LT4800B - Aii antagonisto sulėtinto atpalaidavimo preparatas, jo gavimas ir panaudojimas - Google Patents

Aii antagonisto sulėtinto atpalaidavimo preparatas, jo gavimas ir panaudojimas Download PDF

Info

Publication number: LT4800B
Authority: LT; Lithuania
Prior art keywords: compound; group; sustained release; angiotensin; acid
Prior art date: 1998-03-04

Application number

LT2000082A

Other languages

English (en)

Lithuanian (lt)

Other versions

LT2000082A (en

Inventor

Yasutaka Igari

Akira Saikawa

Yoshiyuki Inada

Shigeru Kamei

Original Assignee

Takeda Chemical Industries,Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-03-04

Filing date

2000-08-31

Publication date

2001-06-25

2000-08-31 Application filed by Takeda Chemical Industries,Ltd filed Critical Takeda Chemical Industries,Ltd

2001-03-26 Publication of LT2000082A publication Critical patent/LT2000082A/xx

2001-06-25 Publication of LT4800B publication Critical patent/LT4800B/lt

Links

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125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
239000006186 oral dosage form Substances 0.000 description 1
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150000007530 organic bases Chemical class 0.000 description 1
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239000011368 organic material Substances 0.000 description 1
229960003104 ornithine Drugs 0.000 description 1
230000003204 osmotic effect Effects 0.000 description 1
ZVTQYRVARPYRRE-UHFFFAOYSA-N oxadiazol-4-one Chemical group O=C1CON=N1 ZVTQYRVARPYRRE-UHFFFAOYSA-N 0.000 description 1
JNGDFYLGDPAEBY-UHFFFAOYSA-N oxadiazole-4-thione Chemical group S=C1CON=N1 JNGDFYLGDPAEBY-UHFFFAOYSA-N 0.000 description 1
KJIFKLIQANRMOU-UHFFFAOYSA-N oxidanium;4-methylbenzenesulfonate Chemical compound O.CC1=CC=C(S(O)(=O)=O)C=C1 KJIFKLIQANRMOU-UHFFFAOYSA-N 0.000 description 1
TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 1
125000006503 p-nitrobenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1[N+]([O-])=O)C([H])([H])* 0.000 description 1
125000001312 palmitoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
150000002972 pentoses Chemical class 0.000 description 1
125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
230000035699 permeability Effects 0.000 description 1
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125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 description 1
229920001308 poly(aminoacid) Polymers 0.000 description 1
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229920001223 polyethylene glycol Polymers 0.000 description 1
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238000006116 polymerization reaction Methods 0.000 description 1
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239000001267 polyvinylpyrrolidone Substances 0.000 description 1
229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
239000011591 potassium Substances 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 description 1
230000003389 potentiating effect Effects 0.000 description 1
239000000047 product Substances 0.000 description 1
230000035755 proliferation Effects 0.000 description 1
125000001325 propanoyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 description 1
235000019260 propionic acid Nutrition 0.000 description 1
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
UORVCLMRJXCDCP-UHFFFAOYSA-N propynoic acid Chemical compound OC(=O)C#C UORVCLMRJXCDCP-UHFFFAOYSA-N 0.000 description 1
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
150000008512 pyrimidinediones Chemical class 0.000 description 1
150000008318 pyrimidones Chemical class 0.000 description 1
125000002294 quinazolinyl group Chemical class N1=C(N=CC2=CC=CC=C12)* 0.000 description 1
IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 description 1
239000002994 raw material Substances 0.000 description 1
210000000664 rectum Anatomy 0.000 description 1
230000036454 renin-angiotensin system Effects 0.000 description 1
238000012827 research and development Methods 0.000 description 1
HEBKCHPVOIAQTA-ZXFHETKHSA-N ribitol Chemical compound OC[C@H](O)[C@H](O)[C@H](O)CO HEBKCHPVOIAQTA-ZXFHETKHSA-N 0.000 description 1
238000007142 ring opening reaction Methods 0.000 description 1
229960004889 salicylic acid Drugs 0.000 description 1
229920006395 saturated elastomer Polymers 0.000 description 1
229920002545 silicone oil Polymers 0.000 description 1
235000010413 sodium alginate Nutrition 0.000 description 1
239000000661 sodium alginate Substances 0.000 description 1
229940005550 sodium alginate Drugs 0.000 description 1
229940010747 sodium hyaluronate Drugs 0.000 description 1
RYYKJJJTJZKILX-UHFFFAOYSA-M sodium octadecanoate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC([O-])=O RYYKJJJTJZKILX-UHFFFAOYSA-M 0.000 description 1
