EE200000499A - Angiotensiin II antagonistliku toimega toimeainetprolongeeritult vabastav preparaat, selle valmistamise meetod ja kasutamine - Google Patents
Angiotensiin II antagonistliku toimega toimeainetprolongeeritult vabastav preparaat, selle valmistamise meetod ja kasutamineInfo
- Publication number
- EE200000499A EE200000499A EEP200000499A EEP200000499A EE200000499A EE 200000499 A EE200000499 A EE 200000499A EE P200000499 A EEP200000499 A EE P200000499A EE P200000499 A EEP200000499 A EE P200000499A EE 200000499 A EE200000499 A EE 200000499A
- Authority
- EE
- Estonia
- Prior art keywords
- preparation
- angiotensin
- prolonged
- antagonist activity
- release preparation
- Prior art date
Links
- 229940123413 Angiotensin II antagonist Drugs 0.000 title 1
- 239000002333 angiotensin II receptor antagonist Substances 0.000 title 1
- 230000000694 effects Effects 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 230000002035 prolonged effect Effects 0.000 title 1
- 102000005862 Angiotensin II Human genes 0.000 abstract 2
- 101800000733 Angiotensin-2 Proteins 0.000 abstract 2
- CZGUSIXMZVURDU-JZXHSEFVSA-N Ile(5)-angiotensin II Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C([O-])=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=[NH2+])NC(=O)[C@@H]([NH3+])CC([O-])=O)C(C)C)C1=CC=C(O)C=C1 CZGUSIXMZVURDU-JZXHSEFVSA-N 0.000 abstract 2
- 229950006323 angiotensin ii Drugs 0.000 abstract 2
- 230000003042 antagnostic effect Effects 0.000 abstract 2
- 229920002988 biodegradable polymer Polymers 0.000 abstract 1
- 239000004621 biodegradable polymer Substances 0.000 abstract 1
- 230000036772 blood pressure Effects 0.000 abstract 1
- 230000027288 circadian rhythm Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003405 delayed action preparation Substances 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Cardiology (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Plural Heterocyclic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5236698 | 1998-03-04 | ||
| PCT/JP1999/001011 WO1999044590A1 (en) | 1998-03-04 | 1999-03-03 | Sustained-release preparation for aii antagonist, production and use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EE200000499A true EE200000499A (et) | 2002-02-15 |
Family
ID=12912818
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EEP200000499A EE200000499A (et) | 1998-03-04 | 1999-03-03 | Angiotensiin II antagonistliku toimega toimeainetprolongeeritult vabastav preparaat, selle valmistamise meetod ja kasutamine |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US6589547B1 (et) |
| EP (1) | EP1058541B1 (et) |
| KR (1) | KR20010086245A (et) |
| CN (1) | CN1291888A (et) |
| AT (1) | ATE258430T1 (et) |
| AU (1) | AU2745199A (et) |
| BR (1) | BR9908474A (et) |
| CA (1) | CA2318446C (et) |
| DE (1) | DE69914460T2 (et) |
| EE (1) | EE200000499A (et) |
| ES (1) | ES2214013T3 (et) |
| HU (1) | HUP0101439A3 (et) |
| ID (1) | ID25640A (et) |
| IL (1) | IL137979A0 (et) |
| LT (1) | LT4800B (et) |
| LV (1) | LV12585B (et) |
| NO (1) | NO20004350L (et) |
| PL (1) | PL342684A1 (et) |
| SK (1) | SK11902000A3 (et) |
| WO (1) | WO1999044590A1 (et) |
