Cheng
Original Assignee
Zoetis Services Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21959336&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LU91076(I9) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Zoetis Services Llc filed Critical Zoetis Services Llc
Publication of LU91076I2 publication Critical patent/LU91076I2/fr
Publication of LU91076I9 publication Critical patent/LU91076I9/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
LU91076C 1997-06-11 2004-05-05 4"-substituted-9-deoxo-9a-aza-9a-homoerythromycin a derivatives LU91076I9 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4934897P 1997-06-11 1997-06-11
PCT/IB1998/000839 WO1998056802A1 (fr) 1997-06-11 1998-05-29 Derives de homo-erythromycine -9-deoxo-9a-aza-9aa substitution en position 4

Publications (2)

Publication Number Publication Date
LU91076I2 LU91076I2 (fr) 2004-07-05
LU91076I9 true LU91076I9 (en) 2018-07-02

Family

ID=21959336

Family Applications (1)

Application Number Title Priority Date Filing Date
LU91076C LU91076I9 (en) 1997-06-11 2004-05-05 4"-substituted-9-deoxo-9a-aza-9a-homoerythromycin a derivatives

Country Status (49)

Country Link
US (4) US6420536B1 (fr)
EP (1) EP0988310B9 (fr)
JP (2) JP3315704B2 (fr)
KR (1) KR100396168B1 (fr)
CN (4) CN1243766C (fr)
AP (1) AP1231A (fr)
AR (1) AR013086A1 (fr)
AT (1) ATE251173T1 (fr)
AU (1) AU749816B2 (fr)
BG (1) BG64391B1 (fr)
BR (1) BRPI9810519B8 (fr)
CA (1) CA2293823C (fr)
CO (1) CO4950611A1 (fr)
CZ (1) CZ298556B6 (fr)
DE (2) DE69818665T2 (fr)
DK (1) DK0988310T3 (fr)
DZ (1) DZ2514A1 (fr)
EA (1) EA002441B1 (fr)
EG (1) EG24081A (fr)
ES (1) ES2205487T3 (fr)
FR (1) FR04C0013I2 (fr)
GT (1) GT199800077A (fr)
HN (1) HN1998000086A (fr)
HR (1) HRP980314B1 (fr)
HU (2) HU228005B1 (fr)
ID (1) ID22992A (fr)
IL (1) IL132809A0 (fr)
IS (1) IS1998B (fr)
LU (1) LU91076I9 (fr)
MA (1) MA24564A1 (fr)
ME (1) ME00876B (fr)
MY (1) MY123354A (fr)
NL (1) NL300150I2 (fr)
NO (1) NO316911B1 (fr)
NZ (2) NZ514871A (fr)
OA (1) OA11224A (fr)
PA (1) PA8452201A1 (fr)
PE (1) PE79699A1 (fr)
PL (1) PL191601B1 (fr)
PT (1) PT988310E (fr)
RS (1) RS49675B (fr)
SI (1) SI0988310T1 (fr)
SK (1) SK284171B6 (fr)
TN (1) TNSN98082A1 (fr)
TW (1) TW472060B (fr)
UA (1) UA67744C2 (fr)
UY (1) UY25040A1 (fr)
WO (1) WO1998056802A1 (fr)
ZA (1) ZA985017B (fr)