ZNCPFRVNHGOPAG-UHFFFAOYSA-L sodium oxalate Chemical compound [Na+].[Na+].[O-]C(=O)C([O-])=O ZNCPFRVNHGOPAG-UHFFFAOYSA-L 0.000 description 1
229940039790 sodium oxalate Drugs 0.000 description 1
YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 1
239000007901 soft capsule Substances 0.000 description 1
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239000003549 soybean oil Substances 0.000 description 1
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239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
239000007858 starting material Substances 0.000 description 1
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238000003756 stirring Methods 0.000 description 1
210000002784 stomach Anatomy 0.000 description 1
239000006203 subcutaneous dosage form Substances 0.000 description 1
125000005415 substituted alkoxy group Chemical group 0.000 description 1
125000000547 substituted alkyl group Chemical group 0.000 description 1
238000006467 substitution reaction Methods 0.000 description 1
125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 description 1
239000004094 surface-active agent Substances 0.000 description 1
239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
229940042055 systemic antimycotics triazole derivative Drugs 0.000 description 1
QIQCZROILFZKAT-UHFFFAOYSA-N tetracarbon dioxide Chemical group O=C=C=C=C=O QIQCZROILFZKAT-UHFFFAOYSA-N 0.000 description 1
125000003718 tetrahydrofuranyl group Chemical group 0.000 description 1
150000004044 tetrasaccharides Chemical class 0.000 description 1
XWMXMWHHTIEXRE-UHFFFAOYSA-N thiadiazole 1-oxide Chemical group O=S1C=CN=N1 XWMXMWHHTIEXRE-UHFFFAOYSA-N 0.000 description 1
229910052723 transition metal Inorganic materials 0.000 description 1
150000003624 transition metals Chemical class 0.000 description 1
238000013519 translation Methods 0.000 description 1
235000013337 tricalcium citrate Nutrition 0.000 description 1
150000003627 tricarboxylic acid derivatives Chemical class 0.000 description 1
ITMCEJHCFYSIIV-UHFFFAOYSA-N triflic acid Chemical compound OS(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-N 0.000 description 1
PLSARIKBYIPYPF-UHFFFAOYSA-H trimagnesium dicitrate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O PLSARIKBYIPYPF-UHFFFAOYSA-H 0.000 description 1
210000004291 uterus Anatomy 0.000 description 1
229940005605 valeric acid Drugs 0.000 description 1
ACWBQPMHZXGDFX-QFIPXVFZSA-N valsartan Chemical compound C1=CC(CN(C(=O)CCCC)[C@@H](C(C)C)C(O)=O)=CC=C1C1=CC=CC=C1C1=NN=NN1 ACWBQPMHZXGDFX-QFIPXVFZSA-N 0.000 description 1
210000005166 vasculature Anatomy 0.000 description 1
239000000811 xylitol Substances 0.000 description 1
HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
235000010447 xylitol Nutrition 0.000 description 1
229960002675 xylitol Drugs 0.000 description 1
229940102001 zinc bromide Drugs 0.000 description 1
239000011667 zinc carbonate Substances 0.000 description 1
235000004416 zinc carbonate Nutrition 0.000 description 1
229910000010 zinc carbonate Inorganic materials 0.000 description 1
239000011592 zinc chloride Substances 0.000 description 1
235000005074 zinc chloride Nutrition 0.000 description 1
239000011576 zinc lactate Substances 0.000 description 1
235000000193 zinc lactate Nutrition 0.000 description 1
229940050168 zinc lactate Drugs 0.000 description 1
229940118827 zinc phenolsulfonate Drugs 0.000 description 1
NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
229910000368 zinc sulfate Inorganic materials 0.000 description 1
229960001763 zinc sulfate Drugs 0.000 description 1
VRGNUPCISFMPEM-ZVGUSBNCSA-L zinc;(2r,3r)-2,3-dihydroxybutanedioate Chemical compound [Zn+2].[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O VRGNUPCISFMPEM-ZVGUSBNCSA-L 0.000 description 1
MCOGTQGPHPAUJN-UHFFFAOYSA-L zinc;2-hydroxyacetate Chemical compound [Zn+2].OCC([O-])=O.OCC([O-])=O MCOGTQGPHPAUJN-UHFFFAOYSA-L 0.000 description 1
BOVNWDGXGNVNQD-UHFFFAOYSA-L zinc;2-hydroxybenzenesulfonate Chemical compound [Zn+2].OC1=CC=CC=C1S([O-])(=O)=O.OC1=CC=CC=C1S([O-])(=O)=O BOVNWDGXGNVNQD-UHFFFAOYSA-L 0.000 description 1
JDLYKQWJXAQNNS-UHFFFAOYSA-L zinc;dibenzoate Chemical compound [Zn+2].[O-]C(=O)C1=CC=CC=C1.[O-]C(=O)C1=CC=CC=C1 JDLYKQWJXAQNNS-UHFFFAOYSA-L 0.000 description 1
MLVWCBYTEFCFSG-UHFFFAOYSA-L zinc;dithiocyanate Chemical compound [Zn+2].[S-]C#N.[S-]C#N MLVWCBYTEFCFSG-UHFFFAOYSA-L 0.000 description 1
FYGDTMLNYKFZSV-BYLHFPJWSA-N β-1,4-galactotrioside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@H](CO)O[C@@H](O[C@@H]2[C@@H](O[C@@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-BYLHFPJWSA-N 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Inorganic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Heart & Thoracic Surgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Cardiology (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Plural Heterocyclic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