| ZA (1) | ZA991706B (et) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ID25640A (id) * | 1998-03-04 | 2000-10-19 | Takeda Chemical Industries Ltd | Preparat pelepasan terus menerus untuk antagonistik aii, produksi dan penggunaannya |
| PT1197223E (pt) | 1999-04-28 | 2005-04-29 | Takeda Pharmaceutical | Preventivos/medicamentos/inibidores da progressao de retinopatia simples ou retinopatia pre-proliferativa |
| SE9903028D0 (sv) * | 1999-08-27 | 1999-08-27 | Astra Ab | New use |
| RU2276997C2 (ru) | 1999-08-30 | 2006-05-27 | Санофи-Авентис Дойчланд Гмбх | Применение ингибиторов ренин-ангиотензиновой системы для профилактики сердечно-сосудистых явлений |
| AU3408801A (en) * | 2000-02-18 | 2001-08-27 | Takeda Chemical Industries Ltd | Tnf-alpha inhibitors |
| AU2001232348A1 (en) * | 2000-02-21 | 2001-08-27 | Takeda Chemical Industries Ltd. | Sustained release preparations of physiologically active compound hardly solublein water and production process and use of the same |
| EP1312379A4 (en) * | 2000-08-25 | 2004-08-25 | Takeda Chemical Industries Ltd | FIBRINOGENING AGENTS |
| AU2002210925A1 (en) * | 2000-10-25 | 2002-05-06 | Takeda Chemical Industries Ltd. | Preventives/remedies for portal hypertension |
| US20040121008A1 (en) * | 2001-03-16 | 2004-06-24 | Keiko Shiraishi | Process for producing sustained release preparation |
| WO2003013609A1 (fr) * | 2001-08-03 | 2003-02-20 | Takeda Chemical Industries, Ltd. | Medicaments a liberation continue |
| BRPI0105509B8 (pt) * | 2001-11-05 | 2021-05-25 | Univ Minas Gerais | formulações do peptídeo angiotensina-(1-7) usando as ciclodextrinas, lipossomas e o polímero plga |
| US7812044B2 (en) | 2001-11-13 | 2010-10-12 | Takeda Pharmaceutical Company Limited | Anticancer agents |
| CA2468827A1 (en) * | 2001-12-03 | 2003-06-12 | Takeda Chemical Industries, Ltd. | Insulin resistance improving agents |
| US7700074B2 (en) * | 2002-02-07 | 2010-04-20 | Pettegrew Jay W | Method and system for diagnosis of neuropsychiatric disorders including chronic alcoholism |
| US7407778B2 (en) * | 2002-02-07 | 2008-08-05 | Pettegrew Jay W | Compounds, compositions and methods for treating neuropsychiatric disorders |
| AU2003292775A1 (en) * | 2002-12-27 | 2004-07-29 | Takeda Pharmaceutical Company Limited | Body weight gain inhibitor |
| US20050038093A1 (en) * | 2003-05-02 | 2005-02-17 | Boehringer Ingelheim International Gmbh | Treating diabetic retinopathy with angiotensin II receptor blockers |
| US7815894B2 (en) * | 2003-05-29 | 2010-10-19 | Jay W. Pettegrew | Compounds, compositions and methods for medical imaging of neuropsychiatric disorders |
| US20060257842A1 (en) * | 2003-05-29 | 2006-11-16 | Pettegrew Jay W | Cryopreservation media and molecules |
| WO2005097109A1 (en) * | 2004-04-01 | 2005-10-20 | Daniel Batlle | Methods for achieving a protective ace2 expression level |
| ATE493973T1 (de) | 2004-06-04 | 2011-01-15 | Teva Pharma | Irbesartan enthaltende pharmazeutische zusammensetzung |
| BRPI0516246A (pt) * | 2004-10-07 | 2008-08-26 | Takeda Pharmaceutical | agente para a profilaxia ou tratamento de sìndrome metabólica, método para a profilaxia ou tratamento de sìndrome metabólica em um mamìfero, e, uso de ácido 2-etóxi-1-[ [2'-(5-oxo-2,5-diidro-1,2,4-oxadiazol-3-il) bifenil-4-il]metil] -1h-benzimidazol-7-carboxìlico ou um sal do mesmo ou uma pró-droga do mesmo em combinação com uma substáncia semelhante ao agonista de ppargama |