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AU731842B2 (en) * 1997-09-10 2001-04-05 Merck & Co., Inc. 9a-azalides as veterinary antimicrobial agents
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CA2292359C (fr) * 1999-01-28 2004-09-28 Pfizer Products Inc. Nouveaux azalides et procede de fabrication
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CA2373117C (fr) * 1999-05-24 2006-02-28 Pfizer Products Inc. Derives de 13-methyl-erythromycine
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EP3738591A3 (fr) 2003-03-10 2021-03-24 Merck Sharp & Dohme Corp. Nouveaux agents antibactériens
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JP4181605B2 (ja) * 2004-03-16 2008-11-19 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング グルコピラノシル置換フェニル誘導体、該化合物を含有する医薬品及びその使用と製造方法
US7468428B2 (en) * 2004-03-17 2008-12-23 App Pharmaceuticals, Llc Lyophilized azithromycin formulation
US20060116336A1 (en) * 2004-03-17 2006-06-01 American Pharmaceutical Partners, Inc. Lyophilized azithromycin formulation
US7402568B2 (en) 2004-09-29 2008-07-22 Enanta Pharmaceuticals, Inc. Bicyclic 9a-azalide derivatives
US7767797B1 (en) * 2004-09-30 2010-08-03 Synovo Gmbh Macrocyclic compounds and methods of use thereof
US7271155B2 (en) 2005-01-07 2007-09-18 Enanta Pharmaceuticals, Inc. 9A, 11-2C-bicyclic 9a-azalide derivatives
DE602006006546D1 (de) * 2005-01-14 2009-06-10 Glaxosmithkline Zagreb 9a-carbamoyl- und thiocarbamoylazalide mit antimalariawirkung
WO2009055557A1 (fr) * 2007-10-25 2009-04-30 Cempra Pharmaceuticals, Inc. Procédé pour la préparation d'agents antibactériens macrolides
HRP20160222T1 (hr) * 2008-10-24 2016-04-08 Cempra Pharmaceuticals, Inc. Biozaštite uporabom makrolida koji sadrže triazol
US9937194B1 (en) * 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
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NZ602544A (en) 2010-03-22 2014-11-28 Cempra Pharmaceuticals Inc Crystalline forms of a macrolide, and uses therefor
RU2608390C2 (ru) 2010-05-20 2017-01-18 Семпра Фармасьютикалз, Инк. Способы получения макролидов и кетолидов, и промежуточных соединений для их получения
JP6042334B2 (ja) 2010-09-10 2016-12-14 センプラ ファーマシューティカルズ，インコーポレイテッド 疾患治療のための水素結合形成フルオロケトライド
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MX2013004013A (es) * 2010-10-10 2013-09-26 Synovo Gmbh Macrolidos antiinflamatorios.
CN102993250B (zh) * 2011-07-06 2016-02-10 洛阳惠中兽药有限公司 C-3取代的-9-脱氧-9a-氮杂-9a-高红霉素a衍生物
CN102260306B (zh) * 2011-07-22 2012-07-18 山东鲁抗舍里乐药业有限公司 一种制备泰拉霉素的方法
EP2736915A1 (fr) 2011-07-27 2014-06-04 Farma GRS, d.o.o. Nouvelles formes cristallines de tulathromycine
HK1205939A1 (en) 2012-03-27 2015-12-31 Cempra Pharmaceuticals, Inc. Parenteral formulations for administering macrolide antibiotics
CN102786569B (zh) * 2012-09-07 2016-12-07 安徽中升药业有限公司 泰拉霉素中间体及其制备方法与泰拉霉素的制备方法
HK1217665A1 (zh) 2013-03-14 2017-01-20 森普拉制药公司 用於治療呼吸道疾病的方法及其製劑
AU2014233240B2 (en) 2013-03-15 2018-08-09 Cempra Pharmaceuticals, Inc. Convergent processes for preparing macrolide antibacterial agents
SI3027634T1 (sl) * 2013-07-31 2018-10-30 Farma Grs, D.O.O. Proces za pripravo tulatromicina
CN103497227B (zh) * 2013-09-13 2015-09-30 青岛科技大学 一种泰拉菌素中间体的制备方法
CN104725446B (zh) * 2015-03-26 2017-10-27 宁夏泰瑞制药股份有限公司 一种从泰拉霉素粗品中分离泰拉霉素a和泰拉霉素b的方法
CN104861018A (zh) * 2015-06-17 2015-08-26 瑞普（天津）生物药业有限公司 一种泰拉菌素的制备方法
CN105646617A (zh) * 2016-01-21 2016-06-08 杭州海尔希畜牧科技有限公司 一种制备泰拉霉素的方法
FR3048612B1 (fr) * 2016-03-14 2020-10-02 Septeos Tulathromycine potentialisee
CN106046077B (zh) * 2016-08-04 2019-07-26 湖北美天生物科技股份有限公司 一种泰拉霉素a的合成方法
CN108003207B (zh) 2017-12-19 2019-05-10 海门慧聚药业有限公司 制备泰拉霉素的方法
CN111087433B (zh) * 2018-10-23 2023-03-21 湖北美天生物科技股份有限公司 一种泰拉霉素中间体的制备方法