LT2000082A 1998-03-04 2000-08-31 Aii antagonisto sulėtinto atpalaidavimo preparatas, jo gavimas ir panaudojimas LT4800B (lt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP5236698		1998-03-04

Publications (2)

Publication Number	Publication Date
LT2000082A LT2000082A (en)	2001-03-26
LT4800B true LT4800B (lt)	2001-06-25

Family

ID=12912818

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
LT2000082A LT4800B (lt)	1998-03-04	2000-08-31	Aii antagonisto sulėtinto atpalaidavimo preparatas, jo gavimas ir panaudojimas

Country Status (21)

Country	Link
US (2)	US6589547B1 (et)
EP (1)	EP1058541B1 (et)
KR (1)	KR20010086245A (et)
CN (1)	CN1291888A (et)
AT (1)	ATE258430T1 (et)
AU (1)	AU2745199A (et)
BR (1)	BR9908474A (et)
CA (1)	CA2318446C (et)
DE (1)	DE69914460T2 (et)
EE (1)	EE200000499A (et)
ES (1)	ES2214013T3 (et)
HU (1)	HUP0101439A3 (et)
ID (1)	ID25640A (et)
IL (1)	IL137979A0 (et)
LT (1)	LT4800B (et)
LV (1)	LV12585B (et)
NO (1)	NO20004350L (et)
PL (1)	PL342684A1 (et)
SK (1)	SK11902000A3 (et)
WO (1)	WO1999044590A1 (et)
ZA (1)	ZA991706B (et)