| JPWO2006046528A1 (ja) * | 2004-10-29 | 2008-05-22 | 興和株式会社 | 糸球体疾患治療剤 |
| CA2598410A1 (fr) * | 2005-02-21 | 2006-08-24 | Flamel Technologies | Forme pharmaceutique orale de losartan |
| EP1863801B1 (en) * | 2005-03-30 | 2010-09-29 | Takeda Pharmaceutical Company Limited | Benzimidazole derivative and use thereof |
| EP1926705B3 (en) * | 2005-08-22 | 2010-09-15 | Alembic Limited | Process for preparing valsartan |
| EA016728B1 (ru) * | 2006-08-10 | 2012-07-30 | Такеда Фармасьютикал Компани Лимитед | Фармацевтическая композиция |
| EP1897537A1 (en) * | 2006-09-04 | 2008-03-12 | Novartis AG | Composition comprising an angiotensin II receptor antagonist |
| PE20081364A1 (es) * | 2006-09-04 | 2008-12-04 | Novartis Ag | Composicion farmaceutica que comprende valsartan |
| EP1908469A1 (en) | 2006-10-06 | 2008-04-09 | Boehringer Ingelheim Vetmedica Gmbh | Angiotensin II receptor antagonist for the treatment of systemic diseases in cats |
| GEP20125597B (en) | 2006-12-18 | 2012-08-10 | Takeda Pharmaceutical | Sustained-release composition and production method thereof |
| CN101011393B (zh) * | 2007-02-16 | 2010-10-06 | 广州柏赛罗药业有限公司 | 厄贝沙坦胃内滞留型缓释药物组合物 |
| AU2008235790B2 (en) * | 2007-03-28 | 2013-06-06 | Takeda Pharmaceutical Company Limited | Solid pharmaceutical composition comprising a benzimidazole-7-carboxylate derivative and a pH control agent |
| US20110117194A1 (en) * | 2008-04-29 | 2011-05-19 | Hanall Biopharma Co., Ltd. | Pharmaceutical formulation containing angiotensin-ii receptor blocker |
| AU2010251194B2 (en) | 2009-05-20 | 2016-02-25 | Boehringer Ingelheim Vetmedica Gmbh | Pharmaceutical oral telmisartan solution |
| WO2018002673A1 (en) | 2016-07-01 | 2018-01-04 | N4 Pharma Uk Limited | Novel formulations of angiotensin ii receptor antagonists |
Family Cites Families (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2751907A (en) * | 1953-09-18 | 1956-06-26 | Bishop & Co Platinum Works J | Pellet injector |
| JPS5671074A (en) | 1979-11-12 | 1981-06-13 | Takeda Chem Ind Ltd | 1,2-disubstituted-4-halogenoimidazole-5-acetic acid derivative |
| JPS5671073A (en) | 1979-11-12 | 1981-06-13 | Takeda Chem Ind Ltd | Imidazole derivative |
| IE802177L (en) | 1980-10-21 | 1981-05-12 | Takeda Chemical Industries Ltd | Imidazol-5-ylacetic acid derivatives |
| JPS58157768A (ja) | 1982-03-16 | 1983-09-19 | Takeda Chem Ind Ltd | 4−クロロ−2−フエニルイミダゾ−ル−5−酢酸誘導体 |
| CA1334092C (en) | 1986-07-11 | 1995-01-24 | David John Carini | Angiotensin ii receptor blocking imidazoles |
| US4820843A (en) | 1987-05-22 | 1989-04-11 | E. I. Du Pont De Nemours And Company | Tetrazole intermediates to antihypertensive compounds |
| US4880804A (en) | 1988-01-07 | 1989-11-14 | E. I. Du Pont De Nemours And Company | Angiotensin II receptor blocking benzimidazoles |
| US5015651A (en) | 1988-01-07 | 1991-05-14 | E. I. Du Pont De Nemours And Company | Treatment of hypertension with 1,2,4-angiotensin II antagonists |