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Also Published As

Publication number Publication date
GT199800077A (es) 1999-12-02
NO996106L (no) 2000-02-10
DE122004000018I1 (de) 2004-09-30
SK168399A3 (en) 2000-11-07
ME00876B (me) 2012-06-20
LU91076I2 (fr) 2004-07-05
EP0988310A1 (fr) 2000-03-29
BG103945A (en) 2000-07-31
AP1231A (en) 2003-12-11
NL300150I2 (nl) 2004-09-01
YU58699A (fr) 2002-08-12
DE122004000018I2 (de) 2011-01-13
NL300150I1 (nl) 2004-08-02
CZ442199A3 (cs) 2000-07-12
HRP980314B1 (en) 2004-04-30
HK1028048A1 (en) 2001-02-02
HK1088014A1 (zh) 2006-10-27
ES2205487T3 (es) 2004-05-01
CN1172947C (zh) 2004-10-27
NZ500660A (en) 2002-03-01
PA8452201A1 (es) 2000-05-24
EA199901015A1 (ru) 2000-06-26
PE79699A1 (es) 1999-08-25
OA11224A (en) 2003-07-16
TW472060B (en) 2002-01-11
JP3315704B2 (ja) 2002-08-19
CN1566129A (zh) 2005-01-19
US6420536B1 (en) 2002-07-16
AU749816B2 (en) 2002-07-04
BRPI9810519B1 (pt) 2012-02-22
BRPI9810519A (pt) 2000-09-19
DE69818665T2 (de) 2004-04-29
HUP0002209A2 (hu) 2000-12-28
HK1068893A1 (en) 2005-07-29
EP0988310B1 (fr) 2003-10-01
CO4950611A1 (es) 2000-09-01
UA67744C2 (uk) 2004-07-15
EA002441B1 (ru) 2002-04-25
CA2293823A1 (fr) 1998-12-17
PL191601B1 (pl) 2006-06-30
ATE251173T1 (de) 2003-10-15
FR04C0013I2 (fr) 2005-10-21
WO1998056802A1 (fr) 1998-12-17
CN1793155A (zh) 2006-06-28
AR013086A1 (es) 2000-12-13
EP0988310B9 (fr) 2006-03-08
US6936592B2 (en) 2005-08-30
SI0988310T1 (en) 2004-02-29
US20040023896A1 (en) 2004-02-05
JP2000514098A (ja) 2000-10-24
ID22992A (id) 1999-12-23
IS5252A (is) 1999-11-16
ZA985017B (en) 1999-12-17
RS49675B (sr) 2007-11-15
HU228005B1 (en) 2012-08-28
JP2002316933A (ja) 2002-10-31
CN101691390A (zh) 2010-04-07
PL337505A1 (en) 2000-08-28
US20040180842A1 (en) 2004-09-16
CN1243766C (zh) 2006-03-01
CN1259136A (zh) 2000-07-05
BRPI9810519B8 (pt) 2022-11-16
AU7347598A (en) 1998-12-30
US20020061858A1 (en) 2002-05-23
DE69818665D1 (de) 2003-11-06
NO996106D0 (no) 1999-12-10
SK284171B6 (sk) 2004-10-05
HRP980314A2 (en) 1999-04-30
CA2293823C (fr) 2004-02-17
DK0988310T3 (da) 2003-12-15
IL132809A0 (en) 2001-03-19
KR20010013632A (ko) 2001-02-26
PT988310E (pt) 2003-12-31
MY123354A (en) 2006-05-31
HUS1200028I1 (hu) 2016-08-29
NZ514871A (en) 2003-08-29
NO316911B1 (no) 2004-06-21
MA24564A1 (fr) 1998-12-31
TNSN98082A1 (fr) 2005-03-15
DZ2514A1 (fr) 2003-02-01
KR100396168B1 (ko) 2003-08-27
HUP0002209A3 (en) 2003-05-28
UY25040A1 (es) 2000-09-29
AP9801255A0 (en) 1998-06-30
HN1998000086A (es) 1999-03-08
EG24081A (en) 2008-05-11
FR04C0013I1 (fr) 2004-06-11
CN1793155B (zh) 2010-05-12
CZ298556B6 (cs) 2007-11-07
BG64391B1 (bg) 2004-12-30
IS1998B (is) 2005-03-15
US6777393B2 (en) 2004-08-17

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