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ID25640A (id) *	1998-03-04	2000-10-19	Takeda Chemical Industries Ltd	Preparat pelepasan terus menerus untuk antagonistik aii, produksi dan penggunaannya
PT1197223E (pt)	1999-04-28	2005-04-29	Takeda Pharmaceutical	Preventivos/medicamentos/inibidores da progressao de retinopatia simples ou retinopatia pre-proliferativa
SE9903028D0 (sv) *	1999-08-27	1999-08-27	Astra Ab	New use
RU2276997C2 (ru)	1999-08-30	2006-05-27	Санофи-Авентис Дойчланд Гмбх	Применение ингибиторов ренин-ангиотензиновой системы для профилактики сердечно-сосудистых явлений
AU3408801A (en) *	2000-02-18	2001-08-27	Takeda Chemical Industries Ltd	Tnf-alpha inhibitors
AU2001232348A1 (en) *	2000-02-21	2001-08-27	Takeda Chemical Industries Ltd.	Sustained release preparations of physiologically active compound hardly solublein water and production process and use of the same
EP1312379A4 (en) *	2000-08-25	2004-08-25	Takeda Chemical Industries Ltd	FIBRINOGENING AGENTS
AU2002210925A1 (en) *	2000-10-25	2002-05-06	Takeda Chemical Industries Ltd.	Preventives/remedies for portal hypertension
US20040121008A1 (en) *	2001-03-16	2004-06-24	Keiko Shiraishi	Process for producing sustained release preparation
WO2003013609A1 (fr) *	2001-08-03	2003-02-20	Takeda Chemical Industries, Ltd.	Medicaments a liberation continue
BRPI0105509B8 (pt) *	2001-11-05	2021-05-25	Univ Minas Gerais	formulações do peptídeo angiotensina-(1-7) usando as ciclodextrinas, lipossomas e o polímero plga
US7812044B2 (en)	2001-11-13	2010-10-12	Takeda Pharmaceutical Company Limited	Anticancer agents
CA2468827A1 (en) *	2001-12-03	2003-06-12	Takeda Chemical Industries, Ltd.	Insulin resistance improving agents
US7700074B2 (en) *	2002-02-07	2010-04-20	Pettegrew Jay W	Method and system for diagnosis of neuropsychiatric disorders including chronic alcoholism
US7407778B2 (en) *	2002-02-07	2008-08-05	Pettegrew Jay W	Compounds, compositions and methods for treating neuropsychiatric disorders
AU2003292775A1 (en) *	2002-12-27	2004-07-29	Takeda Pharmaceutical Company Limited	Body weight gain inhibitor
US20050038093A1 (en) *	2003-05-02	2005-02-17	Boehringer Ingelheim International Gmbh	Treating diabetic retinopathy with angiotensin II receptor blockers
US7815894B2 (en) *	2003-05-29	2010-10-19	Jay W. Pettegrew	Compounds, compositions and methods for medical imaging of neuropsychiatric disorders
US20060257842A1 (en) *	2003-05-29	2006-11-16	Pettegrew Jay W	Cryopreservation media and molecules
WO2005097109A1 (en) *	2004-04-01	2005-10-20	Daniel Batlle	Methods for achieving a protective ace2 expression level
ATE493973T1 (de)	2004-06-04	2011-01-15	Teva Pharma	Irbesartan enthaltende pharmazeutische zusammensetzung
BRPI0516246A (pt) *	2004-10-07	2008-08-26	Takeda Pharmaceutical	agente para a profilaxia ou tratamento de sìndrome metabólica, método para a profilaxia ou tratamento de sìndrome metabólica em um mamìfero, e, uso de ácido 2-etóxi-1-[ [2'-(5-oxo-2,5-diidro-1,2,4-oxadiazol-3-il) bifenil-4-il]metil] -1h-benzimidazol-7-carboxìlico ou um sal do mesmo ou uma pró-droga do mesmo em combinação com uma substáncia semelhante ao agonista de ppargama
JPWO2006046528A1 (ja) *	2004-10-29	2008-05-22	興和株式会社	糸球体疾患治療剤
CA2598410A1 (fr) *	2005-02-21	2006-08-24	Flamel Technologies	Forme pharmaceutique orale de losartan
EP1863801B1 (en) *	2005-03-30	2010-09-29	Takeda Pharmaceutical Company Limited	Benzimidazole derivative and use thereof
EP1926705B3 (en) *	2005-08-22	2010-09-15	Alembic Limited	Process for preparing valsartan
EA016728B1 (ru) *	2006-08-10	2012-07-30	Такеда Фармасьютикал Компани Лимитед	Фармацевтическая композиция
EP1897537A1 (en) *	2006-09-04	2008-03-12	Novartis AG	Composition comprising an angiotensin II receptor antagonist
PE20081364A1 (es) *	2006-09-04	2008-12-04	Novartis Ag	Composicion farmaceutica que comprende valsartan
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HUP0101439A3 (en)	2002-09-30
IL137979A0 (en)	2001-10-31
LV12585A (en)	2000-12-20
BR9908474A (pt)	2000-12-05
US6589547B1 (en)	2003-07-08
HUP0101439A2 (hu)	2001-10-28
CN1291888A (zh)	2001-04-18
DE69914460T2 (de)	2004-10-28
CA2318446A1 (en)	1999-09-10
NO20004350L (no)	2000-10-03
CA2318446C (en)	2008-09-23
US20030198676A1 (en)	2003-10-23
LT2000082A (en)	2001-03-26
WO1999044590A1 (en)	1999-09-10
ZA991706B (en)	2000-10-03
NO20004350D0 (no)	2000-09-01
ID25640A (id)	2000-10-19
ATE258430T1 (de)	2004-02-15
LV12585B (en)	2001-03-20
PL342684A1 (en)	2001-07-02
ES2214013T3 (es)	2004-09-01
AU2745199A (en)	1999-09-20
KR20010086245A (ko)	2001-09-10
SK11902000A3 (sk)	2001-02-12
EP1058541B1 (en)	2004-01-28
US7294344B2 (en)	2007-11-13
DE69914460D1 (de)	2004-03-04
EE200000499A (et)	2002-02-15
EP1058541A1 (en)	2000-12-13