| CA1338238C (en) | 1988-01-07 | 1996-04-09 | David John Carini | Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids |
| US4898732A (en) * | 1988-05-04 | 1990-02-06 | The Clinipad Corporation | Inhibiting of tumor growth with an antagonist of the renin-angioten-sin system |
| DE3928177A1 (de) | 1989-04-08 | 1991-02-28 | Thomae Gmbh Dr K | Benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| IE64514B1 (en) | 1989-05-23 | 1995-08-09 | Zeneca Ltd | Azaindenes |
| ATE107517T1 (de) * | 1989-05-25 | 1994-07-15 | Takeda Chemical Industries Ltd | Transdermales therapeutisches mittel. |
| CA2018443A1 (en) | 1989-06-14 | 1990-12-14 | Joseph A. Finkelstein | Imidazolyl-alkenoic acids |
| WO1991000277A1 (en) | 1989-06-30 | 1991-01-10 | E.I. Du Pont De Nemours And Company | Substituted imidazoles |
| CA2020073A1 (en) | 1989-07-03 | 1991-01-04 | Eric E. Allen | Substituted quinazolinones as angiotensin ii antagonists |
| EP0407342A3 (en) | 1989-07-06 | 1991-07-10 | Ciba-Geigy Ag | Pyrimidine derivatives |
| EP0409332A3 (en) | 1989-07-19 | 1991-08-07 | Merck & Co. Inc. | Substituted triazoles as angiotensin ii antagonists |
| US5225205A (en) * | 1989-07-28 | 1993-07-06 | Debiopharm S.A. | Pharmaceutical composition in the form of microparticles |
| ATE113281T1 (de) | 1989-08-02 | 1994-11-15 | Takeda Chemical Industries Ltd | Pyrazol-derivate, verfahren zu deren herstellung und anwendung. |
| IL95975A (en) | 1989-10-24 | 1997-06-10 | Takeda Chemical Industries Ltd | N-benzyl- 2-alkylbenzimidazole derivatives, their production and pharmaceutical compositions containing them |
| EP0434038A1 (en) | 1989-12-22 | 1991-06-26 | Takeda Chemical Industries, Ltd. | Fused imidazole derivatives, their production and use |
| DE69129998T2 (de) | 1990-02-15 | 1998-12-24 | Takeda Chemical Industries, Ltd., Osaka | Pyrimidindionderivate, deren Herstellung und Verwendung |
| CA2036618C (en) * | 1990-02-22 | 2002-10-29 | Akira Morimoto | Fused thiophene derivatives, their production and use |
| IL99246A0 (en) * | 1990-09-10 | 1992-07-15 | Abbott Lab | Angiotensin ii receptor antagonists and pharmaceutical compositions containing them |
| US5171217A (en) * | 1991-02-28 | 1992-12-15 | Indiana University Foundation | Method for delivery of smooth muscle cell inhibitors |
| TW274551B (et) | 1991-04-16 | 1996-04-21 | Takeda Pharm Industry Co Ltd | |
| CZ36394A3 (en) * | 1991-08-19 | 1994-07-13 | Du Pont | Substituted imidazilonone derivatives and pharmaceutical preparations based thereon |
| TW284688B (et) * | 1991-11-20 | 1996-09-01 | Takeda Pharm Industry Co Ltd | |
| US5656297A (en) | 1992-03-12 | 1997-08-12 | Alkermes Controlled Therapeutics, Incorporated | Modulated release from biocompatible polymers |
| GB2272899A (en) * | 1992-11-30 | 1994-06-01 | Du Pont Merck Pharma | Angiotensin-11 receptor blocking cycloalkylbenzylimidazoles |
| EP0603712B1 (en) | 1992-12-22 | 2001-08-16 | Takeda Chemical Industries, Ltd. | Heterocyclic compounds having angiotensin II antagonistic activity and use thereof |
| US5288720A (en) * | 1993-04-23 | 1994-02-22 | American Cyanamid Company | Angiotensin II receptor blocking 2,3,6 substituted quinazolinones |
| US5721263A (en) * | 1993-06-07 | 1998-02-24 | Takeda Chemical Industries, Ltd. | Pharmaceutical composition for angiotensin II-mediated diseases |
| EP1652539B8 (en) * | 1993-07-19 | 2011-06-15 | Angiotech Pharmaceuticals, Inc. | Method of manufacturing a stent comprising an anti-angiogenic composition |
| JPH0789849A (ja) | 1993-09-20 | 1995-04-04 | Fujisawa Pharmaceut Co Ltd | 徐放性製剤 |
| WO1997001331A2 (en) * | 1995-06-27 | 1997-01-16 | Takeda Chemical Industries, Ltd. | Method of producing sustained-release preparation |
| NZ332008A (en) | 1996-03-29 | 1999-05-28 | Smithkline Beecham Corp | Eprosartan dihydrate and a process for its production and formulation |
| GB9613470D0 (en) * | 1996-06-27 | 1996-08-28 | Ciba Geigy Ag | Small solid oral dosage form |
| US6201002B1 (en) * | 1997-01-10 | 2001-03-13 | Merck & Co., Inc. | Method for reducing mortality with an angiotensin II antagonist |
| US5958884A (en) * | 1997-04-11 | 1999-09-28 | The Brigham And Women's Hospital, Inc. | Compositions and methods for treating erectile dysfunction |
| US6306826B1 (en) * | 1997-06-04 | 2001-10-23 | The Regents Of The University Of California | Treatment of heart failure with growth hormone |
| DE19741635A1 (de) * | 1997-09-22 | 1999-03-25 | Hoechst Marion Roussel De Gmbh | Biphenylsulfonylcyanamide, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament |
| ID25640A (id) * | 1998-03-04 | 2000-10-19 | Takeda Chemical Industries Ltd | Preparat pelepasan terus menerus untuk antagonistik aii, produksi dan penggunaannya |
-
1999
- 1999-03-03 ID IDW20001680A patent/ID25640A/id unknown
- 1999-03-03 CN CN99803444A patent/CN1291888A/zh active Pending
- 1999-03-03 PL PL99342684A patent/PL342684A1/xx unknown
- 1999-03-03 HU HU0101439A patent/HUP0101439A3/hu unknown
- 1999-03-03 AT AT99907846T patent/ATE258430T1/de not_active IP Right Cessation
- 1999-03-03 ES ES99907846T patent/ES2214013T3/es not_active Expired - Lifetime
- 1999-03-03 KR KR1020007008919A patent/KR20010086245A/ko not_active Abandoned
- 1999-03-03 DE DE69914460T patent/DE69914460T2/de not_active Expired - Lifetime
- 1999-03-03 AU AU27451/99A patent/AU2745199A/en not_active Abandoned
- 1999-03-03 BR BR9908474-0A patent/BR9908474A/pt not_active IP Right Cessation
- 1999-03-03 EP EP99907846A patent/EP1058541B1/en not_active Expired - Lifetime
- 1999-03-03 EE EEP200000499A patent/EE200000499A/et unknown
- 1999-03-03 CA CA002318446A patent/CA2318446C/en not_active Expired - Fee Related
- 1999-03-03 SK SK1190-2000A patent/SK11902000A3/sk unknown
- 1999-03-03 WO PCT/JP1999/001011 patent/WO1999044590A1/en not_active Ceased
- 1999-03-03 ZA ZA9901706A patent/ZA991706B/xx unknown
- 1999-03-03 IL IL13797999A patent/IL137979A0/xx unknown
- 1999-03-09 US US09/601,986 patent/US6589547B1/en not_active Expired - Fee Related
-
2000
- 2000-08-16 LV LVP-00-110A patent/LV12585B/en unknown
- 2000-08-31 LT LT2000082A patent/LT4800B/lt not_active IP Right Cessation
- 2000-09-01 NO NO20004350A patent/NO20004350L/no unknown
-
2003
- 2003-05-22 US US10/443,308 patent/US7294344B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0101439A3 (en) | 2002-09-30 |
| IL137979A0 (en) | 2001-10-31 |
| LV12585A (en) | 2000-12-20 |
| BR9908474A (pt) | 2000-12-05 |
| US6589547B1 (en) | 2003-07-08 |