Publication	Publication Date	Title
LT4800B (lt)	2001-06-25	Aii antagonisto sulėtinto atpalaidavimo preparatas, jo gavimas ir panaudojimas
EP1346722B1 (en)	2008-12-10	Method for producing preparation containing bioactive substance
US20040219208A1 (en)	2004-11-04	Sustained-release medicines
WO2002074340A1 (fr)	2002-09-26	Procede de fabrication d'une preparation a liberation continue
KR100245395B1 (ko)	2000-03-02	장기간의 국소 마취를 제공하는 제형 및 그 방법
JP2670680B2 (ja)	1997-10-29	生理活性物質含有ポリ乳酸系微小球およびその製造法
JP2020506232A (ja)	2020-02-27	ゴナドトロピン放出ホルモン（ＧｎＲＨ）拮抗薬の長期放出のための組成物および方法
US20030068374A1 (en)	2003-04-10	Sustained release preparations of physiologically active compound hardly soluble in water and production process and use of the same
CA2407472A1 (en)	2002-10-23	Sustained release compositions
JPS63233926A (ja)	1988-09-29	ペプチド含有マイクロカプセルおよびその製造法
US20040102502A1 (en)	2004-05-27	Preventing/remedies for portal hypertension
KR101663561B1 (ko)	2016-10-10	서방출성 미립구의 제조방법
JPH11315034A (ja)	1999-11-16	アンギオテンシンｉｉ拮抗作用を有する化合物の徐放性製剤、その製造法および用途
EP1867342A1 (en)	2007-12-19	Agents for ameliorating troubles following cerebrovascular failure and inhibiting progress thereof
JP2003113120A (ja)	2003-04-18	徐放性医薬
PL196895B1 (pl)	2008-02-29	Zastosowanie związku o aktywności antagonistycznej angiotensyny II lub jego soli do wytwarzania kompozycji farmaceutycznej do leczenia lub hamowania rozwoju retynopatii prostej lub retynopatii przed-proliferacyjnej
JP2003212758A (ja)	2003-07-30	徐放性製剤の製造法
CZ20003164A3 (cs)	2000-11-15	Prostředek s prodlouženým uvolňováním pro antagonistů angiotensinu II, jeho příprava a použití
JP2001316296A (ja)	2001-11-13	水に難溶性の生理活性化合物の徐放性製剤、その製造法および用途
MXPA00008171A (en)	2001-07-31	Sustained-release preparation for aii antagonist, production and use thereof
JP2002201128A (ja)	2002-07-16	門脈圧亢進症予防・治療剤
JP2002068982A (ja)	2002-03-08	徐放性組成物
JP2004002282A (ja)	2004-01-08	抗癌剤
JP2002293742A (ja)	2002-10-09	鎮痛・抗炎症剤
JP2003192595A (ja)	2003-07-09	局所投与剤

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