| HUP0101439A2 (hu) | 2001-10-28 |
| CN1291888A (zh) | 2001-04-18 |
| DE69914460T2 (de) | 2004-10-28 |
| CA2318446A1 (en) | 1999-09-10 |
| NO20004350L (no) | 2000-10-03 |
| CA2318446C (en) | 2008-09-23 |
| US20030198676A1 (en) | 2003-10-23 |
| LT2000082A (en) | 2001-03-26 |
| LT4800B (lt) | 2001-06-25 |
| WO1999044590A1 (en) | 1999-09-10 |
| ZA991706B (en) | 2000-10-03 |
| NO20004350D0 (no) | 2000-09-01 |
| ID25640A (id) | 2000-10-19 |
| ATE258430T1 (de) | 2004-02-15 |
| LV12585B (en) | 2001-03-20 |
| PL342684A1 (en) | 2001-07-02 |
| ES2214013T3 (es) | 2004-09-01 |
| AU2745199A (en) | 1999-09-20 |
| KR20010086245A (ko) | 2001-09-10 |
| SK11902000A3 (sk) | 2001-02-12 |
| EP1058541B1 (en) | 2004-01-28 |
| US7294344B2 (en) | 2007-11-13 |
| DE69914460D1 (de) | 2004-03-04 |
| EP1058541A1 (en) | 2000-12-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EE200000499A (et) | Angiotensiin II antagonistliku toimega toimeainetprolongeeritult vabastav preparaat, selle valmistamise meetod ja kasutamine | |
| DE69926919D1 (de) | N-ureidoalkylpiperidine als modulatoren der aktivität der chemokinrezeptoren | |
| DK1288223T3 (da) | Terapeutiske peptidderivater | |
| CY1115869T1 (el) | Χρηση ανταγωνιστων του υποδοχεα τυπου 1 της αγγειοτενσινης ii για την προληψη του διαβητη | |
| TR200101859T2 (tr) | Kemokin alıcı aktivitesinin modülatörleri olarak N-üreidoalkil-piperidinler | |
| BR0110028A (pt) | Uso de antagonistas-ngf para a prevenção ou tratamento de dor visceral crÈnica | |
| BG66085B1 (bg) | Фенилаланинови производни | |
| EA200301165A1 (ru) | Лекарственное средство на основе оксикодона | |
| DK0976722T3 (da) | Benzamidin-derivater | |
| EA199700253A1 (ru) | Производные нодулиспоровой кислоты | |
| CY1118924T1 (el) | Μεθοδος για θεραπεια της πρωτοπαθους αϋπνιας | |
| EA200200742A1 (ru) | 1,2-диарилбензимидазолы для лечения заболеваний, связанных с активацией микроглии | |
| EE05054B1 (et) | 5-HT4 agonisti v?i antagonisti peroraalne ravimkoostis ja selle kasutamine meditsiinis | |
| ATE295183T1 (de) | Mittel zur linderung von juckreiz, enthaltend pgd2- antagonisten | |
| UA27713C2 (uk) | Амідинові похідні бензолу, що мають гіпоглікемічну активність, та їх фармацевтично прийнятні солі | |
| CO4940452A1 (es) | Modificacion a cristal de una sustancia activa de medicamen- to | |
| DE60028928D1 (de) | Verwendung von angiotensin ii rezeptorantagonisten zur behandlung von akutem myokardischen infarkt | |
| EA200100089A1 (ru) | Предотвращение рецидива мигрени | |
| ATE326451T1 (de) | Chinazolin derivate und therapeutische verwendungen davon | |
| EA200601592A1 (ru) | Фармацевтическая композиция, содержащая ингибитор pde4 или pde3/4 и антагонист гистаминового рецептора | |
| ES2166816T3 (es) | Derivados piridil-imidazolicos y procedimientos para su preparacion. | |
| NO20001548D0 (no) | Endotelinantagonist og en renin-angiotensinsystem inhibitor som et kombinert preparat | |
| EA200101106A1 (ru) | Фармацевтический комплекс | |
| DE59910944D1 (de) | Transdermales therapeutisches system zur anwendung von candesartan | |
| EA200401617A1 (ru) | Комбинация nmda-антагониста и ингибиторов ацетилхолинэстеразы для лечения болезни альцгеймера |